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The map label for this gene is lpxB [H]

Identifier: 162149040

GI number: 162149040

Start: 3359871

End: 3361037

Strand: Reverse

Name: lpxB [H]

Synonym: GDI_3270

Alternate gene names: 162149040

Gene position: 3361037-3359871 (Counterclockwise)

Preceding gene: 162149041

Following gene: 162149035

Centisome position: 85.22

GC content: 73.52

Gene sequence:

>1167_bases
ATGAACGCTGCGGCCGGGCGGACGGTCTGGCTTCTGGCGGGCGAGGCCAGCGGCGATGTGCTGGGCGCGCGCCTGATGGC
GGCGCTGCGCCGCCGCGATCCGACCCTGCGCTTCGCCGGTGTCGGCGGCGCGCGGATGGAGGAAGCCGGCCTGCGCAGCC
TGTTCCCGCTGCGCGACCTGGCGGTGATGGGCCTGGTCGAGGTGCTGCCGCGCATCCGGCATCTGTCCCGCCGGCTGGAC
CAGGCGGTGGAGCATATTCGCCAGACCCGGCCCGACCTGGTGGTGACGATCGACAGTCCCGGCTTCACGCTGCGGCTGCT
GCGCCGGATCGAGGGCGAGGGGATTCCCCGGGTTCATTATGTCGCGCCGCAGGTCTGGGCGTGGCGCGAGCATCGGGTGC
GCGAATTTCCCGGCCTGTGGGACCGCCTGCTGTGCCTGCTGCCGTTCGAACCCGCCTTCTTCGGCCGTCACGGGCTGGAG
GCCCGGTTCGTCGGCCATCCGGTCCTGCAATCCGGGGCGGGGCGGGGCGACGGCGCGGCGTTTCGCGCCCGGCATGGCAT
TGCGCCCGGCACGCCGATCCTGATCCTGATGCCCGGCAGCCGCCGGTCCGAGGCCCCGCGCCTGCTGCCGGTGCTGGGGC
GGACGCTGCGCATCCTGGCCGCGACCTGCCCCGGAATCGTGCCGGTGGTGCCGGTCTCGGCCGTGGTGGCCGAGACCGTG
CGGCGCGGCGTGGCCGACTGGCCCATGAAGCCGATCATCGTGACCGACCTGGACGAGAAGCATGATGCCTTCGCCGCCGC
CGGCGCGGCGCTGACCAAGTCGGGCACCTCAACCCTGGAACTGGCGCTGGCCGGCGTGCCGATGGCCGTGACCTATCGCG
TCAATCCGCTGACGGCGGCGATGGCGCGGCGGCTGATCCGCGTGCCTTATGTCGCCATGGTTAACCTGCTGGCCGGGCAC
CGGCTGGTGCCGGAACTGCTGCAGGATCGCTGCCGCCCCGACCTGCTGGCCGCCACCGTGCTGCGCCTGCTGACCGACGA
ACGCAGCGCCGCCCTGCAACGGGCCGGCTTCCGCGCCGTGGCGGCCGCCCTGGCCGCCCCGCAGGGCGACCCGGACGACG
CGGCGGCGGCCGAACTGATGGCGGTGCTGGACGGCGGGAAACGTTAA

Upstream 100 bases:

>100_bases
TGCAACCCGTCGCGCGCAGCCTGACCGATGCCGAGATCGATGCGGTGTCGGACAAGGTCGTGGCCGCCGTGACGCGGGCC
TGCGGCGCCACGCTGCGGGG

Downstream 100 bases:

>100_bases
AGAATGCCGCCTGCGATCGGCAGGTTCACGCCCGTCATGTAGCTGGAATCATCGCCCAGCAGGAATTCCACGACCCCGGG
AATTTCCGTGATGTCGCCGT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNAAAGRTVWLLAGEASGDVLGARLMAALRRRDPTLRFAGVGGARMEEAGLRSLFPLRDLAVMGLVEVLPRIRHLSRRLD
QAVEHIRQTRPDLVVTIDSPGFTLRLLRRIEGEGIPRVHYVAPQVWAWREHRVREFPGLWDRLLCLLPFEPAFFGRHGLE
ARFVGHPVLQSGAGRGDGAAFRARHGIAPGTPILILMPGSRRSEAPRLLPVLGRTLRILAATCPGIVPVVPVSAVVAETV
RRGVADWPMKPIIVTDLDEKHDAFAAAGAALTKSGTSTLELALAGVPMAVTYRVNPLTAAMARRLIRVPYVAMVNLLAGH
RLVPELLQDRCRPDLLAATVLRLLTDERSAALQRAGFRAVAAALAAPQGDPDDAAAAELMAVLDGGKR

Sequences:

>Translated_388_residues
MNAAAGRTVWLLAGEASGDVLGARLMAALRRRDPTLRFAGVGGARMEEAGLRSLFPLRDLAVMGLVEVLPRIRHLSRRLD
QAVEHIRQTRPDLVVTIDSPGFTLRLLRRIEGEGIPRVHYVAPQVWAWREHRVREFPGLWDRLLCLLPFEPAFFGRHGLE
ARFVGHPVLQSGAGRGDGAAFRARHGIAPGTPILILMPGSRRSEAPRLLPVLGRTLRILAATCPGIVPVVPVSAVVAETV
RRGVADWPMKPIIVTDLDEKHDAFAAAGAALTKSGTSTLELALAGVPMAVTYRVNPLTAAMARRLIRVPYVAMVNLLAGH
RLVPELLQDRCRPDLLAATVLRLLTDERSAALQRAGFRAVAAALAAPQGDPDDAAAAELMAVLDGGKR
>Mature_388_residues
MNAAAGRTVWLLAGEASGDVLGARLMAALRRRDPTLRFAGVGGARMEEAGLRSLFPLRDLAVMGLVEVLPRIRHLSRRLD
QAVEHIRQTRPDLVVTIDSPGFTLRLLRRIEGEGIPRVHYVAPQVWAWREHRVREFPGLWDRLLCLLPFEPAFFGRHGLE
ARFVGHPVLQSGAGRGDGAAFRARHGIAPGTPILILMPGSRRSEAPRLLPVLGRTLRILAATCPGIVPVVPVSAVVAETV
RRGVADWPMKPIIVTDLDEKHDAFAAAGAALTKSGTSTLELALAGVPMAVTYRVNPLTAAMARRLIRVPYVAMVNLLAGH
RLVPELLQDRCRPDLLAATVLRLLTDERSAALQRAGFRAVAAALAAPQGDPDDAAAAELMAVLDGGKR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=329, Percent_Identity=40.1215805471125, Blast_Score=222, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41914; Mature: 41914

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAAGRTVWLLAGEASGDVLGARLMAALRRRDPTLRFAGVGGARMEEAGLRSLFPLRDL
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHHH
AVMGLVEVLPRIRHLSRRLDQAVEHIRQTRPDLVVTIDSPGFTLRLLRRIEGEGIPRVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEE
VAPQVWAWREHRVREFPGLWDRLLCLLPFEPAFFGRHGLEARFVGHPVLQSGAGRGDGAA
ECCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHCCCCCCEEECCCHHHHCCCCCCCCCH
FRARHGIAPGTPILILMPGSRRSEAPRLLPVLGRTLRILAATCPGIVPVVPVSAVVAETV
HHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RRGVADWPMKPIIVTDLDEKHDAFAAAGAALTKSGTSTLELALAGVPMAVTYRVNPLTAA
HCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEHEECCCCEEEEEECCHHHHH
MARRLIRVPYVAMVNLLAGHRLVPELLQDRCRPDLLAATVLRLLTDERSAALQRAGFRAV
HHHHHHHCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALAAPQGDPDDAAAAELMAVLDGGKR
HHHHHCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNAAAGRTVWLLAGEASGDVLGARLMAALRRRDPTLRFAGVGGARMEEAGLRSLFPLRDL
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHHH
AVMGLVEVLPRIRHLSRRLDQAVEHIRQTRPDLVVTIDSPGFTLRLLRRIEGEGIPRVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEE
VAPQVWAWREHRVREFPGLWDRLLCLLPFEPAFFGRHGLEARFVGHPVLQSGAGRGDGAA
ECCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHCCCCCCEEECCCHHHHCCCCCCCCCH
FRARHGIAPGTPILILMPGSRRSEAPRLLPVLGRTLRILAATCPGIVPVVPVSAVVAETV
HHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RRGVADWPMKPIIVTDLDEKHDAFAAAGAALTKSGTSTLELALAGVPMAVTYRVNPLTAA
HCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEHEECCCCEEEEEECCHHHHH
MARRLIRVPYVAMVNLLAGHRLVPELLQDRCRPDLLAATVLRLLTDERSAALQRAGFRAV
HHHHHHHCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALAAPQGDPDDAAAAELMAVLDGGKR
HHHHHCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA