Click here to switch to the map view.

The map label for this gene is lipB [H]

Identifier: 162420857

GI number: 162420857

Start: 1922008

End: 1922706

Strand: Direct

Name: lipB [H]

Synonym: YpAngola_A1854

Alternate gene names: 162420857

Gene position: 1922008-1922706 (Clockwise)

Preceding gene: 162419084

Following gene: 162420328

Centisome position: 42.67

GC content: 48.93

Gene sequence:

>699_bases
ATGCCTCGCTTGCAACAACACAAGATCATTTTACGTCAGCTAGGGTTACAACCCTATGCACCCGTATCCCAAGCCATGCA
TAACTTTACTGAGTTTCGCACTGATACCACACCAGACGAAATCTGGTTGGTTGAGCATCAGCACGTCTTTACTCAGGGTC
AGGCTGGAAAAGCTGAACATGTCCTGATGCCAGGTGATATTCCGGTTATTCAAAGTGATAGGGGGGGTCAGGTCACCTAC
CATGGCCCCGGCCAGCAAGTGATGTATGTCATGGTTGATCTCAAACGTGCCAAAATCGGTGTACGCCAGCTAGTCACCGT
CATTGAGAATACGGTGATAGAGACTCTCGCCCATTTCAATATTGATTCACATGCTCGCCCAGATGCCCCCGGTGTCTATG
TTGAACAACAGAAAATATGCTCACTGGGGCTACGCATCCGCCGAGGCTGTTCGTTTCACGGTTTAGCATTGAACATTGCG
ATGGATCTGGAACCGTTCCAGCGCATTAATCCGTGCGGCTACGCGGGTATGCAGATGACACAAGTCAGTGCATTACAACC
AGGGGTTACCGTTGCGGATGTGCAGCCTGTATTGGTTCGCGAATTTACCCGCCAATTAGGTTATCCGACGGCAAAATTGC
AGCCGTGGTCATTATCAGACTATTTATTATCAAGCCATTCATCATCAAGCGTGTTGTAA

Upstream 100 bases:

>100_bases
TTATCCCCTTTAGCCATCAAATTATAGCGTTGAACTGTCAAAATAGTGGCCCCACTCAGCGGGGCTGGTATACTGGCGCT
ACCATTTCTGTAACCAGATG

Downstream 100 bases:

>100_bases
ATGACTCATATGCCCGATGTAACTGAAACCGTGAACGCCACCATCGCGCCAAAAGTGAATGGCTGAACGAAACAGAGTAA
AGATGATATAATTTTTAAAC

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MPRLQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLMPGDIPVIQSDRGGQVTY
HGPGQQVMYVMVDLKRAKIGVRQLVTVIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIA
MDLEPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL

Sequences:

>Translated_232_residues
MPRLQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLMPGDIPVIQSDRGGQVTY
HGPGQQVMYVMVDLKRAKIGVRQLVTVIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIA
MDLEPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL
>Mature_231_residues
PRLQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEHVLMPGDIPVIQSDRGGQVTYH
GPGQQVMYVMVDLKRAKIGVRQLVTVIENTVIETLAHFNIDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAM
DLEPFQRINPCGYAGMQMTQVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=134, Percent_Identity=38.0597014925373, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI87081767, Length=206, Percent_Identity=68.4466019417476, Blast_Score=306, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6323268, Length=157, Percent_Identity=35.6687898089172, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355483, Length=194, Percent_Identity=30.9278350515464, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 25892; Mature: 25761

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEH
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCCCCE
VLMPGDIPVIQSDRGGQVTYHGPGQQVMYVMVDLKRAKIGVRQLVTVIENTVIETLAHFN
EEECCCCCEEECCCCCEEEEECCCCEEEEHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDLEPFQRINPCGYAGMQMT
CCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHH
QVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL
HHHHCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PRLQQHKIILRQLGLQPYAPVSQAMHNFTEFRTDTTPDEIWLVEHQHVFTQGQAGKAEH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCCCCE
VLMPGDIPVIQSDRGGQVTYHGPGQQVMYVMVDLKRAKIGVRQLVTVIENTVIETLAHFN
EEECCCCCEEECCCCCEEEEECCCCEEEEHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDSHARPDAPGVYVEQQKICSLGLRIRRGCSFHGLALNIAMDLEPFQRINPCGYAGMQMT
CCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHH
QVSALQPGVTVADVQPVLVREFTRQLGYPTAKLQPWSLSDYLLSSHSSSSVL
HHHHCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA