Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 162447170

GI number: 162447170

Start: 313992

End: 314609

Strand: Direct

Name: gmk [H]

Synonym: ACL_0304

Alternate gene names: 162447170

Gene position: 313992-314609 (Clockwise)

Preceding gene: 162447167

Following gene: 162447171

Centisome position: 20.97

GC content: 36.08

Gene sequence:

>618_bases
ATGAAACTAAATGATCGTGGATTACTCATCGTCATATCCGGACCATCTGGAGTTGGAAAAGGTACAGTGCGTAAAGCGCT
TTTTGACATGAAGAACCATAACCTAGAATATTCTGTATCAGTTACAACAAGAGCACCTAGAGTCGGCGAAGTTGATGGCA
AAGACTATTATTTTGTAAATCGTGCAGCCTTCGAAGAAATGATTCGCCAAGACAGATTTTTAGAGTATGCAGAGTTTGTG
GGTAGCTATTATGGCACACCAAAAGACAAAGTTGAAGAAATGCTTGATAAAGGTAAAGAAGTTGTATTAGAAATTGAAGT
GGATGGTGCACTTCAAGTACGTGAACGTATGAAAGATGCTGTCTTTATATTTTTAGTGCCACCAAGCAAAAAAGCCTTAT
ATGAGCGTTTAAGCAGACGTGGAACGGATACACCTGAAATTGTAAATAAGAGATTTCAAAAAGCTGAAAGTGAATTTAAA
TTAGCATATAAATATGATTATATCGTAGTAAATGATGATGTAAATAATGCTGCAGATCGTATTATGGCGATCATTCGTGC
AGAACATGCACGTACTCAAAGAACTATTCAAAAATATCAACAGTTAATGGAGGAATAA

Upstream 100 bases:

>100_bases
TTCTTACCTCAATAATACTATATCATGAAAATGTCTGAAACTATTTACATAAACCAAACTTTCGTATATAATAAATTAAA
CGAAGAGTTAGGAGAGTCAC

Downstream 100 bases:

>100_bases
CATGAAAAAAAGAAAACATGGTTTAAACTACCCAACAATTGACGTACTATTAGAAAAGATTGATTCTAAGTATAAATTAG
TATATGCAGCGAGTAAAGTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MKLNDRGLLIVISGPSGVGKGTVRKALFDMKNHNLEYSVSVTTRAPRVGEVDGKDYYFVNRAAFEEMIRQDRFLEYAEFV
GSYYGTPKDKVEEMLDKGKEVVLEIEVDGALQVRERMKDAVFIFLVPPSKKALYERLSRRGTDTPEIVNKRFQKAESEFK
LAYKYDYIVVNDDVNNAADRIMAIIRAEHARTQRTIQKYQQLMEE

Sequences:

>Translated_205_residues
MKLNDRGLLIVISGPSGVGKGTVRKALFDMKNHNLEYSVSVTTRAPRVGEVDGKDYYFVNRAAFEEMIRQDRFLEYAEFV
GSYYGTPKDKVEEMLDKGKEVVLEIEVDGALQVRERMKDAVFIFLVPPSKKALYERLSRRGTDTPEIVNKRFQKAESEFK
LAYKYDYIVVNDDVNNAADRIMAIIRAEHARTQRTIQKYQQLMEE
>Mature_205_residues
MKLNDRGLLIVISGPSGVGKGTVRKALFDMKNHNLEYSVSVTTRAPRVGEVDGKDYYFVNRAAFEEMIRQDRFLEYAEFV
GSYYGTPKDKVEEMLDKGKEVVLEIEVDGALQVRERMKDAVFIFLVPPSKKALYERLSRRGTDTPEIVNKRFQKAESEFK
LAYKYDYIVVNDDVNNAADRIMAIIRAEHARTQRTIQKYQQLMEE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:
GO:0000166: Guanylate kinase
GO:0004385: Guanylate kinase
GO:0005524: Guanylate kinase
GO:0005737: Guanylate kinase
GO:0006163: Guanylate kinase
GO:0016301: Guanylate kinase
GO:0016310: Guanylate kinase
GO:0016740: Guanylate kinase

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=34.9206349206349, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=34.9206349206349, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=34.9206349206349, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI14780902, Length=202, Percent_Identity=28.2178217821782, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=30.8988764044944, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4505237, Length=172, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI262118263, Length=172, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI21389483, Length=204, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI21361598, Length=184, Percent_Identity=25, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI111154074, Length=176, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI119943106, Length=180, Percent_Identity=31.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI119943108, Length=180, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI261862237, Length=180, Percent_Identity=31.6666666666667, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=43.7185929648241, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508835, Length=189, Percent_Identity=39.6825396825397, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI193203132, Length=189, Percent_Identity=39.6825396825397, Blast_Score=136, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17557440, Length=167, Percent_Identity=29.3413173652695, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988048, Length=196, Percent_Identity=24.4897959183673, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988041, Length=186, Percent_Identity=24.1935483870968, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=151, Percent_Identity=24.5033112582781, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17556244, Length=115, Percent_Identity=32.1739130434783, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=43.4782608695652, Blast_Score=146, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356141, Length=171, Percent_Identity=39.766081871345, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330164, Length=185, Percent_Identity=28.1081081081081, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330166, Length=185, Percent_Identity=28.1081081081081, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330162, Length=185, Percent_Identity=28.1081081081081, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85816281, Length=126, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85816106, Length=126, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551002, Length=126, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23689; Mature: 23689

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNDRGLLIVISGPSGVGKGTVRKALFDMKNHNLEYSVSVTTRAPRVGEVDGKDYYFVN
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEEE
RAAFEEMIRQDRFLEYAEFVGSYYGTPKDKVEEMLDKGKEVVLEIEVDGALQVRERMKDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCE
VFIFLVPPSKKALYERLSRRGTDTPEIVNKRFQKAESEFKLAYKYDYIVVNDDVNNAADR
EEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCHHHHH
IMAIIRAEHARTQRTIQKYQQLMEE
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLNDRGLLIVISGPSGVGKGTVRKALFDMKNHNLEYSVSVTTRAPRVGEVDGKDYYFVN
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEEE
RAAFEEMIRQDRFLEYAEFVGSYYGTPKDKVEEMLDKGKEVVLEIEVDGALQVRERMKDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCE
VFIFLVPPSKKALYERLSRRGTDTPEIVNKRFQKAESEFKLAYKYDYIVVNDDVNNAADR
EEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCHHHHH
IMAIIRAEHARTQRTIQKYQQLMEE
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA