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The map label for this gene is potA2 [H]

Identifier: 162420338

GI number: 162420338

Start: 2567248

End: 2567985

Strand: Direct

Name: potA2 [H]

Synonym: YpAngola_A2448

Alternate gene names: 162420338

Gene position: 2567248-2567985 (Clockwise)

Preceding gene: 162418355

Following gene: 162420043

Centisome position: 57.0

GC content: 55.96

Gene sequence:

>738_bases
TTGGCGCGACTGGCAGAGGCACTGAAGCAGGTGGGGCTAGAAAGCCAACGCCTGAAAATGCCCGCCCAACTCTCCGGCGG
CCAGCAGCAGCGCGTGGCACTGGCCCGAGCGATGATCACCCGCCCAGACGTGATCCTGTTTGATGAACCGCTCTCTAATC
TTGATGCTAAACTGCGCGAAAGCGTGCGTTTTGAGATTAAAGAACTGCAACGTCAGTACCATCTCACCTCTATTTACGTC
ACCCATGATCAGGCAGAAGCGCTGGCGATGTCGGACAAAATCGTGGTACTCAACGCAGGTAATGTGGAGCAAATCGGGGC
ACCTGAGGAGATTTACTACCGCCCGACCAGCCGCTTTGTGGCGGATTTCATCGGCGCGGCCAATATCGACACAGCTCATA
TTACTGCTGCAGAGCAACCCGGCTCTTGGCGAGTACGCTGCGCCATGGGCGAATTTTACGTCCATTCAACCACTCCGCCG
CGTGCAGAGCACTGCTATATCTGCTGGCGGCCGGAAGATGTGCAATTTGTCGGCCCTCATCAGAGCGGCGACAACCACTT
TACCCTGACACTCGAAAAAATGGCGTTTATGGGCAATCTCACTGAGGCCTGGGGCCATAATGATGCGGGGCTGTCGGTAC
GTCTGCAACTGATTAAAAAACCTCCGGTGGTACTTGGCGGGCGGGCGTGTTTCCGCCTGCCGGAGAACGCTATTCACTTT
TTGGAGCCGGTATCATGA

Upstream 100 bases:

>100_bases
AAAAGGGGTTTTTATAACTGACCCAAAGCTGAAAGCTTTACTGAACCCCCAGCCTAGCTGGGGGTTTTCTGGGCACAAAA
AAGTCGCTATCAATGAGCAA

Downstream 100 bases:

>100_bases
AAAGCTGGCGCAACGACCTGCTTGCCTGGTCGCTGATGTTGAGTGGCCTGGGCACCATTCTGTTATTGATGGGTTCCACC
TTTTATGTCGTGGTGGTGCA

Product: MalK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MARLAEALKQVGLESQRLKMPAQLSGGQQQRVALARAMITRPDVILFDEPLSNLDAKLRESVRFEIKELQRQYHLTSIYV
THDQAEALAMSDKIVVLNAGNVEQIGAPEEIYYRPTSRFVADFIGAANIDTAHITAAEQPGSWRVRCAMGEFYVHSTTPP
RAEHCYICWRPEDVQFVGPHQSGDNHFTLTLEKMAFMGNLTEAWGHNDAGLSVRLQLIKKPPVVLGGRACFRLPENAIHF
LEPVS

Sequences:

>Translated_245_residues
MARLAEALKQVGLESQRLKMPAQLSGGQQQRVALARAMITRPDVILFDEPLSNLDAKLRESVRFEIKELQRQYHLTSIYV
THDQAEALAMSDKIVVLNAGNVEQIGAPEEIYYRPTSRFVADFIGAANIDTAHITAAEQPGSWRVRCAMGEFYVHSTTPP
RAEHCYICWRPEDVQFVGPHQSGDNHFTLTLEKMAFMGNLTEAWGHNDAGLSVRLQLIKKPPVVLGGRACFRLPENAIHF
LEPVS
>Mature_244_residues
ARLAEALKQVGLESQRLKMPAQLSGGQQQRVALARAMITRPDVILFDEPLSNLDAKLRESVRFEIKELQRQYHLTSIYVT
HDQAEALAMSDKIVVLNAGNVEQIGAPEEIYYRPTSRFVADFIGAANIDTAHITAAEQPGSWRVRCAMGEFYVHSTTPPR
AEHCYICWRPEDVQFVGPHQSGDNHFTLTLEKMAFMGNLTEAWGHNDAGLSVRLQLIKKPPVVLGGRACFRLPENAIHFL
EPVS

Specific function: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system [H]

COG id: COG3842

COG function: function code E; ABC-type spermidine/putrescine transport systems, ATPase components

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI42490749, Length=122, Percent_Identity=34.4262295081967, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI87081709, Length=128, Percent_Identity=58.59375, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1787370, Length=188, Percent_Identity=45.2127659574468, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1787712, Length=124, Percent_Identity=51.6129032258064, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI87082267, Length=247, Percent_Identity=37.246963562753, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790467, Length=112, Percent_Identity=54.4642857142857, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI87081791, Length=208, Percent_Identity=34.1346153846154, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1788761, Length=127, Percent_Identity=44.0944881889764, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1789032, Length=124, Percent_Identity=39.5161290322581, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788450, Length=128, Percent_Identity=40.625, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787164, Length=92, Percent_Identity=47.8260869565217, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788225, Length=127, Percent_Identity=39.3700787401575, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1787500, Length=128, Percent_Identity=32.8125, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787029, Length=119, Percent_Identity=36.1344537815126, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788644, Length=126, Percent_Identity=38.0952380952381, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788506, Length=122, Percent_Identity=30.327868852459, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789672, Length=117, Percent_Identity=35.042735042735, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994883, Length=174, Percent_Identity=27.0114942528736, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787758, Length=130, Percent_Identity=33.8461538461538, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786872, Length=118, Percent_Identity=36.4406779661017, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789962, Length=165, Percent_Identity=27.8787878787879, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786398, Length=122, Percent_Identity=33.6065573770492, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789891, Length=103, Percent_Identity=39.8058252427184, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786703, Length=97, Percent_Identity=44.3298969072165, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI145693107, Length=129, Percent_Identity=30.2325581395349, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786563, Length=95, Percent_Identity=38.9473684210526, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787547, Length=130, Percent_Identity=33.8461538461538, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789864, Length=115, Percent_Identity=31.304347826087, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI87081834, Length=93, Percent_Identity=41.9354838709677, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789963, Length=116, Percent_Identity=35.3448275862069, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1787089, Length=106, Percent_Identity=35.8490566037736, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789873, Length=100, Percent_Identity=39, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786253, Length=104, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787105, Length=102, Percent_Identity=41.1764705882353, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790162, Length=101, Percent_Identity=34.6534653465347, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994997, Length=109, Percent_Identity=29.3577981651376, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788053, Length=78, Percent_Identity=43.5897435897436, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790190, Length=82, Percent_Identity=40.2439024390244, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1790544, Length=123, Percent_Identity=32.520325203252, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115534520, Length=115, Percent_Identity=33.9130434782609, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17511077, Length=86, Percent_Identity=44.1860465116279, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209708, Length=89, Percent_Identity=43.8202247191011, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=98, Percent_Identity=33.6734693877551, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324985, Length=94, Percent_Identity=32.9787234042553, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR008995
- InterPro:   IPR017879
- InterPro:   IPR005893
- InterPro:   IPR013611 [H]

Pfam domain/function: PF00005 ABC_tran; PF08402 TOBE_2 [H]

EC number: =3.6.3.31 [H]

Molecular weight: Translated: 27435; Mature: 27304

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLAEALKQVGLESQRLKMPAQLSGGQQQRVALARAMITRPDVILFDEPLSNLDAKLRE
CCHHHHHHHHHCCCHHHCCCCHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHH
SVRFEIKELQRQYHLTSIYVTHDQAEALAMSDKIVVLNAGNVEQIGAPEEIYYRPTSRFV
HHHHHHHHHHHHHCEEEEEEECCCCHHEEECCCEEEEECCCHHHCCCCHHEEECCHHHHH
ADFIGAANIDTAHITAAEQPGSWRVRCAMGEFYVHSTTPPRAEHCYICWRPEDVQFVGPH
HHHHCCCCCCCEEEEECCCCCCEEEEEEECEEEEECCCCCCCCEEEEEECCCCCEEECCC
QSGDNHFTLTLEKMAFMGNLTEAWGHNDAGLSVRLQLIKKPPVVLGGRACFRLPENAIHF
CCCCCEEEEEEEHHHHHCCCHHHCCCCCCCEEEEEEEECCCCEEECCHHHEECCCHHHHH
LEPVS
CCCCC
>Mature Secondary Structure 
ARLAEALKQVGLESQRLKMPAQLSGGQQQRVALARAMITRPDVILFDEPLSNLDAKLRE
CHHHHHHHHHCCCHHHCCCCHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHH
SVRFEIKELQRQYHLTSIYVTHDQAEALAMSDKIVVLNAGNVEQIGAPEEIYYRPTSRFV
HHHHHHHHHHHHHCEEEEEEECCCCHHEEECCCEEEEECCCHHHCCCCHHEEECCHHHHH
ADFIGAANIDTAHITAAEQPGSWRVRCAMGEFYVHSTTPPRAEHCYICWRPEDVQFVGPH
HHHHCCCCCCCEEEEECCCCCCEEEEEEECEEEEECCCCCCCCEEEEEECCCCCEEECCC
QSGDNHFTLTLEKMAFMGNLTEAWGHNDAGLSVRLQLIKKPPVVLGGRACFRLPENAIHF
CCCCCEEEEEEEHHHHHCCCHHHCCCCCCCEEEEEEEECCCCEEECCHHHEECCCHHHHH
LEPVS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]