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The map label for this gene is nouF [H]

Identifier: 162148806

GI number: 162148806

Start: 3126676

End: 3128001

Strand: Reverse

Name: nouF [H]

Synonym: GDI_3035

Alternate gene names: 162148806

Gene position: 3128001-3126676 (Counterclockwise)

Preceding gene: 162148807

Following gene: 162148805

Centisome position: 79.31

GC content: 65.69

Gene sequence:

>1326_bases
ATGCTTCAGGACAAGGACCGGATCTTCACCAACCTGTATGGTCAGCAGGACTGGCGTCTGGCCGGCGCCCGGGCGCGCGG
CGACTGGGACGGCACGGCCGAGATCATCGCCCGCGGGCGCGATGCGATCATCAACGAGATGAAGGCGTCCGGCCTGCGCG
GCCGGGGCGGCGCGGGCTTCCCCACCGGCGTGAAATGGTCGTTCATGCCCAAGAATTCGGACGGCCGTCCTCATTACCTG
GTGATCAACGGCGACGAATCCGAACCCGGCACCTGCAAGGATCGCGAGATCCTGCGCCATGACCCGCACAAGCTGATCGA
GAGCGCGCTGATCGCCTCGTTCGCCATGGGGGCGCATGTCGCCTACATCTACATTCGCGGCGAATTCTTCAACGAAGCCC
GGCATCTGCAGATCGCGATCGACGAGGCCTATGCCGCCGGCCTGATCGGCCAGAACGCCGCCGGCTCGGGCTGGGATTTC
GATTTCTACATTCATCGCGGCGCCGGCGCCTATATCTGCGGCGAGGAAACCGCGCTGCTGGAAAGCCTGGAAGGCAAGAA
GGGCCAGCCCCGGATGAAGCCGCCTTTCCCGGCGGCAATGGGCCTGTATGGCTGCCCGACCACGGTGAACAACGTGGAAA
GCATTGCCGTCGCCGCGACCATCCTGCGGCGCGGGGCTACGTGGTTCTCGTCGCTGGGACGCCCGAACAACGCGGGCACC
AAGCTGATGGCCATATCGGGCCACGTGAACACGCCCTGCGTGTTCGAGGAAGAACTCGGCGTTCCGCTGAAGGACATCAT
CGAAAAGCATGGCGGTGGCGTGCGCGGCGGCTGGGACAACCTGCTGGCGGTGATCCCGGGCGGCTCTTCGGTCCCGCTGC
TGCCGGCCTCGGTCTGCGAGACCGTGCTGATGGATTACGACAGCCTGCGGGCCGAACGGTCGGGCCTGGGCACGGCATGC
ATGATCGTCATGGACAAATCCACCGACGTCATCCGCGCCATCGCCCGCTTCTCGCAATTCTACAAGCATGAAAGCTGCGG
CCAGTGCACGCCCTGCCGCGAAGGCACGGGCTGGATGATGCGGGTCATGCACCGCATGGTCGAAGGCCGGGCCGAAATCG
AGGAAATCGACATGCTCGAACAGGTGACGCGCCAGGTCGAAGGGCACACGATCTGTGCCCTCGGCGATGCGGCGGCATGG
CCGATCCAGGGCCTGATCCGGCATTTCCGCCCGGTGATGGAGGAGCGGATCCGGGCCTACAAGGCCACCCACGGCGGCGG
TCAGATCACGCAGGTGCCCCCGGGTATCCCCGTGGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
CATCGATAGAATGGGTGCCGCCCCCGCGGGGGGGCGCAAGACGCTGACGGACAGTCCGGCGGACAGCCGGTCGGACCAGG
GTTGAGCGGGAGAGACGGCA

Downstream 100 bases:

>100_bases
GGGCGATGGTGAAGGTTACCGTCGACGGGATTCCGGTCGAAGTTCCCGGCGGGTCCAGCGCGTTGCAGGCGTGCGAGGCC
GCGGGCAAGGAAATTCCGCG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 1; NDH-1, chain 1 [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MLQDKDRIFTNLYGQQDWRLAGARARGDWDGTAEIIARGRDAIINEMKASGLRGRGGAGFPTGVKWSFMPKNSDGRPHYL
VINGDESEPGTCKDREILRHDPHKLIESALIASFAMGAHVAYIYIRGEFFNEARHLQIAIDEAYAAGLIGQNAAGSGWDF
DFYIHRGAGAYICGEETALLESLEGKKGQPRMKPPFPAAMGLYGCPTTVNNVESIAVAATILRRGATWFSSLGRPNNAGT
KLMAISGHVNTPCVFEEELGVPLKDIIEKHGGGVRGGWDNLLAVIPGGSSVPLLPASVCETVLMDYDSLRAERSGLGTAC
MIVMDKSTDVIRAIARFSQFYKHESCGQCTPCREGTGWMMRVMHRMVEGRAEIEEIDMLEQVTRQVEGHTICALGDAAAW
PIQGLIRHFRPVMEERIRAYKATHGGGQITQVPPGIPVAAE

Sequences:

>Translated_441_residues
MLQDKDRIFTNLYGQQDWRLAGARARGDWDGTAEIIARGRDAIINEMKASGLRGRGGAGFPTGVKWSFMPKNSDGRPHYL
VINGDESEPGTCKDREILRHDPHKLIESALIASFAMGAHVAYIYIRGEFFNEARHLQIAIDEAYAAGLIGQNAAGSGWDF
DFYIHRGAGAYICGEETALLESLEGKKGQPRMKPPFPAAMGLYGCPTTVNNVESIAVAATILRRGATWFSSLGRPNNAGT
KLMAISGHVNTPCVFEEELGVPLKDIIEKHGGGVRGGWDNLLAVIPGGSSVPLLPASVCETVLMDYDSLRAERSGLGTAC
MIVMDKSTDVIRAIARFSQFYKHESCGQCTPCREGTGWMMRVMHRMVEGRAEIEEIDMLEQVTRQVEGHTICALGDAAAW
PIQGLIRHFRPVMEERIRAYKATHGGGQITQVPPGIPVAAE
>Mature_441_residues
MLQDKDRIFTNLYGQQDWRLAGARARGDWDGTAEIIARGRDAIINEMKASGLRGRGGAGFPTGVKWSFMPKNSDGRPHYL
VINGDESEPGTCKDREILRHDPHKLIESALIASFAMGAHVAYIYIRGEFFNEARHLQIAIDEAYAAGLIGQNAAGSGWDF
DFYIHRGAGAYICGEETALLESLEGKKGQPRMKPPFPAAMGLYGCPTTVNNVESIAVAATILRRGATWFSSLGRPNNAGT
KLMAISGHVNTPCVFEEELGVPLKDIIEKHGGGVRGGWDNLLAVIPGGSSVPLLPASVCETVLMDYDSLRAERSGLGTAC
MIVMDKSTDVIRAIARFSQFYKHESCGQCTPCREGTGWMMRVMHRMVEGRAEIEEIDMLEQVTRQVEGHTICALGDAAAW
PIQGLIRHFRPVMEERIRAYKATHGGGQITQVPPGIPVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=69.6897374701671, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=69.6897374701671, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI1788620, Length=386, Percent_Identity=42.2279792746114, Blast_Score=327, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=434, Percent_Identity=67.0506912442396, Blast_Score=629, Evalue=0.0,
Organism=Drosophila melanogaster, GI19920794, Length=419, Percent_Identity=68.9737470167064, Blast_Score=635, Evalue=0.0,
Organism=Drosophila melanogaster, GI45550452, Length=421, Percent_Identity=65.7957244655582, Blast_Score=604, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24653819, Length=421, Percent_Identity=48.6935866983373, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24653817, Length=421, Percent_Identity=45.6057007125891, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48085; Mature: 48085

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDKDRIFTNLYGQQDWRLAGARARGDWDGTAEIIARGRDAIINEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGVKWSFMPKNSDGRPHYLVINGDESEPGTCKDREILRHDPHKLIESALIASFAMGAHV
CCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCEE
AYIYIRGEFFNEARHLQIAIDEAYAAGLIGQNAAGSGWDFDFYIHRGAGAYICGEETALL
EEEEEEEEHHCCCCEEEEEEEHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRMKPPFPAAMGLYGCPTTVNNVESIAVAATILRRGATWFSSLGRPNNAGT
HHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
KLMAISGHVNTPCVFEEELGVPLKDIIEKHGGGVRGGWDNLLAVIPGGSSVPLLPASVCE
EEEEEECCCCCCEEEHHHCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHH
TVLMDYDSLRAERSGLGTACMIVMDKSTDVIRAIARFSQFYKHESCGQCTPCREGTGWMM
HHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
RVMHRMVEGRAEIEEIDMLEQVTRQVEGHTICALGDAAAWPIQGLIRHFRPVMEERIRAY
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
KATHGGGQITQVPPGIPVAAE
HCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MLQDKDRIFTNLYGQQDWRLAGARARGDWDGTAEIIARGRDAIINEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGVKWSFMPKNSDGRPHYLVINGDESEPGTCKDREILRHDPHKLIESALIASFAMGAHV
CCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCEE
AYIYIRGEFFNEARHLQIAIDEAYAAGLIGQNAAGSGWDFDFYIHRGAGAYICGEETALL
EEEEEEEEHHCCCCEEEEEEEHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRMKPPFPAAMGLYGCPTTVNNVESIAVAATILRRGATWFSSLGRPNNAGT
HHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
KLMAISGHVNTPCVFEEELGVPLKDIIEKHGGGVRGGWDNLLAVIPGGSSVPLLPASVCE
EEEEEECCCCCCEEEHHHCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHH
TVLMDYDSLRAERSGLGTACMIVMDKSTDVIRAIARFSQFYKHESCGQCTPCREGTGWMM
HHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
RVMHRMVEGRAEIEEIDMLEQVTRQVEGHTICALGDAAAWPIQGLIRHFRPVMEERIRAY
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
KATHGGGQITQVPPGIPVAAE
HCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1905152; 1909571; 1605643 [H]