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The map label for this gene is purK [H]

Identifier: 167039093

GI number: 167039093

Start: 446613

End: 447773

Strand: Direct

Name: purK [H]

Synonym: Teth514_0432

Alternate gene names: 167039093

Gene position: 446613-447773 (Clockwise)

Preceding gene: 167039092

Following gene: 167039094

Centisome position: 18.18

GC content: 33.42

Gene sequence:

>1161_bases
ATGACTAAGAGGATTTTTGGTTATCCAATAATGAAAATTGGCATAATTGGTGGCGGACAGTTAGGAAAAATGTTTGCTCA
AAAGGCAAAGCAAATGGGTTTTTATGTTATTATCTTAGATCCAAATCCTGAATGTCCAGCAACACAGGTTGCAGATGAAC
AAATTATTGGTGATTATTACAATGAGAACAAATTGAAAGAGCTTGTAGAAAAAAGCGATGTCACCACTTATGAGATAGAA
CATATCAATACGGCCATTTTGAAAGAACTATTTGATAAAGGGTATAAAATATACCCCTCACCTTATTCTTTAGAAATTAT
TCAAGATAAACTAAAACAAAAACAGGTGCTAAAAGGTGCTAATCTTCCTGTGCCAAGATTTGAAAAGGTGGAGAATTTTG
AGGTATCTTTCTTTGAAAAATTTGGTTTTCCATTTATTCAAAAAGCTACAAAAGGAGGATATGATGGCAGAGGTGTTGTT
GTTATTAAAGATAAAAATGATTTAGACAAAATGTTGAGGGTAGACTCTTTGATTGAAGAATTTGTCGATATGGGAAAGGA
ATTAGCAGTTATGGTTGCTCGTAATTTACAAGGTGAAATAAAATGTTATCCAGTTGTAGAGATGGTTTTTGACGAATCTG
CGAATATTCTTGATTTGTTAATTGCACCTGCTAGGATTGAAAAAGAAATAGAGGAAAATGTAAAAGAGATAGCAATTAAG
GCAGTTGAAGCTCTTGATGGTATTGGCATTTTTGGTATAGAGATGTTTTTAACAAAAGATAAGAAAATATTGATAAATGA
AATTGCGCCAAGACCACATAACTCTGGGCATTATACAATAGAAGCTTGTGTAACCAGCCAATTTGAACAACACTTAAGAG
CAATTTGTGGTTTTGCATTAGGATCAACCGAATTGTTATCTCCAGCAGTTATGATAAATCTTCTTGGTGAAAAAGGGTAT
AGAGGAGTGCCTTTGATAGAAGGCTTAGAGGAAGTACTCTCAATTGAAGGGGTTTCATTTCATTTTTACGGCAAAAGACT
AACAAGTCCTTACAGAAAAATGGGGCATGTTACAATAGTTGATGATAATTTAGACAGTGCAATAGAAAAGGCTAAAAAAG
TAAAGGAAAGATTGAAAATTAAATCGGAGGTGGAAAGATGA

Upstream 100 bases:

>100_bases
AAATTGGGAGATAATGGATTTTGTCTATGAGGAAGTTATTTGTTATCTTCTAATTATCCTTGTGCGAATCTATTAGAAAG
GAGAGACGTTTTTAGAAAGA

Downstream 100 bases:

>100_bases
AAAAGCCATTGGCTGGGATTATCATGGGTAGTGATTCAGATTTGCCAGTTATGAAAGAAGCAGCAAAAGTCCTGGAGGAT
TTTGGTGTTGAATATGAGAT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTKRIFGYPIMKIGIIGGGQLGKMFAQKAKQMGFYVIILDPNPECPATQVADEQIIGDYYNENKLKELVEKSDVTTYEIE
HINTAILKELFDKGYKIYPSPYSLEIIQDKLKQKQVLKGANLPVPRFEKVENFEVSFFEKFGFPFIQKATKGGYDGRGVV
VIKDKNDLDKMLRVDSLIEEFVDMGKELAVMVARNLQGEIKCYPVVEMVFDESANILDLLIAPARIEKEIEENVKEIAIK
AVEALDGIGIFGIEMFLTKDKKILINEIAPRPHNSGHYTIEACVTSQFEQHLRAICGFALGSTELLSPAVMINLLGEKGY
RGVPLIEGLEEVLSIEGVSFHFYGKRLTSPYRKMGHVTIVDDNLDSAIEKAKKVKERLKIKSEVER

Sequences:

>Translated_386_residues
MTKRIFGYPIMKIGIIGGGQLGKMFAQKAKQMGFYVIILDPNPECPATQVADEQIIGDYYNENKLKELVEKSDVTTYEIE
HINTAILKELFDKGYKIYPSPYSLEIIQDKLKQKQVLKGANLPVPRFEKVENFEVSFFEKFGFPFIQKATKGGYDGRGVV
VIKDKNDLDKMLRVDSLIEEFVDMGKELAVMVARNLQGEIKCYPVVEMVFDESANILDLLIAPARIEKEIEENVKEIAIK
AVEALDGIGIFGIEMFLTKDKKILINEIAPRPHNSGHYTIEACVTSQFEQHLRAICGFALGSTELLSPAVMINLLGEKGY
RGVPLIEGLEEVLSIEGVSFHFYGKRLTSPYRKMGHVTIVDDNLDSAIEKAKKVKERLKIKSEVER
>Mature_385_residues
TKRIFGYPIMKIGIIGGGQLGKMFAQKAKQMGFYVIILDPNPECPATQVADEQIIGDYYNENKLKELVEKSDVTTYEIEH
INTAILKELFDKGYKIYPSPYSLEIIQDKLKQKQVLKGANLPVPRFEKVENFEVSFFEKFGFPFIQKATKGGYDGRGVVV
IKDKNDLDKMLRVDSLIEEFVDMGKELAVMVARNLQGEIKCYPVVEMVFDESANILDLLIAPARIEKEIEENVKEIAIKA
VEALDGIGIFGIEMFLTKDKKILINEIAPRPHNSGHYTIEACVTSQFEQHLRAICGFALGSTELLSPAVMINLLGEKGYR
GVPLIEGLEEVLSIEGVSFHFYGKRLTSPYRKMGHVTIVDDNLDSAIEKAKKVKERLKIKSEVER

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=360, Percent_Identity=28.6111111111111, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788155, Length=390, Percent_Identity=24.3589743589744, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324702, Length=385, Percent_Identity=38.7012987012987, Blast_Score=252, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 43535; Mature: 43404

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRIFGYPIMKIGIIGGGQLGKMFAQKAKQMGFYVIILDPNPECPATQVADEQIIGDYY
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHC
NENKLKELVEKSDVTTYEIEHINTAILKELFDKGYKIYPSPYSLEIIQDKLKQKQVLKGA
CHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCC
NLPVPRFEKVENFEVSFFEKFGFPFIQKATKGGYDGRGVVVIKDKNDLDKMLRVDSLIEE
CCCCCCHHHCCCCHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FVDMGKELAVMVARNLQGEIKCYPVVEMVFDESANILDLLIAPARIEKEIEENVKEIAIK
HHHCCHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
AVEALDGIGIFGIEMFLTKDKKILINEIAPRPHNSGHYTIEACVTSQFEQHLRAICGFAL
HHHHHCCCCCEEEEEEEECCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHC
GSTELLSPAVMINLLGEKGYRGVPLIEGLEEVLSIEGVSFHFYGKRLTSPYRKMGHVTIV
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCHHHCCHHHHCCCEEEE
DDNLDSAIEKAKKVKERLKIKSEVER
ECCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKRIFGYPIMKIGIIGGGQLGKMFAQKAKQMGFYVIILDPNPECPATQVADEQIIGDYY
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHC
NENKLKELVEKSDVTTYEIEHINTAILKELFDKGYKIYPSPYSLEIIQDKLKQKQVLKGA
CHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCC
NLPVPRFEKVENFEVSFFEKFGFPFIQKATKGGYDGRGVVVIKDKNDLDKMLRVDSLIEE
CCCCCCHHHCCCCHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FVDMGKELAVMVARNLQGEIKCYPVVEMVFDESANILDLLIAPARIEKEIEENVKEIAIK
HHHCCHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
AVEALDGIGIFGIEMFLTKDKKILINEIAPRPHNSGHYTIEACVTSQFEQHLRAICGFAL
HHHHHCCCCCEEEEEEEECCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHC
GSTELLSPAVMINLLGEKGYRGVPLIEGLEEVLSIEGVSFHFYGKRLTSPYRKMGHVTIV
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCHHHCCHHHHCCCEEEE
DDNLDSAIEKAKKVKERLKIKSEVER
ECCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA