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The map label for this gene is fabF [H]

Identifier: 162148713

GI number: 162148713

Start: 3029717

End: 3031024

Strand: Reverse

Name: fabF [H]

Synonym: GDI_2941

Alternate gene names: 162148713

Gene position: 3031024-3029717 (Counterclockwise)

Preceding gene: 162148714

Following gene: 162148712

Centisome position: 76.85

GC content: 67.74

Gene sequence:

>1308_bases
GTGATCAGGGAGCGGAGCGGGTTGATACAGTCTGCCGGAGTGGCGTCGGAACGTCGACGCGTCGTTGTCACCGGTATGGG
CATTGTCAGCCCGCTCGGGCTGGGGCTCGAACATAACTGGTCGCGCCTGATCGCGGGGGAAAACGGCTTCGGCCGTATTT
CCTCGTTCGACCCATCCGATCTGCCCGCGCATGTCGCGGGCGAAGTGCCTGCCGGCCCGACCGCCGAGGGTCGCCTGACC
CTGTCGGACTGGGTGCCCGTCAAGGACCAGAAGAAGATGGATCGCTTCATCCATCTGGGCCTCGTCGCGGCGACCGAGGC
GGTCGAGGATTCGGGCTGGAAGCCGGAATCCGAGGAAGATCGCTGCCGGACCGGCGTCATGATCGGCTCGGGCATCGGCG
GCCTGCAGACGATCTACGATGCGTCGGTGACGGTGCATGAGGGACGCGCGCGGCGCCTGTCGCCCTTCTTCATCCCGTCC
GCGCTGATCAACCTGGTCTCGGGCCATGTGTCGATCAAATACGGTTTCAAGGGACCGAACCATTCGGTCGTGACCGCCTG
CGCCACCGGCGTGCATGCGATCGGCGACGCCTCGCGGCTGATCATGCTCGGTGATGCCGACGTCATGGTCGCCGGCGGGG
CCGAGGCCGCCGTCTGCCCGCTGGGCATCGCGGGCTTCAGTTCGGCGCGCGCGCTGTCCACCGCCTTCAACGACACGCCG
GAAAAGGCGTCGCGTCCCTGGGACCGCGACCGCGACGGCTTCGTGATGGGCGAGGGCGCCGGCATCGTGGTGCTGGAAGA
GTACGAGCACGCGAAGGCCCGCGGCGCCAAGATCTATGGCGAAGTCATCGGATACGGCATGTCCGGCGACGCCTATCACA
TCACCGCCCCCGCCGAGGGGCACGAGGGCGCCTATCGCGCCATGCAGGCCGCCGTGCGCAGCGCCGGGATCGACGTGGCG
GATATCGGCTACGTCAACGCCCACGGCACCTCGACCATGGCGGACGACCTGGAACTGCAGGCGGTCGAACGCCTGTTCGG
CGACGATGCCGGCAAGGTGGCCATGTCCTCGACCAAGTCCGCCATCGGCCATCTGCTGGGCGCGGCCGGCGCGGTCGAGG
CGATCTTCTCGATCCTGGCGATCCGCGACAATGTCGCACCGCCCACGCTGAACCTGGACAATCCGTCTCGCGAGAGCGCG
ATCGACCGGGTGGCGCACGAGGCCCAGCGCCGCAAGATCGATATCGCCCTGTCGAACAGCTTCGGCTTCGGGGGCACCAA
CGCCAGCGTCATCCTGCGCGGCGTCTGA

Upstream 100 bases:

>100_bases
TTCCGGAAGACGCGGCCGAAAAGATCGCGACCGTGAAGGACGCGATCGACTACATCGAGAAGCAGAAGGCCGCCTGAAGT
CGGCCGGGAAATCGGATTTC

Downstream 100 bases:

>100_bases
CCGGCCGCGCCATCGGCCGCCGACAGGCAGGATGTTCAAGCGCCTCATTATAACCGGCCTGCTGCTGCTGGCCCTCCTGT
GTATGGGGGCGGGCGGCGTC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIRERSGLIQSAGVASERRRVVVTGMGIVSPLGLGLEHNWSRLIAGENGFGRISSFDPSDLPAHVAGEVPAGPTAEGRLT
LSDWVPVKDQKKMDRFIHLGLVAATEAVEDSGWKPESEEDRCRTGVMIGSGIGGLQTIYDASVTVHEGRARRLSPFFIPS
ALINLVSGHVSIKYGFKGPNHSVVTACATGVHAIGDASRLIMLGDADVMVAGGAEAAVCPLGIAGFSSARALSTAFNDTP
EKASRPWDRDRDGFVMGEGAGIVVLEEYEHAKARGAKIYGEVIGYGMSGDAYHITAPAEGHEGAYRAMQAAVRSAGIDVA
DIGYVNAHGTSTMADDLELQAVERLFGDDAGKVAMSSTKSAIGHLLGAAGAVEAIFSILAIRDNVAPPTLNLDNPSRESA
IDRVAHEAQRRKIDIALSNSFGFGGTNASVILRGV

Sequences:

>Translated_435_residues
MIRERSGLIQSAGVASERRRVVVTGMGIVSPLGLGLEHNWSRLIAGENGFGRISSFDPSDLPAHVAGEVPAGPTAEGRLT
LSDWVPVKDQKKMDRFIHLGLVAATEAVEDSGWKPESEEDRCRTGVMIGSGIGGLQTIYDASVTVHEGRARRLSPFFIPS
ALINLVSGHVSIKYGFKGPNHSVVTACATGVHAIGDASRLIMLGDADVMVAGGAEAAVCPLGIAGFSSARALSTAFNDTP
EKASRPWDRDRDGFVMGEGAGIVVLEEYEHAKARGAKIYGEVIGYGMSGDAYHITAPAEGHEGAYRAMQAAVRSAGIDVA
DIGYVNAHGTSTMADDLELQAVERLFGDDAGKVAMSSTKSAIGHLLGAAGAVEAIFSILAIRDNVAPPTLNLDNPSRESA
IDRVAHEAQRRKIDIALSNSFGFGGTNASVILRGV
>Mature_435_residues
MIRERSGLIQSAGVASERRRVVVTGMGIVSPLGLGLEHNWSRLIAGENGFGRISSFDPSDLPAHVAGEVPAGPTAEGRLT
LSDWVPVKDQKKMDRFIHLGLVAATEAVEDSGWKPESEEDRCRTGVMIGSGIGGLQTIYDASVTVHEGRARRLSPFFIPS
ALINLVSGHVSIKYGFKGPNHSVVTACATGVHAIGDASRLIMLGDADVMVAGGAEAAVCPLGIAGFSSARALSTAFNDTP
EKASRPWDRDRDGFVMGEGAGIVVLEEYEHAKARGAKIYGEVIGYGMSGDAYHITAPAEGHEGAYRAMQAAVRSAGIDVA
DIGYVNAHGTSTMADDLELQAVERLFGDDAGKVAMSSTKSAIGHLLGAAGAVEAIFSILAIRDNVAPPTLNLDNPSRESA
IDRVAHEAQRRKIDIALSNSFGFGGTNASVILRGV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=438, Percent_Identity=48.4018264840183, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI223972627, Length=255, Percent_Identity=36.8627450980392, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI41872631, Length=441, Percent_Identity=25.6235827664399, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=54.5238095238095, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=36.9304556354916, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=41.5676959619952, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=46.0377358490566, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=26.7955801104972, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=274, Percent_Identity=27.007299270073, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=39.7291196388262, Blast_Score=304, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24644341, Length=427, Percent_Identity=47.3067915690867, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221330659, Length=362, Percent_Identity=25.9668508287293, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19920632, Length=357, Percent_Identity=26.3305322128852, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24581345, Length=362, Percent_Identity=22.9281767955801, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45583; Mature: 45583

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRERSGLIQSAGVASERRRVVVTGMGIVSPLGLGLEHNWSRLIAGENGFGRISSFDPSD
CCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCC
LPAHVAGEVPAGPTAEGRLTLSDWVPVKDQKKMDRFIHLGLVAATEAVEDSGWKPESEED
CCHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
RCRTGVMIGSGIGGLQTIYDASVTVHEGRARRLSPFFIPSALINLVSGHVSIKYGFKGPN
HHHHCEEEECCCCCHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCC
HSVVTACATGVHAIGDASRLIMLGDADVMVAGGAEAAVCPLGIAGFSSARALSTAFNDTP
CCEEEHHHHCHHHCCCCCEEEEEECCCEEEECCCCCEECCCCCCCCCHHHHHHHHHCCCH
EKASRPWDRDRDGFVMGEGAGIVVLEEYEHAKARGAKIYGEVIGYGMSGDAYHITAPAEG
HHHCCCCCCCCCCEEEECCCCEEEEECCCCHHHCCCEEEEHHHCCCCCCCEEEEECCCCC
HEGAYRAMQAAVRSAGIDVADIGYVNAHGTSTMADDLELQAVERLFGDDAGKVAMSSTKS
CCHHHHHHHHHHHHCCCCEECCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHH
AIGHLLGAAGAVEAIFSILAIRDNVAPPTLNLDNPSRESAIDRVAHEAQRRKIDIALSNS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHCEEEEEEECC
FGFGGTNASVILRGV
CCCCCCCCEEEEECC
>Mature Secondary Structure
MIRERSGLIQSAGVASERRRVVVTGMGIVSPLGLGLEHNWSRLIAGENGFGRISSFDPSD
CCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCC
LPAHVAGEVPAGPTAEGRLTLSDWVPVKDQKKMDRFIHLGLVAATEAVEDSGWKPESEED
CCHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
RCRTGVMIGSGIGGLQTIYDASVTVHEGRARRLSPFFIPSALINLVSGHVSIKYGFKGPN
HHHHCEEEECCCCCHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCC
HSVVTACATGVHAIGDASRLIMLGDADVMVAGGAEAAVCPLGIAGFSSARALSTAFNDTP
CCEEEHHHHCHHHCCCCCEEEEEECCCEEEECCCCCEECCCCCCCCCHHHHHHHHHCCCH
EKASRPWDRDRDGFVMGEGAGIVVLEEYEHAKARGAKIYGEVIGYGMSGDAYHITAPAEG
HHHCCCCCCCCCCEEEECCCCEEEEECCCCHHHCCCEEEEHHHCCCCCCCEEEEECCCCC
HEGAYRAMQAAVRSAGIDVADIGYVNAHGTSTMADDLELQAVERLFGDDAGKVAMSSTKS
CCHHHHHHHHHHHHCCCCEECCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHH
AIGHLLGAAGAVEAIFSILAIRDNVAPPTLNLDNPSRESAIDRVAHEAQRRKIDIALSNS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHCEEEEEEECC
FGFGGTNASVILRGV
CCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]