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The map label for this gene is aqpZ [H]

Identifier: 162448005

GI number: 162448005

Start: 1217282

End: 1217965

Strand: Direct

Name: aqpZ [H]

Synonym: ACL_1162

Alternate gene names: 162448005

Gene position: 1217282-1217965 (Clockwise)

Preceding gene: 162447990

Following gene: 162448006

Centisome position: 81.32

GC content: 36.11

Gene sequence:

>684_bases
ATGAAATATATGAAGTTAAAAGCCTATATGGCAGAGTTTATTGGAGCGTTCGCTCTAGTTTTAGTGGGTTCAACCGCTGC
AGTATTAAACTTAGAATTATCTAGTATTGCCTTAGCATTTGGACTTATTCTTATGGCTATGATTTATGCAGTAGGTTCCA
CATCAGGAGGTCACTTTAATCCTGCAGTATCGTTTGCGATGGCACTGACTAAAAGATTATCTTGGAAAGATTTTGGAATG
TATAGTTTCTTCCAATTACTTGGTTCCTTAATCGCAGTGTTATGTTTAGTACCATTTGTTGGTGACTTATCTAATTTAGG
TGCTAACCAAATATTTGGTGACTTTGGTGGTCAAACAGGCATCTTAATTTTATTATTAGGTGTCTTAGTTGAAGTGATTG
GTACATTCTTATTTGTCTTTGTGATCTTGCGTGTTACAAAAGAACCAAATCTAAAGAGTCTTGCAGGTTTAATCATTGGT
TTAACACTTGCAGCACTTATTTATTTTACAGGTCCTCTTACAAATGCAAGTTTAAACCCAGTGCGTTCGATCTTCTCAGG
ACTATTTCAAGGTGGTAAAGCATTAGAACAAGTTTGGATATTTATTGTAGGACCTATGATTGGTGCATTTCTAGCTGCTG
TTGCTGCACCGTATTTTGATCAAGTGCCTGAAGAAAAGGCTTAA

Upstream 100 bases:

>100_bases
TAATTTTTATCATATTTTCACCACCTTGATTATAACATGAAACTTTTGTTTATATTTTGGTATAATTGTAATAAAGAAAA
AATACTTTAGAATCAAGGAG

Downstream 100 bases:

>100_bases
CATATTATGTATAGAAAACATCTATACTTAATCAGTTTAATTCTACAAAGCATTCTACTTCTATTATTTATTATTTTTTT
AGTGGATACCTTAGTTAGAT

Product: major intrinsic protein family permease

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKYMKLKAYMAEFIGAFALVLVGSTAAVLNLELSSIALAFGLILMAMIYAVGSTSGGHFNPAVSFAMALTKRLSWKDFGM
YSFFQLLGSLIAVLCLVPFVGDLSNLGANQIFGDFGGQTGILILLLGVLVEVIGTFLFVFVILRVTKEPNLKSLAGLIIG
LTLAALIYFTGPLTNASLNPVRSIFSGLFQGGKALEQVWIFIVGPMIGAFLAAVAAPYFDQVPEEKA

Sequences:

>Translated_227_residues
MKYMKLKAYMAEFIGAFALVLVGSTAAVLNLELSSIALAFGLILMAMIYAVGSTSGGHFNPAVSFAMALTKRLSWKDFGM
YSFFQLLGSLIAVLCLVPFVGDLSNLGANQIFGDFGGQTGILILLLGVLVEVIGTFLFVFVILRVTKEPNLKSLAGLIIG
LTLAALIYFTGPLTNASLNPVRSIFSGLFQGGKALEQVWIFIVGPMIGAFLAAVAAPYFDQVPEEKA
>Mature_227_residues
MKYMKLKAYMAEFIGAFALVLVGSTAAVLNLELSSIALAFGLILMAMIYAVGSTSGGHFNPAVSFAMALTKRLSWKDFGM
YSFFQLLGSLIAVLCLVPFVGDLSNLGANQIFGDFGGQTGILILLLGVLVEVIGTFLFVFVILRVTKEPNLKSLAGLIIG
LTLAALIYFTGPLTNASLNPVRSIFSGLFQGGKALEQVWIFIVGPMIGAFLAAVAAPYFDQVPEEKA

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502181, Length=218, Percent_Identity=34.8623853211009, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4755125, Length=218, Percent_Identity=34.8623853211009, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI37694062, Length=230, Percent_Identity=31.304347826087, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=33.9712918660287, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71993722, Length=236, Percent_Identity=30.9322033898305, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17558372, Length=221, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24652747, Length=213, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551084, Length=213, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24161; Mature: 24161

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYMKLKAYMAEFIGAFALVLVGSTAAVLNLELSSIALAFGLILMAMIYAVGSTSGGHFN
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
PAVSFAMALTKRLSWKDFGMYSFFQLLGSLIAVLCLVPFVGDLSNLGANQIFGDFGGQTG
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
ILILLLGVLVEVIGTFLFVFVILRVTKEPNLKSLAGLIIGLTLAALIYFTGPLTNASLNP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VRSIFSGLFQGGKALEQVWIFIVGPMIGAFLAAVAAPYFDQVPEEKA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKYMKLKAYMAEFIGAFALVLVGSTAAVLNLELSSIALAFGLILMAMIYAVGSTSGGHFN
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
PAVSFAMALTKRLSWKDFGMYSFFQLLGSLIAVLCLVPFVGDLSNLGANQIFGDFGGQTG
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
ILILLLGVLVEVIGTFLFVFVILRVTKEPNLKSLAGLIIGLTLAALIYFTGPLTNASLNP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VRSIFSGLFQGGKALEQVWIFIVGPMIGAFLAAVAAPYFDQVPEEKA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]