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The map label for this gene is dld [H]

Identifier: 162418973

GI number: 162418973

Start: 1412159

End: 1413871

Strand: Direct

Name: dld [H]

Synonym: YpAngola_A1351

Alternate gene names: 162418973

Gene position: 1412159-1413871 (Clockwise)

Preceding gene: 162421486

Following gene: 162419474

Centisome position: 31.35

GC content: 45.53

Gene sequence:

>1713_bases
ATGAGCCAGTTCAATAATGAAAAAATCCAGCTCTTGCTGACTCAATTACAGCATATAGTGGGTACACGCTATTTACTGAC
CGGTGAACGGCAGACTGAACGCTACCGAACCGGTTTCCGCTCCGGTAAAGGGGTGGCCCTCGCCGTGGTATTTCCGTCAA
CACTACTGCAACAATGGCAGTTACTGCAGGCTTGTGTGGCTGCTGATACCATCATTATCATGCAAGCCGCCAATACTGGG
CTGACAGAAGGCTCGACGCCAAGTGGTGATGATTATGATCGCCCTATCGTCATCTTGAATACCTTACGTCTTAACAACAT
TCAGCTATTGGATGATGGCAAACAAGTTATAGGATTCCCTGGAAGCACACTGAATCAATTAGAAAAACGCTTAAAACCTT
ATGGTCGCGAACCCCATTCGGTTATTGGCTCCTCCTGTATTGGTGCCTCGGTCGTAGGCGGTATTTGCAATAATTCAGGC
GGTTCATTGGTCCAAAGAGGCCCGGCATACACCGAAATGGCTCTGTATGCACAAATTGATGCACAAGGTGAGTTGCAGTT
AATTAATCATTTAGGCATCAGCTTGGGAAATACACCAGAAGAGATTCTACAACGTTTGGAACAAGGCCAATATGGTGCTG
AAGATATCGAACAGACCGGGCAGCAAGCCTCAGATAGTGAATATGCGACGCGGGTAAGAGATATTGATGCAACGACCCCT
TCGCGTTTTAACGCCGACCCCAGACGTTTATTTGAAGCCTCCGGCTGTGCCGGTAAATTGGCAATATTTGCCGTGCGGCT
GGATACCTTCCCCAGTGAGAAACAACAACAAGTTTTTTATATCGGCACCAACCAAACTCAGGTATTGACTGAGTTACGCC
GTATTATTCTCCGCGACTTTAAACATTTACCTATCGCGGGTGAATATCTGCACCGTGATATTTTTGATATTGCGGAAACC
TATGGCAAAGATACGTTTGTGATGATTAACAGCATGGGCACCAATAACATGCCCCGATTCTTCACGTTAAAAGGTAAAAT
TGATGCTCGCCTCAATAAAATTCCGCATTTAGTCGATCACCTGACCGATCGTGTAATGCAAGGCTTTAGTCAGATATTGC
CTAACCATTTACCTAAGCGCCTTAAGACTTACCGTAATCAATATGAACATCATCTGCTGCTCAAAATGTCAGGCGATGGT
ATTACCGAAGCGCAACAACATCTACGCGCCTTTTTTGCCACTGCGGAAGGTAACTTTATTGCCTGCACGGCTGATGAAGG
TAAAAAGGCTTTTCTACACCGTTTTGCGGCGGCAGGTGCGGCAGTGCGCTATCACGCGGTCCACGCCGATCAAGTGGAAG
ATATTTTGGCACTGGATATCGCCCTGCGCCGTAATGAAAAACAGTGGTTTGAAACCTTACCACCAGAAATAGAAAAATGT
CTGATCGCGAAGCTCTATTATGGACATTTTCTGTGCCACGTCTTTCATCAAGACTATATCGTTAAGAAAGGGGTTGATGT
AAAAGCGCTAAAAGAAAAAATGTTATCGATCCTCAATGACAAAGGTGCGGAATACCCCGCAGAACATAATGTCGGCCACC
TCTATCTGGCAAAACCTGCATTAAAAGATTTTTATCAACAGATCGACCCAACCAACAGTTTTAATCCGGGGATTGGTAAA
ACCTCAAAACGTAAGCGTTGGCAGCAAGACTGA

Upstream 100 bases:

>100_bases
AATCAACGTCGATATATTAAACGGTTAAGGGAGTAAAAGGTTGATGTAGTAAAAAGCTAATGCAGTAAAAGGCTAATGTC
ACTAACAGGGAACCACATTG

Downstream 100 bases:

>100_bases
CGCTATTAGCCAGAAATAGCACCATTAGGCTTAGGCATTATCTGAAAGCAAACAATTAGTCACTAAAGCGGAATTTGCCT
CTGCTAGCAAATTCCGCTTC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANTG
LTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSG
GSLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQASDSEYATRVRDIDATTP
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAET
YGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDG
ITEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSILNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIGK
TSKRKRWQQD

Sequences:

>Translated_570_residues
MSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANTG
LTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSG
GSLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQASDSEYATRVRDIDATTP
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAET
YGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDG
ITEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSILNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIGK
TSKRKRWQQD
>Mature_569_residues
SQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANTGL
TEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGG
SLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQASDSEYATRVRDIDATTPS
RFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAETY
GKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGI
TEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKCL
IAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSILNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIGKT
SKRKRWQQD

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=569, Percent_Identity=65.0263620386643, Blast_Score=801, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 64042; Mature: 63911

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQ
CCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHH
LLQACVAADTIIIMQAANTGLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFP
HHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCEEEECC
GSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGGSLVQRGPAYTEMALYAQID
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEEEEEEC
AQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQASDSEYATRVRDIDATTP
CCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCC
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDF
CCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
KHLPIAGEYLHRDIFDIAETYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDH
HCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHH
LTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGITEAQQHLRAFFATAEGNFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEE
ACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
EEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHH
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSILNDKGAEYPAEHNVGHLYLAKPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHH
LKDFYQQIDPTNSFNPGIGKTSKRKRWQQD
HHHHHHHCCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
SQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQ
CCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHH
LLQACVAADTIIIMQAANTGLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFP
HHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCEEEECC
GSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGGSLVQRGPAYTEMALYAQID
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEEEEEEC
AQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQASDSEYATRVRDIDATTP
CCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCC
SRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDF
CCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
KHLPIAGEYLHRDIFDIAETYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDH
HCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHH
LTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGITEAQQHLRAFFATAEGNFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEE
ACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEKC
EEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHH
LIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSILNDKGAEYPAEHNVGHLYLAKPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHH
LKDFYQQIDPTNSFNPGIGKTSKRKRWQQD
HHHHHHHCCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]