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The map label for this gene is hisI [H]

Identifier: 162149037

GI number: 162149037

Start: 3358328

End: 3358783

Strand: Direct

Name: hisI [H]

Synonym: GDI_3267

Alternate gene names: 162149037

Gene position: 3358328-3358783 (Clockwise)

Preceding gene: 162149036

Following gene: 162149038

Centisome position: 85.15

GC content: 69.96

Gene sequence:

>456_bases
GTGGCCGGCGACACGCCGAACGACCGCCCAAGGATGACCATGACCTACCTTCCCCCCGACGACGCCACACGGGCCCGCCT
GCTCGACCAGGTCCATTTCGACGATGCCGGGCTGATCGCCGCCGTGGCGCAGCAGCACGACACGGGCGAGGTGCTGATGC
TGGCCTGGATGAACCGCGCGGCGCTGGACGAGACGCTGCGCACCGGCCGGGTCTGCTATTATTCGCGCAGCCGCGGCGCG
CTGTGGCGCAAGGGCGAGACCTCGGGCCAGGTGCAGACCCTGGTCGATGCCCGCCTGGATTGCGACCGCGATGCCGTCCT
GCTGCTGGTCGAACAGAGCGGGGTGGCCTGTCACACCGGGCGGCGGAGCTGCTTCTACAACGCCATGCGCCCCCTGGGCC
TGATCGAGATCAGCGCGCCCCTGGTGTCGGCCGACGCCCTCTACGGCAAGAACTAG

Upstream 100 bases:

>100_bases
GGACCATCGCAGCGCCGAGCTGACGGCCGAGGGCCATTCGGTCCAGGTCCACATTCCTTCCTGGCTGACGCTCAAGACCG
AAGCCGAAGGCTGACCCGGC

Downstream 100 bases:

>100_bases
GACCAACACCCGTCATGCCTGCTTCCGAAAAGCCGCCCGTCGGCAAACTGGTCTTCCTCACCCTGCTTATCCTGATGACG
ATCGGGATGGGCATCTCCCT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MAGDTPNDRPRMTMTYLPPDDATRARLLDQVHFDDAGLIAAVAQQHDTGEVLMLAWMNRAALDETLRTGRVCYYSRSRGA
LWRKGETSGQVQTLVDARLDCDRDAVLLLVEQSGVACHTGRRSCFYNAMRPLGLIEISAPLVSADALYGKN

Sequences:

>Translated_151_residues
MAGDTPNDRPRMTMTYLPPDDATRARLLDQVHFDDAGLIAAVAQQHDTGEVLMLAWMNRAALDETLRTGRVCYYSRSRGA
LWRKGETSGQVQTLVDARLDCDRDAVLLLVEQSGVACHTGRRSCFYNAMRPLGLIEISAPLVSADALYGKN
>Mature_150_residues
AGDTPNDRPRMTMTYLPPDDATRARLLDQVHFDDAGLIAAVAQQHDTGEVLMLAWMNRAALDETLRTGRVCYYSRSRGAL
WRKGETSGQVQTLVDARLDCDRDAVLLLVEQSGVACHTGRRSCFYNAMRPLGLIEISAPLVSADALYGKN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=47.1910112359551, Blast_Score=93, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319819, Length=108, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 16671; Mature: 16540

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGDTPNDRPRMTMTYLPPDDATRARLLDQVHFDDAGLIAAVAQQHDTGEVLMLAWMNRA
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEHHCHH
ALDETLRTGRVCYYSRSRGALWRKGETSGQVQTLVDARLDCDRDAVLLLVEQSGVACHTG
HHHHHHHCCEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEECC
RRSCFYNAMRPLGLIEISAPLVSADALYGKN
CHHHHHHHCCCCCEEEECCCEEECCCCCCCC
>Mature Secondary Structure 
AGDTPNDRPRMTMTYLPPDDATRARLLDQVHFDDAGLIAAVAQQHDTGEVLMLAWMNRA
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEHHCHH
ALDETLRTGRVCYYSRSRGALWRKGETSGQVQTLVDARLDCDRDAVLLLVEQSGVACHTG
HHHHHHHCCEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEECC
RRSCFYNAMRPLGLIEISAPLVSADALYGKN
CHHHHHHHCCCCCEEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA