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The map label for this gene is envZ [H]

Identifier: 162148850

GI number: 162148850

Start: 3176467

End: 3177870

Strand: Reverse

Name: envZ [H]

Synonym: GDI_3079

Alternate gene names: 162148850

Gene position: 3177870-3176467 (Counterclockwise)

Preceding gene: 162148851

Following gene: 162148848

Centisome position: 80.57

GC content: 69.37

Gene sequence:

>1404_bases
GTGACGGCCGGCGGCGCCAACGGCGGCGTGGGGAGGGACAAGCCATCCTCGCCCATGGCGTGGCTGCGCCGCCGGATGGA
CCGGCCGGTGCGCCGGGTCCTGCCGCGTTCCCTGCTGGGGCGGACCCTGCTGATCGTGTTGATCCCGCTGGTCGTGACGC
AGGGGATCTCGCTGGAACTGTTTTACGGCAATTACCTGCAGGTCGTCTCGCGCCGCATGTCGGGCAGCGTCGCGGCGGAC
ATCGTCCTGACGCTGGACCTGATGGGGCGGTATCACGCGGCCGGCGACCGGGCCTGGATCATGCGGCGGGTGCGTGAGCG
CACGCAGCTGGACATGATCTGGAATCCGGGTCAGCGCCTGGACCGGACGGGATCGACCCACGTGCTGGGACCGATGGACG
AGGATCTGGCCCAGGCGCTGGAGACGTCGATCGGCCGGCCCGCCTTCATCGACTGGATCGACGACCCGCACACCGTTGGT
ATCCGCATCCAGATGCCCGACGGGGTGCTGGATGTCGGCGCCCCGCGCAAGCGGCTGGATGTCGCGCCGATCTGGCTGTT
CGTCGTCTGGACGGTGGGCAGCACGCTGCTGCTGTTCCTGGTTGCCAGCGTGTTCATGCGCAACCAGGTCCGTGCCATTC
GTCGTCTGGCCCGCGCGGCGGAATTGTTCGGGCTGGGCCGCGACACCGGGCCCATCCGTCCCGAAGGCGCGCAGGAGGTA
CGCAAGGCGGCCGTCGCCTTCAACCGCATGCAGGACCGCATCTTCCGCTTCGTGGCGCAGCGCACCGCCGTCCTGGCGGG
CGTGTCGCACGACCTGCGCACGCCGCTGACCCGGCTGCGGCTTTCGCTGGCCATGATCCCGCACCAGGGCGCGATCGATG
CCGAAATGCTCCGCGCCGACGTGGCGGACATGATCGGCGACATCGCGGAAATGGAGCGCATGATCGAAAGCTACCTGTCC
TTCGCGCGGGGCGAGGGGGCCGAGACACCGGTCGCGGTCGATGTCGGCGCATTGCTGGACGAGACCGCCGCCGCCTTCCG
CAGGGCGGGCGGCACCGTCCTGTCGATCTCGCTGCCTGCGCCGGTCGAGGCCACGCTGCGGCCCGATGCCTTCCGCCGGG
TGCTGGACAACGTCATGCAGAACGCGCGCCGCCATGGCGGCCGCGTCGCCCTCAGTGCCAGCCGCGATGGACGCGGCATC
GTCGTCTGCATCGATGATGACGGACCGGGAATCCAGACGGACCGGCTGGAGACGGTCTTTCGCCCATTCGAAAGCGGACA
GAACGGGGGAACCGGCCTGGGGCTGACGATCTCACGCGATATCGTGCGCGCCCATGGCGGGGACATCACCCTGCAGCCCA
GCCGCCTGGGCGGCCTTCAGGTCAGGATCATACTGCCCGTATAG

Upstream 100 bases:

>100_bases
TGCAGGTGACGCGCCTGCGCCGCCGGATCGAGCCCGACCCGCGTGAACCCCGATTCCTCCAGACCGTGCGCGGCAAGGGC
TATGTGCTGAAGCCCGGGCT

Downstream 100 bases:

>100_bases
GGCCGCCGTCAGGGGAGGGAGTTGCCCGTGCCCCCGTGGCCCGGTCCGCTGTTGAAGCCCATCGGGCCGGTGCTGCCGCC
GAAGGTGCTGTTCAGGTTGC

Product: sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTAGGANGGVGRDKPSSPMAWLRRRMDRPVRRVLPRSLLGRTLLIVLIPLVVTQGISLELFYGNYLQVVSRRMSGSVAAD
IVLTLDLMGRYHAAGDRAWIMRRVRERTQLDMIWNPGQRLDRTGSTHVLGPMDEDLAQALETSIGRPAFIDWIDDPHTVG
IRIQMPDGVLDVGAPRKRLDVAPIWLFVVWTVGSTLLLFLVASVFMRNQVRAIRRLARAAELFGLGRDTGPIRPEGAQEV
RKAAVAFNRMQDRIFRFVAQRTAVLAGVSHDLRTPLTRLRLSLAMIPHQGAIDAEMLRADVADMIGDIAEMERMIESYLS
FARGEGAETPVAVDVGALLDETAAAFRRAGGTVLSISLPAPVEATLRPDAFRRVLDNVMQNARRHGGRVALSASRDGRGI
VVCIDDDGPGIQTDRLETVFRPFESGQNGGTGLGLTISRDIVRAHGGDITLQPSRLGGLQVRIILPV

Sequences:

>Translated_467_residues
MTAGGANGGVGRDKPSSPMAWLRRRMDRPVRRVLPRSLLGRTLLIVLIPLVVTQGISLELFYGNYLQVVSRRMSGSVAAD
IVLTLDLMGRYHAAGDRAWIMRRVRERTQLDMIWNPGQRLDRTGSTHVLGPMDEDLAQALETSIGRPAFIDWIDDPHTVG
IRIQMPDGVLDVGAPRKRLDVAPIWLFVVWTVGSTLLLFLVASVFMRNQVRAIRRLARAAELFGLGRDTGPIRPEGAQEV
RKAAVAFNRMQDRIFRFVAQRTAVLAGVSHDLRTPLTRLRLSLAMIPHQGAIDAEMLRADVADMIGDIAEMERMIESYLS
FARGEGAETPVAVDVGALLDETAAAFRRAGGTVLSISLPAPVEATLRPDAFRRVLDNVMQNARRHGGRVALSASRDGRGI
VVCIDDDGPGIQTDRLETVFRPFESGQNGGTGLGLTISRDIVRAHGGDITLQPSRLGGLQVRIILPV
>Mature_466_residues
TAGGANGGVGRDKPSSPMAWLRRRMDRPVRRVLPRSLLGRTLLIVLIPLVVTQGISLELFYGNYLQVVSRRMSGSVAADI
VLTLDLMGRYHAAGDRAWIMRRVRERTQLDMIWNPGQRLDRTGSTHVLGPMDEDLAQALETSIGRPAFIDWIDDPHTVGI
RIQMPDGVLDVGAPRKRLDVAPIWLFVVWTVGSTLLLFLVASVFMRNQVRAIRRLARAAELFGLGRDTGPIRPEGAQEVR
KAAVAFNRMQDRIFRFVAQRTAVLAGVSHDLRTPLTRLRLSLAMIPHQGAIDAEMLRADVADMIGDIAEMERMIESYLSF
ARGEGAETPVAVDVGALLDETAAAFRRAGGTVLSISLPAPVEATLRPDAFRRVLDNVMQNARRHGGRVALSASRDGRGIV
VCIDDDGPGIQTDRLETVFRPFESGQNGGTGLGLTISRDIVRAHGGDITLQPSRLGGLQVRIILPV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=294, Percent_Identity=35.0340136054422, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=29.520295202952, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787894, Length=333, Percent_Identity=29.7297297297297, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788393, Length=270, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=28.8990825688073, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=272, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=213, Percent_Identity=25.8215962441315, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=26.457399103139, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=24.3333333333333, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=23.2283464566929, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=311, Percent_Identity=27.6527331189711, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=206, Percent_Identity=28.6407766990291, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51169; Mature: 51038

Theoretical pI: Translated: 11.13; Mature: 11.13

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGGANGGVGRDKPSSPMAWLRRRMDRPVRRVLPRSLLGRTLLIVLIPLVVTQGISLEL
CCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FYGNYLQVVSRRMSGSVAADIVLTLDLMGRYHAAGDRAWIMRRVRERTQLDMIWNPGQRL
EECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCHHH
DRTGSTHVLGPMDEDLAQALETSIGRPAFIDWIDDPHTVGIRIQMPDGVLDVGAPRKRLD
CCCCCCEECCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCEECCCCHHHCC
VAPIWLFVVWTVGSTLLLFLVASVFMRNQVRAIRRLARAAELFGLGRDTGPIRPEGAQEV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RKAAVAFNRMQDRIFRFVAQRTAVLAGVSHDLRTPLTRLRLSLAMIPHQGAIDAEMLRAD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VADMIGDIAEMERMIESYLSFARGEGAETPVAVDVGALLDETAAAFRRAGGTVLSISLPA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEECCC
PVEATLRPDAFRRVLDNVMQNARRHGGRVALSASRDGRGIVVCIDDDGPGIQTDRLETVF
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHH
RPFESGQNGGTGLGLTISRDIVRAHGGDITLQPSRLGGLQVRIILPV
HHHHCCCCCCCEEEEEEEHHHHHHCCCCEEECCCCCCCEEEEEEECC
>Mature Secondary Structure 
TAGGANGGVGRDKPSSPMAWLRRRMDRPVRRVLPRSLLGRTLLIVLIPLVVTQGISLEL
CCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FYGNYLQVVSRRMSGSVAADIVLTLDLMGRYHAAGDRAWIMRRVRERTQLDMIWNPGQRL
EECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCHHH
DRTGSTHVLGPMDEDLAQALETSIGRPAFIDWIDDPHTVGIRIQMPDGVLDVGAPRKRLD
CCCCCCEECCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCEECCCCHHHCC
VAPIWLFVVWTVGSTLLLFLVASVFMRNQVRAIRRLARAAELFGLGRDTGPIRPEGAQEV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RKAAVAFNRMQDRIFRFVAQRTAVLAGVSHDLRTPLTRLRLSLAMIPHQGAIDAEMLRAD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VADMIGDIAEMERMIESYLSFARGEGAETPVAVDVGALLDETAAAFRRAGGTVLSISLPA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEECCC
PVEATLRPDAFRRVLDNVMQNARRHGGRVALSASRDGRGIVVCIDDDGPGIQTDRLETVF
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHH
RPFESGQNGGTGLGLTISRDIVRAHGGDITLQPSRLGGLQVRIILPV
HHHHCCCCCCCEEEEEEEHHHHHHCCCCEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]