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The map label for this gene is lysA [H]

Identifier: 162148745

GI number: 162148745

Start: 3061290

End: 3062765

Strand: Reverse

Name: lysA [H]

Synonym: GDI_2973

Alternate gene names: 162148745

Gene position: 3062765-3061290 (Counterclockwise)

Preceding gene: 162148747

Following gene: 162148744

Centisome position: 77.65

GC content: 71.82

Gene sequence:

>1476_bases
TTGTCGTTCCTCCCGAAGGCAGGGTCTGTCTATCGGATCGCCGGTGCTGCGAACAGTATCGCGCGGCCCATGCGCGCGGA
CCTTGGAACCGTGGGCCGGAGCCACTATCCTGACGGGATGACCGACCCATCTTCCCGGCTCGCCGAGCAGGACCCGACCG
TGGCAGACCTGCTGGCCGCCCGCCCGCATCTGTCGATGCATGCGCTCGACGGCCTGGTGTTCGAGGACGTTCCGCTGAAC
GCGATCGCGGACGCGGTGGGAACGCCGACCTGGGTCATGGGGGCAGGGACCCTGCGCGCGCGCTATCGCCGCCTGGCGGG
CGCCCTGCGTGACGCGGGGCTGGCCCCGTCGATCCATTTCGCGGTGAAGGCGAACGACCATCTGGCGGTGCTGCGTGTCC
TGGCGGCCGAAGGGGCGGGGGCTGACGTCGTCAGCGGCGGCGAACTGCGCCGCGCCCGCGCCGCCGGCATTCCGGCGGCC
GGTATCGTCTTTTCCGGCGTCGGCAAGTCGCGGGACGAACTGCACCTGGCCGTGACCGAGGGCATCGCCCACATCGCGGT
CGAAAGCGCCGAGGAACTGGACGTCGTGTCCGACGTCGCCGTCGCGGCCGGCCGCACGGCGCGCATCACGCTGCGGGTGA
ACCCGGATGTGGACGCCGGAACGCACGAGAAGATCACGACCGGCCTTTCGACCAACAAGTTCGGCATCGCCTATGCCCGG
GCCGCCGACCTGTATGCCCGCGCGGCGGCGCTGCCGGGACTGCATCCGCTGGGGTTCTCGGTGCATATCGGCAGCCAGAT
CGTGGCCATGGGCCCCTACCGCGCCGCATTCGCGCGGGTGGCCGACCTGGTGCGCGCGGTGCGGGCGCGCGGCCTGTCCG
TCGGGCTGGTCGATTGCGGCGGCGGCTTGGGAATCCGCTACCGTGACGAGGTCGAGGGCGCGCCCATGGCCCTGGCGGGT
GCGATCCGCGCCGAACTGGGTGACCTGGACGTGCGGCTGGCGATCGAGCCCGGCCGCTGGCTGGCCGGTCCGGCCGGCGT
GCTGCTGTCGCGGGTGATCCTGCGCAAGGCCGGGCAGGACGGGCTGCCGCCGTTCCTGATCCTGGACGCGGCGATGAACG
ACCTGGCGCGGCCCAGCCTGTACGATTCGTGGCATGGTATCCTGCCGCTGTCCGCCCGTGACGCGGTCCAGCCGGTCGAA
TCGGTGAACGTCGTGGGACCGGTCTGCGAAAGCGCCGATTCCTTCGCCACCGGCCGGATGCTGCCGCGCATGGGTGACGG
CGCGGCGGTCGCCCTGCTGGATACCGGCGCCTACGGCATGGTCATGAGCTCGACCTATAACGGCCGCCCGCTGGCCGCGC
AGGTCCTGGTCGATGGCGGGCGCTGGAGCGTGATCCGCGCCCGGCAGCCGGTCGAAAGCCTGTGGGCGGCGGACCGGGTT
CCCGATTGGCTTGCCCCCCAGCCGGTGGGGGCCTGA

Upstream 100 bases:

>100_bases
TCCGCGCAGCGCAGCGCCGCACCGACGTGGAAGCGCGAATAGGGGGCATAGGCGTTGGCGCGGACGGCCACCGCGGCATC
GATCAGCGGATCGTCGGACA

Downstream 100 bases:

>100_bases
GCGCCGCATGACGGGCGGGACCGCTCCCCCCCAGGATGTCGCGGATACGGGGGCGGCGCTGTCGTCGTTTCCGGTCCGGC
TGGCGGCCGCGCGGTATCGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSFLPKAGSVYRIAGAANSIARPMRADLGTVGRSHYPDGMTDPSSRLAEQDPTVADLLAARPHLSMHALDGLVFEDVPLN
AIADAVGTPTWVMGAGTLRARYRRLAGALRDAGLAPSIHFAVKANDHLAVLRVLAAEGAGADVVSGGELRRARAAGIPAA
GIVFSGVGKSRDELHLAVTEGIAHIAVESAEELDVVSDVAVAAGRTARITLRVNPDVDAGTHEKITTGLSTNKFGIAYAR
AADLYARAAALPGLHPLGFSVHIGSQIVAMGPYRAAFARVADLVRAVRARGLSVGLVDCGGGLGIRYRDEVEGAPMALAG
AIRAELGDLDVRLAIEPGRWLAGPAGVLLSRVILRKAGQDGLPPFLILDAAMNDLARPSLYDSWHGILPLSARDAVQPVE
SVNVVGPVCESADSFATGRMLPRMGDGAAVALLDTGAYGMVMSSTYNGRPLAAQVLVDGGRWSVIRARQPVESLWAADRV
PDWLAPQPVGA

Sequences:

>Translated_491_residues
MSFLPKAGSVYRIAGAANSIARPMRADLGTVGRSHYPDGMTDPSSRLAEQDPTVADLLAARPHLSMHALDGLVFEDVPLN
AIADAVGTPTWVMGAGTLRARYRRLAGALRDAGLAPSIHFAVKANDHLAVLRVLAAEGAGADVVSGGELRRARAAGIPAA
GIVFSGVGKSRDELHLAVTEGIAHIAVESAEELDVVSDVAVAAGRTARITLRVNPDVDAGTHEKITTGLSTNKFGIAYAR
AADLYARAAALPGLHPLGFSVHIGSQIVAMGPYRAAFARVADLVRAVRARGLSVGLVDCGGGLGIRYRDEVEGAPMALAG
AIRAELGDLDVRLAIEPGRWLAGPAGVLLSRVILRKAGQDGLPPFLILDAAMNDLARPSLYDSWHGILPLSARDAVQPVE
SVNVVGPVCESADSFATGRMLPRMGDGAAVALLDTGAYGMVMSSTYNGRPLAAQVLVDGGRWSVIRARQPVESLWAADRV
PDWLAPQPVGA
>Mature_490_residues
SFLPKAGSVYRIAGAANSIARPMRADLGTVGRSHYPDGMTDPSSRLAEQDPTVADLLAARPHLSMHALDGLVFEDVPLNA
IADAVGTPTWVMGAGTLRARYRRLAGALRDAGLAPSIHFAVKANDHLAVLRVLAAEGAGADVVSGGELRRARAAGIPAAG
IVFSGVGKSRDELHLAVTEGIAHIAVESAEELDVVSDVAVAAGRTARITLRVNPDVDAGTHEKITTGLSTNKFGIAYARA
ADLYARAAALPGLHPLGFSVHIGSQIVAMGPYRAAFARVADLVRAVRARGLSVGLVDCGGGLGIRYRDEVEGAPMALAGA
IRAELGDLDVRLAIEPGRWLAGPAGVLLSRVILRKAGQDGLPPFLILDAAMNDLARPSLYDSWHGILPLSARDAVQPVES
VNVVGPVCESADSFATGRMLPRMGDGAAVALLDTGAYGMVMSSTYNGRPLAAQVLVDGGRWSVIRARQPVESLWAADRVP
DWLAPQPVGA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=376, Percent_Identity=27.6595744680851, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1789203, Length=413, Percent_Identity=34.3825665859564, Blast_Score=165, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=362, Percent_Identity=25.1381215469613, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24586474, Length=351, Percent_Identity=24.2165242165242, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 51115; Mature: 50984

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLPKAGSVYRIAGAANSIARPMRADLGTVGRSHYPDGMTDPSSRLAEQDPTVADLLAA
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHC
RPHLSMHALDGLVFEDVPLNAIADAVGTPTWVMGAGTLRARYRRLAGALRDAGLAPSIHF
CCCCHHHHHCCEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEEE
AVKANDHLAVLRVLAAEGAGADVVSGGELRRARAAGIPAAGIVFSGVGKSRDELHLAVTE
EEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHEEECCCCCCCCEEEEEHH
GIAHIAVESAEELDVVSDVAVAAGRTARITLRVNPDVDAGTHEKITTGLSTNKFGIAYAR
CHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCCCCCEEHHH
AADLYARAAALPGLHPLGFSVHIGSQIVAMGPYRAAFARVADLVRAVRARGLSVGLVDCG
HHHHHHHHHHCCCCCCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGIRYRDEVEGAPMALAGAIRAELGDLDVRLAIEPGRWLAGPAGVLLSRVILRKAGQD
CCCCCEEHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
GLPPFLILDAAMNDLARPSLYDSWHGILPLSARDAVQPVESVNVVGPVCESADSFATGRM
CCCCEEEHHHHHHHHCCCCHHHCCCCEEECCCHHHHCHHHHCCHHHHHHHCCCCHHHCCC
LPRMGDGAAVALLDTGAYGMVMSSTYNGRPLAAQVLVDGGRWSVIRARQPVESLWAADRV
CCCCCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHCC
PDWLAPQPVGA
CCCCCCCCCCC
>Mature Secondary Structure 
SFLPKAGSVYRIAGAANSIARPMRADLGTVGRSHYPDGMTDPSSRLAEQDPTVADLLAA
CCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHC
RPHLSMHALDGLVFEDVPLNAIADAVGTPTWVMGAGTLRARYRRLAGALRDAGLAPSIHF
CCCCHHHHHCCEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEEE
AVKANDHLAVLRVLAAEGAGADVVSGGELRRARAAGIPAAGIVFSGVGKSRDELHLAVTE
EEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHEEECCCCCCCCEEEEEHH
GIAHIAVESAEELDVVSDVAVAAGRTARITLRVNPDVDAGTHEKITTGLSTNKFGIAYAR
CHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCCCCCEEHHH
AADLYARAAALPGLHPLGFSVHIGSQIVAMGPYRAAFARVADLVRAVRARGLSVGLVDCG
HHHHHHHHHHCCCCCCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGIRYRDEVEGAPMALAGAIRAELGDLDVRLAIEPGRWLAGPAGVLLSRVILRKAGQD
CCCCCEEHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
GLPPFLILDAAMNDLARPSLYDSWHGILPLSARDAVQPVESVNVVGPVCESADSFATGRM
CCCCEEEHHHHHHHHCCCCHHHCCCCEEECCCHHHHCHHHHCCHHHHHHHCCCCHHHCCC
LPRMGDGAAVALLDTGAYGMVMSSTYNGRPLAAQVLVDGGRWSVIRARQPVESLWAADRV
CCCCCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHCC
PDWLAPQPVGA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA