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The map label for this gene is emrA [H]

Identifier: 162148621

GI number: 162148621

Start: 2938198

End: 2939190

Strand: Direct

Name: emrA [H]

Synonym: GDI_2848

Alternate gene names: 162148621

Gene position: 2938198-2939190 (Clockwise)

Preceding gene: 162148620

Following gene: 162148622

Centisome position: 74.49

GC content: 65.76

Gene sequence:

>993_bases
GTGCTGCTGCATGGCGACGCGATCGATCTCTGCCTGCACTGCGAAAGCACGAATGACGCCTTCGTGCATGCGGATACGGT
CGTGCTCTCCGCCCACGTCGCCGGATACATCACGCGGGTTCCGGTCGCGGACAATGCACGGGTCAACGCCAGCCAGACCC
TCGTGGCGATCCAGGACGACGATTATCGAGCCCATCTGGCCGAAAAGGACGCCACGCTCGGCGCGGCCAGAGCGGCGCTG
GAGGTTGTGCAACGGCAAATCGGGCTGGAGACGGCGCAGATCGCGGGGGCGGAAGCCGCATTACGCATGGCGGAAGCCGA
TGTCGCGCAACGGCGCCTCGAACGGCGGCGGCAGCACGATCTCATTACCGACGGCAGCACGTCCCGTCGCGACCTTGAGA
TCGCGGATGCCGATCTGGCCCGTCTGTCGGCGGCGCGGGATCGTGACGCCGCCCTTGTGGACGCAGCGCGGCGGACCCAG
GACGTACTGCGCGCCAAACTCGTGCAGGCACAAGAAGACGTCTCGGCGGCCGTATCGGCGCGCGAACTCGCCGCAATCGA
CCTCGGCTACACGCGGATCGCCAGCCCTGTCGCCGGTCAGGTCACCGCGCGGATGGTCTATGTCGGCGAATATGTCGGTA
TCGGTACCCAGGTGGCACGGGTCGCGCCACTGCCGGACGTCTGGATCGTCGCGAACTTCCGCGAGGTGCAGCTGACACAT
ATGCGGGTCGGACAGACCGCGTCGATCACGATCGATGCGTTCCCCGGCGCCATTTTTCGCGGGCATGTGGACAGCATCGG
ACCCGTCTCGGGCGCCGAGACGGCCCTGCTGCCACCCGACAACGCTACCGGCAATTTCACCCATATCGTTCAGAGATTTC
CCGTCAAGATCGTCATCGAGCCGGATCAGGCGGGCACCGACCTCCTGCGACCCGGTATGTCCTCACACGTCTCTGTGCGG
ACTCTCGTCGCCATACGGAGAGACGCGCCATGA

Upstream 100 bases:

>100_bases
TCCGTTCAGACTGATGAAGCATGTTCTGCCTGCCGGATGGGGGCGGATCGTGGCACTAGGCCTGATCCTTATTACATCCG
GGGCGGTCCTCGCGACCCAG

Downstream 100 bases:

>100_bases
CGTCCGAGATGCGAGGACAGCTTCTCACGGGCAGCTGCGGTGTCTGCGCGGCCTGGATGGTCATGATGTCGACGCGGTTC
TTCGCGCTGTCGCTGGCGGA

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MLLHGDAIDLCLHCESTNDAFVHADTVVLSAHVAGYITRVPVADNARVNASQTLVAIQDDDYRAHLAEKDATLGAARAAL
EVVQRQIGLETAQIAGAEAALRMAEADVAQRRLERRRQHDLITDGSTSRRDLEIADADLARLSAARDRDAALVDAARRTQ
DVLRAKLVQAQEDVSAAVSARELAAIDLGYTRIASPVAGQVTARMVYVGEYVGIGTQVARVAPLPDVWIVANFREVQLTH
MRVGQTASITIDAFPGAIFRGHVDSIGPVSGAETALLPPDNATGNFTHIVQRFPVKIVIEPDQAGTDLLRPGMSSHVSVR
TLVAIRRDAP

Sequences:

>Translated_330_residues
MLLHGDAIDLCLHCESTNDAFVHADTVVLSAHVAGYITRVPVADNARVNASQTLVAIQDDDYRAHLAEKDATLGAARAAL
EVVQRQIGLETAQIAGAEAALRMAEADVAQRRLERRRQHDLITDGSTSRRDLEIADADLARLSAARDRDAALVDAARRTQ
DVLRAKLVQAQEDVSAAVSARELAAIDLGYTRIASPVAGQVTARMVYVGEYVGIGTQVARVAPLPDVWIVANFREVQLTH
MRVGQTASITIDAFPGAIFRGHVDSIGPVSGAETALLPPDNATGNFTHIVQRFPVKIVIEPDQAGTDLLRPGMSSHVSVR
TLVAIRRDAP
>Mature_330_residues
MLLHGDAIDLCLHCESTNDAFVHADTVVLSAHVAGYITRVPVADNARVNASQTLVAIQDDDYRAHLAEKDATLGAARAAL
EVVQRQIGLETAQIAGAEAALRMAEADVAQRRLERRRQHDLITDGSTSRRDLEIADADLARLSAARDRDAALVDAARRTQ
DVLRAKLVQAQEDVSAAVSARELAAIDLGYTRIASPVAGQVTARMVYVGEYVGIGTQVARVAPLPDVWIVANFREVQLTH
MRVGQTASITIDAFPGAIFRGHVDSIGPVSGAETALLPPDNATGNFTHIVQRFPVKIVIEPDQAGTDLLRPGMSSHVSVR
TLVAIRRDAP

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=313, Percent_Identity=32.2683706070287, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789041, Length=315, Percent_Identity=29.5238095238095, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1790519, Length=306, Percent_Identity=29.7385620915033, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081951, Length=298, Percent_Identity=23.8255033557047, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 35403; Mature: 35403

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLHGDAIDLCLHCESTNDAFVHADTVVLSAHVAGYITRVPVADNARVNASQTLVAIQDD
CEECCCEEEEEEEECCCCCCEEEEHHEEEHHHHHHHEEECCCCCCCEECCCEEEEEEECC
DYRAHLAEKDATLGAARAALEVVQRQIGLETAQIAGAEAALRMAEADVAQRRLERRRQHD
CCEEHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
LITDGSTSRRDLEIADADLARLSAARDRDAALVDAARRTQDVLRAKLVQAQEDVSAAVSA
CCCCCCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELAAIDLGYTRIASPVAGQVTARMVYVGEYVGIGTQVARVAPLPDVWIVANFREVQLTH
HHHHEEECCHHHHCCCCCCHHEEEEEEEEHHHCCCHHHHHCCCCCCEEEEECCEEEEEEE
MRVGQTASITIDAFPGAIFRGHVDSIGPVSGAETALLPPDNATGNFTHIVQRFPVKIVIE
EECCCEEEEEEECCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCEEEEEC
PDQAGTDLLRPGMSSHVSVRTLVAIRRDAP
CCCCCHHHHCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MLLHGDAIDLCLHCESTNDAFVHADTVVLSAHVAGYITRVPVADNARVNASQTLVAIQDD
CEECCCEEEEEEEECCCCCCEEEEHHEEEHHHHHHHEEECCCCCCCEECCCEEEEEEECC
DYRAHLAEKDATLGAARAALEVVQRQIGLETAQIAGAEAALRMAEADVAQRRLERRRQHD
CCEEHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
LITDGSTSRRDLEIADADLARLSAARDRDAALVDAARRTQDVLRAKLVQAQEDVSAAVSA
CCCCCCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELAAIDLGYTRIASPVAGQVTARMVYVGEYVGIGTQVARVAPLPDVWIVANFREVQLTH
HHHHEEECCHHHHCCCCCCHHEEEEEEEEHHHCCCHHHHHCCCCCCEEEEECCEEEEEEE
MRVGQTASITIDAFPGAIFRGHVDSIGPVSGAETALLPPDNATGNFTHIVQRFPVKIVIE
EECCCEEEEEEECCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCEEEEEC
PDQAGTDLLRPGMSSHVSVRTLVAIRRDAP
CCCCCHHHHCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]