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The map label for this gene is pdhA [H]

Identifier: 163845196

GI number: 163845196

Start: 1056881

End: 1059058

Strand: Reverse

Name: pdhA [H]

Synonym: BSUIS_B1081

Alternate gene names: 163845196

Gene position: 1059058-1056881 (Counterclockwise)

Preceding gene: 163845197

Following gene: 163845195

Centisome position: 75.6

GC content: 58.17

Gene sequence:

>2178_bases
ATGGCAGAGAAAATTGATCTGAAACCATCCGCACCCTGGTATCGGTTGAATACCACGGACGAGGATTGGCAAAATGCAGA
AGCGGCCGATCTGCTGAAATGGTATAGCCAGATGAAGCTGATCCGCCGGTTCGAAGAAAAGATACTCGATTTTGAAAAGG
CGGGTCTGGTCCATGGACCGGCCCATGCAAGCATTGGTCAGGAGGCTGCTGCGGTCGGCGCCATGTCGGTGCTGAAAACC
GATGACCAGATCAATGGCACGCACCGCGCCCACCATCAGGTCCTGACAAAACTGATCAATGCCCAGACGCCATCGGATTT
CGATATTCTTCAGTCCGATTTCACCGATGGCATGCATGACGCGGTTTATCGCCTCATGGCCGAAATCATGGGGCTGAATA
CGGGCTATTGCGGCGGGCGCGGCGGCTCGATGCATATGCGCGATGCGGCTTCGGGCATTGCCGGAACCAGCGCGATCGTC
GGCGGCAATATTCCCCATGCCGCCGGTTATGCCCTCGCAGACAAGATCCTCAACCGGAAGGGAATTTCTGTTGCCTTCTT
CGGCGATGGCGCTTCCTTGCAGGGCGCGACCTATGAAGCGATGAACATCGCCGCGCTCTACCGCCTGCCGGTCATTTTTT
ACGTGGAGAATAATCTCTACGCCGTATCGACCCATATTCAGGATGCAACGCGCGAGACGCGCATTGCCTCGCGCGGTCCC
ATGCTCGGCTTTACCGGCATCGAATGCGACGGCATGGACATTCTTTCCGTCCATCAGGCGATGCGTGAAGCCTGCCGCAT
TATCGAGGAAGAGGGCGGTCCGGTCGTCATCGAGGCGCAGTGCTACAGATATCTGCATCAAAGCGGCAGCAAATCGGGCA
GCGATTTCGGTTATCGCACGCGTGAGGAAGAAGAGGAATGGAAAAGCCGCGATCCGATTGCGCTTGCCGAGCGGCGCCTG
AAGGAACTGGGGATCGCGGGAGATGCCGAGTTTTTGAAGATTGACGAGCGTGTGACCGCCGCCGTTCAAGCGGCTGGAGA
GCGCCTGACCGAAACGGCCGCCGGCAGCAATGTTCTGCGTATTCCCGATGCGCTTTGGCCGTCGGCATCCAGTGTGGACG
ACGGGATTTTGGGAGATGGCAGCGAATTTTCCGGTGCGGAATTTCGCGAGATCGAGGATTATCAGCCCGATGAGCTGGAA
AAGATGCGCTTTGCCGCGGCGGCTTCGGATGTGCTCGGGCGGGCGATGGAAAAGGACCCGACGATCATCGTCATGGGGGA
GGATGTCCATCGTTTTGCAGGCGGTGTCAGCGGCTTTACCAGAAACGCGCTTGAGCTTTTTCCCGACCGGGTTCTCGCCA
TGCCCATCGCCGAAAACGGCTTTACCGGCGTAGCGCTTGGTGCAGCCCTGCGGGGCCTGCGCCCGGTGGTGGAAATCATG
TTCGGTGATTTCTGCTTTGTCGCGGCCGACCAGATCGCGAACGGGATTTCAAAAGTGCGTCATATGTTCGGCGACGGTTT
TCCAGTCCCCATCGTCATGCGTGTGCGCGTTTCGCCCCACACCGGCTATGGTTCGCAGCATTCCGGCGATCCCTCGGCAC
TGTTCGGCATGTTTCCCGGATGGCGCGTCGTCTCGCCCACAAATGCCTTTGATTATATCGGCCTGATGAACAGCGCGCTG
AAATCGAACGATCCCGTCGCGGTTATTGAGCATGTCGAGTTTTACCAGCGCGAAAGCCTAGTTCCGAGGAATGACAGGGA
TTATTGCATCCCGCTCGGCAAGGCGAAGATCGTGCGTCCGGGGTCGGCCTGCACCGTTCTTGCCACATCCGTCATGGTAC
AGGCTTCCATCAAGGCTGCGGAAGAGGCGGGCATCGATGCCGAAATCATCGATATGCGCAGCCTCGACATGTTCGGGATC
GACTGGGCCTTGATTGGCGCTTCCATCGGCAAAACCAACCGGGTGGTGATTGCCGAGCAGGTTGCAAGCGGCTTGTCGCT
CGGACGGCATTGGATCGCCGAAATCCAGAAGCGCTTCTTCAACGATCTCGACCATGAAGTCCTGCATGTGACGGGAAGCA
TGGCCTCGCCGGTCGTGTCGCTGGTTTTAAACAAGGCCGCCCTCGGATCGGCCGACAAGGTCCGGTCGGCCCTTGAGCAG
ATTACGCATTCCGCATGA

Upstream 100 bases:

>100_bases
CACGAACATTCGATCCACGATACCGGGCAAGCCTCTGGCTGCGGCGCCGGGCTGAACTTGGGTTGCGACTGGCAGACTAC
AATTAGGGGAAACTCTCACA

Downstream 100 bases:

>100_bases
CAAAAAACGTAAAATACGAGGAGGACAAAATGCTATTCAAGACAACGGGAACAAGGTCTGGATCATTGAAAACATTGCGA
AGCCTGATGATGGCGGCAAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 725; Mature: 724

Protein sequence:

>725_residues
MAEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKT
DDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHDAVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIV
GGNIPHAAGYALADKILNRKGISVAFFGDGASLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRGP
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRTREEEEEWKSRDPIALAERRL
KELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLRIPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELE
KMRFAAAASDVLGRAMEKDPTIIVMGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVALGAALRGLRPVVEIM
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPGWRVVSPTNAFDYIGLMNSAL
KSNDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRPGSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGI
DWALIGASIGKTNRVVIAEQVASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
ITHSA

Sequences:

>Translated_725_residues
MAEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKT
DDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHDAVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIV
GGNIPHAAGYALADKILNRKGISVAFFGDGASLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRGP
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRTREEEEEWKSRDPIALAERRL
KELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLRIPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELE
KMRFAAAASDVLGRAMEKDPTIIVMGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVALGAALRGLRPVVEIM
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPGWRVVSPTNAFDYIGLMNSAL
KSNDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRPGSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGI
DWALIGASIGKTNRVVIAEQVASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
ITHSA
>Mature_724_residues
AEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKTD
DQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHDAVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIVG
GNIPHAAGYALADKILNRKGISVAFFGDGASLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRGPM
LGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRTREEEEEWKSRDPIALAERRLK
ELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLRIPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELEK
MRFAAAASDVLGRAMEKDPTIIVMGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVALGAALRGLRPVVEIMF
GDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPGWRVVSPTNAFDYIGLMNSALK
SNDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRPGSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGID
WALIGASIGKTNRVVIAEQVASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQI
THSA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=323, Percent_Identity=33.4365325077399, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI291084742, Length=319, Percent_Identity=35.7366771159875, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI4505685, Length=322, Percent_Identity=35.7142857142857, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI156564403, Length=285, Percent_Identity=36.4912280701754, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI291084744, Length=329, Percent_Identity=34.9544072948328, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI291084858, Length=285, Percent_Identity=34.0350877192982, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI4557353, Length=315, Percent_Identity=30.1587301587302, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI34101272, Length=315, Percent_Identity=30.1587301587302, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI291084757, Length=319, Percent_Identity=32.2884012539185, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI11386135, Length=285, Percent_Identity=28.4210526315789, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI258645172, Length=285, Percent_Identity=28.4210526315789, Blast_Score=100, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=35.3312302839117, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32564172, Length=317, Percent_Identity=35.3312302839117, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17538422, Length=324, Percent_Identity=34.8765432098765, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI86563357, Length=359, Percent_Identity=28.133704735376, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI86563355, Length=358, Percent_Identity=28.2122905027933, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17506935, Length=302, Percent_Identity=30.4635761589404, Blast_Score=109, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=35.8024691358025, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319698, Length=306, Percent_Identity=31.0457516339869, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24639740, Length=315, Percent_Identity=37.1428571428571, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24639744, Length=315, Percent_Identity=37.1428571428571, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28571106, Length=315, Percent_Identity=37.1428571428571, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24639748, Length=322, Percent_Identity=33.2298136645963, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24639746, Length=309, Percent_Identity=36.5695792880259, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21358145, Length=300, Percent_Identity=35.3333333333333, Blast_Score=157, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24650940, Length=300, Percent_Identity=35.3333333333333, Blast_Score=157, Evalue=4e-38,
Organism=Drosophila melanogaster, GI160714832, Length=312, Percent_Identity=30.1282051282051, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI160714828, Length=309, Percent_Identity=30.42071197411, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355903, Length=326, Percent_Identity=28.2208588957055, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 78646; Mature: 78515

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGP
CCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AHASIGQEAAAVGAMSVLKTDDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHD
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
AVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIVGGNIPHAAGYALADKILNRK
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCHHEECCCCCCHHHHHHHHHHHCCC
GISVAFFGDGASLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRGP
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEEECHHHHHHHHHHHCCCC
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRT
CCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCC
REEEEEWKSRDPIALAERRLKELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLR
CCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
IPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELEKMRFAAAASDVLGRAMEKDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TIIVMGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVALGAALRGLRPVVEIM
EEEEECCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPG
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCC
WRVVSPTNAFDYIGLMNSALKSNDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRP
CEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECC
GSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGIDWALIGASIGKTNRVVIAEQ
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEEEHHH
VASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
ITHSA
HHCCC
>Mature Secondary Structure 
AEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGP
CCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AHASIGQEAAAVGAMSVLKTDDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHD
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
AVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIVGGNIPHAAGYALADKILNRK
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCHHEECCCCCCHHHHHHHHHHHCCC
GISVAFFGDGASLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRGP
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEEECHHHHHHHHHHHCCCC
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRT
CCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCC
REEEEEWKSRDPIALAERRLKELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLR
CCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
IPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELEKMRFAAAASDVLGRAMEKDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TIIVMGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVALGAALRGLRPVVEIM
EEEEECCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPG
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCC
WRVVSPTNAFDYIGLMNSALKSNDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRP
CEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECC
GSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGIDWALIGASIGKTNRVVIAEQ
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEEEHHH
VASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
ITHSA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]