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The map label for this gene is proA [H]

Identifier: 163845420

GI number: 163845420

Start: 1281990

End: 1283261

Strand: Reverse

Name: proA [H]

Synonym: BSUIS_B1321

Alternate gene names: 163845420

Gene position: 1283261-1281990 (Counterclockwise)

Preceding gene: 163845421

Following gene: 163845419

Centisome position: 91.61

GC content: 61.32

Gene sequence:

>1272_bases
ATGTTGGTCAAGGCGGATATGACGAAGGATATTGCGCAAGTGATGGCGGAGGTTGGCCGCAAGGCAAAAGCCGCTGCGGC
TCCTCTCTCCATTGCCACGAGCGAGCAGAAGAACAAGGCGCTGAATGCCGCTGCCGATGCAATCCTTGAAGCGCGCGCCG
ATATTCTTGAAGCCAACAGGCTTGATCTGGCCAATGCGGAAAAGAACGGCATGGCCGCTTCCTTCGTGGACCGGCTGACG
CTCAACGAAGCGCGCATTGACGCGATTGCGGAAGGTATCCGCGCCATTGCCACACTGCCCGACCCGGTTGGTGAAGTGAT
TGCCGAATGGGACCGCCCCAACGGCCTGCATATCGAACGTGTGCGCACGCCGCTTGGCGTGATCGGTGTCATCTATGAAA
GCCGCCCCAATGTGACCGCCGATGCCGGCGCGCTGTGCCTCAAGGCGGGCAATGCCGTCATCCTGCGTGGCGGCTCGGAT
TCGGCGCATTCCTCGGCTGCCATTCACAAGGCGCTTGAAGCCGCCAATCTGCCGGCCGATGCAATCCAGATCGTGCCGGT
GACGGACAGGGCTGCCGTTGGTGAAATGCTCAAAGGTCTTGGCGGCGCGATTGATGTCATTGTGCCGCGCGGCGGCAAAA
GCCTCGTTGCCCGCGTGCAATCGGAAGCGCGGGTGCCGGTTTTCGCGCATCTGGAAGGCATCTGCCATCTTTATATCGAC
AAGTCGGCTGATCTGGACATGGCGCGCAGGATTGCGCTCGATGCCAAGATGCGGCGCACCGGCATTTGCGGGGCTGCGGA
AACGCTGCTGGTGGATCGTGCCGTAGCTTCGACGCATCTGGCGCCGATCCTCGGCGATCTGGCTGCCGGGGGCTGCGAAA
TTCGCGGCAGCGCGGAGGTGCTGGCGCTCTATCCGGCGGCAAAGCCTGCGACGGAGGAGGACTGGTCAACCGAATATCTC
GACGCGATCATTTCCGTGGCGCTGGTTGACGGCATTTCGGGTGCGATAGACCATATCAACCGCTATTCTTCGCATCACAC
CGAAGCCATCGTGGCCGAGGATGCGCAGACCGTTGCGCGTTTCTTCAACGAGATCGATTCAGCCATTTTGCTGCACAATG
CCTCCACGCAATTTGCCGATGGCGGCGAGTTCGGCATGGGCGCGGAAATCGGCATCGCCACCGGTAAGATGCATGCGCGC
GGGCCGGTTGGCGTCGAGCAGCTGACCTCGTTCAAATATCGTGTGCGCGGCAGCGGCCAGGTTCGGGGTTAA

Upstream 100 bases:

>100_bases
CAGTGCCATTCTTGGCTATGATGCCCGCGCGGCGATGATCCATCGCAACGATCTGGTGGTGCGGGCCGCCAGCGATGCGA
AAGCCGCATAGGGGGATAGG

Downstream 100 bases:

>100_bases
TGAAATTCGGCTTCGGGCTTTCTGCGCTCAAGGAACAATATCCCGGCGTTGATGCGCATTATCTGCGTATGCCGCATGTC
GAAAAGGGCATGACGGTGGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLT
LNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSD
SAHSSAAIHKALEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYID
KSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWSTEYL
DAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHAR
GPVGVEQLTSFKYRVRGSGQVRG

Sequences:

>Translated_423_residues
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLT
LNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSD
SAHSSAAIHKALEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYID
KSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWSTEYL
DAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHAR
GPVGVEQLTSFKYRVRGSGQVRG
>Mature_423_residues
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLT
LNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSD
SAHSSAAIHKALEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYID
KSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWSTEYL
DAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHAR
GPVGVEQLTSFKYRVRGSGQVRG

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=409, Percent_Identity=37.1638141809291, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI21361368, Length=409, Percent_Identity=37.1638141809291, Blast_Score=261, Evalue=9e-70,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=40.1442307692308, Blast_Score=311, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=35.4916067146283, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=35.4916067146283, Blast_Score=251, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=35.4988399071926, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21357643, Length=416, Percent_Identity=36.7788461538462, Blast_Score=244, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44302; Mature: 44302

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANR
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
LDLANAEKNGMAASFVDRLTLNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIER
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHH
VRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAAIHKALEAANLPAD
HHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
AIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYID
CEEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCEEEEEEC
KSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEV
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEE
LALYPAAKPATEEDWSTEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVAR
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
FFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVRGSGQ
HHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCEEECCCCC
VRG
CCC
>Mature Secondary Structure
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANR
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
LDLANAEKNGMAASFVDRLTLNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIER
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHH
VRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAAIHKALEAANLPAD
HHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
AIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYID
CEEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCEEEEEEC
KSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEV
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEE
LALYPAAKPATEEDWSTEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVAR
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
FFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVRGSGQ
HHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCEEECCCCC
VRG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA