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The map label for this gene is galM [H]

Identifier: 162447177

GI number: 162447177

Start: 321458

End: 322363

Strand: Direct

Name: galM [H]

Synonym: ACL_0311

Alternate gene names: 162447177

Gene position: 321458-322363 (Clockwise)

Preceding gene: 162447176

Following gene: 162447178

Centisome position: 21.47

GC content: 29.36

Gene sequence:

>906_bases
ATGTATAAGACATATGTATTAGAAAATGATTATTTAAAAGTAGAAGCAATTGATTATGCTGCAAGCATCTATCAAATATA
TCTAAAAGACAATGGTACGCTAAAACCATTACTTGCAACACCTAAAACAAAAGATTTATTTATTGAAAATACACTTAATT
ATGGACGTACTGTTGGTCGTACAGCAGGTAGGTTATATCCTACTGAAGATACAATAAAGTATGTAGACTTTAAAGGTGAA
CCAAGCTATATGCATGGTGGTCCAAATAGATTTGGTACAAAGACTTTTAAGGTTAGAAAACACACAAGTGATTCCATAGA
ATTTGAATTAAATGTCAAAGACATGTCAGATGGTTACCTGGGTAACTTAAATGTTTTAATAACTTATAGAATATTCCAAG
GTAGTTTGGTTGTTTGGCATCAAGCTAAATCTGATAAAGACACTTTACTTAACTTAACTTTCCACCCATATTTTAATTTA
GAACAGTCAAATCATATAAGAAATCATGAATTAAAAATTGAATCTTCAACATACCTTTCCCAAAATGAACATAAGATCTT
TGCTTATGAAAATGATGTAGAAGGTACACATAGAGATTTTAGAACCTTTAAACCTTTAATCATTAACGAACATAATGCCT
TAGACGATATTTACTTACTACCTAAAGATAGATATACTGCAACCCTAAGAACCAAGGATATCCAAATGCAAGTATATACA
AACTATCCAGCACTTGTTGTTTATACTCAAAAAAAAGTCAATAACACTGATTTAGTCAATGCTAAAAAAGATGAACTTTA
TACAGGTGTAGCAATTGAATGTCAAAAGAGCCAAAAAGATTTAAATGTGCTTAAACATGATCGTGTATATGATCACTATA
TCATGTATAGTTTTAATAAAATATAA

Upstream 100 bases:

>100_bases
AGATGCACAAGGAAGTTTTCAATATGTAGCACCTCATGTAGATCATGATGCGCTCTATGATTTTTTAAAAACACAACACA
TCATATAAGGAGTTAACAAA

Downstream 100 bases:

>100_bases
ACCTATAAAGACCAGTTGATGACTGGTCTTTATGCTTAAAATTCACATATAATGCCTTATGAAAACCATGTTATAATAAT
AAGTAATATAAATAAAAAGT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MYKTYVLENDYLKVEAIDYAASIYQIYLKDNGTLKPLLATPKTKDLFIENTLNYGRTVGRTAGRLYPTEDTIKYVDFKGE
PSYMHGGPNRFGTKTFKVRKHTSDSIEFELNVKDMSDGYLGNLNVLITYRIFQGSLVVWHQAKSDKDTLLNLTFHPYFNL
EQSNHIRNHELKIESSTYLSQNEHKIFAYENDVEGTHRDFRTFKPLIINEHNALDDIYLLPKDRYTATLRTKDIQMQVYT
NYPALVVYTQKKVNNTDLVNAKKDELYTGVAIECQKSQKDLNVLKHDRVYDHYIMYSFNKI

Sequences:

>Translated_301_residues
MYKTYVLENDYLKVEAIDYAASIYQIYLKDNGTLKPLLATPKTKDLFIENTLNYGRTVGRTAGRLYPTEDTIKYVDFKGE
PSYMHGGPNRFGTKTFKVRKHTSDSIEFELNVKDMSDGYLGNLNVLITYRIFQGSLVVWHQAKSDKDTLLNLTFHPYFNL
EQSNHIRNHELKIESSTYLSQNEHKIFAYENDVEGTHRDFRTFKPLIINEHNALDDIYLLPKDRYTATLRTKDIQMQVYT
NYPALVVYTQKKVNNTDLVNAKKDELYTGVAIECQKSQKDLNVLKHDRVYDHYIMYSFNKI
>Mature_301_residues
MYKTYVLENDYLKVEAIDYAASIYQIYLKDNGTLKPLLATPKTKDLFIENTLNYGRTVGRTAGRLYPTEDTIKYVDFKGE
PSYMHGGPNRFGTKTFKVRKHTSDSIEFELNVKDMSDGYLGNLNVLITYRIFQGSLVVWHQAKSDKDTLLNLTFHPYFNL
EQSNHIRNHELKIESSTYLSQNEHKIFAYENDVEGTHRDFRTFKPLIINEHNALDDIYLLPKDRYTATLRTKDIQMQVYT
NYPALVVYTQKKVNNTDLVNAKKDELYTGVAIECQKSQKDLNVLKHDRVYDHYIMYSFNKI

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=330, Percent_Identity=26.969696969697, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786971, Length=301, Percent_Identity=27.5747508305648, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17557428, Length=325, Percent_Identity=26.7692307692308, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI115533334, Length=325, Percent_Identity=26.7692307692308, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24583720, Length=340, Percent_Identity=24.7058823529412, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 35223; Mature: 35223

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKTYVLENDYLKVEAIDYAASIYQIYLKDNGTLKPLLATPKTKDLFIENTLNYGRTVGR
CEEEEEEECCCEEEEEEHEEEEEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCHHCC
TAGRLYPTEDTIKYVDFKGEPSYMHGGPNRFGTKTFKVRKHTSDSIEFELNVKDMSDGYL
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCC
GNLNVLITYRIFQGSLVVWHQAKSDKDTLLNLTFHPYFNLEQSNHIRNHELKIESSTYLS
CCEEEEEEEEEECCCEEEEEECCCCCCEEEEEEECCEECCCCCCCCCCEEEEEECCEEEC
QNEHKIFAYENDVEGTHRDFRTFKPLIINEHNALDDIYLLPKDRYTATLRTKDIQMQVYT
CCCCEEEEEECCCCCCCHHHHCCCCEEEECCCCCCEEEEECCCCEEEEEEEEEEEEEEEE
NYPALVVYTQKKVNNTDLVNAKKDELYTGVAIECQKSQKDLNVLKHDRVYDHYIMYSFNK
CCCEEEEEEECCCCCCCCCCCCCHHEEEEEEEEECCCCCHHHHHHCCCEEEEEEEEEEEC
I
C
>Mature Secondary Structure
MYKTYVLENDYLKVEAIDYAASIYQIYLKDNGTLKPLLATPKTKDLFIENTLNYGRTVGR
CEEEEEEECCCEEEEEEHEEEEEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCHHCC
TAGRLYPTEDTIKYVDFKGEPSYMHGGPNRFGTKTFKVRKHTSDSIEFELNVKDMSDGYL
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCC
GNLNVLITYRIFQGSLVVWHQAKSDKDTLLNLTFHPYFNLEQSNHIRNHELKIESSTYLS
CCEEEEEEEEEECCCEEEEEECCCCCCEEEEEEECCEECCCCCCCCCCEEEEEECCEEEC
QNEHKIFAYENDVEGTHRDFRTFKPLIINEHNALDDIYLLPKDRYTATLRTKDIQMQVYT
CCCCEEEEEECCCCCCCHHHHCCCCEEEECCCCCCEEEEECCCCEEEEEEEEEEEEEEEE
NYPALVVYTQKKVNNTDLVNAKKDELYTGVAIECQKSQKDLNVLKHDRVYDHYIMYSFNK
CCCEEEEEEECCCCCCCCCCCCCHHEEEEEEEEECCCCCHHHHHHCCCEEEEEEEEEEEC
I
C

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]