Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 162447098

GI number: 162447098

Start: 220412

End: 221071

Strand: Direct

Name: rnc [H]

Synonym: ACL_0228

Alternate gene names: 162447098

Gene position: 220412-221071 (Clockwise)

Preceding gene: 162447097

Following gene: 162447099

Centisome position: 14.72

GC content: 33.79

Gene sequence:

>660_bases
ATGAATGATTTATTGAAACAACTTAATATTGAAACAAAACATATAGATTTATACCTTCAAGCATTAACGCATACATCTTA
TGCGCATGAAAACCAAACAGATCATAATGAACGATTAGAGTTTTTAGGTGATGCAGTGATTGAATTAATGATGAGTACAT
ACCTATTTACTCATGATCAATCCAATCAAGGTGTTTTAACTAAAAGACGTGCTCAAGCAGTTCGTGAAGAAGCACTTGTT
TTGTATGCCCAAAAAATGGATTTAGAATCGAAGATGCGTTTAGGCAATGGTGAGCAAATAGCAAAACCAAGCATGATCGC
CGATGCATTTGAAGCGTTTTTTGGTGCACTATATATGGATCAAGGATTTGATAAGACTTATGAAATCTTTAATAAGGTAG
TCATACCACATTTAAATTTAGTGGAGCACATTAAAGACTATAAAACTCAACTTCAAGAATTTATTCAACTTGAAAGGAAA
AGTTTATCTTATAAAACAGTTAAAGTGGGTGGACCATCACATCGCCCAATATTTAAGTCTGAAGTATTTTTAGAAAACAG
TATTATGTTGGGCACAGGACAAGGTAGTTCCACCAAGGAAGCCGAACAAAATGCTGCAAAAGAAGCACTAAGTAAAGTAG
TAAAGGAGCGTAGTTTATGA

Upstream 100 bases:

>100_bases
TCTAGCGAGGCTTACGCATTTATGAATGCTATTAGACAAGCTAAAACAATGGTTTCACATGACGTGATTGGTAAAGTAAA
AAATGTATTGAGGGGTCAAG

Downstream 100 bases:

>100_bases
TTAGAAAATTATATGAAGAGCATTTTTTAGAAATTGATGCACTATTAACTAAAGAATGTAAGCGACTAAAATTAAGTCCT
AATGAAGTGGTTGTTTTAAA

Product: dsRNA-specific ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MNDLLKQLNIETKHIDLYLQALTHTSYAHENQTDHNERLEFLGDAVIELMMSTYLFTHDQSNQGVLTKRRAQAVREEALV
LYAQKMDLESKMRLGNGEQIAKPSMIADAFEAFFGALYMDQGFDKTYEIFNKVVIPHLNLVEHIKDYKTQLQEFIQLERK
SLSYKTVKVGGPSHRPIFKSEVFLENSIMLGTGQGSSTKEAEQNAAKEALSKVVKERSL

Sequences:

>Translated_219_residues
MNDLLKQLNIETKHIDLYLQALTHTSYAHENQTDHNERLEFLGDAVIELMMSTYLFTHDQSNQGVLTKRRAQAVREEALV
LYAQKMDLESKMRLGNGEQIAKPSMIADAFEAFFGALYMDQGFDKTYEIFNKVVIPHLNLVEHIKDYKTQLQEFIQLERK
SLSYKTVKVGGPSHRPIFKSEVFLENSIMLGTGQGSSTKEAEQNAAKEALSKVVKERSL
>Mature_219_residues
MNDLLKQLNIETKHIDLYLQALTHTSYAHENQTDHNERLEFLGDAVIELMMSTYLFTHDQSNQGVLTKRRAQAVREEALV
LYAQKMDLESKMRLGNGEQIAKPSMIADAFEAFFGALYMDQGFDKTYEIFNKVVIPHLNLVEHIKDYKTQLQEFIQLERK
SLSYKTVKVGGPSHRPIFKSEVFLENSIMLGTGQGSSTKEAEQNAAKEALSKVVKERSL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:
GO:0003723: Ribonuclease 3
GO:0003725: Ribonuclease 3
GO:0004518: Ribonuclease 3
GO:0004519: Ribonuclease 3
GO:0004525: Ribonuclease 3
GO:0005622: Ribonuclease 3
GO:0005737: Ribonuclease 3
GO:0006364: Ribonuclease 3
GO:0006396: Ribonuclease 3
GO:0006397: Ribonuclease 3
GO:0016075: Ribonuclease 3
GO:0016787: Ribonuclease 3

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=213, Percent_Identity=29.1079812206573, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI155030236, Length=213, Percent_Identity=29.1079812206573, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788920, Length=222, Percent_Identity=31.981981981982, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17506883, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137682, Length=216, Percent_Identity=31.9444444444444, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25016; Mature: 25016

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLLKQLNIETKHIDLYLQALTHTSYAHENQTDHNERLEFLGDAVIELMMSTYLFTHDQ
CCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SNQGVLTKRRAQAVREEALVLYAQKMDLESKMRLGNGEQIAKPSMIADAFEAFFGALYMD
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHH
QGFDKTYEIFNKVVIPHLNLVEHIKDYKTQLQEFIQLERKSLSYKTVKVGGPSHRPIFKS
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHH
EVFLENSIMLGTGQGSSTKEAEQNAAKEALSKVVKERSL
HHHEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNDLLKQLNIETKHIDLYLQALTHTSYAHENQTDHNERLEFLGDAVIELMMSTYLFTHDQ
CCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SNQGVLTKRRAQAVREEALVLYAQKMDLESKMRLGNGEQIAKPSMIADAFEAFFGALYMD
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHH
QGFDKTYEIFNKVVIPHLNLVEHIKDYKTQLQEFIQLERKSLSYKTVKVGGPSHRPIFKS
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHH
EVFLENSIMLGTGQGSSTKEAEQNAAKEALSKVVKERSL
HHHEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA