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The map label for this gene is yhxA [H]

Identifier: 163845482

GI number: 163845482

Start: 1358990

End: 1360348

Strand: Reverse

Name: yhxA [H]

Synonym: BSUIS_B1396

Alternate gene names: 163845482

Gene position: 1360348-1358990 (Counterclockwise)

Preceding gene: 163845483

Following gene: 163845481

Centisome position: 97.11

GC content: 60.04

Gene sequence:

>1359_bases
ATGCGTGATTCCAATTTCCTGATCGAGAACAATGCCCGCCACCTGTGGCACCCCATGGCGCATCCGGCGGAGATGCAGGC
CAATCCGCCCCGCATCGTCAATGGTGGCGAGGGCGTCGAGGTGATCGACATTCACGGCAAGAAGGTTCTCGATGCGGTGG
GCGGTCTGTGGAACGTCAATCTGGGCTATTCCTGCGAGCCGGTGAAGAAGGCGATCCGCGACCAGCTCGACAGCCTGCCT
TATTATTCGACCTTTCGCGGCACGACCAATTCGCCTCTGATCGAGCTTTCCTATGAGCTGGCCGAATTCTTCAAGGAAGA
CGGGCTGACGCGTGCTTTCTTCACGTCCGGCGGATCGGATTCGGTCGAAACGGCGCTGCGGCTTGCCCGCCAGTTCCACA
AGATCAACGGACAGCCGGAACGCACGAAATTCGTTTCGCTGAAAAAGGGCTATCACGGCACGCATTTTGGCGGCGCTTCG
GTCAATGGCAATGCCAATTTCCGCCGCAACTATGAGCCGCTTCTGCCGGGCGTGTTCCATCTGGCGGCACCCTATCCCTA
TCGCAACCCGTTCAATATGGACGACCCGGCGGCGATTGCTGCGGCCATTGCGCGCCAGTTTGAGGATGAAATCGCGTTTC
AGGGTGCGGACACCATTGCCGCCTTCATCATGGAGCCGGTTCTGGGGGCAGGGGGCGTGATCGTGCCGCATGAAAGCTTC
ATGCCGCTGATGCGTGAAATCTGCGACCGGCACGGCATTCTCCTGATTGCCGATGAGGTCATCACGGCTTTCGGGCGCAC
CGGCGCATGGACCGGCTCGCGCGGCTGGGGCGTGAAACCCGATATGATGACGACCGCCAAGGCGATCACCAATGGCTATT
TCCCCTTCGGTGCGGTGATGATTTCCGACAAGGTGGCAAGCGTTTTTGAGGCGAACAAAAATTCGCTTGGCGCAATCGGC
CATGGCTACACCTATTCCGGCCATCCGGTGGGTGCCGCAGCCGCCCTTGCCACGCTGAAGGAAACGGCGCGCGCCAACAC
GGCGGCCAATGCCGGGGCGCGCGGTGTCGAACTTATGGCGGGGCTCAATCAACTGAAGGAAAAGCACGAGCTTGTGGGTG
ACGTGCGCGGCAAGGGCCTGATGGCGGCGCTGGAACTCGTTTCCGATCGGGAAAAGAAAAGTGCTGCCGCCAAGACCGTG
GTGCAGAAGGTTTATGACGTCGTCTATGAGGAAGGCGTCATGGTGCGCACTTCCGGCGCCAATGTCATCATTTCGCCGCC
GCGTGTCATCACGCCAGCCGATGTGAACCGCATTGTTTCTGCGCTCGATGCTGGCCTTTCCGCCGCGAAGGGACAATGA

Upstream 100 bases:

>100_bases
GGAGGCAGTCCACCTGCCGCATGTGCACTTCGACGTGACCCGGCCTGCGGAAAGCTATGCGCAGGCGCTGAAAATGCTTG
GAATTTGAAAGGTTATCTTC

Downstream 100 bases:

>100_bases
CATGAGCGGAAATCAGGAACTGATTGCCCGCAGGGAGCGGCTGCTTGGCCGCAACATGTCCCTATTTTATCAGGACCCGG
TGCATCTGGTGAAGGGTGAG

Product: hypothetical protein

Products: L-Glutamate; L-Glutamate 5-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVNLGYSCEPVKKAIRDQLDSLP
YYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSDSVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGAS
VNGNANFRRNYEPLLPGVFHLAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVMISDKVASVFEANKNSLGAIG
HGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMAGLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTV
VQKVYDVVYEEGVMVRTSGANVIISPPRVITPADVNRIVSALDAGLSAAKGQ

Sequences:

>Translated_452_residues
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVNLGYSCEPVKKAIRDQLDSLP
YYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSDSVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGAS
VNGNANFRRNYEPLLPGVFHLAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVMISDKVASVFEANKNSLGAIG
HGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMAGLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTV
VQKVYDVVYEEGVMVRTSGANVIISPPRVITPADVNRIVSALDAGLSAAKGQ
>Mature_452_residues
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVNLGYSCEPVKKAIRDQLDSLP
YYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSDSVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGAS
VNGNANFRRNYEPLLPGVFHLAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVMISDKVASVFEANKNSLGAIG
HGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMAGLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTV
VQKVYDVVYEEGVMVRTSGANVIISPPRVITPADVNRIVSALDAGLSAAKGQ

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=433, Percent_Identity=27.4826789838337, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=29.6983758700696, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=27.0454545454545, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=29.7674418604651, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI226442709, Length=393, Percent_Identity=30.5343511450382, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI284507298, Length=316, Percent_Identity=30.379746835443, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=28.9044289044289, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI145693181, Length=411, Percent_Identity=30.4136253041363, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786991, Length=441, Percent_Identity=29.9319727891156, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=31.6901408450704, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1788044, Length=398, Percent_Identity=30.1507537688442, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789759, Length=425, Percent_Identity=28.4705882352941, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787560, Length=422, Percent_Identity=27.0142180094787, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786349, Length=396, Percent_Identity=25.7575757575758, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=30.2222222222222, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=25.7907542579075, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=25.9593679458239, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=221, Percent_Identity=28.5067873303167, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=473, Percent_Identity=26.4270613107822, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6323470, Length=431, Percent_Identity=25.5220417633411, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=355, Percent_Identity=27.0422535211268, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574759, Length=438, Percent_Identity=27.6255707762557, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161085790, Length=439, Percent_Identity=26.6514806378132, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=26.4285714285714, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356575, Length=435, Percent_Identity=28.2758620689655, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.13 [C]

Molecular weight: Translated: 48656; Mature: 48656

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVN
CCCCCEEEECCCHHHHCCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHCCEEECC
LGYSCEPVKKAIRDQLDSLPYYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCH
SVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGASVNGNANFRRNYEPLLPGVFH
HHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHH
LAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCHHH
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVM
HHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEE
ISDKVASVFEANKNSLGAIGHGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHH
GLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTVVQKVYDVVYEEGVMVRTSGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
NVIISPPRVITPADVNRIVSALDAGLSAAKGQ
EEEECCCCEECHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVN
CCCCCEEEECCCHHHHCCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHCCEEECC
LGYSCEPVKKAIRDQLDSLPYYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCH
SVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGASVNGNANFRRNYEPLLPGVFH
HHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHH
LAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCHHH
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVM
HHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEE
ISDKVASVFEANKNSLGAIGHGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHH
GLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTVVQKVYDVVYEEGVMVRTSGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
NVIISPPRVITPADVNRIVSALDAGLSAAKGQ
EEEECCCCEECHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; Ornithine [C]

Specific reaction: 2-Oxoglutarate + Ornithine --> L-Glutamate + L-Glutamate 5-semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]