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The map label for this gene is uvrD [H]

Identifier: 162148662

GI number: 162148662

Start: 2974257

End: 2976356

Strand: Direct

Name: uvrD [H]

Synonym: GDI_2889

Alternate gene names: 162148662

Gene position: 2974257-2976356 (Clockwise)

Preceding gene: 162148657

Following gene: 162148663

Centisome position: 75.41

GC content: 66.9

Gene sequence:

>2100_bases
TTGACTCCAAAGATTTCCAGGGACGCGATCGCGGACGATCCGCTGGCCCGGCTCAATCCCGCCCAGCGCGAAGCCGTCAC
GCATGGGGCCGGAGTCGCGCCCGACGTAGGCGGCTCACCCCCGCTGCTGGTCATCGCCGGCGCGGGATCGGGCAAGACCA
ATACACTCGCCCACCGGGTCGCCCATCTGATCGCCACCGGCACCGATCCCCGCCGCATCCTACTGCTGACCTTCTCGCGT
CGCGCGAGCACCGAGATGACACGGCGGGTGGAGCGCATCTGCCGCGCCGTTCTCGGCGACAAGGCCGGACCTCTGGCCGA
CGCGCTGGCCTGGGCCGGGACGTTCCATTCCATCGGTGCCCGGCTGCTGCGGGAGTATGCGGAGCAGATCGGCATGGACC
CGGCTTTCTCCATCCATGACCGGGAGGATTCCGCCGACCTGATGAACCTGGTCCGCCACGATCTCGGCTTCTCGAAGACC
GAGAAGCGCTTCCCCGCCAAGGGGACGTGCCTCGCCATCTATTCCCGTGTCGTGAACTCCGGCGTTCCGCTCGGCGATGT
GCTGCTGAAGCATTATCCGTGGTGCGCCGGATGGGAGGCGCAGCTCAAACAGCTCTTCGCCGCCTATGTGACAGCGAAGC
AGGCGCAGGGCGTGCTGGATTACGACGATCTGCTGCTGGCCTGGGCGCAGATGGTCGCCGAGCCCGTGCTTGCCGCCGAT
ATCGGCGGCAGATGGGACCATATCCTCGTCGACGAATATCAGGACACCAACCGGCTCCAGGCCGATATCTTGCTCGGCAT
GAAGCCCGACGGGCGCGGCCTGACGGTGGTGGGCGACGACGCGCAGAGCATCTACGCCTTCCGGGCGGCGACGGTGCGCA
ACATCCTCGACTTCCCGGCCGCCTTCGATCCGCCGGCGCGGATCGTGACGCTGGACCGGAACTATCGTTCCACGAAGCCG
ATCCTCGACGCCGCCAACGCGGTGATCGGCGAAGCGGCCGAGCGCTTCACCAAGGATCTCTGGACCGAACGGGCATCCGA
CGAGCGCCCGCGCTTGGTGACGATCGCCGACGACACCGCGCAGGCCGACTATATCGCGGGCAGGGTGCTGGAGGAGCGTG
AGGGCGGCACGGCGCTGAAGGAGCAGGCGGTGCTGTTCCGCGTCTCGCATCACAGCGCCACGCTGGAGGTCGAACTGACC
CGGCGCAACATCCCGTTCGTGAAGTTCGGCGGGCTGAAGTTTCTCGACAGCGCGCATGTGAAGGACGTGCTGACCGTGCT
GCGTTTCGCGCAGAACCCACGTGACCGGATCGCGGGCTTTCGGGTGCTCCAGCTTCTGCCCGGCGTGGGGCCGACTTCCG
CGCGCAGGGTGCTTGATACGCTGGGCGAGAGCGATCGGCCGCTCGAGGCGCTGGCCGAGACGAAGGCGCCCATGCGGAGC
GGCGAGGCCTGGCAGGGCTTCATGGAAACGGTCATGGCTCTTGGTGGCGGCAAAACCGGCTGGCCGGGCGAGATCGCCGC
CGTGCGCGCCTGGTATGAACCGCATCTGGAACGGCTACATGAGGATGCGACCATGCGGCAGGCGGATCTGGTGCAGTTGG
AGCAGATCGCCGGGGGCTATCCGTCGCGGGAGAAGTTCCTGACCGAGCTGACGCTCGATCCGCCGGACGCGACCTCCGAC
CAGGCGGGCGTGCCGCTGCTGGACGAGGATTACCTGATCCTCTCGACGATCCATTCTGCCAAGGGGCAGGAATGGAAGAA
CGTGTTCGTGCTGAACGTGGTGGATGGCTGCATCCCGTCGGACCTCGCCACCGGTGAACGCGACGACATCGAGGAGGAAC
GCCGCCTGCTCTATGTCGCCATGACGCGGGCGAAGGATGCCCTTGATCTGATGGTCCCGCAGCGTTTCTACGTCCACGGG
CAAGGGATGGGCGATCGGCATGTCTATGCCGCGCGGACGCGCTTCGTCACGCGCGAGATGCTGCCGCTCTTTCACGCGAC
CGCCTGGCCAATCGTGGCGCCGGAGGAACAGGCCCGGCAGGAGGCGGTGAAGTCCGTGCGGATCGACATGGGCGCGCGCC
TGCGTTCCCTCTGGTCGTAG

Upstream 100 bases:

>100_bases
GTTCTGGATCGACAGCGAGAGTCAAGGCATAATTCCGTTGTCCGTGCCATGATGGCCGGCGACGCACGGACCGGACCGCG
CATGAGGATGGCGTAAGGAT

Downstream 100 bases:

>100_bases
GAAGCCGACGATGTGCAACCTCTACAGCATGACGACCAACCAGCAGGCCATCCGCGAGGCGGCGAACGTCATGACGGATC
GGACTGGCAACCTGCCGCCG

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MTPKISRDAIADDPLARLNPAQREAVTHGAGVAPDVGGSPPLLVIAGAGSGKTNTLAHRVAHLIATGTDPRRILLLTFSR
RASTEMTRRVERICRAVLGDKAGPLADALAWAGTFHSIGARLLREYAEQIGMDPAFSIHDREDSADLMNLVRHDLGFSKT
EKRFPAKGTCLAIYSRVVNSGVPLGDVLLKHYPWCAGWEAQLKQLFAAYVTAKQAQGVLDYDDLLLAWAQMVAEPVLAAD
IGGRWDHILVDEYQDTNRLQADILLGMKPDGRGLTVVGDDAQSIYAFRAATVRNILDFPAAFDPPARIVTLDRNYRSTKP
ILDAANAVIGEAAERFTKDLWTERASDERPRLVTIADDTAQADYIAGRVLEEREGGTALKEQAVLFRVSHHSATLEVELT
RRNIPFVKFGGLKFLDSAHVKDVLTVLRFAQNPRDRIAGFRVLQLLPGVGPTSARRVLDTLGESDRPLEALAETKAPMRS
GEAWQGFMETVMALGGGKTGWPGEIAAVRAWYEPHLERLHEDATMRQADLVQLEQIAGGYPSREKFLTELTLDPPDATSD
QAGVPLLDEDYLILSTIHSAKGQEWKNVFVLNVVDGCIPSDLATGERDDIEEERRLLYVAMTRAKDALDLMVPQRFYVHG
QGMGDRHVYAARTRFVTREMLPLFHATAWPIVAPEEQARQEAVKSVRIDMGARLRSLWS

Sequences:

>Translated_699_residues
MTPKISRDAIADDPLARLNPAQREAVTHGAGVAPDVGGSPPLLVIAGAGSGKTNTLAHRVAHLIATGTDPRRILLLTFSR
RASTEMTRRVERICRAVLGDKAGPLADALAWAGTFHSIGARLLREYAEQIGMDPAFSIHDREDSADLMNLVRHDLGFSKT
EKRFPAKGTCLAIYSRVVNSGVPLGDVLLKHYPWCAGWEAQLKQLFAAYVTAKQAQGVLDYDDLLLAWAQMVAEPVLAAD
IGGRWDHILVDEYQDTNRLQADILLGMKPDGRGLTVVGDDAQSIYAFRAATVRNILDFPAAFDPPARIVTLDRNYRSTKP
ILDAANAVIGEAAERFTKDLWTERASDERPRLVTIADDTAQADYIAGRVLEEREGGTALKEQAVLFRVSHHSATLEVELT
RRNIPFVKFGGLKFLDSAHVKDVLTVLRFAQNPRDRIAGFRVLQLLPGVGPTSARRVLDTLGESDRPLEALAETKAPMRS
GEAWQGFMETVMALGGGKTGWPGEIAAVRAWYEPHLERLHEDATMRQADLVQLEQIAGGYPSREKFLTELTLDPPDATSD
QAGVPLLDEDYLILSTIHSAKGQEWKNVFVLNVVDGCIPSDLATGERDDIEEERRLLYVAMTRAKDALDLMVPQRFYVHG
QGMGDRHVYAARTRFVTREMLPLFHATAWPIVAPEEQARQEAVKSVRIDMGARLRSLWS
>Mature_698_residues
TPKISRDAIADDPLARLNPAQREAVTHGAGVAPDVGGSPPLLVIAGAGSGKTNTLAHRVAHLIATGTDPRRILLLTFSRR
ASTEMTRRVERICRAVLGDKAGPLADALAWAGTFHSIGARLLREYAEQIGMDPAFSIHDREDSADLMNLVRHDLGFSKTE
KRFPAKGTCLAIYSRVVNSGVPLGDVLLKHYPWCAGWEAQLKQLFAAYVTAKQAQGVLDYDDLLLAWAQMVAEPVLAADI
GGRWDHILVDEYQDTNRLQADILLGMKPDGRGLTVVGDDAQSIYAFRAATVRNILDFPAAFDPPARIVTLDRNYRSTKPI
LDAANAVIGEAAERFTKDLWTERASDERPRLVTIADDTAQADYIAGRVLEEREGGTALKEQAVLFRVSHHSATLEVELTR
RNIPFVKFGGLKFLDSAHVKDVLTVLRFAQNPRDRIAGFRVLQLLPGVGPTSARRVLDTLGESDRPLEALAETKAPMRSG
EAWQGFMETVMALGGGKTGWPGEIAAVRAWYEPHLERLHEDATMRQADLVQLEQIAGGYPSREKFLTELTLDPPDATSDQ
AGVPLLDEDYLILSTIHSAKGQEWKNVFVLNVVDGCIPSDLATGERDDIEEERRLLYVAMTRAKDALDLMVPQRFYVHGQ
GMGDRHVYAARTRFVTREMLPLFHATAWPIVAPEEQARQEAVKSVRIDMGARLRSLWS

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=668, Percent_Identity=31.2874251497006, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI48994965, Length=675, Percent_Identity=29.7777777777778, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787196, Length=434, Percent_Identity=26.7281105990783, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322369, Length=449, Percent_Identity=28.2850779510022, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77119; Mature: 76988

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKISRDAIADDPLARLNPAQREAVTHGAGVAPDVGGSPPLLVIAGAGSGKTNTLAHRV
CCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
AHLIATGTDPRRILLLTFSRRASTEMTRRVERICRAVLGDKAGPLADALAWAGTFHSIGA
HHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RLLREYAEQIGMDPAFSIHDREDSADLMNLVRHDLGFSKTEKRFPAKGTCLAIYSRVVNS
HHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHC
GVPLGDVLLKHYPWCAGWEAQLKQLFAAYVTAKQAQGVLDYDDLLLAWAQMVAEPVLAAD
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IGGRWDHILVDEYQDTNRLQADILLGMKPDGRGLTVVGDDAQSIYAFRAATVRNILDFPA
CCCCCCEEEEECCCCCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
AFDPPARIVTLDRNYRSTKPILDAANAVIGEAAERFTKDLWTERASDERPRLVTIADDTA
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
QADYIAGRVLEEREGGTALKEQAVLFRVSHHSATLEVELTRRNIPFVKFGGLKFLDSAHV
HHHHHHHHHHHHCCCCCHHHHCEEEEEEECCCEEEEEEEECCCCCEEEECCCHHHHHHHH
KDVLTVLRFAQNPRDRIAGFRVLQLLPGVGPTSARRVLDTLGESDRPLEALAETKAPMRS
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCC
GEAWQGFMETVMALGGGKTGWPGEIAAVRAWYEPHLERLHEDATMRQADLVQLEQIAGGY
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSREKFLTELTLDPPDATSDQAGVPLLDEDYLILSTIHSAKGQEWKNVFVLNVVDGCIPS
CCHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCCCEEEEEECCCCCCC
DLATGERDDIEEERRLLYVAMTRAKDALDLMVPQRFYVHGQGMGDRHVYAARTRFVTREM
CCCCCCCCCHHHHHHEEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHH
LPLFHATAWPIVAPEEQARQEAVKSVRIDMGARLRSLWS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPKISRDAIADDPLARLNPAQREAVTHGAGVAPDVGGSPPLLVIAGAGSGKTNTLAHRV
CCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
AHLIATGTDPRRILLLTFSRRASTEMTRRVERICRAVLGDKAGPLADALAWAGTFHSIGA
HHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RLLREYAEQIGMDPAFSIHDREDSADLMNLVRHDLGFSKTEKRFPAKGTCLAIYSRVVNS
HHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHC
GVPLGDVLLKHYPWCAGWEAQLKQLFAAYVTAKQAQGVLDYDDLLLAWAQMVAEPVLAAD
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IGGRWDHILVDEYQDTNRLQADILLGMKPDGRGLTVVGDDAQSIYAFRAATVRNILDFPA
CCCCCCEEEEECCCCCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
AFDPPARIVTLDRNYRSTKPILDAANAVIGEAAERFTKDLWTERASDERPRLVTIADDTA
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
QADYIAGRVLEEREGGTALKEQAVLFRVSHHSATLEVELTRRNIPFVKFGGLKFLDSAHV
HHHHHHHHHHHHCCCCCHHHHCEEEEEEECCCEEEEEEEECCCCCEEEECCCHHHHHHHH
KDVLTVLRFAQNPRDRIAGFRVLQLLPGVGPTSARRVLDTLGESDRPLEALAETKAPMRS
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCC
GEAWQGFMETVMALGGGKTGWPGEIAAVRAWYEPHLERLHEDATMRQADLVQLEQIAGGY
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSREKFLTELTLDPPDATSDQAGVPLLDEDYLILSTIHSAKGQEWKNVFVLNVVDGCIPS
CCHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCCCEEEEEECCCCCCC
DLATGERDDIEEERRLLYVAMTRAKDALDLMVPQRFYVHGQGMGDRHVYAARTRFVTREM
CCCCCCCCCHHHHHHEEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHH
LPLFHATAWPIVAPEEQARQEAVKSVRIDMGARLRSLWS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]