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The map label for this gene is mhqO [H]

Identifier: 162447425

GI number: 162447425

Start: 600343

End: 601542

Strand: Direct

Name: mhqO [H]

Synonym: ACL_0563

Alternate gene names: 162447425

Gene position: 600343-601542 (Clockwise)

Preceding gene: 162447422

Following gene: 162447426

Centisome position: 40.1

GC content: 32.25

Gene sequence:

>1200_bases
ATGTATATGAAAATACAAGGGATACATCATATTTCAACCATTGTATGGCATGCACAAGAAAATGTTGATTTCTATGCAGG
TGTATTAGGATTAAAATTAATTAAGAGAACTTTAAACTTTGATGATCACAATGTGTATCATCTATATTATGGAAATCACA
ATGCAGATTTAGGTACAGCAATCACATTCTTTCCATGGCCAAAACACTATAAAGAAGGTATGGTTGGAGATGGACAAGTT
GGTGTAACAAGTTACATGGTACCAGCGGGTTCATTAGATTATTGGAAAGAAAGACTTACTAAATTCAATGTATCATTCGA
AGCACAAGAAAGATTAGGAAATAAGTTTTTAAGATTTAGCGATCCTCATGGCATTAAAAATGAATTAATTGAATCTGATG
AAGGTGACCAAAACTTATTTGAATTTAATGGTGTTACAAAAGATGTAGCAATTAAAGGTTTTTACGGGGCACTTATGTAT
TCATCTAACTATAAAGGCACTGTAGAACACTTAACTAACGATTTAGGATTAACTTTTGTCAAAGAAGATGATGACTATAT
CAGACTAGATACAGGACGTACGCTTGGTAGATATGTAGATATTTATAAACATAAGACTGGACGTTCTAGTATGGGCGCTG
GTTCTGTTCACCATATTGCTTTTGGTGTTGAAGCATCTGAAATTGAAACTTGGAAAACTAACTTAGAAGCTAAAGGATTT
ACAATTACTGGTGTTAAGGATAGAAAATTCTTTAAATCACTATATTATAGAGAACCAGGTGGTGTAATTATTGAACTTGC
AACACTTACTCCAGGATTTGAAATGGATAGTGAATATAAAGAAGCACCAGATCTCTATATGCCACCACATTATATGCACT
TAAAAGATGAAGTGGAAGCAAAACTCATGCCACTCTTTATTAGAAACATTGATAGTCTTTATGAGTATCCTTATCAAAAC
AAGGAAGAATATGAACGCTGGAAGGCACATCAAGATTTATTGAATAAAATTAATTATTATGCTAAAGAAGCCAAACTAAG
AACATTAACAGATGAAGAAATTGAAGAACGACAAGAACTTAGACACAAATATGTTAAAAGCATTCGTGGTGCAATTCAAA
ACAATCTGGAAAATATAAGAGTTGAAGATGAAGATGGAAACTTCCAAGAACTTAATAGAAAAGAAGGTAATGTACAATGA

Upstream 100 bases:

>100_bases
TGTGTTAAATTCTTATATATTATACCACAATTTGCCTAAAAATGCATATTGATGGAAATTATTTCGAATTCGAAATATAA
TGTAACCATGAAAAGAGGTA

Downstream 100 bases:

>100_bases
CGAATCTATTAGGTATTCACCATATTACTGCAATTACTAGCAGTGCTCCAAAAATCTATGATTTTTATACAAATGTATTA
GGTTTAAGATTAGTAAAGAA

Product: glyoxalase domain-containing protein

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MYMKIQGIHHISTIVWHAQENVDFYAGVLGLKLIKRTLNFDDHNVYHLYYGNHNADLGTAITFFPWPKHYKEGMVGDGQV
GVTSYMVPAGSLDYWKERLTKFNVSFEAQERLGNKFLRFSDPHGIKNELIESDEGDQNLFEFNGVTKDVAIKGFYGALMY
SSNYKGTVEHLTNDLGLTFVKEDDDYIRLDTGRTLGRYVDIYKHKTGRSSMGAGSVHHIAFGVEASEIETWKTNLEAKGF
TITGVKDRKFFKSLYYREPGGVIIELATLTPGFEMDSEYKEAPDLYMPPHYMHLKDEVEAKLMPLFIRNIDSLYEYPYQN
KEEYERWKAHQDLLNKINYYAKEAKLRTLTDEEIEERQELRHKYVKSIRGAIQNNLENIRVEDEDGNFQELNRKEGNVQ

Sequences:

>Translated_399_residues
MYMKIQGIHHISTIVWHAQENVDFYAGVLGLKLIKRTLNFDDHNVYHLYYGNHNADLGTAITFFPWPKHYKEGMVGDGQV
GVTSYMVPAGSLDYWKERLTKFNVSFEAQERLGNKFLRFSDPHGIKNELIESDEGDQNLFEFNGVTKDVAIKGFYGALMY
SSNYKGTVEHLTNDLGLTFVKEDDDYIRLDTGRTLGRYVDIYKHKTGRSSMGAGSVHHIAFGVEASEIETWKTNLEAKGF
TITGVKDRKFFKSLYYREPGGVIIELATLTPGFEMDSEYKEAPDLYMPPHYMHLKDEVEAKLMPLFIRNIDSLYEYPYQN
KEEYERWKAHQDLLNKINYYAKEAKLRTLTDEEIEERQELRHKYVKSIRGAIQNNLENIRVEDEDGNFQELNRKEGNVQ
>Mature_399_residues
MYMKIQGIHHISTIVWHAQENVDFYAGVLGLKLIKRTLNFDDHNVYHLYYGNHNADLGTAITFFPWPKHYKEGMVGDGQV
GVTSYMVPAGSLDYWKERLTKFNVSFEAQERLGNKFLRFSDPHGIKNELIESDEGDQNLFEFNGVTKDVAIKGFYGALMY
SSNYKGTVEHLTNDLGLTFVKEDDDYIRLDTGRTLGRYVDIYKHKTGRSSMGAGSVHHIAFGVEASEIETWKTNLEAKGF
TITGVKDRKFFKSLYYREPGGVIIELATLTPGFEMDSEYKEAPDLYMPPHYMHLKDEVEAKLMPLFIRNIDSLYEYPYQN
KEEYERWKAHQDLLNKINYYAKEAKLRTLTDEEIEERQELRHKYVKSIRGAIQNNLENIRVEDEDGNFQELNRKEGNVQ

Specific function: Putative ring-cleavage dioxygenase that may contribute to the degradation of aromatic compounds (Potential) [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the extradiol ring-cleavage dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 46360; Mature: 46360

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMKIQGIHHISTIVWHAQENVDFYAGVLGLKLIKRTLNFDDHNVYHLYYGNHNADLGTA
CEEEECCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCE
ITFFPWPKHYKEGMVGDGQVGVTSYMVPAGSLDYWKERLTKFNVSFEAQERLGNKFLRFS
EEECCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEHHHHHCCCCEECC
DPHGIKNELIESDEGDQNLFEFNGVTKDVAIKGFYGALMYSSNYKGTVEHLTNDLGLTFV
CCCCCHHHHHCCCCCCCCCEEECCCCHHHEEEEEEEEEEECCCCCCHHHHHHHCCCEEEE
KEDDDYIRLDTGRTLGRYVDIYKHKTGRSSMGAGSVHHIAFGVEASEIETWKTNLEAKGF
ECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCE
TITGVKDRKFFKSLYYREPGGVIIELATLTPGFEMDSEYKEAPDLYMPPHYMHLKDEVEA
EEECCCHHHHHHHHHEECCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHH
KLMPLFIRNIDSLYEYPYQNKEEYERWKAHQDLLNKINYYAKEAKLRTLTDEEIEERQEL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RHKYVKSIRGAIQNNLENIRVEDEDGNFQELNRKEGNVQ
HHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MYMKIQGIHHISTIVWHAQENVDFYAGVLGLKLIKRTLNFDDHNVYHLYYGNHNADLGTA
CEEEECCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCE
ITFFPWPKHYKEGMVGDGQVGVTSYMVPAGSLDYWKERLTKFNVSFEAQERLGNKFLRFS
EEECCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEHHHHHCCCCEECC
DPHGIKNELIESDEGDQNLFEFNGVTKDVAIKGFYGALMYSSNYKGTVEHLTNDLGLTFV
CCCCCHHHHHCCCCCCCCCEEECCCCHHHEEEEEEEEEEECCCCCCHHHHHHHCCCEEEE
KEDDDYIRLDTGRTLGRYVDIYKHKTGRSSMGAGSVHHIAFGVEASEIETWKTNLEAKGF
ECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCE
TITGVKDRKFFKSLYYREPGGVIIELATLTPGFEMDSEYKEAPDLYMPPHYMHLKDEVEA
EEECCCHHHHHHHHHEECCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHH
KLMPLFIRNIDSLYEYPYQNKEEYERWKAHQDLLNKINYYAKEAKLRTLTDEEIEERQEL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RHKYVKSIRGAIQNNLENIRVEDEDGNFQELNRKEGNVQ
HHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]