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The map label for this gene is mdtE [H]

Identifier: 163845032

GI number: 163845032

Start: 887558

End: 888664

Strand: Reverse

Name: mdtE [H]

Synonym: BSUIS_B0908

Alternate gene names: 163845032

Gene position: 888664-887558 (Counterclockwise)

Preceding gene: 163845033

Following gene: 163845031

Centisome position: 63.44

GC content: 62.15

Gene sequence:

>1107_bases
ATGAAAATCCATATGAACCCCATGTTCCGTGCTGCCGGTTGCGCGGTCCTGTTTGGCGCGCTGACGGTGCTTGCCGCTTG
CGGCAAAGAGGATGAAAAGGCGCAGGAAGCTGCGCCCATCCGCCCGGTTCTCTATACGATCGTGGAGCCGAAGCCCGTCG
CCCAGACGGGTTTTGCGGGCACAGTCGAGCCGCGCTATTCGACCGATCTGGCTTTCCGCGTTCTGGGGCGGGTCATAGCC
CGGCCTGTGAAGGTGGGCGATCTCGTGAAGAAGGGCGAGATGGTGGCAATGCTCTATCCATCGGCGCTTGATCTTGCGGT
GCAATCGGCAAGGGCCGACCTTGCCAGTGCCGAGGCACAATATGCCAATGCTTCGGCAAGCGAGGAACGCCAGTGTATCC
TGCTGCGTGGCAACAATGTTTCGCAGGCCGATTATGACGCGGCCAGGCAGGCGCGCGACAGCGCCGAGGCAGGGCTGGAA
AAGGCGCAGGCCGGTTTGCGCAAGGCCGAAGAGCAGCGGGGATATGCCGTGCTGCGTCCCGATTTCGATGGCGTGATCTC
CGCAACGGCTGCCGAAGTCGGGCAGGTGGTTTCGGCGGGTCAGGCGATCGTGACCGTGGCGCGTCCCGATGTCCGGGAAG
CGGTGGTGGATATTCCCGACAGCATGACCGAATATTTCAAGCCCGGCACTCCTTTCAATGTGCAGCTTCAGGCCGATCCT
TCCGTGAAAGGAACGGGAAGCGTGCGCGAGGTCGCGCCGCAGGCCGATGCACAAACGCGCACACGCCGGGTGCGCATCGC
ACTTGACAATCCGCCCGAAGGGTTCCGCCTCGGCGCAACCATTCAGGCCGCTCGTTCCACGCCGGAAACGGGCTTCGTTT
CCCTGCCCATGCCGTCGCTTCTCGAACAGGACGGCAAAACCAGCATATGGGTGATCGATCCCGGAACACAGACCGTGAGC
CTTCACGATGTGCGCGTTATCGAGCGCAAGGGAGCAAGTTTTGCGGCAGGCGGGGTCGAGGCCGGCAGCTATGTGGCAAT
TGCCGGTGTGCATGAACTGAAAGCAGGGCAGAAAGTCCGTCTGGACGAGAAAGGAAGCGGGCTGTGA

Upstream 100 bases:

>100_bases
GCCTTAATAAAGGTGAGCTTATCGTGACCAAAGGTGCGCAGATGCTGCGCTCCGGCGAGCCGGTAGAGATCATGCAGGGG
CCTGAAGGAGCTGGCTCGCA

Downstream 100 bases:

>100_bases
AAAAGGGATTCAATCTGTCTGACTGGGCTTTGAATCATCGCTCCCTGGTCTGGTATTTCATGCTCGTTTTTCTCGTTGCG
GGGCTTGTGTCCTATCTGGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKIHMNPMFRAAGCAVLFGALTVLAACGKEDEKAQEAAPIRPVLYTIVEPKPVAQTGFAGTVEPRYSTDLAFRVLGRVIA
RPVKVGDLVKKGEMVAMLYPSALDLAVQSARADLASAEAQYANASASEERQCILLRGNNVSQADYDAARQARDSAEAGLE
KAQAGLRKAEEQRGYAVLRPDFDGVISATAAEVGQVVSAGQAIVTVARPDVREAVVDIPDSMTEYFKPGTPFNVQLQADP
SVKGTGSVREVAPQADAQTRTRRVRIALDNPPEGFRLGATIQAARSTPETGFVSLPMPSLLEQDGKTSIWVIDPGTQTVS
LHDVRVIERKGASFAAGGVEAGSYVAIAGVHELKAGQKVRLDEKGSGL

Sequences:

>Translated_368_residues
MKIHMNPMFRAAGCAVLFGALTVLAACGKEDEKAQEAAPIRPVLYTIVEPKPVAQTGFAGTVEPRYSTDLAFRVLGRVIA
RPVKVGDLVKKGEMVAMLYPSALDLAVQSARADLASAEAQYANASASEERQCILLRGNNVSQADYDAARQARDSAEAGLE
KAQAGLRKAEEQRGYAVLRPDFDGVISATAAEVGQVVSAGQAIVTVARPDVREAVVDIPDSMTEYFKPGTPFNVQLQADP
SVKGTGSVREVAPQADAQTRTRRVRIALDNPPEGFRLGATIQAARSTPETGFVSLPMPSLLEQDGKTSIWVIDPGTQTVS
LHDVRVIERKGASFAAGGVEAGSYVAIAGVHELKAGQKVRLDEKGSGL
>Mature_368_residues
MKIHMNPMFRAAGCAVLFGALTVLAACGKEDEKAQEAAPIRPVLYTIVEPKPVAQTGFAGTVEPRYSTDLAFRVLGRVIA
RPVKVGDLVKKGEMVAMLYPSALDLAVQSARADLASAEAQYANASASEERQCILLRGNNVSQADYDAARQARDSAEAGLE
KAQAGLRKAEEQRGYAVLRPDFDGVISATAAEVGQVVSAGQAIVTVARPDVREAVVDIPDSMTEYFKPGTPFNVQLQADP
SVKGTGSVREVAPQADAQTRTRRVRIALDNPPEGFRLGATIQAARSTPETGFVSLPMPSLLEQDGKTSIWVIDPGTQTVS
LHDVRVIERKGASFAAGGVEAGSYVAIAGVHELKAGQKVRLDEKGSGL

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=367, Percent_Identity=26.7029972752044, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082036, Length=342, Percent_Identity=26.0233918128655, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38983; Mature: 38983

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHMNPMFRAAGCAVLFGALTVLAACGKEDEKAQEAAPIRPVLYTIVEPKPVAQTGFAG
CEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCC
TVEPRYSTDLAFRVLGRVIARPVKVGDLVKKGEMVAMLYPSALDLAVQSARADLASAEAQ
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
YANASASEERQCILLRGNNVSQADYDAARQARDSAEAGLEKAQAGLRKAEEQRGYAVLRP
HCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
DFDGVISATAAEVGQVVSAGQAIVTVARPDVREAVVDIPDSMTEYFKPGTPFNVQLQADP
CCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHHCCCCCCEEEEEEECC
SVKGTGSVREVAPQADAQTRTRRVRIALDNPPEGFRLGATIQAARSTPETGFVSLPMPSL
CCCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCEEECCEEEECCCCCCCCEEECCCHHH
LEQDGKTSIWVIDPGTQTVSLHDVRVIERKGASFAAGGVEAGSYVAIAGVHELKAGQKVR
HHCCCCEEEEEECCCCCEEEEEHEEEEHHCCCCEECCCCCCCCEEEEECHHHHCCCCEEE
LDEKGSGL
ECCCCCCC
>Mature Secondary Structure
MKIHMNPMFRAAGCAVLFGALTVLAACGKEDEKAQEAAPIRPVLYTIVEPKPVAQTGFAG
CEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCC
TVEPRYSTDLAFRVLGRVIARPVKVGDLVKKGEMVAMLYPSALDLAVQSARADLASAEAQ
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
YANASASEERQCILLRGNNVSQADYDAARQARDSAEAGLEKAQAGLRKAEEQRGYAVLRP
HCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
DFDGVISATAAEVGQVVSAGQAIVTVARPDVREAVVDIPDSMTEYFKPGTPFNVQLQADP
CCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHHCCCCCCEEEEEEECC
SVKGTGSVREVAPQADAQTRTRRVRIALDNPPEGFRLGATIQAARSTPETGFVSLPMPSL
CCCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCEEECCEEEECCCCCCCCEEECCCHHH
LEQDGKTSIWVIDPGTQTVSLHDVRVIERKGASFAAGGVEAGSYVAIAGVHELKAGQKVR
HHCCCCEEEEEECCCCCEEEEEHEEEEHHCCCCEECCCCCCCCEEEEECHHHHCCCCEEE
LDEKGSGL
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]