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The map label for this gene is acsA [H]

Identifier: 163844616

GI number: 163844616

Start: 439182

End: 440852

Strand: Reverse

Name: acsA [H]

Synonym: BSUIS_B0451

Alternate gene names: 163844616

Gene position: 440852-439182 (Counterclockwise)

Preceding gene: 163844620

Following gene: 163844615

Centisome position: 31.47

GC content: 60.2

Gene sequence:

>1671_bases
ATGACTGAAAGCCCTGCTTCAGCACGGCTCGACCGCTACGATGATGCCGTTGCGCAGTTCGATATTGCAAAAGCCATTGC
GCTTCTTGCAGGAAATCCTGATACGGGTATCAATGCCTGCATTGAATGCTGCGACCGATATACGGGCGAAAATCGCGTGG
CGCTGCGCGCCATTTCCATCGACAATACGTTGACTGAACTCACCTTTGAAGACCTGCGCGATATGTCCGCGCGGGTCGGC
AATATGCTGGCCGATGCCGGGATCAGCGCAGGCGATGTGGTTGCCGGTCTTCTCCCCCGCACGCCTGAACTCGTCGCCAC
CATTCTCGGCGCCTGGCGCATCGGCGCAATCTATCAGCCGCTTTTCACCGCCTTCGGCCCAAAAGCCATCGAACAGCGTT
TCGGCACCAGTGGCGCCAAACTCGTCGTCACCAACCTGGCCAATCGTTCCAAATTGGCCGAAGTGGAAAACTGCCCCCGC
GTCGCAACCATTCTTGCCCCCGGTGAAAGCCTGCCGGAAGGCGATATCGACTTTCGCGCAGCCGTGGCGGCAGCATCGAC
CGAATGCGAGCCCGTCATGCGCAAGGGCAGCGACCTTTTCATGATGATGTCCACCTCCGGCACGGCGGGCCTGCCCAAAG
GCGTCCCGGTGCCGCTGCGCGCCCTGATGGCTTTCGGCGCCTATATGCGCGATGCCGTGGGCCTGCGCAGCGACGATATT
TTCTGGAATATCGCCGATCCGGGCTGGGCATATGGGCTTTACTATGCCGTGACGGGTCCCCTGCTTCTGGGTGTGCCGAC
GATCCTGAACGAAGGCGGTTTCACCGCCGAAAACACCTATGACATCATCGAACGCCTCGGCGTGACGAGCCTTGCGGGCT
CTCCGACTGCCTTCCGCCTGCTTATGGCCGCCGGGCCGGAATCTGCTGCCCGCGTCAAGGGCCGCTTGCGCGTGGTATCC
AGCGCGGGCGAGCCGCTGAACCCGGAAGTCATTCGCTGGTTCGATGCCTGTCTTGGCGCGCCGATCCACGATCATTACGC
CCAGACGGAACTGGGCATGGTGGTGAACAACCATCATGGATTGGAACATCCGGTGCGGCAGGGTTCGGCGGGCTATGCCA
TGCCGGGCTACAGGGTTGCGGTTCTGGATGAAGCGGGCAAAGAAGTCGACCCCAATGAACCGGGCGTTCTGGCCATTGAT
ATCGACAATTCGCCGCTTCTCTGGTTCACCGGCTATTATAAAAAGGATACGCCCTCCATCTCCGGCGGATATTATCGCAC
CGGCGATACGGTGGAATTCGAGCCGGATGGGTCTATCAGCTTCATCGGCCGCGCCGATGACGTCATCACCTCCTCCGGCT
ATCGCATCGGGCCTTTCGATGTGGAAAGCGCGCTTCTGGAACATCCTGCGGTCAACGAGGCTGCGGTGGTCGGCGTTCCC
GATCCGCAACGCACCGAAATCGTGAAGGCCTTTGTCATCCTGGCCCCCGGCTTCGAGGGTACGCCGGAACTGGCGGAAGA
ACTGGCGCTTCACGTCAAGAAACAGCTTTCCGCCCATACCTATCCGCGGCAGATCGACTTTGTGGCGGAGCTTCCCAAGA
CGCCGAGCGGAAAAATACAGCGCTTCCTCCTGCGCAAGGCGGAAGTCGAAAAGCAACAGCAACAGAATTAG

Upstream 100 bases:

>100_bases
AGAGATTAAGACACGTAATGTCATTGTTTGCCATGATGAGGCGATTAATTTTTAGCCAGGATTGCCCACGAGGAGGTGGG
CTGCAAGCGAGGACCACCGA

Downstream 100 bases:

>100_bases
GGCCTGAAGCAAATGCAGATAGAAAATCGCGTATTTCTGATTACCGGCGCAGGCTCCGGCCTTGGCGCTGCCGTTTCCAA
AATGGCTGTTGAGGCGGGCG

Product: hypothetical protein

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MTESPASARLDRYDDAVAQFDIAKAIALLAGNPDTGINACIECCDRYTGENRVALRAISIDNTLTELTFEDLRDMSARVG
NMLADAGISAGDVVAGLLPRTPELVATILGAWRIGAIYQPLFTAFGPKAIEQRFGTSGAKLVVTNLANRSKLAEVENCPR
VATILAPGESLPEGDIDFRAAVAAASTECEPVMRKGSDLFMMMSTSGTAGLPKGVPVPLRALMAFGAYMRDAVGLRSDDI
FWNIADPGWAYGLYYAVTGPLLLGVPTILNEGGFTAENTYDIIERLGVTSLAGSPTAFRLLMAAGPESAARVKGRLRVVS
SAGEPLNPEVIRWFDACLGAPIHDHYAQTELGMVVNNHHGLEHPVRQGSAGYAMPGYRVAVLDEAGKEVDPNEPGVLAID
IDNSPLLWFTGYYKKDTPSISGGYYRTGDTVEFEPDGSISFIGRADDVITSSGYRIGPFDVESALLEHPAVNEAAVVGVP
DPQRTEIVKAFVILAPGFEGTPELAEELALHVKKQLSAHTYPRQIDFVAELPKTPSGKIQRFLLRKAEVEKQQQQN

Sequences:

>Translated_556_residues
MTESPASARLDRYDDAVAQFDIAKAIALLAGNPDTGINACIECCDRYTGENRVALRAISIDNTLTELTFEDLRDMSARVG
NMLADAGISAGDVVAGLLPRTPELVATILGAWRIGAIYQPLFTAFGPKAIEQRFGTSGAKLVVTNLANRSKLAEVENCPR
VATILAPGESLPEGDIDFRAAVAAASTECEPVMRKGSDLFMMMSTSGTAGLPKGVPVPLRALMAFGAYMRDAVGLRSDDI
FWNIADPGWAYGLYYAVTGPLLLGVPTILNEGGFTAENTYDIIERLGVTSLAGSPTAFRLLMAAGPESAARVKGRLRVVS
SAGEPLNPEVIRWFDACLGAPIHDHYAQTELGMVVNNHHGLEHPVRQGSAGYAMPGYRVAVLDEAGKEVDPNEPGVLAID
IDNSPLLWFTGYYKKDTPSISGGYYRTGDTVEFEPDGSISFIGRADDVITSSGYRIGPFDVESALLEHPAVNEAAVVGVP
DPQRTEIVKAFVILAPGFEGTPELAEELALHVKKQLSAHTYPRQIDFVAELPKTPSGKIQRFLLRKAEVEKQQQQN
>Mature_555_residues
TESPASARLDRYDDAVAQFDIAKAIALLAGNPDTGINACIECCDRYTGENRVALRAISIDNTLTELTFEDLRDMSARVGN
MLADAGISAGDVVAGLLPRTPELVATILGAWRIGAIYQPLFTAFGPKAIEQRFGTSGAKLVVTNLANRSKLAEVENCPRV
ATILAPGESLPEGDIDFRAAVAAASTECEPVMRKGSDLFMMMSTSGTAGLPKGVPVPLRALMAFGAYMRDAVGLRSDDIF
WNIADPGWAYGLYYAVTGPLLLGVPTILNEGGFTAENTYDIIERLGVTSLAGSPTAFRLLMAAGPESAARVKGRLRVVSS
AGEPLNPEVIRWFDACLGAPIHDHYAQTELGMVVNNHHGLEHPVRQGSAGYAMPGYRVAVLDEAGKEVDPNEPGVLAIDI
DNSPLLWFTGYYKKDTPSISGGYYRTGDTVEFEPDGSISFIGRADDVITSSGYRIGPFDVESALLEHPAVNEAAVVGVPD
PQRTEIVKAFVILAPGFEGTPELAEELALHVKKQLSAHTYPRQIDFVAELPKTPSGKIQRFLLRKAEVEKQQQQN

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=500, Percent_Identity=37.4, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI122937307, Length=497, Percent_Identity=36.8209255533199, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI42544132, Length=491, Percent_Identity=33.6048879837067, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI115511026, Length=493, Percent_Identity=33.4685598377282, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI58082049, Length=493, Percent_Identity=34.8884381338742, Blast_Score=245, Evalue=9e-65,
Organism=Homo sapiens, GI157311624, Length=493, Percent_Identity=34.8884381338742, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI157311622, Length=493, Percent_Identity=34.8884381338742, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI8923896, Length=609, Percent_Identity=30.2134646962233, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI253970489, Length=622, Percent_Identity=29.7427652733119, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI28416953, Length=570, Percent_Identity=29.2982456140351, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI13375727, Length=553, Percent_Identity=29.6564195298373, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI195947378, Length=411, Percent_Identity=26.2773722627737, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI42544134, Length=329, Percent_Identity=26.1398176291793, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI156151445, Length=548, Percent_Identity=26.2773722627737, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI187761345, Length=520, Percent_Identity=25.5769230769231, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI187761343, Length=520, Percent_Identity=25.5769230769231, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38524616, Length=535, Percent_Identity=23.3644859813084, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1790505, Length=572, Percent_Identity=30.0699300699301, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1786529, Length=547, Percent_Identity=30.5301645338208, Blast_Score=170, Evalue=3e-43,
Organism=Escherichia coli, GI145693145, Length=518, Percent_Identity=27.4131274131274, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788107, Length=530, Percent_Identity=25.4716981132075, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI221142682, Length=506, Percent_Identity=23.5177865612648, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786801, Length=442, Percent_Identity=22.3981900452489, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786810, Length=305, Percent_Identity=27.5409836065574, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71982997, Length=525, Percent_Identity=30.0952380952381, Blast_Score=176, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71983001, Length=525, Percent_Identity=30.4761904761905, Blast_Score=176, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17557194, Length=538, Percent_Identity=24.907063197026, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17558820, Length=485, Percent_Identity=24.1237113402062, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=24.8618784530387, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32563687, Length=468, Percent_Identity=25.4273504273504, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17559526, Length=523, Percent_Identity=24.6653919694073, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=515, Percent_Identity=25.2427184466019, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17531443, Length=514, Percent_Identity=23.3463035019455, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=508, Percent_Identity=24.4094488188976, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71994703, Length=364, Percent_Identity=25.5494505494505, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=364, Percent_Identity=25.5494505494505, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=364, Percent_Identity=25.5494505494505, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560308, Length=357, Percent_Identity=25.7703081232493, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=400, Percent_Identity=24.25, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319264, Length=566, Percent_Identity=31.4487632508834, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6323182, Length=572, Percent_Identity=30.4195804195804, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6319699, Length=516, Percent_Identity=24.4186046511628, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI62472339, Length=532, Percent_Identity=30.8270676691729, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24667955, Length=585, Percent_Identity=29.5726495726496, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24667959, Length=501, Percent_Identity=30.3393213572854, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI21355225, Length=562, Percent_Identity=27.2241992882562, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI19922652, Length=502, Percent_Identity=25.4980079681275, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24656500, Length=501, Percent_Identity=26.1477045908184, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI18859661, Length=527, Percent_Identity=25.9962049335863, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581924, Length=353, Percent_Identity=26.9121813031161, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24648260, Length=503, Percent_Identity=24.2544731610338, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20130357, Length=499, Percent_Identity=23.6472945891784, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21358303, Length=465, Percent_Identity=24.5161290322581, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355181, Length=496, Percent_Identity=24.3951612903226, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356947, Length=495, Percent_Identity=21.2121212121212, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648257, Length=569, Percent_Identity=23.1985940246046, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281365686, Length=465, Percent_Identity=23.6559139784946, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653035, Length=492, Percent_Identity=20.5284552845528, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161076582, Length=496, Percent_Identity=20.3629032258065, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356441, Length=494, Percent_Identity=22.0647773279352, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24648253, Length=425, Percent_Identity=22.5882352941176, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24648255, Length=503, Percent_Identity=21.272365805169, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 59697; Mature: 59566

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESPASARLDRYDDAVAQFDIAKAIALLAGNPDTGINACIECCDRYTGENRVALRAISI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEC
DNTLTELTFEDLRDMSARVGNMLADAGISAGDVVAGLLPRTPELVATILGAWRIGAIYQP
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LFTAFGPKAIEQRFGTSGAKLVVTNLANRSKLAEVENCPRVATILAPGESLPEGDIDFRA
HHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHH
AVAAASTECEPVMRKGSDLFMMMSTSGTAGLPKGVPVPLRALMAFGAYMRDAVGLRSDDI
HHHHCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
FWNIADPGWAYGLYYAVTGPLLLGVPTILNEGGFTAENTYDIIERLGVTSLAGSPTAFRL
EEEECCCCHHHHHHHHHHCHHHHCCHHHHCCCCCCCCHHHHHHHHCCCHHCCCCCHHHEE
LMAAGPESAARVKGRLRVVSSAGEPLNPEVIRWFDACLGAPIHDHYAQTELGMVVNNHHG
EECCCCCHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEECCCC
LEHPVRQGSAGYAMPGYRVAVLDEAGKEVDPNEPGVLAIDIDNSPLLWFTGYYKKDTPSI
CCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCC
SGGYYRTGDTVEFEPDGSISFIGRADDVITSSGYRIGPFDVESALLEHPAVNEAAVVGVP
CCCEEECCCEEEECCCCCEEEEECCCHHEECCCCEECCCCHHHHHHCCCCCCCEEEEECC
DPQRTEIVKAFVILAPGFEGTPELAEELALHVKKQLSAHTYPRQIDFVAELPKTPSGKIQ
CCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHH
RFLLRKAEVEKQQQQN
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TESPASARLDRYDDAVAQFDIAKAIALLAGNPDTGINACIECCDRYTGENRVALRAISI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEC
DNTLTELTFEDLRDMSARVGNMLADAGISAGDVVAGLLPRTPELVATILGAWRIGAIYQP
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LFTAFGPKAIEQRFGTSGAKLVVTNLANRSKLAEVENCPRVATILAPGESLPEGDIDFRA
HHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHH
AVAAASTECEPVMRKGSDLFMMMSTSGTAGLPKGVPVPLRALMAFGAYMRDAVGLRSDDI
HHHHCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
FWNIADPGWAYGLYYAVTGPLLLGVPTILNEGGFTAENTYDIIERLGVTSLAGSPTAFRL
EEEECCCCHHHHHHHHHHCHHHHCCHHHHCCCCCCCCHHHHHHHHCCCHHCCCCCHHHEE
LMAAGPESAARVKGRLRVVSSAGEPLNPEVIRWFDACLGAPIHDHYAQTELGMVVNNHHG
EECCCCCHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEECCCC
LEHPVRQGSAGYAMPGYRVAVLDEAGKEVDPNEPGVLAIDIDNSPLLWFTGYYKKDTPSI
CCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCC
SGGYYRTGDTVEFEPDGSISFIGRADDVITSSGYRIGPFDVESALLEHPAVNEAAVVGVP
CCCEEECCCEEEECCCCCEEEEECCCHHEECCCCEECCCCHHHHHHCCCCCCCEEEEECC
DPQRTEIVKAFVILAPGFEGTPELAEELALHVKKQLSAHTYPRQIDFVAELPKTPSGKIQ
CCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHH
RFLLRKAEVEKQQQQN
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]