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The map label for this gene is icd [H]

Identifier: 167038994

GI number: 167038994

Start: 341882

End: 343093

Strand: Reverse

Name: icd [H]

Synonym: Teth514_0327

Alternate gene names: 167038994

Gene position: 343093-341882 (Counterclockwise)

Preceding gene: 167038995

Following gene: 167038959

Centisome position: 13.96

GC content: 36.47

Gene sequence:

>1212_bases
ATGGCTAACAAAATTCAAATGAAGGTACCCCTCGTTGAAATGGACGGGGACGAAATGACAAGAATCATATGGAAATTGAT
AAAAGAAATACTTTTAGAGCCCTATATAGACCTTAAAACGGAATATTATGACCTTGGAATTAAAAACAGAGATAAAACAG
AGGATCAGGTCACGGTTAATGCGGCATATGCCATCAAAAAATATGGTGTCGGCGTAAAATGTGCAACAATTACTCCAAAT
GCCCAGAGAGTTGAAGAATACAACCTTAAAAAAATGTGGAAAAGCCCTAATGGTACAATCAGAGCAATACTTGATGGCAC
AGTTTTTCGCACACCTATTATTGTGGAAAGTATTAAACCTCTCGTAAAAACATGGAAAAAGCCCATTACAATTGCAAGGC
ATGCCTATGGAGACATTTATAAAGATGTAGAATATCGGGTTGAAAACAAAGGAAAAGCAGAACTTGTTTTTACCTCTGAA
ACAGGTGAAGTGTCAAGGCAAACAATACATGAATTTGAAGGTCCTGGTGTCATCCTTGGCATGCACAACACTGATGAATC
GATAAAGAGTTTTGCAAGAGCATGTTTTAACTATGCCTTAGATACAAAGCAAGATTTGTGGTTCGCAACCAAAGACACCA
TATCAAAAATTTATGACCACAGATTTAAAGACATATTCCAGGAAATATACGAAAATGAATATAAAGAAAAATTTGAGAAA
GCGGGAATTGAATATTTCTATACTCTTATTGACGATGCTGTGGCTCGAATTATAAGGTCTGAAGGCGGAATGATTTGGGC
ATGCAAAAATTATGACGGCGATGTAATGTCAGATATGGTAGCAACAGCATTTGGAAGCCTCGCCATGATGACATCTGTGC
TAGTATCTCCTGATGGCAAATACGAATTTGAAGCAGCTCATGGAACAGTTACAAGGCATTATTACAAATACCTTAAAGGA
GAAGAGACCTCTACAAATTCTATTGCTACAATTTTCGCATGGACAGGTGCTTTGAAAAAGAGAGGAGAACTTGACGGAAT
AGAAAGCCTCGTAAACTTTGCTGACAAACTGGAAAATGCATCTCTTCAAACAATTGAAAAAGGTATAATGACAAAAGATT
TAGCAGCTCTCTCTGATTTGCCAAATAAAACTGTTGTAAATACAGAAAGTTTTCTTCTTGAAATTAAAAAGACCTTGGAA
GAGATAATGTAA

Upstream 100 bases:

>100_bases
ATGACTTATCCTATATAATAATATTCAAGTTATGCTTTATCAATTTGTATTGATAAATTTTCGAAGTTTTTGTTATATCT
TAGACAAAGGAGAGAAGTAA

Downstream 100 bases:

>100_bases
AAAGTAGTATGTGTCTTCCCCTGTAGGAGCGTGGGCGGGCTCTGCCGACACTTTTATAACACTTTCAGCAAATGTTGCTG
TAATACCCCTAGTAGTAGAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MANKIQMKVPLVEMDGDEMTRIIWKLIKEILLEPYIDLKTEYYDLGIKNRDKTEDQVTVNAAYAIKKYGVGVKCATITPN
AQRVEEYNLKKMWKSPNGTIRAILDGTVFRTPIIVESIKPLVKTWKKPITIARHAYGDIYKDVEYRVENKGKAELVFTSE
TGEVSRQTIHEFEGPGVILGMHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEK
AGIEYFYTLIDDAVARIIRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGKYEFEAAHGTVTRHYYKYLKG
EETSTNSIATIFAWTGALKKRGELDGIESLVNFADKLENASLQTIEKGIMTKDLAALSDLPNKTVVNTESFLLEIKKTLE
EIM

Sequences:

>Translated_403_residues
MANKIQMKVPLVEMDGDEMTRIIWKLIKEILLEPYIDLKTEYYDLGIKNRDKTEDQVTVNAAYAIKKYGVGVKCATITPN
AQRVEEYNLKKMWKSPNGTIRAILDGTVFRTPIIVESIKPLVKTWKKPITIARHAYGDIYKDVEYRVENKGKAELVFTSE
TGEVSRQTIHEFEGPGVILGMHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEK
AGIEYFYTLIDDAVARIIRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGKYEFEAAHGTVTRHYYKYLKG
EETSTNSIATIFAWTGALKKRGELDGIESLVNFADKLENASLQTIEKGIMTKDLAALSDLPNKTVVNTESFLLEIKKTLE
EIM
>Mature_402_residues
ANKIQMKVPLVEMDGDEMTRIIWKLIKEILLEPYIDLKTEYYDLGIKNRDKTEDQVTVNAAYAIKKYGVGVKCATITPNA
QRVEEYNLKKMWKSPNGTIRAILDGTVFRTPIIVESIKPLVKTWKKPITIARHAYGDIYKDVEYRVENKGKAELVFTSET
GEVSRQTIHEFEGPGVILGMHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEKA
GIEYFYTLIDDAVARIIRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGKYEFEAAHGTVTRHYYKYLKGE
ETSTNSIATIFAWTGALKKRGELDGIESLVNFADKLENASLQTIEKGIMTKDLAALSDLPNKTVVNTESFLLEIKKTLEE
IM

Specific function: Catalyzes The Oxidation Of 3-Carboxy-2-Hydroxy-4- Methylpentanoate (3-Isopropylmalate) To 3-Carboxy-4-Methyl-2- Oxopentanoate. The Product Decarboxylates To 4-Methyl-2 Oxopentanoate. [C]

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=55.7739557739558, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI28178825, Length=397, Percent_Identity=57.9345088161209, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17540874, Length=393, Percent_Identity=57.2519083969466, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=52.8255528255528, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320137, Length=405, Percent_Identity=57.5308641975309, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6324319, Length=406, Percent_Identity=54.1871921182266, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6323203, Length=404, Percent_Identity=53.4653465346535, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI21356561, Length=376, Percent_Identity=59.5744680851064, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24660856, Length=376, Percent_Identity=59.5744680851064, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI221330987, Length=376, Percent_Identity=59.5744680851064, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI221330985, Length=376, Percent_Identity=59.5744680851064, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI28574947, Length=376, Percent_Identity=59.5744680851064, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24660849, Length=376, Percent_Identity=59.5744680851064, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24660868, Length=376, Percent_Identity=59.5744680851064, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24660860, Length=376, Percent_Identity=59.5744680851064, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI221330983, Length=376, Percent_Identity=59.5744680851064, Blast_Score=450, Evalue=1e-127,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45903; Mature: 45772

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKIQMKVPLVEMDGDEMTRIIWKLIKEILLEPYIDLKTEYYDLGIKNRDKTEDQVTVN
CCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCCCCCCCEEEEH
AAYAIKKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRTPIIVESIKP
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHCCHHHHHHHHH
LVKTWKKPITIARHAYGDIYKDVEYRVENKGKAELVFTSETGEVSRQTIHEFEGPGVILG
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
MHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEK
ECCCHHHHHHHHHHHHHHHCCCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIEYFYTLIDDAVARIIRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGK
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
YEFEAAHGTVTRHYYKYLKGEETSTNSIATIFAWTGALKKRGELDGIESLVNFADKLENA
EEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHCCC
SLQTIEKGIMTKDLAALSDLPNKTVVNTESFLLEIKKTLEEIM
HHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
ANKIQMKVPLVEMDGDEMTRIIWKLIKEILLEPYIDLKTEYYDLGIKNRDKTEDQVTVN
CCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCCCCCCCEEEEH
AAYAIKKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRTPIIVESIKP
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHCCHHHHHHHHH
LVKTWKKPITIARHAYGDIYKDVEYRVENKGKAELVFTSETGEVSRQTIHEFEGPGVILG
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
MHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKFEK
ECCCHHHHHHHHHHHHHHHCCCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIEYFYTLIDDAVARIIRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPDGK
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
YEFEAAHGTVTRHYYKYLKGEETSTNSIATIFAWTGALKKRGELDGIESLVNFADKLENA
EEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHCCC
SLQTIEKGIMTKDLAALSDLPNKTVVNTESFLLEIKKTLEEIM
HHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]