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The map label for this gene is purE [H]

Identifier: 167039094

GI number: 167039094

Start: 447770

End: 448297

Strand: Direct

Name: purE [H]

Synonym: Teth514_0433

Alternate gene names: 167039094

Gene position: 447770-448297 (Clockwise)

Preceding gene: 167039093

Following gene: 167039095

Centisome position: 18.22

GC content: 39.39

Gene sequence:

>528_bases
ATGAAAAAGCCATTGGCTGGGATTATCATGGGTAGTGATTCAGATTTGCCAGTTATGAAAGAAGCAGCAAAAGTCCTGGA
GGATTTTGGTGTTGAATATGAGATAACAATTGTCTCTGCTCACAGAACCCTTGAGAGGATGTTCAAATATGCAAAAGAGG
CTGAACAAAGAGGGATAGATGTGATTATTGCCGGTGCTGGCGGCGCTGCACATCTTCCTGGAATGGTTGCAGCAATTTCC
TCTTTGCCAGTTATTGGAGTTCCAGTAAAAACATCTTCATTAAATGGTTTGGATTCTCTTTTGTCAATTGTCCAGATGCC
AGCAGGAGTGCCAGTTGCAACTGTAGCAATAAATAATGCCAAAAATGCTGGAATTTTGGCAGCTGAAATCCTTGGCATAA
AGTATCCTGAGATTAGAGAAAAAATAATTGAATTTAAAGAGAAAATGAGAAAAGAAGTAGAAGAAAAGGCTAAAGACTTA
GAAAATATCGGGTATGAAGAGTATCTTGGGAGGAGGCAAAATGCGTAA

Upstream 100 bases:

>100_bases
AAATGGGGCATGTTACAATAGTTGATGATAATTTAGACAGTGCAATAGAAAAGGCTAAAAAAGTAAAGGAAAGATTGAAA
ATTAAATCGGAGGTGGAAAG

Downstream 100 bases:

>100_bases
AGAATCTTACTTTCAAAGACTTCCAAGCAGTAAAACGCGCTGGATTTACATAGCTTTGGGACTGACCATGAACTTCTGCC
TCGGCTCTGTCTATTCGTGG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MKKPLAGIIMGSDSDLPVMKEAAKVLEDFGVEYEITIVSAHRTLERMFKYAKEAEQRGIDVIIAGAGGAAHLPGMVAAIS
SLPVIGVPVKTSSLNGLDSLLSIVQMPAGVPVATVAINNAKNAGILAAEILGIKYPEIREKIIEFKEKMRKEVEEKAKDL
ENIGYEEYLGRRQNA

Sequences:

>Translated_175_residues
MKKPLAGIIMGSDSDLPVMKEAAKVLEDFGVEYEITIVSAHRTLERMFKYAKEAEQRGIDVIIAGAGGAAHLPGMVAAIS
SLPVIGVPVKTSSLNGLDSLLSIVQMPAGVPVATVAINNAKNAGILAAEILGIKYPEIREKIIEFKEKMRKEVEEKAKDL
ENIGYEEYLGRRQNA
>Mature_175_residues
MKKPLAGIIMGSDSDLPVMKEAAKVLEDFGVEYEITIVSAHRTLERMFKYAKEAEQRGIDVIIAGAGGAAHLPGMVAAIS
SLPVIGVPVKTSSLNGLDSLLSIVQMPAGVPVATVAINNAKNAGILAAEILGIKYPEIREKIIEFKEKMRKEVEEKAKDL
ENIGYEEYLGRRQNA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=108, Percent_Identity=55.5555555555556, Blast_Score=130, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=169, Percent_Identity=65.0887573964497, Blast_Score=212, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18890; Mature: 18890

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPLAGIIMGSDSDLPVMKEAAKVLEDFGVEYEITIVSAHRTLERMFKYAKEAEQRGID
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCE
VIIAGAGGAAHLPGMVAAISSLPVIGVPVKTSSLNGLDSLLSIVQMPAGVPVATVAINNA
EEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
KNAGILAAEILGIKYPEIREKIIEFKEKMRKEVEEKAKDLENIGYEEYLGRRQNA
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
>Mature Secondary Structure
MKKPLAGIIMGSDSDLPVMKEAAKVLEDFGVEYEITIVSAHRTLERMFKYAKEAEQRGID
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCE
VIIAGAGGAAHLPGMVAAISSLPVIGVPVKTSSLNGLDSLLSIVQMPAGVPVATVAINNA
EEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
KNAGILAAEILGIKYPEIREKIIEFKEKMRKEVEEKAKDLENIGYEEYLGRRQNA
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]