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The map label for this gene is ilvB [H]

Identifier: 167038694

GI number: 167038694

Start: 22312

End: 23976

Strand: Direct

Name: ilvB [H]

Synonym: Teth514_0019

Alternate gene names: 167038694

Gene position: 22312-23976 (Clockwise)

Preceding gene: 167038693

Following gene: 167038695

Centisome position: 0.91

GC content: 37.6

Gene sequence:

>1665_bases
ATGAAGTTAAAAGGAGCGCAAGTAATTATAGAAGTTTTAAAAGAGATGGGCGTTGATACTATATTTGGCATACCAGGAGG
GGCAGTTATTCCCATTTATGATGCTCTTTATGACTCTGATATAAGGCATATTTTAGCTACTCACGAGCAAATGGCAGCCC
ATATGGCAGATGGTTATGCGAGAGTTACTGGAAGAGTAGGAGTTTGTTTTGCTACCTCTGGCCCCGGTGCTACTAATCTT
GTGACGGGTATAGCCAACGCTTATATGGATTCTGTACCTGTTGTGGCGATAACAGGACAGGTGCCTACAAATCTTATAGG
AAAGGATGCTTTTCAAGAAGTAGATATAACAGGTATTACAATGCCTATAACTAAACACAACTTTATTGTAAAGTCTCCTG
ATAAATTAACAGATACTATAAGACAGGCATTTGCAATTGCTAAGAGTGGAAGACCAGGTCCTGTATTAGTAGATATTCCA
AAAGATATACAAAACGCCGATATAGAATATGTAAAGGGAATAGGAGATAGTATTGATATAAAAAACGATATCAATGGAGT
AGTTTCGCAAAAAGAATTAGACAAAGCTATAGAGCTTATTTTACAAAGTAAAAAACCTGTAATCTTTGCAGGAGGAGGAG
TGATTTGGGGAGAAGCATCAAACGAACTCGTAGAATTTGCCGAGAAGACCAATATACCTGTTGCTACTTCTTTGATGGGA
TTGGGAGCTTTTCCAGAAGACCATCCTTTGTCATTAGGTCTTATTGGTATGCATGGAAGCAGATTTGCGAATTTGGCTGT
GTATAAATCAGACCTTGTGATAGCGATAGGGACGAGATTTAGCGACAGAGTTGCTGGCAAAGCAGGAGGACTTGCACCAA
ATGCTAAAATAATCCATATTGATATTGACCCTGCAGAATTAGGGAAAAATGTAGAAGTAGATGTAGCAATTATAGGTAAA
GTAAAAGAAGTTTTAAGACTCTTAATGAATAAACTTTCATTCATTGAAAGAAAGGAATGGTTAGAGGAAATTTCTTTCTT
GAGAGAAAAGCACGGATTAAAGTATAAAAACGATGAAGTTTTAAGGCCTCAGTGGATAGTAGAAAAAATTCAACAGCTTT
CAAACGATGACCTTATAATAGCCACGGAAGTGGGACAAAATCAAATGTGGGCTGCGCAGTATTATAAATTTAAGCAGCCG
AGGACTTTTGTTACCTCAGGAGGACTCGGGACAATGGGCTTTGGGCTTCCTGCTGCAATAGGTGCACAGGTGGGAAAGCC
AGACAAAAGGGTTGTGAACATTGCAGGTGATGGAAGTTTAAGAATGAATATACATGCTTTGGAGACAGCTGCAGTATACA
ATATTCCGGTTATAACGGTATTACTCAACAACCGGACTTTAGGTATGGTAAGACAATGGCAAAATCTTTTGTACAATAAA
AGATTTTCGCAGACAGATTTAAATGCAAATTTAAACTTTGCAAATCTTGCCAATGATTTTGGAGTAGAAGGAATAAGAGT
GACAACAAAAGAGGAATTTGAAAACGCTTTTAAAAAAGCCTATAGTCAAAAAAGACCTTTTATGATAGAATGTATTATAG
ACAAAGACGAAATGGTGCTTCCATTTATCCCCGCAGGTGGAACTGTTGAAAATACAATTGGATAA

Upstream 100 bases:

>100_bases
GGGTAAGACCTGAACCAAAGATAAAAACTGGTTATATGGCAAGATATGCAGAACAAGTGACTTCTGCAAATACAGGTGCA
GTTTTTAAGGGGGGAGGTAT

Downstream 100 bases:

>100_bases
AACCTTCAGGGATCGGTGAAATTCCGTACCGGCGGTATAGCCCGCGAGCCTTTTGGCAGACTCGGTGAAATTCCGAGGCC
GACAGTTAAAGTCTGGATGG

Product: acetolactate synthase, large subunit, biosynthetic type

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MKLKGAQVIIEVLKEMGVDTIFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYARVTGRVGVCFATSGPGATNL
VTGIANAYMDSVPVVAITGQVPTNLIGKDAFQEVDITGITMPITKHNFIVKSPDKLTDTIRQAFAIAKSGRPGPVLVDIP
KDIQNADIEYVKGIGDSIDIKNDINGVVSQKELDKAIELILQSKKPVIFAGGGVIWGEASNELVEFAEKTNIPVATSLMG
LGAFPEDHPLSLGLIGMHGSRFANLAVYKSDLVIAIGTRFSDRVAGKAGGLAPNAKIIHIDIDPAELGKNVEVDVAIIGK
VKEVLRLLMNKLSFIERKEWLEEISFLREKHGLKYKNDEVLRPQWIVEKIQQLSNDDLIIATEVGQNQMWAAQYYKFKQP
RTFVTSGGLGTMGFGLPAAIGAQVGKPDKRVVNIAGDGSLRMNIHALETAAVYNIPVITVLLNNRTLGMVRQWQNLLYNK
RFSQTDLNANLNFANLANDFGVEGIRVTTKEEFENAFKKAYSQKRPFMIECIIDKDEMVLPFIPAGGTVENTIG

Sequences:

>Translated_554_residues
MKLKGAQVIIEVLKEMGVDTIFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYARVTGRVGVCFATSGPGATNL
VTGIANAYMDSVPVVAITGQVPTNLIGKDAFQEVDITGITMPITKHNFIVKSPDKLTDTIRQAFAIAKSGRPGPVLVDIP
KDIQNADIEYVKGIGDSIDIKNDINGVVSQKELDKAIELILQSKKPVIFAGGGVIWGEASNELVEFAEKTNIPVATSLMG
LGAFPEDHPLSLGLIGMHGSRFANLAVYKSDLVIAIGTRFSDRVAGKAGGLAPNAKIIHIDIDPAELGKNVEVDVAIIGK
VKEVLRLLMNKLSFIERKEWLEEISFLREKHGLKYKNDEVLRPQWIVEKIQQLSNDDLIIATEVGQNQMWAAQYYKFKQP
RTFVTSGGLGTMGFGLPAAIGAQVGKPDKRVVNIAGDGSLRMNIHALETAAVYNIPVITVLLNNRTLGMVRQWQNLLYNK
RFSQTDLNANLNFANLANDFGVEGIRVTTKEEFENAFKKAYSQKRPFMIECIIDKDEMVLPFIPAGGTVENTIG
>Mature_554_residues
MKLKGAQVIIEVLKEMGVDTIFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYARVTGRVGVCFATSGPGATNL
VTGIANAYMDSVPVVAITGQVPTNLIGKDAFQEVDITGITMPITKHNFIVKSPDKLTDTIRQAFAIAKSGRPGPVLVDIP
KDIQNADIEYVKGIGDSIDIKNDINGVVSQKELDKAIELILQSKKPVIFAGGGVIWGEASNELVEFAEKTNIPVATSLMG
LGAFPEDHPLSLGLIGMHGSRFANLAVYKSDLVIAIGTRFSDRVAGKAGGLAPNAKIIHIDIDPAELGKNVEVDVAIIGK
VKEVLRLLMNKLSFIERKEWLEEISFLREKHGLKYKNDEVLRPQWIVEKIQQLSNDDLIIATEVGQNQMWAAQYYKFKQP
RTFVTSGGLGTMGFGLPAAIGAQVGKPDKRVVNIAGDGSLRMNIHALETAAVYNIPVITVLLNNRTLGMVRQWQNLLYNK
RFSQTDLNANLNFANLANDFGVEGIRVTTKEEFENAFKKAYSQKRPFMIECIIDKDEMVLPFIPAGGTVENTIG

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=566, Percent_Identity=26.678445229682, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI21361361, Length=506, Percent_Identity=25.6916996047431, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI87081685, Length=558, Percent_Identity=43.5483870967742, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1790104, Length=555, Percent_Identity=43.0630630630631, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1786717, Length=562, Percent_Identity=35.2313167259786, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1787096, Length=549, Percent_Identity=28.0510018214936, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI1788716, Length=564, Percent_Identity=27.1276595744681, Blast_Score=184, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17531299, Length=563, Percent_Identity=27.708703374778, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17531301, Length=563, Percent_Identity=27.708703374778, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17542570, Length=550, Percent_Identity=26.7272727272727, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323755, Length=576, Percent_Identity=42.1875, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6320816, Length=558, Percent_Identity=24.5519713261649, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321524, Length=485, Percent_Identity=24.7422680412371, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323073, Length=484, Percent_Identity=25, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323163, Length=481, Percent_Identity=24.3243243243243, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320123, Length=501, Percent_Identity=22.9540918163673, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320588, Length=524, Percent_Identity=20.8015267175573, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922626, Length=559, Percent_Identity=25.9391771019678, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60366; Mature: 60366

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKGAQVIIEVLKEMGVDTIFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYA
CCCCHHHHHHHHHHHCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
RVTGRVGVCFATSGPGATNLVTGIANAYMDSVPVVAITGQVPTNLIGKDAFQEVDITGIT
EEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHCCEEEEE
MPITKHNFIVKSPDKLTDTIRQAFAIAKSGRPGPVLVDIPKDIQNADIEYVKGIGDSIDI
EEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHCCCCCCCC
KNDINGVVSQKELDKAIELILQSKKPVIFAGGGVIWGEASNELVEFAEKTNIPVATSLMG
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCHHHHHHHHHCCCCCHHHHHH
LGAFPEDHPLSLGLIGMHGSRFANLAVYKSDLVIAIGTRFSDRVAGKAGGLAPNAKIIHI
CCCCCCCCCCEEEEEECCCCCCEEEEEEECCEEEEECCCCCHHHCCCCCCCCCCCEEEEE
DIDPAELGKNVEVDVAIIGKVKEVLRLLMNKLSFIERKEWLEEISFLREKHGLKYKNDEV
ECCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LRPQWIVEKIQQLSNDDLIIATEVGQNQMWAAQYYKFKQPRTFVTSGGLGTMGFGLPAAI
CCHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHCCCCCEEEECCCCCCCCCCCHHHH
GAQVGKPDKRVVNIAGDGSLRMNIHALETAAVYNIPVITVLLNNRTLGMVRQWQNLLYNK
HCCCCCCCCEEEEEECCCEEEEEEEEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCC
RFSQTDLNANLNFANLANDFGVEGIRVTTKEEFENAFKKAYSQKRPFMIECIIDKDEMVL
CCCCCCCCCCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCEEE
PFIPAGGTVENTIG
EEECCCCCCCCCCC
>Mature Secondary Structure
MKLKGAQVIIEVLKEMGVDTIFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYA
CCCCHHHHHHHHHHHCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
RVTGRVGVCFATSGPGATNLVTGIANAYMDSVPVVAITGQVPTNLIGKDAFQEVDITGIT
EEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHCCEEEEE
MPITKHNFIVKSPDKLTDTIRQAFAIAKSGRPGPVLVDIPKDIQNADIEYVKGIGDSIDI
EEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHCCCCCCCC
KNDINGVVSQKELDKAIELILQSKKPVIFAGGGVIWGEASNELVEFAEKTNIPVATSLMG
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCHHHHHHHHHCCCCCHHHHHH
LGAFPEDHPLSLGLIGMHGSRFANLAVYKSDLVIAIGTRFSDRVAGKAGGLAPNAKIIHI
CCCCCCCCCCEEEEEECCCCCCEEEEEEECCEEEEECCCCCHHHCCCCCCCCCCCEEEEE
DIDPAELGKNVEVDVAIIGKVKEVLRLLMNKLSFIERKEWLEEISFLREKHGLKYKNDEV
ECCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LRPQWIVEKIQQLSNDDLIIATEVGQNQMWAAQYYKFKQPRTFVTSGGLGTMGFGLPAAI
CCHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHCCCCCEEEECCCCCCCCCCCHHHH
GAQVGKPDKRVVNIAGDGSLRMNIHALETAAVYNIPVITVLLNNRTLGMVRQWQNLLYNK
HCCCCCCCCEEEEEECCCEEEEEEEEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCC
RFSQTDLNANLNFANLANDFGVEGIRVTTKEEFENAFKKAYSQKRPFMIECIIDKDEMVL
CCCCCCCCCCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCEEE
PFIPAGGTVENTIG
EEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]