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The map label for this gene is prsA [H]

Identifier: 162446905

GI number: 162446905

Start: 20972

End: 21937

Strand: Direct

Name: prsA [H]

Synonym: ACL_0018

Alternate gene names: 162446905

Gene position: 20972-21937 (Clockwise)

Preceding gene: 162446904

Following gene: 162446906

Centisome position: 1.4

GC content: 35.4

Gene sequence:

>966_bases
ATGACTATAGATGAAAAAAAGGCTAAATTATTTACACTTTCCGCTAATAAACCGCTAGCTGAAAAAATAGCTAAAAGTGC
AGGAATTCCATTATCAAATGTTGAAGTTATTCGATTTGCTGATGGAGAGATTACCGTTAACATTGAAGAATCTGTAAGAG
GTAACCATGTTTTTGTGATTCAACCAACATCAGAACCAGCAAATGACCATTTAATGGAGGTATTGGTATTAACGGATGCA
CTTAAGAGAGCATCTGCAGCATCTATTACAATCATCATGCCATATTTTGGTTATTCAAGACAAGATAGAAAAGTTAAGTC
ACGTCAACCAATTACCGCTAAATTAGTAGCTAACCTACTGACTGTAGCAGGTGTTGATCGTGTCGTAAGTATTGACTTAC
ACGCGGCTCAAATTCAAGGTTTCTTTGATATTCCAATTGACAATTTCCCTGCTGCACCAACACTAGCTTCATATTTTAGA
AGAAAAAAATTAGAAAACGTTGTTGTAGTATCTCCTGACCATGGTGGTGTGACACGTGCACGTGTATTTGCATCATTTTT
TAATGCCCCACTTGCAATCATAGATAAGAGAAGACCTGAACCTAATAAGGCAGAGGTTATGAATATCATTGGTGATGTAA
AAGGTGCAACATGTATCATGATTGATGACATCATAGATACTGGTGGTACATTAATGGCTGGAGCAAATGCTTTAAAAGAA
GCAGGTGCTAAAGAAGTATATGCAGCAGCAACACATGGTGTATTAACTTCTAATGCAACAGAAAGATTACAAAACTCAGT
GATTAATGAGATTGTTATTACAGATACAATCTACTTAGATCCAGCTAAAAATCAACCAAAACTTAAACAATTATCTATTG
GTGCACTGTTAGGTGAAGCAATCATCCATATTTTACAAGACGAACCAATCTCTCAAATCTTTAATAGAATTCAAGAGGAT
CAATAA

Upstream 100 bases:

>100_bases
AGACAACAATTCGCGTAAATGGTTGTTTTTTTCGCTTAGATGCTTTATTAAAACATAATTGATGATATAATGGAAATTAG
AAAAGGGAGGCTTACTAACA

Downstream 100 bases:

>100_bases
TGAAACTCATTGTCGGTTTAGGAAATCCCGGCAAACAATATGTTCAAACAAGACACAACATAGGTTTTATCGCTATAGAC
AAACTCTTAAGTTACCTAAA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK 1; Phosphoribosyl pyrophosphate synthase 1; P-Rib-PP synthase 1; PRPP synthase 1 [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTIDEKKAKLFTLSANKPLAEKIAKSAGIPLSNVEVIRFADGEITVNIEESVRGNHVFVIQPTSEPANDHLMEVLVLTDA
LKRASAASITIIMPYFGYSRQDRKVKSRQPITAKLVANLLTVAGVDRVVSIDLHAAQIQGFFDIPIDNFPAAPTLASYFR
RKKLENVVVVSPDHGGVTRARVFASFFNAPLAIIDKRRPEPNKAEVMNIIGDVKGATCIMIDDIIDTGGTLMAGANALKE
AGAKEVYAAATHGVLTSNATERLQNSVINEIVITDTIYLDPAKNQPKLKQLSIGALLGEAIIHILQDEPISQIFNRIQED
Q

Sequences:

>Translated_321_residues
MTIDEKKAKLFTLSANKPLAEKIAKSAGIPLSNVEVIRFADGEITVNIEESVRGNHVFVIQPTSEPANDHLMEVLVLTDA
LKRASAASITIIMPYFGYSRQDRKVKSRQPITAKLVANLLTVAGVDRVVSIDLHAAQIQGFFDIPIDNFPAAPTLASYFR
RKKLENVVVVSPDHGGVTRARVFASFFNAPLAIIDKRRPEPNKAEVMNIIGDVKGATCIMIDDIIDTGGTLMAGANALKE
AGAKEVYAAATHGVLTSNATERLQNSVINEIVITDTIYLDPAKNQPKLKQLSIGALLGEAIIHILQDEPISQIFNRIQED
Q
>Mature_320_residues
TIDEKKAKLFTLSANKPLAEKIAKSAGIPLSNVEVIRFADGEITVNIEESVRGNHVFVIQPTSEPANDHLMEVLVLTDAL
KRASAASITIIMPYFGYSRQDRKVKSRQPITAKLVANLLTVAGVDRVVSIDLHAAQIQGFFDIPIDNFPAAPTLASYFRR
KKLENVVVVSPDHGGVTRARVFASFFNAPLAIIDKRRPEPNKAEVMNIIGDVKGATCIMIDDIIDTGGTLMAGANALKEA
GAKEVYAAATHGVLTSNATERLQNSVINEIVITDTIYLDPAKNQPKLKQLSIGALLGEAIIHILQDEPISQIFNRIQEDQ

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:
GO:0000166: Ribose-phosphate pyrophosphokinase
GO:0000287: Ribose-phosphate pyrophosphokinase
GO:0004749: Ribose-phosphate pyrophosphokinase
GO:0005524: Ribose-phosphate pyrophosphokinase
GO:0005737: Ribose-phosphate pyrophosphokinase
GO:0009116: Ribose-phosphate pyrophosphokinase
GO:0009156: Ribose-phosphate pyrophosphokinase
GO:0009165: Ribose-phosphate pyrophosphokinase
GO:0016301: Ribose-phosphate pyrophosphokinase
GO:0016310: Ribose-phosphate pyrophosphokinase
GO:0016740: Ribose-phosphate pyrophosphokinase
GO:0044249: Ribose-phosphate pyrophosphokinase
GO:0046872: Ribose-phosphate pyrophosphokinase

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=41.6666666666667, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=41.1575562700965, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI28557709, Length=312, Percent_Identity=40.3846153846154, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=40.7643312101911, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI4506133, Length=357, Percent_Identity=35.0140056022409, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=34.2105263157895, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=33.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=33.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=33.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=33.5714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787458, Length=309, Percent_Identity=52.7508090614887, Blast_Score=324, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=40.0641025641026, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=40.0641025641026, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=39.871382636656, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=40.0641025641026, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=33.4310850439883, Blast_Score=191, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=43.5897435897436, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=42.443729903537, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6321776, Length=313, Percent_Identity=42.8115015974441, Blast_Score=242, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=40.6091370558376, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=34.8623853211009, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=40.7051282051282, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=37.6119402985075, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24651458, Length=345, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651456, Length=345, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI281362873, Length=345, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24651454, Length=345, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24651462, Length=190, Percent_Identity=35.2631578947368, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24651464, Length=190, Percent_Identity=35.2631578947368, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45552010, Length=190, Percent_Identity=35.2631578947368, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34916; Mature: 34784

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDEKKAKLFTLSANKPLAEKIAKSAGIPLSNVEVIRFADGEITVNIEESVRGNHVFVI
CCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCEEEEEEHHCCCCCEEEEE
QPTSEPANDHLMEVLVLTDALKRASAASITIIMPYFGYSRQDRKVKSRQPITAKLVANLL
ECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHH
TVAGVDRVVSIDLHAAQIQGFFDIPIDNFPAAPTLASYFRRKKLENVVVVSPDHGGVTRA
HHHCCCEEEEEEEEHHHCCCEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHH
RVFASFFNAPLAIIDKRRPEPNKAEVMNIIGDVKGATCIMIDDIIDTGGTLMAGANALKE
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHCHHHHHH
AGAKEVYAAATHGVLTSNATERLQNSVINEIVITDTIYLDPAKNQPKLKQLSIGALLGEA
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHH
IIHILQDEPISQIFNRIQEDQ
HHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TIDEKKAKLFTLSANKPLAEKIAKSAGIPLSNVEVIRFADGEITVNIEESVRGNHVFVI
CCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCEEEEEEHHCCCCCEEEEE
QPTSEPANDHLMEVLVLTDALKRASAASITIIMPYFGYSRQDRKVKSRQPITAKLVANLL
ECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHH
TVAGVDRVVSIDLHAAQIQGFFDIPIDNFPAAPTLASYFRRKKLENVVVVSPDHGGVTRA
HHHCCCEEEEEEEEHHHCCCEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHH
RVFASFFNAPLAIIDKRRPEPNKAEVMNIIGDVKGATCIMIDDIIDTGGTLMAGANALKE
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHCHHHHHH
AGAKEVYAAATHGVLTSNATERLQNSVINEIVITDTIYLDPAKNQPKLKQLSIGALLGEA
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHH
IIHILQDEPISQIFNRIQEDQ
HHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]