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The map label for this gene is 167039165

Identifier: 167039165

GI number: 167039165

Start: 520243

End: 521136

Strand: Direct

Name: 167039165

Synonym: Teth514_0506

Alternate gene names: NA

Gene position: 520243-521136 (Clockwise)

Preceding gene: 167039164

Following gene: 167039166

Centisome position: 21.17

GC content: 33.0

Gene sequence:

>894_bases
ATGAAATATAGTGTGGAAGAAAAGGGGACAAAGGTAATTGTAAGGGGGATTGAAGACTTTAATCTTAAGGAGACTTTTGA
ATGCGGACAGTGTTTTAGATGGAATGAAGAAGAGGATGGGAGCTATACAGGAGTTGCTTACGATAGAGTCATAAACGTGA
AATTGGAAGAAGACATGTTGATAATTGACAATACAGATTTAAATGACTTTTATGACATTTGGTTTGACTATTTTGATTTG
GGAAGGGATTATAAGCAAATAAAAGAAAATCTTTCAAGAGATCCCATATTAAAAGAAGCAATTCAATATGGGCAAGGTAT
AAGGATTTTGCGCCAAGATACATGGGAAACTCTAGTCTCTTTTATAATCTCACAAAATAATAGAATACCCCAAATAAAAA
AAGTTATAGAAAATCTTGCTAGTTCCTTTGGAGAGCCAATTGAGTACAAAGGAAAAATCTATTACACTTTTCCTAAAGCA
GAAGAATTAGTTATGTTTGATGTTGAGACGATTGCCAAGACAAAATGCGGTTTTAGAGCGAAATATATACTGGACGCGGC
TTCTAAAGTTTTTTCTGGAGAAATAGATCTTTTAAAATTGTTTGAATACAGCACTAATGACATAAGAGATATTCTTATGA
ATATAAACGGAGTGGGTCCTAAAGTTGCAGATTGTGTCATTTTGTATTCAATAGGGAGATATGACACTTTTCCTACAGAT
GTATGGATAAAAAGAATTGTTGAATATTTGTATTTAAAAAGAGAGGGAACCCCTTTGGAGATTCAACTATTTGCAATAGA
TAAATTTGGAGATTTGTCTGGTTTTGCGCAACAGTATTTATTCTATTATGGTAGGGAGATGGGGAAAAAAATCTTTAACG
AAAGGAAGAAATAG

Upstream 100 bases:

>100_bases
TTCGGCTTTTTTTTGTACAGAAAAAATTATATAATAATAATTAACAGGATAGAGAAATATGATAGTTAGTAAGTAAATAA
ACTCAATGTGGGTGAGGAAG

Downstream 100 bases:

>100_bases
ATGCTAGGAACTATTGTAAATTCAATTGCAATAATTGTGGGTGGTACTATTGGTACCCTTCTTAAAGTAGGAATTCCAGA
AAGGTTTAAAAATATAGTCA

Product: 8-oxoguanine DNA glycosylase domain-containing protein

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKYSVEEKGTKVIVRGIEDFNLKETFECGQCFRWNEEEDGSYTGVAYDRVINVKLEEDMLIIDNTDLNDFYDIWFDYFDL
GRDYKQIKENLSRDPILKEAIQYGQGIRILRQDTWETLVSFIISQNNRIPQIKKVIENLASSFGEPIEYKGKIYYTFPKA
EELVMFDVETIAKTKCGFRAKYILDAASKVFSGEIDLLKLFEYSTNDIRDILMNINGVGPKVADCVILYSIGRYDTFPTD
VWIKRIVEYLYLKREGTPLEIQLFAIDKFGDLSGFAQQYLFYYGREMGKKIFNERKK

Sequences:

>Translated_297_residues
MKYSVEEKGTKVIVRGIEDFNLKETFECGQCFRWNEEEDGSYTGVAYDRVINVKLEEDMLIIDNTDLNDFYDIWFDYFDL
GRDYKQIKENLSRDPILKEAIQYGQGIRILRQDTWETLVSFIISQNNRIPQIKKVIENLASSFGEPIEYKGKIYYTFPKA
EELVMFDVETIAKTKCGFRAKYILDAASKVFSGEIDLLKLFEYSTNDIRDILMNINGVGPKVADCVILYSIGRYDTFPTD
VWIKRIVEYLYLKREGTPLEIQLFAIDKFGDLSGFAQQYLFYYGREMGKKIFNERKK
>Mature_297_residues
MKYSVEEKGTKVIVRGIEDFNLKETFECGQCFRWNEEEDGSYTGVAYDRVINVKLEEDMLIIDNTDLNDFYDIWFDYFDL
GRDYKQIKENLSRDPILKEAIQYGQGIRILRQDTWETLVSFIISQNNRIPQIKKVIENLASSFGEPIEYKGKIYYTFPKA
EELVMFDVETIAKTKCGFRAKYILDAASKVFSGEIDLLKLFEYSTNDIRDILMNINGVGPKVADCVILYSIGRYDTFPTD
VWIKRIVEYLYLKREGTPLEIQLFAIDKFGDLSGFAQQYLFYYGREMGKKIFNERKK

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI4505495, Length=288, Percent_Identity=29.5138888888889, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI8670542, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI8670540, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI8670532, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI8670530, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI8670534, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI8670536, Length=219, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI8670538, Length=158, Percent_Identity=30.379746835443, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323580, Length=311, Percent_Identity=30.8681672025724, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640654, Length=271, Percent_Identity=29.1512915129151, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 34831; Mature: 34831

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYSVEEKGTKVIVRGIEDFNLKETFECGQCFRWNEEEDGSYTGVAYDRVINVKLEEDML
CCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCEE
IIDNTDLNDFYDIWFDYFDLGRDYKQIKENLSRDPILKEAIQYGQGIRILRQDTWETLVS
EEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEHHHHHHHHHHH
FIISQNNRIPQIKKVIENLASSFGEPIEYKGKIYYTFPKAEELVMFDVETIAKTKCGFRA
HHHHCCCCCHHHHHHHHHHHHHCCCCCEECCEEEEECCCCCCEEEEEHHHHHHHHCCCHH
KYILDAASKVFSGEIDLLKLFEYSTNDIRDILMNINGVGPKVADCVILYSIGRYDTFPTD
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEEECCCCCCCCHH
VWIKRIVEYLYLKREGTPLEIQLFAIDKFGDLSGFAQQYLFYYGREMGKKIFNERKK
HHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYSVEEKGTKVIVRGIEDFNLKETFECGQCFRWNEEEDGSYTGVAYDRVINVKLEEDML
CCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCEE
IIDNTDLNDFYDIWFDYFDLGRDYKQIKENLSRDPILKEAIQYGQGIRILRQDTWETLVS
EEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEHHHHHHHHHHH
FIISQNNRIPQIKKVIENLASSFGEPIEYKGKIYYTFPKAEELVMFDVETIAKTKCGFRA
HHHHCCCCCHHHHHHHHHHHHHCCCCCEECCEEEEECCCCCCEEEEEHHHHHHHHCCCHH
KYILDAASKVFSGEIDLLKLFEYSTNDIRDILMNINGVGPKVADCVILYSIGRYDTFPTD
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEEECCCCCCCCHH
VWIKRIVEYLYLKREGTPLEIQLFAIDKFGDLSGFAQQYLFYYGREMGKKIFNERKK
HHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]