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The map label for this gene is serS

Identifier: 162446896

GI number: 162446896

Start: 13187

End: 14458

Strand: Direct

Name: serS

Synonym: ACL_0009

Alternate gene names: 162446896

Gene position: 13187-14458 (Clockwise)

Preceding gene: 162446895

Following gene: 162446897

Centisome position: 0.88

GC content: 32.23

Gene sequence:

>1272_bases
ATGTTAGATTTAAAATATATAACTGAAAATATAGATGAAGTCATCTTGAAGTTAAATACTAGAGGTGGTGATTTTAGCCA
CTTAAGACAATTAATAGATTTACAAGAAGAGCGTAAATCTGTAATTAAAGAAGTTGAAGACTTAAAAGCAAAAAGAAACG
AATACTCCAAAGAAATTGGGGAACTTAAAAGACAAAAACAAGATGCTTCTCACGTGTTATTAAAAGTAGAGTCCATTAAA
AGTGACATACCAGCACTTGAGTTAAAACTTGGTGAGATTGATGAAAAAATTAATAAAGAACTCATCGTTTTACCAAATAT
TCCTGCTGACGATGTACCGGTTGGTAAAGATGAATCTGCAAATATTGAAATTAAAAAATGGGGTACTATTAGACATTTTG
ATTTTGAAGTAAAAGATCATACTCAATTAGGTGAAGCACTAAATATATTAGACTTTGAACGTGCAACTAAAATCACTGGT
CCACGTTTTGTAGTAGATAAAGGGCTAGGTGCTAGACTGGAAAGAGCGCTTATAAACTTTATGATAGATACACATGCGTA
TACACATGGTTATACCGAAATCATTCCACCGTTTATTGTAAATGATAAATCTATGTATGCAACAGGACAATTTCCTAAGT
TTAAAGAAGATGCTTTTAAATTAGAAGGATTTGATTGGTATTTAAATCCAACAGCAGAAGTACCAACTATTAACCTATTT
AGAGATGAAATCATTGATAATGATGCATTACCAATTCAGTATGTAGCTTATACAACAGCATTTAGATCAGAGGCAGGTTC
TGCTGGACGAGATACTAAGGGTATTTTAAGACAACATCAATTCAATAAAGTTGAATTAATTAAATTTGCACGACCTGAAG
ATTCTGAACAAGCTCATCAAGATATGTTAGCAAACTCAGAAAGAATACTACAACTATTAAATATTCCTTATCGAGTAGTT
GTCTTATCAACAGGAGACATGGGCTTTGGTATGAGTAAGACATACGATATTGAAGTATGGTTACCAGGTCAAAATATGTA
CCGTGAAATTGGATCTATTTCAAATGCTAGAGACTTTCAAGCAAGAAGAGCCAACATTCGCTTTAAACGTTCAAAAGATG
CTAAAACAGAATATGTGCATACATTAAACGGTTCTGGTTTAGCTGTTGGTAGAACAATGATTGCAGTACTAGAGAACTAT
CAAAATCAAGATGGATCAATTACAATACCAGAAGTCTTAAAACCATATATGGGTGTAGAAGTTATTAAATAA

Upstream 100 bases:

>100_bases
GTTTATATACAATAGAATTAAGGTGGCACCGCGATAATCAATGGATCGTCCTTAGACTATTTTTAGTCTAAGGACGTTTA
TTTTATAAGGAGAAGGAAAA

Downstream 100 bases:

>100_bases
TGTTATTCATTACAATAAATAACATAGTTTTTCATAAAGATTGAGAAATAAAGGTACAGACTATATACTAGAGGTACTTC
ATTTTTCTCTCTCGAAACGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDLKYITENIDEVILKLNTRGGDFSHLRQLIDLQEERKSVIKEVEDLKAKRNEYSKEIGELKRQKQDASHVLLKVESIK
SDIPALELKLGEIDEKINKELIVLPNIPADDVPVGKDESANIEIKKWGTIRHFDFEVKDHTQLGEALNILDFERATKITG
PRFVVDKGLGARLERALINFMIDTHAYTHGYTEIIPPFIVNDKSMYATGQFPKFKEDAFKLEGFDWYLNPTAEVPTINLF
RDEIIDNDALPIQYVAYTTAFRSEAGSAGRDTKGILRQHQFNKVELIKFARPEDSEQAHQDMLANSERILQLLNIPYRVV
VLSTGDMGFGMSKTYDIEVWLPGQNMYREIGSISNARDFQARRANIRFKRSKDAKTEYVHTLNGSGLAVGRTMIAVLENY
QNQDGSITIPEVLKPYMGVEVIK

Sequences:

>Translated_423_residues
MLDLKYITENIDEVILKLNTRGGDFSHLRQLIDLQEERKSVIKEVEDLKAKRNEYSKEIGELKRQKQDASHVLLKVESIK
SDIPALELKLGEIDEKINKELIVLPNIPADDVPVGKDESANIEIKKWGTIRHFDFEVKDHTQLGEALNILDFERATKITG
PRFVVDKGLGARLERALINFMIDTHAYTHGYTEIIPPFIVNDKSMYATGQFPKFKEDAFKLEGFDWYLNPTAEVPTINLF
RDEIIDNDALPIQYVAYTTAFRSEAGSAGRDTKGILRQHQFNKVELIKFARPEDSEQAHQDMLANSERILQLLNIPYRVV
VLSTGDMGFGMSKTYDIEVWLPGQNMYREIGSISNARDFQARRANIRFKRSKDAKTEYVHTLNGSGLAVGRTMIAVLENY
QNQDGSITIPEVLKPYMGVEVIK
>Mature_423_residues
MLDLKYITENIDEVILKLNTRGGDFSHLRQLIDLQEERKSVIKEVEDLKAKRNEYSKEIGELKRQKQDASHVLLKVESIK
SDIPALELKLGEIDEKINKELIVLPNIPADDVPVGKDESANIEIKKWGTIRHFDFEVKDHTQLGEALNILDFERATKITG
PRFVVDKGLGARLERALINFMIDTHAYTHGYTEIIPPFIVNDKSMYATGQFPKFKEDAFKLEGFDWYLNPTAEVPTINLF
RDEIIDNDALPIQYVAYTTAFRSEAGSAGRDTKGILRQHQFNKVELIKFARPEDSEQAHQDMLANSERILQLLNIPYRVV
VLSTGDMGFGMSKTYDIEVWLPGQNMYREIGSISNARDFQARRANIRFKRSKDAKTEYVHTLNGSGLAVGRTMIAVLENY
QNQDGSITIPEVLKPYMGVEVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=433, Percent_Identity=33.4872979214781, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI8923421, Length=447, Percent_Identity=28.8590604026846, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI225579074, Length=446, Percent_Identity=28.2511210762332, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=50.6976744186047, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=437, Percent_Identity=30.6636155606407, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17542084, Length=335, Percent_Identity=31.3432835820896, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=390, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6321799, Length=418, Percent_Identity=30.1435406698565, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24581334, Length=326, Percent_Identity=35.5828220858896, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI17737985, Length=286, Percent_Identity=32.5174825174825, Blast_Score=158, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ACHLI (A9NE72)

Other databases:

- EMBL:   CP000896
- RefSeq:   YP_001620028.1
- ProteinModelPortal:   A9NE72
- SMR:   A9NE72
- GeneID:   5803497
- GenomeReviews:   CP000896_GR
- KEGG:   acl:ACL_0009
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- BioCyc:   ALAI441768:ACL_0009-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48264; Mature: 48264

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKYITENIDEVILKLNTRGGDFSHLRQLIDLQEERKSVIKEVEDLKAKRNEYSKEIG
CCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELKRQKQDASHVLLKVESIKSDIPALELKLGEIDEKINKELIVLPNIPADDVPVGKDESA
HHHHHHHCHHHHEEEHHHHHCCCCEEEEEHHHHHHHCCCCEEEECCCCCCCCCCCCCCCC
NIEIKKWGTIRHFDFEVKDHTQLGEALNILDFERATKITGPRFVVDKGLGARLERALINF
CEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
MIDTHAYTHGYTEIIPPFIVNDKSMYATGQFPKFKEDAFKLEGFDWYLNPTAEVPTINLF
HHHCCHHCCCCHHHCCCEEECCCCEEECCCCCCCCCCCEEECCEEEEECCCCCCCEEHHH
RDEIIDNDALPIQYVAYTTAFRSEAGSAGRDTKGILRQHQFNKVELIKFARPEDSEQAHQ
HHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHH
DMLANSERILQLLNIPYRVVVLSTGDMGFGMSKTYDIEVWLPGQNMYREIGSISNARDFQ
HHHHCHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCHHHH
ARRANIRFKRSKDAKTEYVHTLNGSGLAVGRTMIAVLENYQNQDGSITIPEVLKPYMGVE
HHHCCEEEECCCCCCHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCE
VIK
ECC
>Mature Secondary Structure
MLDLKYITENIDEVILKLNTRGGDFSHLRQLIDLQEERKSVIKEVEDLKAKRNEYSKEIG
CCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELKRQKQDASHVLLKVESIKSDIPALELKLGEIDEKINKELIVLPNIPADDVPVGKDESA
HHHHHHHCHHHHEEEHHHHHCCCCEEEEEHHHHHHHCCCCEEEECCCCCCCCCCCCCCCC
NIEIKKWGTIRHFDFEVKDHTQLGEALNILDFERATKITGPRFVVDKGLGARLERALINF
CEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
MIDTHAYTHGYTEIIPPFIVNDKSMYATGQFPKFKEDAFKLEGFDWYLNPTAEVPTINLF
HHHCCHHCCCCHHHCCCEEECCCCEEECCCCCCCCCCCEEECCEEEEECCCCCCCEEHHH
RDEIIDNDALPIQYVAYTTAFRSEAGSAGRDTKGILRQHQFNKVELIKFARPEDSEQAHQ
HHHHCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHH
DMLANSERILQLLNIPYRVVVLSTGDMGFGMSKTYDIEVWLPGQNMYREIGSISNARDFQ
HHHHCHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCHHHH
ARRANIRFKRSKDAKTEYVHTLNGSGLAVGRTMIAVLENYQNQDGSITIPEVLKPYMGVE
HHHCCEEEECCCCCCHHEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCE
VIK
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA