Click here to switch to the map view.

The map label for this gene is atoB [H]

Identifier: 162447365

GI number: 162447365

Start: 526905

End: 528116

Strand: Direct

Name: atoB [H]

Synonym: ACL_0503

Alternate gene names: 162447365

Gene position: 526905-528116 (Clockwise)

Preceding gene: 162447363

Following gene: 162447366

Centisome position: 35.2

GC content: 35.15

Gene sequence:

>1212_bases
ATGAATAAAGTTTTTGTTGTAGCTGCTAAGAGAAGTGCCATTGGATCTTACTTAGGTACATTGTCACAAATCAGTCCAGC
AGATTTTGGTTCTCAAGTTTTAAAACAAACATTGGAACTTAATGACATCAAACCAGAGTGGGTTGATGAAGTTATTATTG
GTAATGTACTACCAGCAGGTCAAAAACAAGGGTTACCAAGACAAATCTCTATCAAAGCAGGTATTTCTCCAGAAGTACCA
GCGTATGGTGTAAATATGATTTGTGGTTCTGGTATGAAATCAGTTATCACAGGTGTTGCAAACATTAAAGCTGGTTTTGC
AAACTTAGTTGTTGCAGGTGGTGTGGAATCTATGTCACAAGCTCCATATTTAGTACCAGGCACTGTTAGAAACGGTGTAA
AAATGGGTAATTTAGAATTGGTTGACTACATGGTTACAGATGGTCTTTCAGATGCGTTTGAAGGCTATCACATGGGTATT
ACTGCTGAAAACATCGTAGAAAAACATAAATTTACTCGTGAAATGCAAGATGATTTTGCATATCACTCACAAGTTAAAGC
AAAACAAGCTCAAGAAAAAGGCTTATTTGATAAAGAAATCGTTCCAGTAAAAATTCAATCTAGAAAAGCTGAAATTGTGT
TTGATAAAGATGAATATATCAATTACACGACTACTAGAGAAAAAATTGCTCAATTACGTCCAGCATTCAAAAAAGATGGA
ACAGTCACTGCAGCAAGTTCATCAGGTATTAATGATGGTGCAAGTTTTATGGTCTTAGCAAGTGAAGCATTTGTAAAAGA
ACATAATTTAAAACCATTAGCTGAAATTGTTGGTGTTGGTCAAGCTGGTGTTGAACCAAGCGTTATGGGTTTAGGACCTG
TACCTGCAATTAAAAATTCATTAAAACAAGCGAACCTTAAGATTAGTGATATTGATACATTTGAATTAAACGAAGCATTT
GCAGCACAAGCATTAGGTGTTGTACGTGAACTTTCTGAAGATTTAGGTATTAAAGAATCAGCAATCTTAGATAAAACAAA
TCCAAATGGTGGTGCGATCGCGTTAGGTCACCCAGTTGGAGCATCAGGTAATAGAATCATGGTTACACTATTACATAATA
TGTTAAGAAATGAAAACCATAATATTGGTTTAGCAAGTCTATGTATCGGTGGCGGTATGGGAACATCTGTCATCTTTAAA
AAAGTTAAATAA

Upstream 100 bases:

>100_bases
GTTTTCATTTTGTATTGACACAGTGATAAAAAAGTGATAAAATAAACATGAACAAACATTCATATTTCAAATATACTATA
TAAAGAAAAGAGGAAATGTT

Downstream 100 bases:

>100_bases
GGAGAACTATAGATATGAAAAAACTAGAAGGTAAAGTTGCAGTTATTACAGGTGGTGCAAAAGGTTTAGGACAAGCAATC
GCTTTAGCTTATGCTGAAGA

Product: acetyl-CoA acetyltransferase, thiolase II

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNKVFVVAAKRSAIGSYLGTLSQISPADFGSQVLKQTLELNDIKPEWVDEVIIGNVLPAGQKQGLPRQISIKAGISPEVP
AYGVNMICGSGMKSVITGVANIKAGFANLVVAGGVESMSQAPYLVPGTVRNGVKMGNLELVDYMVTDGLSDAFEGYHMGI
TAENIVEKHKFTREMQDDFAYHSQVKAKQAQEKGLFDKEIVPVKIQSRKAEIVFDKDEYINYTTTREKIAQLRPAFKKDG
TVTAASSSGINDGASFMVLASEAFVKEHNLKPLAEIVGVGQAGVEPSVMGLGPVPAIKNSLKQANLKISDIDTFELNEAF
AAQALGVVRELSEDLGIKESAILDKTNPNGGAIALGHPVGASGNRIMVTLLHNMLRNENHNIGLASLCIGGGMGTSVIFK
KVK

Sequences:

>Translated_403_residues
MNKVFVVAAKRSAIGSYLGTLSQISPADFGSQVLKQTLELNDIKPEWVDEVIIGNVLPAGQKQGLPRQISIKAGISPEVP
AYGVNMICGSGMKSVITGVANIKAGFANLVVAGGVESMSQAPYLVPGTVRNGVKMGNLELVDYMVTDGLSDAFEGYHMGI
TAENIVEKHKFTREMQDDFAYHSQVKAKQAQEKGLFDKEIVPVKIQSRKAEIVFDKDEYINYTTTREKIAQLRPAFKKDG
TVTAASSSGINDGASFMVLASEAFVKEHNLKPLAEIVGVGQAGVEPSVMGLGPVPAIKNSLKQANLKISDIDTFELNEAF
AAQALGVVRELSEDLGIKESAILDKTNPNGGAIALGHPVGASGNRIMVTLLHNMLRNENHNIGLASLCIGGGMGTSVIFK
KVK
>Mature_403_residues
MNKVFVVAAKRSAIGSYLGTLSQISPADFGSQVLKQTLELNDIKPEWVDEVIIGNVLPAGQKQGLPRQISIKAGISPEVP
AYGVNMICGSGMKSVITGVANIKAGFANLVVAGGVESMSQAPYLVPGTVRNGVKMGNLELVDYMVTDGLSDAFEGYHMGI
TAENIVEKHKFTREMQDDFAYHSQVKAKQAQEKGLFDKEIVPVKIQSRKAEIVFDKDEYINYTTTREKIAQLRPAFKKDG
TVTAASSSGINDGASFMVLASEAFVKEHNLKPLAEIVGVGQAGVEPSVMGLGPVPAIKNSLKQANLKISDIDTFELNEAF
AAQALGVVRELSEDLGIKESAILDKTNPNGGAIALGHPVGASGNRIMVTLLHNMLRNENHNIGLASLCIGGGMGTSVIFK
KVK

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:
GO:0003824: Acetyl-CoA acetyltransferase, thiolase II
GO:0003985: Acetyl-CoA acetyltransferase, thiolase II
GO:0008152: Acetyl-CoA acetyltransferase, thiolase II
GO:0016740: Acetyl-CoA acetyltransferase, thiolase II
GO:0016746: Acetyl-CoA acetyltransferase, thiolase II
GO:0016747: Acetyl-CoA acetyltransferase, thiolase II

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=47.0149253731343, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=44.0298507462687, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=37.1287128712871, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI4501853, Length=403, Percent_Identity=37.468982630273, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4504327, Length=407, Percent_Identity=31.9410319410319, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI194353979, Length=398, Percent_Identity=29.1457286432161, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1788554, Length=402, Percent_Identity=47.7611940298507, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=42.8927680798005, Blast_Score=321, Evalue=6e-89,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=38.9705882352941, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI48994986, Length=413, Percent_Identity=37.5302663438257, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788683, Length=402, Percent_Identity=28.8557213930348, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=44.8877805486284, Blast_Score=319, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=35.6608478802993, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17535921, Length=403, Percent_Identity=37.7171215880893, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=29.6758104738155, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=400, Percent_Identity=28.5, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=42.5061425061425, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6322031, Length=408, Percent_Identity=35.2941176470588, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24655093, Length=402, Percent_Identity=50.7462686567164, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI17648125, Length=401, Percent_Identity=41.3965087281795, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24640423, Length=405, Percent_Identity=38.0246913580247, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI17137578, Length=416, Percent_Identity=31.25, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42955; Mature: 42955

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVFVVAAKRSAIGSYLGTLSQISPADFGSQVLKQTLELNDIKPEWVDEVIIGNVLPAG
CCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
QKQGLPRQISIKAGISPEVPAYGVNMICGSGMKSVITGVANIKAGFANLVVAGGVESMSQ
CCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCHHHEEEECCHHHHCC
APYLVPGTVRNGVKMGNLELVDYMVTDGLSDAFEGYHMGITAENIVEKHKFTREMQDDFA
CCEECCCHHHCCEEECCCEEEHHHHHCCCHHHHCCEECCCCHHHHHHHHHHHHHHHHHHH
YHSQVKAKQAQEKGLFDKEIVPVKIQSRKAEIVFDKDEYINYTTTREKIAQLRPAFKKDG
HHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCHHHCCCCHHHHHHHHHCCHHHCCC
TVTAASSSGINDGASFMVLASEAFVKEHNLKPLAEIVGVGQAGVEPSVMGLGPVPAIKNS
CEEEECCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHCCCCCCCCCCEECCCCCHHHHHH
LKQANLKISDIDTFELNEAFAAQALGVVRELSEDLGIKESAILDKTNPNGGAIALGHPVG
HHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEEECCCCC
ASGNRIMVTLLHNMLRNENHNIGLASLCIGGGMGTSVIFKKVK
CCCCEEHHHHHHHHHHCCCCCCCHHHEEECCCCCHHHHHEECC
>Mature Secondary Structure
MNKVFVVAAKRSAIGSYLGTLSQISPADFGSQVLKQTLELNDIKPEWVDEVIIGNVLPAG
CCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
QKQGLPRQISIKAGISPEVPAYGVNMICGSGMKSVITGVANIKAGFANLVVAGGVESMSQ
CCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCHHHEEEECCHHHHCC
APYLVPGTVRNGVKMGNLELVDYMVTDGLSDAFEGYHMGITAENIVEKHKFTREMQDDFA
CCEECCCHHHCCEEECCCEEEHHHHHCCCHHHHCCEECCCCHHHHHHHHHHHHHHHHHHH
YHSQVKAKQAQEKGLFDKEIVPVKIQSRKAEIVFDKDEYINYTTTREKIAQLRPAFKKDG
HHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCHHHCCCCHHHHHHHHHCCHHHCCC
TVTAASSSGINDGASFMVLASEAFVKEHNLKPLAEIVGVGQAGVEPSVMGLGPVPAIKNS
CEEEECCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHCCCCCCCCCCEECCCCCHHHHHH
LKQANLKISDIDTFELNEAFAAQALGVVRELSEDLGIKESAILDKTNPNGGAIALGHPVG
HHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEEECCCCC
ASGNRIMVTLLHNMLRNENHNIGLASLCIGGGMGTSVIFKKVK
CCCCEEHHHHHHHHHHCCCCCCCHHHEEECCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]