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The map label for this gene is groL

Identifier: 162148428

GI number: 162148428

Start: 2742115

End: 2743740

Strand: Reverse

Name: groL

Synonym: GDI_2647

Alternate gene names: 162148428

Gene position: 2743740-2742115 (Counterclockwise)

Preceding gene: 162148429

Following gene: 162148427

Centisome position: 69.56

GC content: 65.87

Gene sequence:

>1626_bases
ATGGCCAGCAAAGACGTCAAGTTCGCCGGCGACGCACGGGCGCGCCTGCTTTCCGGAATCGACACGCTTGCCGACGCGGT
CAAGGTGACGCTGGGGCCGAAGGGCCGCAACGTCGTCATCGACAAGAGCTTCGGCGCGCCAAGGATCACCAAGGACGGTG
TCACGGTCGCCAAGGAGATCGAACTGTCCGACAAGTTCGAGAACCTGGGCGCGCAGCTTCTGCGTGAGGTCGCCAGCAAG
ACCAACGACCTGGCGGGCGACGGGACGACGACCGCGACCGTCCTGGCGCAGTCCATCGTGCGCGAGGGGCTGAAGGCGGT
CGCCGCCGGTTTCAACCCGCAGGACGTCAAGCGCGGAATCGATCACGCGACGACCGCGGTGATCGAGGAACTGCGGACGC
GTACCCGCCCGATCGCGACCCGGGAGGAAACCGCCCAGGTGGCCACGATTTCGGCCAACGGCGAGGTGGAAATCGGCCGC
ATCATTTCCGAGGCGGTGCAGAAGGTCGGCAAGGACGGTGTGATCACCGTCGAGGAAGCCAAGGGATTCGAGACCGAACT
GGACGTAGTCGAGGGGTTGCAGTTCGACCGGGGCTATATCTCGCCCTATTTCGTGACGAACAGCGAGAAGCTGATCGCGG
ACCTGGAAAATCCCTATATCCTGATCCATGAAAAGAAGCTGTCGTCGCTGCAGCCCCTGCTGCCGCTGCTGGAGAACGTG
GTCAAATCCGGGCGCCCGCTGCTGAGCATCGCCGAGGATGTCGAGGGCGAGGCCCTGGCGACCCTGGTGGTGAACAAGTT
GCGCGGCGGGCTGAAGATCGCGGCTGTCAAGGCGCCGGGCTTCGGCGACCGGCGCAAGGCCATTCTGGAGGATATCGCGA
TCCTGACGGGTGGCGAGGTCATCAGCGAGGATCTGGGCATCAAGCTGGAAAGCGTGACGCTGTCGCAGCTTGGCCAGGCG
CGGCGCATCGTGATCGACAAGGACAACACGACCATCGTCGACGGCGAGGGCGACGCCGACGCCATCAAGGGCCGCGTCGG
GCAGATCCGCGCGCAGATCGAGGAAACCACCTCGGACTACGATCGGGAAAAATTGCAGGAGCGCCTGGCGAAGCTGGCGG
GCGGAGTGGCCATCATCCGGGTCGGCGGTTCGACCGAAATCGAGGTGAAGGAGCGCAAGGATCGCGTCGATGACGCGCTG
AACGCCACGCGCGCGGCCGTCGAGGAAGGCATCGTCCCGGGCGGCGGGACCGCGCTGGCGCGCGCGGCGGAGGTCGTGGC
GCGGCTGCAGTTCCATAATGACGACCAGCGCATCGGCGGCGACATCGTCCGCAAGGCATTGCAGGCGCCGCTGCGCCAGA
TCGCGGAGAATGCCGGCGAGGACGGTGCGGTCGTGGCCGGAAAGGTGCTGGAGAACGGCGCATACAATTTCGGATTCGAT
GCGCAGATCGGCGAATTCAAGGATCTGGTCGCCGCCGGCATCATCGACCCGACCAAGGTCGTGCGCACGGCCCTGCAGGA
CGCGGCCTCGGTCGGCAGCCTGCTGATCACGACCGAGGTCCTGGTCACCGAAAAGGCCGAACCCAAGCCGGCCGCCCCAC
CGGCGGGTGCCGACCTCGGATACTGA

Upstream 100 bases:

>100_bases
GTCAGGATCGCGGGCGAGGACCTGCTGATCGCCAAGGAATCCGACCTGTTCGGTATCGTCGGGTCCACGCGCTGACATCT
CAGGGACAGGAAAAACTTCA

Downstream 100 bases:

>100_bases
CCAAGGATGCCCAGGGGTTGCGCCGGACCGGTCGTCCGGCGCAACCGCCTGCATCGCCAGGGGCTGAAGCGGAAAAGACA
TGCCAGGACACGTCACGAGT

Product: 60 kDa chaperonin

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MASKDVKFAGDARARLLSGIDTLADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELSDKFENLGAQLLREVASK
TNDLAGDGTTTATVLAQSIVREGLKAVAAGFNPQDVKRGIDHATTAVIEELRTRTRPIATREETAQVATISANGEVEIGR
IISEAVQKVGKDGVITVEEAKGFETELDVVEGLQFDRGYISPYFVTNSEKLIADLENPYILIHEKKLSSLQPLLPLLENV
VKSGRPLLSIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTGGEVISEDLGIKLESVTLSQLGQA
RRIVIDKDNTTIVDGEGDADAIKGRVGQIRAQIEETTSDYDREKLQERLAKLAGGVAIIRVGGSTEIEVKERKDRVDDAL
NATRAAVEEGIVPGGGTALARAAEVVARLQFHNDDQRIGGDIVRKALQAPLRQIAENAGEDGAVVAGKVLENGAYNFGFD
AQIGEFKDLVAAGIIDPTKVVRTALQDAASVGSLLITTEVLVTEKAEPKPAAPPAGADLGY

Sequences:

>Translated_541_residues
MASKDVKFAGDARARLLSGIDTLADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELSDKFENLGAQLLREVASK
TNDLAGDGTTTATVLAQSIVREGLKAVAAGFNPQDVKRGIDHATTAVIEELRTRTRPIATREETAQVATISANGEVEIGR
IISEAVQKVGKDGVITVEEAKGFETELDVVEGLQFDRGYISPYFVTNSEKLIADLENPYILIHEKKLSSLQPLLPLLENV
VKSGRPLLSIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTGGEVISEDLGIKLESVTLSQLGQA
RRIVIDKDNTTIVDGEGDADAIKGRVGQIRAQIEETTSDYDREKLQERLAKLAGGVAIIRVGGSTEIEVKERKDRVDDAL
NATRAAVEEGIVPGGGTALARAAEVVARLQFHNDDQRIGGDIVRKALQAPLRQIAENAGEDGAVVAGKVLENGAYNFGFD
AQIGEFKDLVAAGIIDPTKVVRTALQDAASVGSLLITTEVLVTEKAEPKPAAPPAGADLGY
>Mature_540_residues
ASKDVKFAGDARARLLSGIDTLADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELSDKFENLGAQLLREVASKT
NDLAGDGTTTATVLAQSIVREGLKAVAAGFNPQDVKRGIDHATTAVIEELRTRTRPIATREETAQVATISANGEVEIGRI
ISEAVQKVGKDGVITVEEAKGFETELDVVEGLQFDRGYISPYFVTNSEKLIADLENPYILIHEKKLSSLQPLLPLLENVV
KSGRPLLSIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTGGEVISEDLGIKLESVTLSQLGQAR
RIVIDKDNTTIVDGEGDADAIKGRVGQIRAQIEETTSDYDREKLQERLAKLAGGVAIIRVGGSTEIEVKERKDRVDDALN
ATRAAVEEGIVPGGGTALARAAEVVARLQFHNDDQRIGGDIVRKALQAPLRQIAENAGEDGAVVAGKVLENGAYNFGFDA
QIGEFKDLVAAGIIDPTKVVRTALQDAASVGSLLITTEVLVTEKAEPKPAAPPAGADLGY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=53.4839924670433, Blast_Score=559, Evalue=1e-159,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=53.4839924670433, Blast_Score=559, Evalue=1e-159,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=63.9312977099237, Blast_Score=674, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=523, Percent_Identity=52.1988527724665, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193210679, Length=205, Percent_Identity=53.1707317073171, Blast_Score=214, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.0836501901141, Blast_Score=580, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24641193, Length=523, Percent_Identity=57.17017208413, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24641191, Length=523, Percent_Identity=57.17017208413, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=53.0534351145038, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=53.0534351145038, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=53.0534351145038, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=47.7186311787072, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=39.1385767790262, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=39.1385767790262, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_GLUDA (A9HPH6)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602889.1
- RefSeq:   YP_002275266.1
- ProteinModelPortal:   A9HPH6
- SMR:   A9HPH6
- GeneID:   5790272
- GeneID:   6974258
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0861
- HOGENOM:   HBG625289
- OMA:   RIISEAV
- ProtClustDB:   CLSK2516813
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57334; Mature: 57203

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKDVKFAGDARARLLSGIDTLADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHH
ELSDKFENLGAQLLREVASKTNDLAGDGTTTATVLAQSIVREGLKAVAAGFNPQDVKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DHATTAVIEELRTRTRPIATREETAQVATISANGEVEIGRIISEAVQKVGKDGVITVEEA
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCEEEEECC
KGFETELDVVEGLQFDRGYISPYFVTNSEKLIADLENPYILIHEKKLSSLQPLLPLLENV
CCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHEECCCCEEEEECCHHHHHHHHHHHHHHH
VKSGRPLLSIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTGGEV
HHCCCCEEHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLESVTLSQLGQARRIVIDKDNTTIVDGEGDADAIKGRVGQIRAQIEETTSDY
HHHHHCCEEEEEEHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAIIRVGGSTEIEVKERKDRVDDALNATRAAVEEGIVPGGGTALA
HHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAAEVVARLQFHNDDQRIGGDIVRKALQAPLRQIAENAGEDGAVVAGKVLENGAYNFGFD
HHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCC
AQIGEFKDLVAAGIIDPTKVVRTALQDAASVGSLLITTEVLVTEKAEPKPAAPPAGADLG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCCCCCCCCCCC
Y
C
>Mature Secondary Structure 
ASKDVKFAGDARARLLSGIDTLADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHH
ELSDKFENLGAQLLREVASKTNDLAGDGTTTATVLAQSIVREGLKAVAAGFNPQDVKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DHATTAVIEELRTRTRPIATREETAQVATISANGEVEIGRIISEAVQKVGKDGVITVEEA
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCEEEEECC
KGFETELDVVEGLQFDRGYISPYFVTNSEKLIADLENPYILIHEKKLSSLQPLLPLLENV
CCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHEECCCCEEEEECCHHHHHHHHHHHHHHH
VKSGRPLLSIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTGGEV
HHCCCCEEHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLESVTLSQLGQARRIVIDKDNTTIVDGEGDADAIKGRVGQIRAQIEETTSDY
HHHHHCCEEEEEEHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAIIRVGGSTEIEVKERKDRVDDALNATRAAVEEGIVPGGGTALA
HHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAAEVVARLQFHNDDQRIGGDIVRKALQAPLRQIAENAGEDGAVVAGKVLENGAYNFGFD
HHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCC
AQIGEFKDLVAAGIIDPTKVVRTALQDAASVGSLLITTEVLVTEKAEPKPAAPPAGADLG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCCCCCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA