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The map label for this gene is glmU [H]

Identifier: 167039245

GI number: 167039245

Start: 607768

End: 609177

Strand: Direct

Name: glmU [H]

Synonym: Teth514_0586

Alternate gene names: 167039245

Gene position: 607768-609177 (Clockwise)

Preceding gene: 167039244

Following gene: 167039246

Centisome position: 24.73

GC content: 37.87

Gene sequence:

>1410_bases
ATGAGAATTAAATTTAGTATAGAGGGTGTGGAAAAATTGGAAGGGCTAGTGACGCTTATTTTAGCGGCGGGTCTTGGGAA
AAGAATGAAATCTAAGCATCCCAAGGTGATTCATAAAGTTTGTGGTAAACCGATGATAGAATGGGTAGTAGATGCGGTGG
AAAAAATAGGAAGTAACGAAGTAATTGTAGTAGTCGGCCACAAAGCAGAAGAAGTTAAGGAAGTTTTAAAAGAAAGAGTC
AAGTATGCTTATCAAGAAGTGCAGTTAGGCACAGGTCATGCTGTGATGATGGCGGAAGACTTACTCCCTGAGGAAGGTAA
TGTTCTGATTTTGACTGGAGATACGCCCCTTATTACCTCCAATACCTTAAAAGAATTAATAAATTTTCATATTAAAGAGC
ATAACAGTGTCACTATTTTGTCTTCAGTATTAGAAGACCCTACAGGTTATGGGAGGATAATAAGGGATGAAAGTGGAAAC
GTTATAAAGATTGTGGAAGATAAAGATGCGACGGAAGAAGAAAAAAGCATCCATGAGATAAATTCTGCCATGTACGTTAT
GGATATAGCCAAACTAAAAAAGGCGTTAAGAAGGATAACCAATAATAACGCACAGGGTGAATATTATCTGACGGATGCTG
TGGAAATTATAAGAGATATGGATGGAAAAATTGGCGCTTTTACTGTACCTTCAGAGGAGATAACGGGAGTAAATTCAAGG
GTCCAGCTTTTTGAAGCAGAGAAAATAATGAGAAAGCGGATTAATTATCGTCACATGGAAAACGGAGTAACAATAGTGGA
CCCTGATACCACTTATATAGGAGCTGAAGTGGAGATTGGAGCAGATACTGTAATATTGCCTGGTTGTGTTATAGAAGGGA
AAACGAAAATAGGAAGTGATTGTGAGATAGGGCCTAATTGTAGGATTGTTGATTCAGAAATCGGTGATGGATGTAGTGTC
ACGTATTCGGTAATACTCTCTTCAAAAATAGGAAATAATGTTAAAATAGGACCTTTTGCCCACATAAGGCCAGAAACTGT
GATACAGAGTAATGTCAAAATAGGGGATTTTGTAGAGATAAAGAAGTCAATAATTGATGAAGGGAGTAAAGTTCCTCATC
TTACGTATGTGGGAGACGCGGAAGTTGGTAAAAATGTCAATATGGGATGTGGCTCTATTACAGTTAATTATGATGGTAAA
CAAAAGTACAAGACAGTGATAGGAGATAATGTTTTCGTGGGATGTAATGTAAATCTTGTAGCGCCAGTAAAGATTGGAAA
TAATGCTTATATTGCTGCTGGTTCAACTATAACAGAGAATGTTCCTGAAGGAGCCCTTGCCATAGCCAGAAATAGGCAAA
CTAATAAAGAGGGCTGGGTACAGGAAAGAATAAAAAAAGGGAGGCTTTAA

Upstream 100 bases:

>100_bases
AAAAGAACAAGAAGCTGCACATAAGGAATAAAAAGGAGCTTGTCTCCTTTTTATTTTTTTGTTGAACTTTGCTGCAATTA
TAGTTAAAATAGTATAGGGT

Downstream 100 bases:

>100_bases
ATTAAATGGTAAGATATAATAGTTCTCTAAAAATTTTTTCAGGAAATTCAAATCCTAAGTTAGCCAGTGAAATAGCAGAA
CATCTTGGACTTAAACTTTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRIKFSIEGVEKLEGLVTLILAAGLGKRMKSKHPKVIHKVCGKPMIEWVVDAVEKIGSNEVIVVVGHKAEEVKEVLKERV
KYAYQEVQLGTGHAVMMAEDLLPEEGNVLILTGDTPLITSNTLKELINFHIKEHNSVTILSSVLEDPTGYGRIIRDESGN
VIKIVEDKDATEEEKSIHEINSAMYVMDIAKLKKALRRITNNNAQGEYYLTDAVEIIRDMDGKIGAFTVPSEEITGVNSR
VQLFEAEKIMRKRINYRHMENGVTIVDPDTTYIGAEVEIGADTVILPGCVIEGKTKIGSDCEIGPNCRIVDSEIGDGCSV
TYSVILSSKIGNNVKIGPFAHIRPETVIQSNVKIGDFVEIKKSIIDEGSKVPHLTYVGDAEVGKNVNMGCGSITVNYDGK
QKYKTVIGDNVFVGCNVNLVAPVKIGNNAYIAAGSTITENVPEGALAIARNRQTNKEGWVQERIKKGRL

Sequences:

>Translated_469_residues
MRIKFSIEGVEKLEGLVTLILAAGLGKRMKSKHPKVIHKVCGKPMIEWVVDAVEKIGSNEVIVVVGHKAEEVKEVLKERV
KYAYQEVQLGTGHAVMMAEDLLPEEGNVLILTGDTPLITSNTLKELINFHIKEHNSVTILSSVLEDPTGYGRIIRDESGN
VIKIVEDKDATEEEKSIHEINSAMYVMDIAKLKKALRRITNNNAQGEYYLTDAVEIIRDMDGKIGAFTVPSEEITGVNSR
VQLFEAEKIMRKRINYRHMENGVTIVDPDTTYIGAEVEIGADTVILPGCVIEGKTKIGSDCEIGPNCRIVDSEIGDGCSV
TYSVILSSKIGNNVKIGPFAHIRPETVIQSNVKIGDFVEIKKSIIDEGSKVPHLTYVGDAEVGKNVNMGCGSITVNYDGK
QKYKTVIGDNVFVGCNVNLVAPVKIGNNAYIAAGSTITENVPEGALAIARNRQTNKEGWVQERIKKGRL
>Mature_469_residues
MRIKFSIEGVEKLEGLVTLILAAGLGKRMKSKHPKVIHKVCGKPMIEWVVDAVEKIGSNEVIVVVGHKAEEVKEVLKERV
KYAYQEVQLGTGHAVMMAEDLLPEEGNVLILTGDTPLITSNTLKELINFHIKEHNSVTILSSVLEDPTGYGRIIRDESGN
VIKIVEDKDATEEEKSIHEINSAMYVMDIAKLKKALRRITNNNAQGEYYLTDAVEIIRDMDGKIGAFTVPSEEITGVNSR
VQLFEAEKIMRKRINYRHMENGVTIVDPDTTYIGAEVEIGADTVILPGCVIEGKTKIGSDCEIGPNCRIVDSEIGDGCSV
TYSVILSSKIGNNVKIGPFAHIRPETVIQSNVKIGDFVEIKKSIIDEGSKVPHLTYVGDAEVGKNVNMGCGSITVNYDGK
QKYKTVIGDNVFVGCNVNLVAPVKIGNNAYIAAGSTITENVPEGALAIARNRQTNKEGWVQERIKKGRL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=371, Percent_Identity=22.911051212938, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI11761619, Length=320, Percent_Identity=23.75, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=43.2372505543237, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931050, Length=387, Percent_Identity=25.8397932816537, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=381, Percent_Identity=24.9343832020997, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21355443, Length=387, Percent_Identity=23.2558139534884, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644084, Length=387, Percent_Identity=23.2558139534884, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 51383; Mature: 51383

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKFSIEGVEKLEGLVTLILAAGLGKRMKSKHPKVIHKVCGKPMIEWVVDAVEKIGSNE
CEEEEECCHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCC
VIVVVGHKAEEVKEVLKERVKYAYQEVQLGTGHAVMMAEDLLPEEGNVLILTGDTPLITS
EEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEH
NTLKELINFHIKEHNSVTILSSVLEDPTGYGRIIRDESGNVIKIVEDKDATEEEKSIHEI
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHH
NSAMYVMDIAKLKKALRRITNNNAQGEYYLTDAVEIIRDMDGKIGAFTVPSEEITGVNSR
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCEEEEECCHHHHCCCCHH
VQLFEAEKIMRKRINYRHMENGVTIVDPDTTYIGAEVEIGADTVILPGCVIEGKTKIGSD
HHHHHHHHHHHHHCCHHHHCCCCEEECCCCEEEEEEEEECCCEEEECCEEEECCCCCCCC
CEIGPNCRIVDSEIGDGCSVTYSVILSSKIGNNVKIGPFAHIRPETVIQSNVKIGDFVEI
CCCCCCCEEEECCCCCCCCEEEEEEEHHCCCCCEEECCCCCCCCHHHHHCCCCCCHHHHH
KKSIIDEGSKVPHLTYVGDAEVGKNVNMGCGSITVNYDGKQKYKTVIGDNVFVGCNVNLV
HHHHHCCCCCCCEEEEECCHHCCCCCCCCCCEEEEECCCCHHHHHHCCCCEEEECCEEEE
APVKIGNNAYIAAGSTITENVPEGALAIARNRQTNKEGWVQERIKKGRL
EEEEECCCEEEEECCCHHCCCCCCCEEEECCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRIKFSIEGVEKLEGLVTLILAAGLGKRMKSKHPKVIHKVCGKPMIEWVVDAVEKIGSNE
CEEEEECCHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCC
VIVVVGHKAEEVKEVLKERVKYAYQEVQLGTGHAVMMAEDLLPEEGNVLILTGDTPLITS
EEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEH
NTLKELINFHIKEHNSVTILSSVLEDPTGYGRIIRDESGNVIKIVEDKDATEEEKSIHEI
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHH
NSAMYVMDIAKLKKALRRITNNNAQGEYYLTDAVEIIRDMDGKIGAFTVPSEEITGVNSR
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCEEEEECCHHHHCCCCHH
VQLFEAEKIMRKRINYRHMENGVTIVDPDTTYIGAEVEIGADTVILPGCVIEGKTKIGSD
HHHHHHHHHHHHHCCHHHHCCCCEEECCCCEEEEEEEEECCCEEEECCEEEECCCCCCCC
CEIGPNCRIVDSEIGDGCSVTYSVILSSKIGNNVKIGPFAHIRPETVIQSNVKIGDFVEI
CCCCCCCEEEECCCCCCCCEEEEEEEHHCCCCCEEECCCCCCCCHHHHHCCCCCCHHHHH
KKSIIDEGSKVPHLTYVGDAEVGKNVNMGCGSITVNYDGKQKYKTVIGDNVFVGCNVNLV
HHHHHCCCCCCCEEEEECCHHCCCCCCCCCCEEEEECCCCHHHHHHCCCCEEEECCEEEE
APVKIGNNAYIAAGSTITENVPEGALAIARNRQTNKEGWVQERIKKGRL
EEEEECCCEEEEECCCHHCCCCCCCEEEECCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA