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The map label for this gene is rnr [H]

Identifier: 162447270

GI number: 162447270

Start: 424924

End: 427110

Strand: Direct

Name: rnr [H]

Synonym: ACL_0405

Alternate gene names: 162447270

Gene position: 424924-427110 (Clockwise)

Preceding gene: 162447269

Following gene: 162447271

Centisome position: 28.39

GC content: 31.18

Gene sequence:

>2187_bases
ATGAATAAAGAATTCATTAAATGGTTTTATGACCAAAAAAGTATACAAGTAACTTATGAACTTGTAAAAGAAGTATATAA
AGAAAAAACAGATGAATTATTAGAAGCACATAAAGAATATTTTGATATTATTGATAACACACATATTCAATTAAAAAAGC
GCTATGCATTAGGTAAAATTACGATTAAAAGAACTATCGCTTTTTTAATGATGCCAGAAGGCGCAAAAGATATTGCTATT
GATTTATTTGATTTAAATGGAGCAATGGAAAGTGATATTGTACTTGCAGATATTGTAGGATACAATCCATACATTAAAGA
GATTATTCACTCAAATCTAACTAAATTAATCGCAGACGTTAAAATACGTAGTGATAAGAAGATGAGATTTGATGCCAATG
AAGCTCAGAATAAATTGATTATTGTAAAAGATGTACCAGATTACCTTGTAGATGGACATGTGGTGCTACTAGATGTAACT
GAGGTTACAAGAACTCAAATATTTACCAAATTTAGAGAAGTTATTGGTCATAAAAACGATCCTGACATGGAAATTGTTAA
GATTGTTTATGAGTATGAATGGCCACTTAAATTTAGTAAAGAAGTATTAAATGAACTACATCATATTAAAATTGATCATG
AATATGAACGTAAAACAAGAAGAGATATCACAGATAAATTAGTTGTAACAATTGATGGTGCAGATGCTAAAGACTTAGAT
GATGCGATTAGTTTAGAATATTTAGAAAATGGTAACTTCAAATTAGGTGTTCATATTGCAGACGTCTCATACTTTGTAAA
AGAAGGTAGTTATTTAAATGAGGCAGCTTATAACCGTGCAACATCTGTTTATTTAGCAGATAGAGTTATCCCTATGATAC
CTCATGGTTTAAGTAATGATTTATGTAGTTTAAATCCAAACGAAGATAAATACACAATTACTTGTGAAATGGAATTAAAC
CCTGATATTGAAGTAGTTAACTATGATATTTATGCATCTATTATTCAAAGTAAACATCGTCTAACTTATCATGATGTCAA
TCAGTTGTTTAAAGAACATCAATCTACTGGTTTTAAGGAAGTAGATAAGATGTTATTTACAATGAATGAAATTGCTCAAA
AGTTAAAACAAATCCGCACAAAACGTGGTGCGATAGATTTTAATTCTACAGAACTTAAATTTGTATTAGATGTTAATGGT
GATGTTCTAGGTGTTGAAGAGCGTACCACAGATGAGGCGGAAGCACTCATTGAATCTTTCATGATTCTTGCAAATGAAAC
GGTCTCAAGACATTTCTTCTTTAATGATTTACCGGGTATCTACAGAGTGCATGAAAAGCCTACTTCTGAAAAATTAGATA
TTGCTTTTGAATCCAGTGCTAAACTTGGGTTTCGAGTTGATCAAAGTGCTAAATCAAGTGCTCAAAAACTTCAAAGATTA
ACCAAGAAAGTTGCCCAGACACCTTACGAATATATCATTAACATGATTTTATTAAGAAGTATGCAAAAAGCAATCTACTC
AGAAAAACCAATTGGTCACTTCGGTCTAGCTAGTGCATACTACTCACACTTTACATCACCGATTAGAAGATATCCTGACC
TTTTACTCCACCGTATGATTAGAGACTTAATGCTTAACAATCCGGATGCTGAAACTCTAAAAAAACTAAAGAAACACTAT
AGAGATTTAATGCCTTCCTATTCAGAACATACATCTAATCAAGAACGTCAAGCTGTAAATATGGAAAGAGAAGTCAATAA
ATTAAAGAGCCGTCAATATATGGCACAATTTATCAATCAATCATTTGATGGACAAATTGTATCGATGATGCCAAGTGGTT
TCTTTGTAAAATTAGAAAATGGTATTGAAGGTTTAGTAAATGTTAGAAACGTTAATCAATATTTAATCTATGATGATGAA
GCACTCTTATTTTATACAGAACGTGGTAAAAGATACCGCTTAGGTGATAAAATTAGAGTGAAACTGATTAAAGTAGATGA
AGTGGAAAATAATATCGACTTTACAATTGATCCACAAAATCACGCAGAAGACTATAAAGCACATAAAACAAGTACATCTA
AGGTCAAGCGTAAACCAAATCCTGCGGATATGGGTAAATCTAGAAAGACTAAATCGAAAGCGCCAAAAAGTGGTAAAAAA
GGATTTGGACCTAAGAAAAACAGATAG

Upstream 100 bases:

>100_bases
AAAAGCAAATGGCTCTAGCAGAAATTAAGTTTTATGAAAGTTTAAGTGATGCAGATACTAAAGTCAATTAAGAAAAACAA
GAAAAGAGGTGTCTGACACC

Downstream 100 bases:

>100_bases
TACATAAAGGAATCTTACATGAAAATTATTACTCAAAATAAAAAAGCACATTTTGAATATTTTATTGAACAAAAATTCGT
GGCTGGTATTAAACTTCAAG

Product: 3'-5' exoribonuclease

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 728; Mature: 728

Protein sequence:

>728_residues
MNKEFIKWFYDQKSIQVTYELVKEVYKEKTDELLEAHKEYFDIIDNTHIQLKKRYALGKITIKRTIAFLMMPEGAKDIAI
DLFDLNGAMESDIVLADIVGYNPYIKEIIHSNLTKLIADVKIRSDKKMRFDANEAQNKLIIVKDVPDYLVDGHVVLLDVT
EVTRTQIFTKFREVIGHKNDPDMEIVKIVYEYEWPLKFSKEVLNELHHIKIDHEYERKTRRDITDKLVVTIDGADAKDLD
DAISLEYLENGNFKLGVHIADVSYFVKEGSYLNEAAYNRATSVYLADRVIPMIPHGLSNDLCSLNPNEDKYTITCEMELN
PDIEVVNYDIYASIIQSKHRLTYHDVNQLFKEHQSTGFKEVDKMLFTMNEIAQKLKQIRTKRGAIDFNSTELKFVLDVNG
DVLGVEERTTDEAEALIESFMILANETVSRHFFFNDLPGIYRVHEKPTSEKLDIAFESSAKLGFRVDQSAKSSAQKLQRL
TKKVAQTPYEYIINMILLRSMQKAIYSEKPIGHFGLASAYYSHFTSPIRRYPDLLLHRMIRDLMLNNPDAETLKKLKKHY
RDLMPSYSEHTSNQERQAVNMEREVNKLKSRQYMAQFINQSFDGQIVSMMPSGFFVKLENGIEGLVNVRNVNQYLIYDDE
ALLFYTERGKRYRLGDKIRVKLIKVDEVENNIDFTIDPQNHAEDYKAHKTSTSKVKRKPNPADMGKSRKTKSKAPKSGKK
GFGPKKNR

Sequences:

>Translated_728_residues
MNKEFIKWFYDQKSIQVTYELVKEVYKEKTDELLEAHKEYFDIIDNTHIQLKKRYALGKITIKRTIAFLMMPEGAKDIAI
DLFDLNGAMESDIVLADIVGYNPYIKEIIHSNLTKLIADVKIRSDKKMRFDANEAQNKLIIVKDVPDYLVDGHVVLLDVT
EVTRTQIFTKFREVIGHKNDPDMEIVKIVYEYEWPLKFSKEVLNELHHIKIDHEYERKTRRDITDKLVVTIDGADAKDLD
DAISLEYLENGNFKLGVHIADVSYFVKEGSYLNEAAYNRATSVYLADRVIPMIPHGLSNDLCSLNPNEDKYTITCEMELN
PDIEVVNYDIYASIIQSKHRLTYHDVNQLFKEHQSTGFKEVDKMLFTMNEIAQKLKQIRTKRGAIDFNSTELKFVLDVNG
DVLGVEERTTDEAEALIESFMILANETVSRHFFFNDLPGIYRVHEKPTSEKLDIAFESSAKLGFRVDQSAKSSAQKLQRL
TKKVAQTPYEYIINMILLRSMQKAIYSEKPIGHFGLASAYYSHFTSPIRRYPDLLLHRMIRDLMLNNPDAETLKKLKKHY
RDLMPSYSEHTSNQERQAVNMEREVNKLKSRQYMAQFINQSFDGQIVSMMPSGFFVKLENGIEGLVNVRNVNQYLIYDDE
ALLFYTERGKRYRLGDKIRVKLIKVDEVENNIDFTIDPQNHAEDYKAHKTSTSKVKRKPNPADMGKSRKTKSKAPKSGKK
GFGPKKNR
>Mature_728_residues
MNKEFIKWFYDQKSIQVTYELVKEVYKEKTDELLEAHKEYFDIIDNTHIQLKKRYALGKITIKRTIAFLMMPEGAKDIAI
DLFDLNGAMESDIVLADIVGYNPYIKEIIHSNLTKLIADVKIRSDKKMRFDANEAQNKLIIVKDVPDYLVDGHVVLLDVT
EVTRTQIFTKFREVIGHKNDPDMEIVKIVYEYEWPLKFSKEVLNELHHIKIDHEYERKTRRDITDKLVVTIDGADAKDLD
DAISLEYLENGNFKLGVHIADVSYFVKEGSYLNEAAYNRATSVYLADRVIPMIPHGLSNDLCSLNPNEDKYTITCEMELN
PDIEVVNYDIYASIIQSKHRLTYHDVNQLFKEHQSTGFKEVDKMLFTMNEIAQKLKQIRTKRGAIDFNSTELKFVLDVNG
DVLGVEERTTDEAEALIESFMILANETVSRHFFFNDLPGIYRVHEKPTSEKLDIAFESSAKLGFRVDQSAKSSAQKLQRL
TKKVAQTPYEYIINMILLRSMQKAIYSEKPIGHFGLASAYYSHFTSPIRRYPDLLLHRMIRDLMLNNPDAETLKKLKKHY
RDLMPSYSEHTSNQERQAVNMEREVNKLKSRQYMAQFINQSFDGQIVSMMPSGFFVKLENGIEGLVNVRNVNQYLIYDDE
ALLFYTERGKRYRLGDKIRVKLIKVDEVENNIDFTIDPQNHAEDYKAHKTSTSKVKRKPNPADMGKSRKTKSKAPKSGKK
GFGPKKNR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=472, Percent_Identity=33.4745762711864, Blast_Score=201, Evalue=3e-51,
Organism=Homo sapiens, GI190014625, Length=523, Percent_Identity=29.2543021032505, Blast_Score=190, Evalue=5e-48,
Organism=Homo sapiens, GI190014623, Length=523, Percent_Identity=29.2543021032505, Blast_Score=190, Evalue=5e-48,
Organism=Homo sapiens, GI19115966, Length=530, Percent_Identity=29.2452830188679, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI219521928, Length=530, Percent_Identity=29.2452830188679, Blast_Score=168, Evalue=2e-41,
Organism=Escherichia coli, GI87082383, Length=673, Percent_Identity=31.7979197622585, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1787542, Length=332, Percent_Identity=30.7228915662651, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553506, Length=412, Percent_Identity=33.0097087378641, Blast_Score=183, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=334, Percent_Identity=33.2335329341317, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324552, Length=431, Percent_Identity=30.6264501160093, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323943, Length=428, Percent_Identity=23.5981308411215, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320499, Length=417, Percent_Identity=22.0623501199041, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24649634, Length=385, Percent_Identity=33.5064935064935, Blast_Score=203, Evalue=4e-52,
Organism=Drosophila melanogaster, GI19922976, Length=351, Percent_Identity=32.7635327635328, Blast_Score=176, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24654597, Length=351, Percent_Identity=32.7635327635328, Blast_Score=176, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24654592, Length=351, Percent_Identity=32.7635327635328, Blast_Score=176, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84442; Mature: 84442

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEFIKWFYDQKSIQVTYELVKEVYKEKTDELLEAHKEYFDIIDNTHIQLKKRYALGKI
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHE
TIKRTIAFLMMPEGAKDIAIDLFDLNGAMESDIVLADIVGYNPYIKEIIHSNLTKLIADV
EHHHHEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
KIRSDKKMRFDANEAQNKLIIVKDVPDYLVDGHVVLLDVTEVTRTQIFTKFREVIGHKND
HCCCCCCEEECCCCCCCCEEEEECCCHHHHCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
PDMEIVKIVYEYEWPLKFSKEVLNELHHIKIDHEYERKTRRDITDKLVVTIDGADAKDLD
CCHHEEEEEECCCCCCHHHHHHHHHHHEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCH
DAISLEYLENGNFKLGVHIADVSYFVKEGSYLNEAAYNRATSVYLADRVIPMIPHGLSND
HHHHHHEEECCCEEEEEEEEHHHHHHHCCCHHHHHHHHHHHEEEEHHHHHHHCCCCCCCC
LCSLNPNEDKYTITCEMELNPDIEVVNYDIYASIIQSKHRLTYHDVNQLFKEHQSTGFKE
CCCCCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
VDKMLFTMNEIAQKLKQIRTKRGAIDFNSTELKFVLDVNGDVLGVEERTTDEAEALIESF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHH
MILANETVSRHFFFNDLPGIYRVHEKPTSEKLDIAFESSAKLGFRVDQSAKSSAQKLQRL
HHHHCCHHHHHEECCCCCCCEEECCCCCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHH
TKKVAQTPYEYIINMILLRSMQKAIYSEKPIGHFGLASAYYSHFTSPIRRYPDLLLHRMI
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLMLNNPDAETLKKLKKHYRDLMPSYSEHTSNQERQAVNMEREVNKLKSRQYMAQFINQ
HHHHCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
SFDGQIVSMMPSGFFVKLENGIEGLVNVRNVNQYLIYDDEALLFYTERGKRYRLGDKIRV
CCCCEEEEECCCCEEEEECCCCCHHEEHCCCCEEEEEECCEEEEEECCCCEEECCCEEEE
KLIKVDEVENNIDFTIDPQNHAEDYKAHKTSTSKVKRKPNPADMGKSRKTKSKAPKSGKK
EEEEEECCCCCCCEEECCCCCHHHHHHHCCCHHHHCCCCCHHHCCCCCCCCCCCCCCCCC
GFGPKKNR
CCCCCCCC
>Mature Secondary Structure
MNKEFIKWFYDQKSIQVTYELVKEVYKEKTDELLEAHKEYFDIIDNTHIQLKKRYALGKI
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHE
TIKRTIAFLMMPEGAKDIAIDLFDLNGAMESDIVLADIVGYNPYIKEIIHSNLTKLIADV
EHHHHEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
KIRSDKKMRFDANEAQNKLIIVKDVPDYLVDGHVVLLDVTEVTRTQIFTKFREVIGHKND
HCCCCCCEEECCCCCCCCEEEEECCCHHHHCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
PDMEIVKIVYEYEWPLKFSKEVLNELHHIKIDHEYERKTRRDITDKLVVTIDGADAKDLD
CCHHEEEEEECCCCCCHHHHHHHHHHHEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCH
DAISLEYLENGNFKLGVHIADVSYFVKEGSYLNEAAYNRATSVYLADRVIPMIPHGLSND
HHHHHHEEECCCEEEEEEEEHHHHHHHCCCHHHHHHHHHHHEEEEHHHHHHHCCCCCCCC
LCSLNPNEDKYTITCEMELNPDIEVVNYDIYASIIQSKHRLTYHDVNQLFKEHQSTGFKE
CCCCCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
VDKMLFTMNEIAQKLKQIRTKRGAIDFNSTELKFVLDVNGDVLGVEERTTDEAEALIESF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHH
MILANETVSRHFFFNDLPGIYRVHEKPTSEKLDIAFESSAKLGFRVDQSAKSSAQKLQRL
HHHHCCHHHHHEECCCCCCCEEECCCCCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHH
TKKVAQTPYEYIINMILLRSMQKAIYSEKPIGHFGLASAYYSHFTSPIRRYPDLLLHRMI
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLMLNNPDAETLKKLKKHYRDLMPSYSEHTSNQERQAVNMEREVNKLKSRQYMAQFINQ
HHHHCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
SFDGQIVSMMPSGFFVKLENGIEGLVNVRNVNQYLIYDDEALLFYTERGKRYRLGDKIRV
CCCCEEEEECCCCEEEEECCCCCHHEEHCCCCEEEEEECCEEEEEECCCCEEECCCEEEE
KLIKVDEVENNIDFTIDPQNHAEDYKAHKTSTSKVKRKPNPADMGKSRKTKSKAPKSGKK
EEEEEECCCCCCCEEECCCCCHHHHHHHCCCHHHHCCCCCHHHCCCCCCCCCCCCCCCCC
GFGPKKNR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]