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The map label for this gene is hchA [H]

Identifier: 162148616

GI number: 162148616

Start: 2934462

End: 2935244

Strand: Reverse

Name: hchA [H]

Synonym: GDI_2843

Alternate gene names: 162148616

Gene position: 2935244-2934462 (Counterclockwise)

Preceding gene: 162148619

Following gene: 162148615

Centisome position: 74.42

GC content: 62.58

Gene sequence:

>783_bases
ATGCTGGCTGCAGGTGTCGCGTGGTTCGCAGCCCACGGGTCGAGCATCGCCCAGACGCGGCGACGCGACGCACCGGAGAA
ACAGGGAGGCAAAACACGGATGAACATCCTCATGATCGCGACGTCTGCGGACAAGCTGGGGCAGAGCGGCCATGCGACCG
GCGTGTGGTTGGAGGAACTGACGACGCCGTTCTATGCGTTCCGGGATGGGGGCGGCGAAGTCACGCTTGCCTCCATCGAA
GGGGGCGCCATACCGATCGATACACGGAGCGTGAAAGAAGCCGGCCAGAACGAGGCATCGGTGGAACGCTATCTGTCAGA
CCCGGCGTTCAGGCATAGGGTCGCCGATACTCCGAAATTCACGAATATCGATCTCAGCGGCTTTGACGCGGTGTTTCTTC
CTGGGGGACACGGAACGATGACGGACTATCCGGAGAATTCCGCGCTCGCGCGTCTGATCGAACAGTTCGACCGAAGTGGC
CGGATCGTGTCGGCGGTCTGCCACGGCCCGGCGGGACTACTCTCTGCCCGGAAGGCGGACGGGACGCCTTTCGTCGCCGG
GCGCCGTGTCAGCGCTTTTGCCGATAGTGAGGAGCGGGCTGTCGGACTGGAGCATACGGTGCCGTTTCTGCTTGAGGACC
GTTTGCGTGCATCAGGCGCTCTCTACGAACGCGGCCCTGACTTTACATCGTTCGCCATACAGGACGGAAATCTCCTGACC
GGTCAGAATCCGGCCTCGGCGGCACGCGTCGCAAATTTGGTCATGGAGCGGCTCAAGGCGTGA

Upstream 100 bases:

>100_bases
TAGCAGCCCGCCTGTCTTCTTTGATGTCGTTATGACTGTTCGGGCTTAGGCTCCTGTTTTCAAAAGGGAGAAAACGGCTA
TGCGCGGTCGCCGGGAACTG

Downstream 100 bases:

>100_bases
GAGAACGATCATGACCCAACCAGTCGCTCTGGTCGCCGGGGCAAACGGCATCATCGGGAACGCCACCGCACAGGAACTTC
GCCGTCAGGGATGGAAGGTC

Product: intracellular protease/amidase

Products: NA

Alternate protein names: Hsp31 [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLAAGVAWFAAHGSSIAQTRRRDAPEKQGGKTRMNILMIATSADKLGQSGHATGVWLEELTTPFYAFRDGGGEVTLASIE
GGAIPIDTRSVKEAGQNEASVERYLSDPAFRHRVADTPKFTNIDLSGFDAVFLPGGHGTMTDYPENSALARLIEQFDRSG
RIVSAVCHGPAGLLSARKADGTPFVAGRRVSAFADSEERAVGLEHTVPFLLEDRLRASGALYERGPDFTSFAIQDGNLLT
GQNPASAARVANLVMERLKA

Sequences:

>Translated_260_residues
MLAAGVAWFAAHGSSIAQTRRRDAPEKQGGKTRMNILMIATSADKLGQSGHATGVWLEELTTPFYAFRDGGGEVTLASIE
GGAIPIDTRSVKEAGQNEASVERYLSDPAFRHRVADTPKFTNIDLSGFDAVFLPGGHGTMTDYPENSALARLIEQFDRSG
RIVSAVCHGPAGLLSARKADGTPFVAGRRVSAFADSEERAVGLEHTVPFLLEDRLRASGALYERGPDFTSFAIQDGNLLT
GQNPASAARVANLVMERLKA
>Mature_260_residues
MLAAGVAWFAAHGSSIAQTRRRDAPEKQGGKTRMNILMIATSADKLGQSGHATGVWLEELTTPFYAFRDGGGEVTLASIE
GGAIPIDTRSVKEAGQNEASVERYLSDPAFRHRVADTPKFTNIDLSGFDAVFLPGGHGTMTDYPENSALARLIEQFDRSG
RIVSAVCHGPAGLLSARKADGTPFVAGRRVSAFADSEERAVGLEHTVPFLLEDRLRASGALYERGPDFTSFAIQDGNLLT
GQNPASAARVANLVMERLKA

Specific function: Uses temperature-induced exposure of structured hydrophobic domains to capture and stabilize early unfolding protein intermediates under severe thermal stress. It rapidly releases them once stress has abated [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family. HchA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788278, Length=266, Percent_Identity=25.9398496240602, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320742, Length=237, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324967, Length=212, Percent_Identity=25.9433962264151, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324975, Length=212, Percent_Identity=25.9433962264151, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323984, Length=211, Percent_Identity=24.6445497630332, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017283
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 27761; Mature: 27761

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAAGVAWFAAHGSSIAQTRRRDAPEKQGGKTRMNILMIATSADKLGQSGHATGVWLEEL
CCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEEEECHHHHCCCCCCCEEEHHHH
TTPFYAFRDGGGEVTLASIEGGAIPIDTRSVKEAGQNEASVERYLSDPAFRHRVADTPKF
CCCCEEEECCCCEEEEEEECCCEEECCCHHHHHCCCCHHHHHHHHCCHHHHHHCCCCCCE
TNIDLSGFDAVFLPGGHGTMTDYPENSALARLIEQFDRSGRIVSAVCHGPAGLLSARKAD
EEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCC
GTPFVAGRRVSAFADSEERAVGLEHTVPFLLEDRLRASGALYERGPDFTSFAIQDGNLLT
CCCEECCCEEEECCCCHHHEECHHHCCHHHHHHHHHHCCCHHHCCCCCEEEEEECCCEEC
GQNPASAARVANLVMERLKA
CCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLAAGVAWFAAHGSSIAQTRRRDAPEKQGGKTRMNILMIATSADKLGQSGHATGVWLEEL
CCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEEEECHHHHCCCCCCCEEEHHHH
TTPFYAFRDGGGEVTLASIEGGAIPIDTRSVKEAGQNEASVERYLSDPAFRHRVADTPKF
CCCCEEEECCCCEEEEEEECCCEEECCCHHHHHCCCCHHHHHHHHCCHHHHHHCCCCCCE
TNIDLSGFDAVFLPGGHGTMTDYPENSALARLIEQFDRSGRIVSAVCHGPAGLLSARKAD
EEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCC
GTPFVAGRRVSAFADSEERAVGLEHTVPFLLEDRLRASGALYERGPDFTSFAIQDGNLLT
CCCEECCCEEEECCCCHHHEECHHHCCHHHHHHHHHHCCCHHHCCCCCEEEEEECCCEEC
GQNPASAARVANLVMERLKA
CCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA