Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 162148813

GI number: 162148813

Start: 3132629

End: 3135142

Strand: Reverse

Name: lon [H]

Synonym: GDI_3042

Alternate gene names: 162148813

Gene position: 3135142-3132629 (Counterclockwise)

Preceding gene: 162148814

Following gene: 162148812

Centisome position: 79.49

GC content: 65.08

Gene sequence:

>2514_bases
ATGCCCGATTCCAATCGGTCCGATTCCAAACGGCTAAACCGCGACCAGTCCGTTGCGGCCGAGGCGGAAACCTCCGTCCA
CGCGCCCGAAACCACCGATGACGCGCAGGCGGTGTCCGACTCCGACCCCGGGATGATGGCGGTGCTGCCGTTGCGCGACA
TCGTCGTGTTCCCGCACATGATCGTTCCGCTGTTCGTCGGCCGCGAGAAATCGGTTCGCGCCCTGGAGGCCGTGACCAAG
CATGACAAGCAGATCCTGCTGGTCGCGCAGAAGAACGCGTCGCAGGACGATCCGGCGGCCGACGACATCTATCGCTACGG
CACGGTCTCGACGATCCTGCAACTGCTGAAGCTGCCTGACGGCACGGTCAAGGTGCTGGTCGAGGGCAGCCGCCGCGCCC
ACATCACCGCGCTGCACGACATCGACGGCCATTTCGAGGCCGAGATCGCACCCGTGGCCGAGGACCCGGCCAGCGGCAGC
GAAGGCGAGGCGCTGGGCCGCACGGTCGTGTCGCAGTTCGAGCAATATATCAAGCTGAACAAGAAGATCGCGCCCGAGGT
CCTGGTGTCGCTGAACCAGATCGAGGATCTGTCGAAGCTCGCGGATACGATCGCCAGCCACCTGAACCTGAAGATCGCCG
AGAAGCAGGAAATCCTGGAGATCCCGGGCGTCAACGCCCGGCTGGAACGCGTCTTCGCGCATATGGAAGCCGAAATCGGC
GTCCTGCAGGTGGAAAAGCGAATCCGCAACCGCGTCAAGCGGCAGATGGAGAAGACGCAGCGCGAGTACTACCTGAACGA
GCAGCTCAAGGCGATCCAGAAGGAACTGGGCGAGGGCGAGGAAGGCAAGGACGAGACCGCCGAGCTGGAAGAGCGCATCG
CCAAGACCCGCCTGCCGAAGGAAGCGCGCGACAAGGCGCTGGCCGAGCTGAAGAAGCTGCGGACCATGAGCCCGATGTCG
GCCGAATCGACGGTGGTGCGCAACTATCTCGACTGGATCCTCAGCATCCCCTGGAAGAAGCCGTCCAAGGTCCGTCGTGA
CCTGGACGGTGCCGAGAAGGTGCTGGATACCGACCATTACGGGCTGGAGAAGGTCAAGGAGCGGATTCTGGAATATCTGG
CGGTCCAGAGCCGTGCCAAGAAGATCAAGGGACCGATTCTCTGCCTGGTCGGGCCGCCGGGCGTGGGCAAGACCTCGCTG
GCGCGGTCGATCGCCAAGGCGACGGGGCGGCATTACGTGCGCATGTCGCTGGGCGGCGTGCGGGACGAGGCCGAGATCCG
GGGGCATCGCCGGACCTATATCGGTTCGATGCCCGGCAAGATCATCCAGGGGATGAAGAAGGCCAAGTCGTCCAATCCGC
TCTTCCTGCTGGATGAAATCGACAAGCTGGGCGCCGACTGGCGCGGCGATCCGTCCTCGGCGCTGCTCGAGGTCCTGGAC
CCCGAACAGAATTCCACCTTCGCCGACCATTACCTGGAGGTCGATTACGACCTGTCCGACGTCATGTTCGTGACCACGGC
CAACAGCCTGAACATGCCCCAGCCGCTGCTGGACCGCATGGAGGTCATCCGCCTGTCCGGCTACACCGAGGACGAGAAGG
TCGAAATCGCGAAGCGGCACCTGCTGAACAAGCAGGGCGAGGCCCACAGCCTGCGTGCCGACGAATGGTCGGTCAGCGAC
GACGCCCTGCGCGAACTGGTGCGCAGCTACACGCGTGAGGCCGGGGTCCGCAACCTGGAACGCGAAATCGCGACCCTGGC
CCGCAAGGCGGTGCGCGAGATCGTGACGGGCAAGGCCAAGAAGGTCTCCATCACGCGCAAGAACCTGGAAAAATACGCGG
GCGTGAAGCGGTTCCGCTATGGCGAGACCGAGGCCGAGGACATGGTCGGCGTCGTGACCGGCCTGGCCTGGACCGAGGTC
GGGGGCGAGATCCTGACCATCGAGAGCGTGATGGTGCCGGGCAAGGGCGCGGTCAAGCAGACGGGCAAGCTCGGTGACGT
GATGCAGGAAAGCGTGGCGGCGGCCCTGTCCTATGTCCGCAGCCGCGCGGTGACGTTCGGCATCAAGCCGACCCTGTTCG
AAAAGCGCGACCTGCATGTCCACGTGCCCGAAGGGGCGACTCCCAAGGACGGTCCGTCGGCGGGCATCGCCATGGCGACG
TCGCTGGTCAGCGTGCTGACCGGTATTCCGGTGCGGCGTGACGTGGCGATGACGGGTGAAATCACCCTGCGTGGCCGGGT
GCTGGCCATCGGCGGGCTGAAGGAAAAGCTGCTGGCCGCCCATCGGGCCGGCATCAAGACGGTCTTCATCCCCAAGGACA
ACGAGAAGGACCTGGTCGACATTCCCGACACGGTGAAGAAGGGCCTGCGGATTCTGCCGGTCGCCCATGTCGACGACGTG
ATCGGCCAGGCCCTGGTGACGCGCCCCGAACCCATCGAGTGGAGCGAAGCGCCCGAGCCCGTCGCCGCTTCGGCCCCCGC
CGCGGGAATAGCTGCCTCGTCCCTGCCGCATTGA

Upstream 100 bases:

>100_bases
TGACGACATATCTCTCAGGTGATCGCGTCAGCGACACGCCGGGTGGTGCAGGCCGCGTCTGGATGCCCGCCCGGGATCGT
CCTTCAGGAGGTCACACGAT

Downstream 100 bases:

>100_bases
ATGTGTCAAAAACGCACCAGCCCTCCGATTTGGCCGGGTTTTCCGCCGGACCGGGCGGGCTGGTCGGTTGACGCCGCGAA
AAACGGCTGCATAGTGCGGC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 837; Mature: 836

Protein sequence:

>837_residues
MPDSNRSDSKRLNRDQSVAAEAETSVHAPETTDDAQAVSDSDPGMMAVLPLRDIVVFPHMIVPLFVGREKSVRALEAVTK
HDKQILLVAQKNASQDDPAADDIYRYGTVSTILQLLKLPDGTVKVLVEGSRRAHITALHDIDGHFEAEIAPVAEDPASGS
EGEALGRTVVSQFEQYIKLNKKIAPEVLVSLNQIEDLSKLADTIASHLNLKIAEKQEILEIPGVNARLERVFAHMEAEIG
VLQVEKRIRNRVKRQMEKTQREYYLNEQLKAIQKELGEGEEGKDETAELEERIAKTRLPKEARDKALAELKKLRTMSPMS
AESTVVRNYLDWILSIPWKKPSKVRRDLDGAEKVLDTDHYGLEKVKERILEYLAVQSRAKKIKGPILCLVGPPGVGKTSL
ARSIAKATGRHYVRMSLGGVRDEAEIRGHRRTYIGSMPGKIIQGMKKAKSSNPLFLLDEIDKLGADWRGDPSSALLEVLD
PEQNSTFADHYLEVDYDLSDVMFVTTANSLNMPQPLLDRMEVIRLSGYTEDEKVEIAKRHLLNKQGEAHSLRADEWSVSD
DALRELVRSYTREAGVRNLEREIATLARKAVREIVTGKAKKVSITRKNLEKYAGVKRFRYGETEAEDMVGVVTGLAWTEV
GGEILTIESVMVPGKGAVKQTGKLGDVMQESVAAALSYVRSRAVTFGIKPTLFEKRDLHVHVPEGATPKDGPSAGIAMAT
SLVSVLTGIPVRRDVAMTGEITLRGRVLAIGGLKEKLLAAHRAGIKTVFIPKDNEKDLVDIPDTVKKGLRILPVAHVDDV
IGQALVTRPEPIEWSEAPEPVAASAPAAGIAASSLPH

Sequences:

>Translated_837_residues
MPDSNRSDSKRLNRDQSVAAEAETSVHAPETTDDAQAVSDSDPGMMAVLPLRDIVVFPHMIVPLFVGREKSVRALEAVTK
HDKQILLVAQKNASQDDPAADDIYRYGTVSTILQLLKLPDGTVKVLVEGSRRAHITALHDIDGHFEAEIAPVAEDPASGS
EGEALGRTVVSQFEQYIKLNKKIAPEVLVSLNQIEDLSKLADTIASHLNLKIAEKQEILEIPGVNARLERVFAHMEAEIG
VLQVEKRIRNRVKRQMEKTQREYYLNEQLKAIQKELGEGEEGKDETAELEERIAKTRLPKEARDKALAELKKLRTMSPMS
AESTVVRNYLDWILSIPWKKPSKVRRDLDGAEKVLDTDHYGLEKVKERILEYLAVQSRAKKIKGPILCLVGPPGVGKTSL
ARSIAKATGRHYVRMSLGGVRDEAEIRGHRRTYIGSMPGKIIQGMKKAKSSNPLFLLDEIDKLGADWRGDPSSALLEVLD
PEQNSTFADHYLEVDYDLSDVMFVTTANSLNMPQPLLDRMEVIRLSGYTEDEKVEIAKRHLLNKQGEAHSLRADEWSVSD
DALRELVRSYTREAGVRNLEREIATLARKAVREIVTGKAKKVSITRKNLEKYAGVKRFRYGETEAEDMVGVVTGLAWTEV
GGEILTIESVMVPGKGAVKQTGKLGDVMQESVAAALSYVRSRAVTFGIKPTLFEKRDLHVHVPEGATPKDGPSAGIAMAT
SLVSVLTGIPVRRDVAMTGEITLRGRVLAIGGLKEKLLAAHRAGIKTVFIPKDNEKDLVDIPDTVKKGLRILPVAHVDDV
IGQALVTRPEPIEWSEAPEPVAASAPAAGIAASSLPH
>Mature_836_residues
PDSNRSDSKRLNRDQSVAAEAETSVHAPETTDDAQAVSDSDPGMMAVLPLRDIVVFPHMIVPLFVGREKSVRALEAVTKH
DKQILLVAQKNASQDDPAADDIYRYGTVSTILQLLKLPDGTVKVLVEGSRRAHITALHDIDGHFEAEIAPVAEDPASGSE
GEALGRTVVSQFEQYIKLNKKIAPEVLVSLNQIEDLSKLADTIASHLNLKIAEKQEILEIPGVNARLERVFAHMEAEIGV
LQVEKRIRNRVKRQMEKTQREYYLNEQLKAIQKELGEGEEGKDETAELEERIAKTRLPKEARDKALAELKKLRTMSPMSA
ESTVVRNYLDWILSIPWKKPSKVRRDLDGAEKVLDTDHYGLEKVKERILEYLAVQSRAKKIKGPILCLVGPPGVGKTSLA
RSIAKATGRHYVRMSLGGVRDEAEIRGHRRTYIGSMPGKIIQGMKKAKSSNPLFLLDEIDKLGADWRGDPSSALLEVLDP
EQNSTFADHYLEVDYDLSDVMFVTTANSLNMPQPLLDRMEVIRLSGYTEDEKVEIAKRHLLNKQGEAHSLRADEWSVSDD
ALRELVRSYTREAGVRNLEREIATLARKAVREIVTGKAKKVSITRKNLEKYAGVKRFRYGETEAEDMVGVVTGLAWTEVG
GEILTIESVMVPGKGAVKQTGKLGDVMQESVAAALSYVRSRAVTFGIKPTLFEKRDLHVHVPEGATPKDGPSAGIAMATS
LVSVLTGIPVRRDVAMTGEITLRGRVLAIGGLKEKLLAAHRAGIKTVFIPKDNEKDLVDIPDTVKKGLRILPVAHVDDVI
GQALVTRPEPIEWSEAPEPVAASAPAAGIAASSLPH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=831, Percent_Identity=38.2671480144404, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=44.0497335701599, Blast_Score=499, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=763, Percent_Identity=66.8414154652687, Blast_Score=1025, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=699, Percent_Identity=40.9155937052933, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17556486, Length=649, Percent_Identity=37.442218798151, Blast_Score=440, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=708, Percent_Identity=40.6779661016949, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221513036, Length=695, Percent_Identity=41.294964028777, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=695, Percent_Identity=41.294964028777, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 92178; Mature: 92047

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSNRSDSKRLNRDQSVAAEAETSVHAPETTDDAQAVSDSDPGMMAVLPLRDIVVFPHM
CCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEECHHHHHHHHHH
IVPLFVGREKSVRALEAVTKHDKQILLVAQKNASQDDPAADDIYRYGTVSTILQLLKLPD
HHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHCCC
GTVKVLVEGSRRAHITALHDIDGHFEAEIAPVAEDPASGSEGEALGRTVVSQFEQYIKLN
CCEEEEEECCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KKIAPEVLVSLNQIEDLSKLADTIASHLNLKIAEKQEILEIPGVNARLERVFAHMEAEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHHH
VLQVEKRIRNRVKRQMEKTQREYYLNEQLKAIQKELGEGEEGKDETAELEERIAKTRLPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCH
EARDKALAELKKLRTMSPMSAESTVVRNYLDWILSIPWKKPSKVRRDLDGAEKVLDTDHY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCC
GLEKVKERILEYLAVQSRAKKIKGPILCLVGPPGVGKTSLARSIAKATGRHYVRMSLGGV
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCC
RDEAEIRGHRRTYIGSMPGKIIQGMKKAKSSNPLFLLDEIDKLGADWRGDPSSALLEVLD
CCHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHC
PEQNSTFADHYLEVDYDLSDVMFVTTANSLNMPQPLLDRMEVIRLSGYTEDEKVEIAKRH
CCCCCCHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
LLNKQGEAHSLRADEWSVSDDALRELVRSYTREAGVRNLEREIATLARKAVREIVTGKAK
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KVSITRKNLEKYAGVKRFRYGETEAEDMVGVVTGLAWTEVGGEILTIESVMVPGKGAVKQ
EEEHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHH
TGKLGDVMQESVAAALSYVRSRAVTFGIKPTLFEKRDLHVHVPEGATPKDGPSAGIAMAT
CCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHH
SLVSVLTGIPVRRDVAMTGEITLRGRVLAIGGLKEKLLAAHRAGIKTVFIPKDNEKDLVD
HHHHHHHCCCCCCCEEEECEEEEEEEEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCCC
IPDTVKKGLRILPVAHVDDVIGQALVTRPEPIEWSEAPEPVAASAPAAGIAASSLPH
CCHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDSNRSDSKRLNRDQSVAAEAETSVHAPETTDDAQAVSDSDPGMMAVLPLRDIVVFPHM
CCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEECHHHHHHHHHH
IVPLFVGREKSVRALEAVTKHDKQILLVAQKNASQDDPAADDIYRYGTVSTILQLLKLPD
HHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHCCC
GTVKVLVEGSRRAHITALHDIDGHFEAEIAPVAEDPASGSEGEALGRTVVSQFEQYIKLN
CCEEEEEECCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KKIAPEVLVSLNQIEDLSKLADTIASHLNLKIAEKQEILEIPGVNARLERVFAHMEAEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHHH
VLQVEKRIRNRVKRQMEKTQREYYLNEQLKAIQKELGEGEEGKDETAELEERIAKTRLPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCH
EARDKALAELKKLRTMSPMSAESTVVRNYLDWILSIPWKKPSKVRRDLDGAEKVLDTDHY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCC
GLEKVKERILEYLAVQSRAKKIKGPILCLVGPPGVGKTSLARSIAKATGRHYVRMSLGGV
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCC
RDEAEIRGHRRTYIGSMPGKIIQGMKKAKSSNPLFLLDEIDKLGADWRGDPSSALLEVLD
CCHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHC
PEQNSTFADHYLEVDYDLSDVMFVTTANSLNMPQPLLDRMEVIRLSGYTEDEKVEIAKRH
CCCCCCHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
LLNKQGEAHSLRADEWSVSDDALRELVRSYTREAGVRNLEREIATLARKAVREIVTGKAK
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KVSITRKNLEKYAGVKRFRYGETEAEDMVGVVTGLAWTEVGGEILTIESVMVPGKGAVKQ
EEEHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHH
TGKLGDVMQESVAAALSYVRSRAVTFGIKPTLFEKRDLHVHVPEGATPKDGPSAGIAMAT
CCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHH
SLVSVLTGIPVRRDVAMTGEITLRGRVLAIGGLKEKLLAAHRAGIKTVFIPKDNEKDLVD
HHHHHHHCCCCCCCEEEECEEEEEEEEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCCC
IPDTVKKGLRILPVAHVDDVIGQALVTRPEPIEWSEAPEPVAASAPAAGIAASSLPH
CCHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655539 [H]