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The map label for this gene is pth

Identifier: 162446906

GI number: 162446906

Start: 21937

End: 22512

Strand: Direct

Name: pth

Synonym: ACL_0019

Alternate gene names: 162446906

Gene position: 21937-22512 (Clockwise)

Preceding gene: 162446905

Following gene: 162446907

Centisome position: 1.47

GC content: 33.85

Gene sequence:

>576_bases
ATGAAACTCATTGTCGGTTTAGGAAATCCCGGCAAACAATATGTTCAAACAAGACACAACATAGGTTTTATCGCTATAGA
CAAACTCTTAAGTTACCTAAATACGGAATTAAAAGTCGATTCAAAACTACAAGCAGCATACACTAAAACTAAAATTGAAG
GTGAGGATGTTATCATCGCTAAACCACTGACCTACATGAATTTATCTGGTGATGCTGTTACAAAATTAATGAACTTCTAT
AAAATAGATGTAGAAGATATATTAGTTATCCTAGATGATACTGCATTACCTTTAGGCAAGATAAGAATACGCCAAACAGG
TAGCCATGGTGGTCAAAATGGGTTAAAAGATATCATTAACAAATTAGGAACTAAAGACTTTAAAAGATTAAGAATCGGTA
TTGGAGAACATGCCCATATGGACAAAGTAGACTATGTCCTTGGCAAGTTCTCAACAAATGAGTTAAATACGATACTACCT
ACGATTGAATATGTAAATGATGCCATCATTGAGTGGATTTCAACAAACAATTTTAATAACATCATGACCAAATACAACAC
CCCCCAGACTCTTTAG

Upstream 100 bases:

>100_bases
AACAATTATCTATTGGTGCACTGTTAGGTGAAGCAATCATCCATATTTTACAAGACGAACCAATCTCTCAAATCTTTAAT
AGAATTCAAGAGGATCAATA

Downstream 100 bases:

>100_bases
TCTGGGCTTTATCACGTGCAAAAAGGAAGCATTTTATGACTAAAAATTTATTAAACTCCATATATAAAGATGCCGCCATT
TTAAACGCCAGAACAGGTGA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKLIVGLGNPGKQYVQTRHNIGFIAIDKLLSYLNTELKVDSKLQAAYTKTKIEGEDVIIAKPLTYMNLSGDAVTKLMNFY
KIDVEDILVILDDTALPLGKIRIRQTGSHGGQNGLKDIINKLGTKDFKRLRIGIGEHAHMDKVDYVLGKFSTNELNTILP
TIEYVNDAIIEWISTNNFNNIMTKYNTPQTL

Sequences:

>Translated_191_residues
MKLIVGLGNPGKQYVQTRHNIGFIAIDKLLSYLNTELKVDSKLQAAYTKTKIEGEDVIIAKPLTYMNLSGDAVTKLMNFY
KIDVEDILVILDDTALPLGKIRIRQTGSHGGQNGLKDIINKLGTKDFKRLRIGIGEHAHMDKVDYVLGKFSTNELNTILP
TIEYVNDAIIEWISTNNFNNIMTKYNTPQTL
>Mature_191_residues
MKLIVGLGNPGKQYVQTRHNIGFIAIDKLLSYLNTELKVDSKLQAAYTKTKIEGEDVIIAKPLTYMNLSGDAVTKLMNFY
KIDVEDILVILDDTALPLGKIRIRQTGSHGGQNGLKDIINKLGTKDFKRLRIGIGEHAHMDKVDYVLGKFSTNELNTILP
TIEYVNDAIIEWISTNNFNNIMTKYNTPQTL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:
GO:0004045: Peptidyl-tRNA hydrolase
GO:0005737: Peptidyl-tRNA hydrolase
GO:0016787: Peptidyl-tRNA hydrolase

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=27.5280898876405, Blast_Score=87, Evalue=8e-18,
Organism=Escherichia coli, GI1787455, Length=176, Percent_Identity=42.0454545454545, Blast_Score=116, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321983, Length=183, Percent_Identity=31.6939890710383, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ACHLI (A9NE82)

Other databases:

- EMBL:   CP000896
- RefSeq:   YP_001620038.1
- ProteinModelPortal:   A9NE82
- SMR:   A9NE82
- GeneID:   5803658
- GenomeReviews:   CP000896_GR
- KEGG:   acl:ACL_0019
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- BioCyc:   ALAI441768:ACL_0019-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21455; Mature: 21455

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIVGLGNPGKQYVQTRHNIGFIAIDKLLSYLNTELKVDSKLQAAYTKTKIEGEDVIIA
CEEEEECCCCHHHHHHHHCCCCCEEHHHHHHHHCCCCEECCHHHHHHHHCEECCCCEEEE
KPLTYMNLSGDAVTKLMNFYKIDVEDILVILDDTALPLGKIRIRQTGSHGGQNGLKDIIN
CCCEEEECCHHHHHHHHHHHEECHHHEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHH
KLGTKDFKRLRIGIGEHAHMDKVDYVLGKFSTNELNTILPTIEYVNDAIIEWISTNNFNN
HHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
IMTKYNTPQTL
HEEECCCCCCC
>Mature Secondary Structure
MKLIVGLGNPGKQYVQTRHNIGFIAIDKLLSYLNTELKVDSKLQAAYTKTKIEGEDVIIA
CEEEEECCCCHHHHHHHHCCCCCEEHHHHHHHHCCCCEECCHHHHHHHHCEECCCCEEEE
KPLTYMNLSGDAVTKLMNFYKIDVEDILVILDDTALPLGKIRIRQTGSHGGQNGLKDIIN
CCCEEEECCHHHHHHHHHHHEECHHHEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHH
KLGTKDFKRLRIGIGEHAHMDKVDYVLGKFSTNELNTILPTIEYVNDAIIEWISTNNFNN
HHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
IMTKYNTPQTL
HEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA