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The map label for this gene is ada [H]

Identifier: 162421118

GI number: 162421118

Start: 81568

End: 82389

Strand: Direct

Name: ada [H]

Synonym: YpAngola_A0076

Alternate gene names: 162421118

Gene position: 81568-82389 (Clockwise)

Preceding gene: 162420074

Following gene: 162421422

Centisome position: 1.81

GC content: 50.73

Gene sequence:

>822_bases
ATGAATAACGTAAAAGACCCTCGCTGGGCCGCGATTATCAATCGGGATAAAACCGCCGATGGTCAGTTTGTGTATGCGGT
AAAAACGACGGGCATATATTGCCGCCCCTCTTGCCCATCTCGTCGAGCCAAAGCAGAAAACATTGAATTCTTTATCGATA
ATACGGCAGCAGAGCAAGCCGGTTATCGGCCTTGTAAGCGTTGCCAGCCAACTCAATTATCGCGGGCGCAGCAACAGGTA
GAAAAAATCAGTCAGGCATGTCGGTTGATTGAACTGGCAGAAACTCCCCCTAAGCTGAATGAATTGGCAGCTCAACTGGG
GCTTAGCACTTTTTATTTTCATCGGTTGTTTAAAGCCATCACCGGGCTGACGCCCAAAGGATATGCTAACGCGACCCGCA
GTGAGCGTATTCGTGCACAACTGTCTCATGGCGGTTCGGTCACTGACGCTATCTTTGAGGCCGGTTATAACTCGAGTAGT
CGATTTTATGCGCAATCACAGCAGTTGCTGGGAATGACACCAACCCGTTACCGCAAAGGGGGCTGTGATGCCAGGTTGCA
TTTTGCCGTTGGGGAGAGTTCTCTGGGCGCGATTTTAGTGGCAAAAAGTGAGTTGGGCGTCTGTGCTATTTTGCTGGGTG
ATGACCCAGTGCGGTTAGTACAACAGCTACAGGATAAATTTCCACAGGCCAATTTAGTCGGCGGTGATGCTGAGTTTGAG
CAATGGGTGGCGCAGGTTGTGGGGTGCGTTGAGGCACCCAAACTTGGGTTGAACCTACCGTTGGATATCCGTGGCACTGC
ATTCCAGCAGCGGGTATTGTAA

Upstream 100 bases:

>100_bases
AAAAGCAAGGAGCGGAGTGTGTGACCAGTGGCATCTTTTATATGCTGGTTGGCACAGTTAAGAGTAATGGGGTATTTATC
ATGACATCAGTGGGGTATTC

Downstream 100 bases:

>100_bases
CGAACGGTGCAATAGTGATCCACACCCAACGCCTGAAATCAGATCCAGGGGGTAATCTGCTCTCCTGATTCAGGAGAGTT
TATGGTCACTTTTGAGACAG

Product: adaptative response regulatory protein Ada

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MNNVKDPRWAAIINRDKTADGQFVYAVKTTGIYCRPSCPSRRAKAENIEFFIDNTAAEQAGYRPCKRCQPTQLSRAQQQV
EKISQACRLIELAETPPKLNELAAQLGLSTFYFHRLFKAITGLTPKGYANATRSERIRAQLSHGGSVTDAIFEAGYNSSS
RFYAQSQQLLGMTPTRYRKGGCDARLHFAVGESSLGAILVAKSELGVCAILLGDDPVRLVQQLQDKFPQANLVGGDAEFE
QWVAQVVGCVEAPKLGLNLPLDIRGTAFQQRVL

Sequences:

>Translated_273_residues
MNNVKDPRWAAIINRDKTADGQFVYAVKTTGIYCRPSCPSRRAKAENIEFFIDNTAAEQAGYRPCKRCQPTQLSRAQQQV
EKISQACRLIELAETPPKLNELAAQLGLSTFYFHRLFKAITGLTPKGYANATRSERIRAQLSHGGSVTDAIFEAGYNSSS
RFYAQSQQLLGMTPTRYRKGGCDARLHFAVGESSLGAILVAKSELGVCAILLGDDPVRLVQQLQDKFPQANLVGGDAEFE
QWVAQVVGCVEAPKLGLNLPLDIRGTAFQQRVL
>Mature_273_residues
MNNVKDPRWAAIINRDKTADGQFVYAVKTTGIYCRPSCPSRRAKAENIEFFIDNTAAEQAGYRPCKRCQPTQLSRAQQQV
EKISQACRLIELAETPPKLNELAAQLGLSTFYFHRLFKAITGLTPKGYANATRSERIRAQLSHGGSVTDAIFEAGYNSSS
RFYAQSQQLLGMTPTRYRKGGCDARLHFAVGESSLGAILVAKSELGVCAILLGDDPVRLVQQLQDKFPQANLVGGDAEFE
QWVAQVVGCVEAPKLGLNLPLDIRGTAFQQRVL

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788542, Length=267, Percent_Identity=48.314606741573, Blast_Score=270, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 30042; Mature: 30042

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVKDPRWAAIINRDKTADGQFVYAVKTTGIYCRPSCPSRRAKAENIEFFIDNTAAEQA
CCCCCCCCEEEEECCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEECCHHHHC
GYRPCKRCQPTQLSRAQQQVEKISQACRLIELAETPPKLNELAAQLGLSTFYFHRLFKAI
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TGLTPKGYANATRSERIRAQLSHGGSVTDAIFEAGYNSSSRFYAQSQQLLGMTPTRYRKG
HCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHCCC
GCDARLHFAVGESSLGAILVAKSELGVCAILLGDDPVRLVQQLQDKFPQANLVGGDAEFE
CCCEEEEEEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCEECCCCHHHH
QWVAQVVGCVEAPKLGLNLPLDIRGTAFQQRVL
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MNNVKDPRWAAIINRDKTADGQFVYAVKTTGIYCRPSCPSRRAKAENIEFFIDNTAAEQA
CCCCCCCCEEEEECCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCEEEEEECCHHHHC
GYRPCKRCQPTQLSRAQQQVEKISQACRLIELAETPPKLNELAAQLGLSTFYFHRLFKAI
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TGLTPKGYANATRSERIRAQLSHGGSVTDAIFEAGYNSSSRFYAQSQQLLGMTPTRYRKG
HCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHCCC
GCDARLHFAVGESSLGAILVAKSELGVCAILLGDDPVRLVQQLQDKFPQANLVGGDAEFE
CCCEEEEEEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCEECCCCHHHH
QWVAQVVGCVEAPKLGLNLPLDIRGTAFQQRVL
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2987251; 3887409; 9097040; 9278503; 2982792; 3536913; 3009022; 3529081; 1581309; 8202360; 8500619; 8156986 [H]