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The map label for this gene is phbA [H]

Identifier: 163845349

GI number: 163845349

Start: 1210301

End: 1211485

Strand: Reverse

Name: phbA [H]

Synonym: BSUIS_B1248

Alternate gene names: 163845349

Gene position: 1211485-1210301 (Counterclockwise)

Preceding gene: 163845352

Following gene: 163845348

Centisome position: 86.48

GC content: 62.03

Gene sequence:

>1185_bases
ATGTCCGATCCGAAATCCATCGTCATCGCCAGTGCAGCGCGCACCGCGGTGGGTGCCTTTAATGGCGCCTTTGCCAATGT
TCCTGCTCATGAACTGGGTGCAGTGGCCATCAAGGCTGCTCTGGAGCGTGCTGGTGTCGATGCGGCGGATGTCGATGAGG
TTATTCTGGGGCAGGTGCTGACGGCAGGCGAAGGGCAGAATCCCGCCCGTCAGGCCGCCATGGGGGCCGGTTGCCCGAAG
GAAACCACCGCTTTTGCCATCAACCAGCTCTGCGGTTCCGGCCTGCGGGCGGTTGCGCTCGGGATGCAGCAGATTGTTTC
CGGCGATGCGAAGATTATCGTGGCGGGCGGGCAGGAATCCATGTCCATGGCGCCGCATTGTGCCTATCTGCGCTCCGGCG
TGAAGATGGGCGATTTCAAGATGATCGACACCATGCTGAAAGACGGCCTGACCGATGCTTTCCATGGCTATCACATGGGC
ATCACCGCTGAAAATATTGCGCGCCAATGGCAGTTGAGCCGCAGCGAGCAGGACGAGTTCGCACTCGCCTCGCAGCACAA
AGCCGAGGCCGCGCAGAAGGCAGGCCGCTTCGATGAGGAGATCGTGCCTTTCACCGTCAAGGCCCGCAAGGGGGATGTTG
TGGTTTCGGCAGATGAATATATCCGTCCGGGCACGACGATGGAGGTGCTGGCCAAGCTGAAGCCGGCTTTTGACAAGGAA
GGCACGGTGACGGCGGGCAATGCATCCGGCATCAATGACGGTGCCGCAGCGGTTGTGCTGATGGATGCTGGCGAGGCAGC
CAGGCGTGGCGTGAAGCCTCTGGCGCGCATCGTATCCTGGGCGACGGCTGGCGTTGATCCGTCGATCATGGGAACCGGGC
CGATTCCCGCAACGCGGAAGGCGCTGGAAAAGGCAGGCTGGAGCGTTGGCGACCTTGATCTTGTTGAGGCCAATGAGGCC
TTTGCAGCGCAGTCATGCGCGGTGGTGCGCGATCTGGGTCTCAATCCTGAAATCGTCAATGTCAATGGCGGCGCAATCGC
CATCGGCCATCCGATCGGCGCCTCCGGCGCCCGCGTGCTGACGACGCTGCTCTACGAAATGGAGCGTCGCGATGCCAAGC
GTGGTCTGGCGACGCTTTGTATCGGCGGCGGCATGGGCGTGGCCCTTTGTGTCGAGCGGGATTGA

Upstream 100 bases:

>100_bases
GGGAAAAACACCTTCTCGATTTTCATGAAGGCGGCGCGGGGAGCTTGCCAAGGCCGGTTTTTTGGTCTTTGTGTTGCGCC
ACATGCTTAAGGAGGAAAGA

Downstream 100 bases:

>100_bases
TCCGGTTTTAGAACGTCATCTGAAACCAACCGCCAATTTCGGGCGTGTGCCGGAAGAGGGGTGTTTTTTTCCGGCAAAAG
TTAACGCAGAACGGAAACAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVLTAGEGQNPARQAAMGAGCPK
ETTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGLTDAFHGYHMG
ITAENIARQWQLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVLAKLKPAFDKE
GTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRKALEKAGWSVGDLDLVEANEA
FAAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVLTTLLYEMERRDAKRGLATLCIGGGMGVALCVERD

Sequences:

>Translated_394_residues
MSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVLTAGEGQNPARQAAMGAGCPK
ETTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGLTDAFHGYHMG
ITAENIARQWQLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVLAKLKPAFDKE
GTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRKALEKAGWSVGDLDLVEANEA
FAAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVLTTLLYEMERRDAKRGLATLCIGGGMGVALCVERD
>Mature_393_residues
SDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVLTAGEGQNPARQAAMGAGCPKE
TTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQESMSMAPHCAYLRSGVKMGDFKMIDTMLKDGLTDAFHGYHMGI
TAENIARQWQLSRSEQDEFALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVLAKLKPAFDKEG
TVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRKALEKAGWSVGDLDLVEANEAF
AAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVLTTLLYEMERRDAKRGLATLCIGGGMGVALCVERD

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=60.253164556962, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=45.5242966751918, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=43.1122448979592, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=42.0253164556962, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=33.5680751173709, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.8200514138817, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=57.8005115089514, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=54.2199488491049, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=44.1102756892231, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=44.139650872818, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=32.843137254902, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=46.2915601023018, Blast_Score=340, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=40.5128205128205, Blast_Score=294, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=41.3098236775819, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.5699745547074, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=32.0754716981132, Blast_Score=174, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=43.3583959899749, Blast_Score=300, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=37.6884422110553, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=58.7786259541985, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=43.9897698209719, Blast_Score=307, Evalue=9e-84,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=43.2225063938619, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=33.4894613583138, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40726; Mature: 40595

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVL
CCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TAGEGQNPARQAAMGAGCPKETTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQES
HCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCC
MSMAPHCAYLRSGVKMGDFKMIDTMLKDGLTDAFHGYHMGITAENIARQWQLSRSEQDEF
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCEECCCCHHHHHHHHHCCCCCCHHH
ALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVLAKLKPAFDKE
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEECHHHCCCCCHHHHHHHHCCCCCCC
GTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRK
CCEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHH
ALEKAGWSVGDLDLVEANEAFAAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVL
HHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCHHHHH
TTLLYEMERRDAKRGLATLCIGGGMGVALCVERD
HHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
SDPKSIVIASAARTAVGAFNGAFANVPAHELGAVAIKAALERAGVDAADVDEVILGQVL
CCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TAGEGQNPARQAAMGAGCPKETTAFAINQLCGSGLRAVALGMQQIVSGDAKIIVAGGQES
HCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCC
MSMAPHCAYLRSGVKMGDFKMIDTMLKDGLTDAFHGYHMGITAENIARQWQLSRSEQDEF
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCEECCCCHHHHHHHHHCCCCCCHHH
ALASQHKAEAAQKAGRFDEEIVPFTVKARKGDVVVSADEYIRPGTTMEVLAKLKPAFDKE
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEECHHHCCCCCHHHHHHHHCCCCCCC
GTVTAGNASGINDGAAAVVLMDAGEAARRGVKPLARIVSWATAGVDPSIMGTGPIPATRK
CCEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHH
ALEKAGWSVGDLDLVEANEAFAAQSCAVVRDLGLNPEIVNVNGGAIAIGHPIGASGARVL
HHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCHHHHH
TTLLYEMERRDAKRGLATLCIGGGMGVALCVERD
HHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]