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The map label for this gene is mutM [H]

Identifier: 162447217

GI number: 162447217

Start: 368412

End: 369770

Strand: Direct

Name: mutM [H]

Synonym: ACL_0351

Alternate gene names: 162447217

Gene position: 368412-369770 (Clockwise)

Preceding gene: 162447216

Following gene: 162447218

Centisome position: 24.61

GC content: 30.39

Gene sequence:

>1359_bases
ATGCCTGAACTACCTGAGGTAGAAACCATTCGTAGAAATTTAAATACAGTATTAGAAGGTGAAATCATACGTGAGGTTTT
AGTATACTATCGACCTATTGTTTCAAATGATGCGTCATTTGAAACCAAATTAAAAGGTCAACGTATACATAAAGTAGAAC
GTGAAGCAAAGTATTTAAAGTTTATTTTAGATGACTATCTTTTAGTATCTCATTTACGTATGGAAGGCAAATACTTTATG
GACGCGCCTTTAAATAAACATATACATGTAGTGTTTAATCTATCAAGCGGTCACACGTTAAGTTATGAAGATACACGTAA
ATTTGGCCGTTTTGAACTGGTAGATATTAAATATAAAGACACTTATTTAAAAGATATTAAAGGGCTTGCTAAAGACCCTG
ATACCCTAGATTTAAACACCTTTTATAGTAGTTTTAATCAAAGAAGTAAAACGATTAAAGAAATATTACTGGATCAATCC
ATTATTGGTGGTATTGGTAATATTTATGCAAATGAAATACTTTACTTATCTAAAATACATCCAGCCAAAAAAGGTTTTTT
AATCAGTAAAGATGAAGCAAAAACCTTACTAAATAACTCTAATCTTGTTTTAAACAAGGCCATCGAAATGGGTGGAACGA
CAATTGACACCTTTGAATCATTAGGGCATAAGGGTGAGTTTCAACAGGAGTTAAATGTTCATGGCAAAACTGGAGAGATT
TGTAAGGTATGTGGCACTAAAATAATTAAATTTCAGTTAAAAGGACGAGGTACTTATATTTGTCCTAAATGCCAACCATC
TTATGTAGTCGCAATCACAGGTGGTATTGCAACCGGTAAATCTACTGCAACAAACTATTTAAGAAAAAAAGGATTTGTAG
TTGTAGATTCTGATGAAATTGTAGGAAGTCTTTATCAAGATAGTGATGTACTAAATTTAATTGCAAAAACCTTTAAAATG
GAAACACCAATTGATAAAGCAAAACTTGCAAACATCGTTTTCCATGATGAAAAACAAAGAAAAAAATTAGAACACATCTT
ACATCCACTCGTTTTTGATGAAATTAGCAAACAAAAACAATTAAATAATGAACATATCTTATTTTTAGATATTCCTTTAT
TATTTGAATCGAATTACAAAGAGTTTGATGAATCCATCTTAATAGATACAACTGAAGCACTTCAACTGGATAGATTAATG
AAGCGCAACAAATATACTCAAGAAGAAGCACTTGTTCGTATAAAAGCGCAGATACCTTTAAGTAAAAAGCGCAAACTAGC
TACACACATTATAAAAAATAATGGATCTATAGATGCGTTATATGAAAAAATAGATAAATTATTAGAAAGGTATGTATAA

Upstream 100 bases:

>100_bases
ACCAAACATCATGGAAAAAGCCTTTAATTTAGGCGTTAGACTGAAAACATCATGTGATGTTGGAAACAACTGGTATGAAT
TAAAATAAAGGAGAAGTACT

Downstream 100 bases:

>100_bases
AGTGAAAGCAAAATCAACATTTAATATTATCAGTCAATCAGCACTTTCAAGTGATGAGTGGAAAGTTTTAGGTATTTTAT
ACCAACCAATTATTGGTGTT

Product: bifunctional formamidopyrimidine-DNA glycosylase/dephospho-CoA kinase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPELPEVETIRRNLNTVLEGEIIREVLVYYRPIVSNDASFETKLKGQRIHKVEREAKYLKFILDDYLLVSHLRMEGKYFM
DAPLNKHIHVVFNLSSGHTLSYEDTRKFGRFELVDIKYKDTYLKDIKGLAKDPDTLDLNTFYSSFNQRSKTIKEILLDQS
IIGGIGNIYANEILYLSKIHPAKKGFLISKDEAKTLLNNSNLVLNKAIEMGGTTIDTFESLGHKGEFQQELNVHGKTGEI
CKVCGTKIIKFQLKGRGTYICPKCQPSYVVAITGGIATGKSTATNYLRKKGFVVVDSDEIVGSLYQDSDVLNLIAKTFKM
ETPIDKAKLANIVFHDEKQRKKLEHILHPLVFDEISKQKQLNNEHILFLDIPLLFESNYKEFDESILIDTTEALQLDRLM
KRNKYTQEEALVRIKAQIPLSKKRKLATHIIKNNGSIDALYEKIDKLLERYV

Sequences:

>Translated_452_residues
MPELPEVETIRRNLNTVLEGEIIREVLVYYRPIVSNDASFETKLKGQRIHKVEREAKYLKFILDDYLLVSHLRMEGKYFM
DAPLNKHIHVVFNLSSGHTLSYEDTRKFGRFELVDIKYKDTYLKDIKGLAKDPDTLDLNTFYSSFNQRSKTIKEILLDQS
IIGGIGNIYANEILYLSKIHPAKKGFLISKDEAKTLLNNSNLVLNKAIEMGGTTIDTFESLGHKGEFQQELNVHGKTGEI
CKVCGTKIIKFQLKGRGTYICPKCQPSYVVAITGGIATGKSTATNYLRKKGFVVVDSDEIVGSLYQDSDVLNLIAKTFKM
ETPIDKAKLANIVFHDEKQRKKLEHILHPLVFDEISKQKQLNNEHILFLDIPLLFESNYKEFDESILIDTTEALQLDRLM
KRNKYTQEEALVRIKAQIPLSKKRKLATHIIKNNGSIDALYEKIDKLLERYV
>Mature_451_residues
PELPEVETIRRNLNTVLEGEIIREVLVYYRPIVSNDASFETKLKGQRIHKVEREAKYLKFILDDYLLVSHLRMEGKYFMD
APLNKHIHVVFNLSSGHTLSYEDTRKFGRFELVDIKYKDTYLKDIKGLAKDPDTLDLNTFYSSFNQRSKTIKEILLDQSI
IGGIGNIYANEILYLSKIHPAKKGFLISKDEAKTLLNNSNLVLNKAIEMGGTTIDTFESLGHKGEFQQELNVHGKTGEIC
KVCGTKIIKFQLKGRGTYICPKCQPSYVVAITGGIATGKSTATNYLRKKGFVVVDSDEIVGSLYQDSDVLNLIAKTFKME
TPIDKAKLANIVFHDEKQRKKLEHILHPLVFDEISKQKQLNNEHILFLDIPLLFESNYKEFDESILIDTTEALQLDRLMK
RNKYTQEEALVRIKAQIPLSKKRKLATHIIKNNGSIDALYEKIDKLLERYV

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=179, Percent_Identity=31.2849162011173, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI191252795, Length=179, Percent_Identity=31.2849162011173, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790066, Length=280, Percent_Identity=35.7142857142857, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1786292, Length=192, Percent_Identity=29.1666666666667, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17554944, Length=195, Percent_Identity=31.7948717948718, Blast_Score=95, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320402, Length=198, Percent_Identity=30.8080808080808, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644728, Length=182, Percent_Identity=35.7142857142857, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24658602, Length=210, Percent_Identity=28.0952380952381, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 51824; Mature: 51693

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETIRRNLNTVLEGEIIREVLVYYRPIVSNDASFETKLKGQRIHKVEREAKYLK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHH
FILDDYLLVSHLRMEGKYFMDAPLNKHIHVVFNLSSGHTLSYEDTRKFGRFELVDIKYKD
HHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCEECCHHHHCCCCEEEEEEEECH
TYLKDIKGLAKDPDTLDLNTFYSSFNQRSKTIKEILLDQSIIGGIGNIYANEILYLSKIH
HHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCC
PAKKGFLISKDEAKTLLNNSNLVLNKAIEMGGTTIDTFESLGHKGEFQQELNVHGKTGEI
CCCCCEEEECHHHHHHHCCCCEEEEHHHHHCCCCHHHHHHCCCCCCCHHHHCCCCCCCHH
CKVCGTKIIKFQLKGRGTYICPKCQPSYVVAITGGIATGKSTATNYLRKKGFVVVDSDEI
HHHCCCEEEEEEECCCCCEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECHHH
VGSLYQDSDVLNLIAKTFKMETPIDKAKLANIVFHDEKQRKKLEHILHPLVFDEISKQKQ
HHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LNNEHILFLDIPLLFESNYKEFDESILIDTTEALQLDRLMKRNKYTQEEALVRIKAQIPL
CCCCEEEEEEEHHHHCCCHHHHCCEEEEECHHHHHHHHHHHHCCCCCHHHHEEEEECCCC
SKKRKLATHIIKNNGSIDALYEKIDKLLERYV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PELPEVETIRRNLNTVLEGEIIREVLVYYRPIVSNDASFETKLKGQRIHKVEREAKYLK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHH
FILDDYLLVSHLRMEGKYFMDAPLNKHIHVVFNLSSGHTLSYEDTRKFGRFELVDIKYKD
HHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCEECCHHHHCCCCEEEEEEEECH
TYLKDIKGLAKDPDTLDLNTFYSSFNQRSKTIKEILLDQSIIGGIGNIYANEILYLSKIH
HHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCC
PAKKGFLISKDEAKTLLNNSNLVLNKAIEMGGTTIDTFESLGHKGEFQQELNVHGKTGEI
CCCCCEEEECHHHHHHHCCCCEEEEHHHHHCCCCHHHHHHCCCCCCCHHHHCCCCCCCHH
CKVCGTKIIKFQLKGRGTYICPKCQPSYVVAITGGIATGKSTATNYLRKKGFVVVDSDEI
HHHCCCEEEEEEECCCCCEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECHHH
VGSLYQDSDVLNLIAKTFKMETPIDKAKLANIVFHDEKQRKKLEHILHPLVFDEISKQKQ
HHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LNNEHILFLDIPLLFESNYKEFDESILIDTTEALQLDRLMKRNKYTQEEALVRIKAQIPL
CCCCEEEEEEEHHHHCCCHHHHCCEEEEECHHHHHHHHHHHHCCCCCHHHHEEEEECCCC
SKKRKLATHIIKNNGSIDALYEKIDKLLERYV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]