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The map label for this gene is ctaD [H]

Identifier: 162148378

GI number: 162148378

Start: 2688316

End: 2689938

Strand: Reverse

Name: ctaD [H]

Synonym: GDI_2596

Alternate gene names: 162148378

Gene position: 2689938-2688316 (Counterclockwise)

Preceding gene: 162148379

Following gene: 162148377

Centisome position: 68.2

GC content: 63.77

Gene sequence:

>1623_bases
ATGTCGGAAAGCTATCTCTGGCAGGACGGAACCCTGCGATCCTGGCTGCTGACGCGTGACCACAAGCGGATCGGCCTGCT
CTATCTGGGCTCGATCACCGCCTTCTTTGTGCTGGGCAGCGTCGGGGCGGCGCTGGTGCGGCTGCAGTTGCTGGAACCGA
ACGGCACCATCCTGTCCGATGCGACCTATAACCGGATGTTCACCATGCATGGCGTGGTGATGGTCTGGCTGTTCCTGGTG
CCGTCGATTCCGGTCACGCTGGGGAACTTCCTGGTCCCGCTGATGCTGGGCGCCCGCGACCTTGCGTTTCCGCGCCTCAA
CCTTATCAGTTGGTACCTCTTCGTCGCGTCGGGCCTGCTGGTGGTCTACGGGCTGTTCCGGGGCGGCCTGGAAACCGGCT
GGACGTTCTATACCCCGCTTTCGTCGGATTATACCGAGGGCCGGGTACTGCCGGTCGTGCTGGGTATCTTCCTCAACGGG
TTTTCCTCGATCGCGACGGGGGTGAACTTCATCGTCAGCATCCATCAGCTCCGCGCGCCGGGCATGACGTGGTACCGCCT
GCCGCTGATGCTGTGGGCGCTGTATGCCACCAGCGTCATCTTCGTGCTGGCGACACCGGTCCTGGGCATCACGCTGCTGC
TGCTGGCGTTCGAACGCCTGTTCCACGTGGGCGTGTTCGACCCGACGCTGGGCGGCGATCCGCTGCTGTTCCAGCAGATG
TTCTGGTTCTACTCCCACCCCGCCGTCTACATCATGATCCTGCCCGGCATGGGCGTGGTCAGCGAAATCGTCAGCACGTT
CTGCCACAAGCCGGTGTTCGGCTACCGCTTCGTGGCATGGTCGTCGGTCTCGATCGCGGCGATCGGCTTCATCGTGTGGG
GGCACCACATGTTCGTCGCCGGAACGTCGCTCTATTCCGCCATCGTCTTTTCGATGTTCAGCTTCTTCGTCTCGGTCCCG
TCGGCCATCAAGGTCTTCAACTGGCTGGGCACGATGCATGGCGGTTCCATCCGCCTGGACGCCCCGATGCTGTATGCGAT
GGGCTTCATCGGCCTGTTCACCGTGGGCGGCCTGACCGGCCTGTTCCTGGCCTCGCTGGCCGCCGACGTGCATCTGACGC
AGACCTATTTCGTGGTCGCGCATTTCCACTACATCATGGTCGGCGGCATGGTATCGGCCTATTTCGGCGGCCTGCATTAC
TGGTGGCCCAAGATCACGGGCCGGATGTACCCCGAAATGTGGGGACGCCTGGCGGCCGCCCTGATCTTCTTCGGCTTCAA
CCTGACCTTCTTCCCCCAGTTCATCCTGGGGTTCGAGGGCATGCCCCGCCGCTATGCCACCTATCCCGCGCAGTTCCAGG
TCCTGAACGTGCTGTCCTCGGCCGGGGCGAGTATCCTGGCCGTCGCCTATGCGATGCCGCTGGTCTATTTCACCTGGTCG
CTGTTTCGCGGCGCCCGCGCGCCCGACAACCCGTGGGGGGCGACGGGCCTGGAATGGCGGACGACATCGCCCCCGCCCAC
CGAGAATTTCGCCGTCACACCGGTCGTGACCACCGACGCGTACGATTACGCGGACCTGGATACCCATGCCGGGCTGGCGG
ATACGGGGGTGCCGCATGTCTGA

Upstream 100 bases:

>100_bases
TCCTTTCGCGGCGTCCTGGCCGAGGACGACCTGGCCGCGCTGGTCGCCTACCTGCAGACCCTCTCGCCCGCCCTTCCTCC
AGTTGCAGGGAATTGACGCG

Downstream 100 bases:

>100_bases
CGGTTCGACGCTCGACCACCATTCCCCTTACGAGACGCCCCTGCATCGCGACGAAAGCGCGCTTGCCGGCATGTGGCTGT
TCCTGGCCAGCGAGGCGCTG

Product: cytochrome c oxidase subunit 1

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSESYLWQDGTLRSWLLTRDHKRIGLLYLGSITAFFVLGSVGAALVRLQLLEPNGTILSDATYNRMFTMHGVVMVWLFLV
PSIPVTLGNFLVPLMLGARDLAFPRLNLISWYLFVASGLLVVYGLFRGGLETGWTFYTPLSSDYTEGRVLPVVLGIFLNG
FSSIATGVNFIVSIHQLRAPGMTWYRLPLMLWALYATSVIFVLATPVLGITLLLLAFERLFHVGVFDPTLGGDPLLFQQM
FWFYSHPAVYIMILPGMGVVSEIVSTFCHKPVFGYRFVAWSSVSIAAIGFIVWGHHMFVAGTSLYSAIVFSMFSFFVSVP
SAIKVFNWLGTMHGGSIRLDAPMLYAMGFIGLFTVGGLTGLFLASLAADVHLTQTYFVVAHFHYIMVGGMVSAYFGGLHY
WWPKITGRMYPEMWGRLAAALIFFGFNLTFFPQFILGFEGMPRRYATYPAQFQVLNVLSSAGASILAVAYAMPLVYFTWS
LFRGARAPDNPWGATGLEWRTTSPPPTENFAVTPVVTTDAYDYADLDTHAGLADTGVPHV

Sequences:

>Translated_540_residues
MSESYLWQDGTLRSWLLTRDHKRIGLLYLGSITAFFVLGSVGAALVRLQLLEPNGTILSDATYNRMFTMHGVVMVWLFLV
PSIPVTLGNFLVPLMLGARDLAFPRLNLISWYLFVASGLLVVYGLFRGGLETGWTFYTPLSSDYTEGRVLPVVLGIFLNG
FSSIATGVNFIVSIHQLRAPGMTWYRLPLMLWALYATSVIFVLATPVLGITLLLLAFERLFHVGVFDPTLGGDPLLFQQM
FWFYSHPAVYIMILPGMGVVSEIVSTFCHKPVFGYRFVAWSSVSIAAIGFIVWGHHMFVAGTSLYSAIVFSMFSFFVSVP
SAIKVFNWLGTMHGGSIRLDAPMLYAMGFIGLFTVGGLTGLFLASLAADVHLTQTYFVVAHFHYIMVGGMVSAYFGGLHY
WWPKITGRMYPEMWGRLAAALIFFGFNLTFFPQFILGFEGMPRRYATYPAQFQVLNVLSSAGASILAVAYAMPLVYFTWS
LFRGARAPDNPWGATGLEWRTTSPPPTENFAVTPVVTTDAYDYADLDTHAGLADTGVPHV
>Mature_539_residues
SESYLWQDGTLRSWLLTRDHKRIGLLYLGSITAFFVLGSVGAALVRLQLLEPNGTILSDATYNRMFTMHGVVMVWLFLVP
SIPVTLGNFLVPLMLGARDLAFPRLNLISWYLFVASGLLVVYGLFRGGLETGWTFYTPLSSDYTEGRVLPVVLGIFLNGF
SSIATGVNFIVSIHQLRAPGMTWYRLPLMLWALYATSVIFVLATPVLGITLLLLAFERLFHVGVFDPTLGGDPLLFQQMF
WFYSHPAVYIMILPGMGVVSEIVSTFCHKPVFGYRFVAWSSVSIAAIGFIVWGHHMFVAGTSLYSAIVFSMFSFFVSVPS
AIKVFNWLGTMHGGSIRLDAPMLYAMGFIGLFTVGGLTGLFLASLAADVHLTQTYFVVAHFHYIMVGGMVSAYFGGLHYW
WPKITGRMYPEMWGRLAAALIFFGFNLTFFPQFILGFEGMPRRYATYPAQFQVLNVLSSAGASILAVAYAMPLVYFTWSL
FRGARAPDNPWGATGLEWRTTSPPPTENFAVTPVVTTDAYDYADLDTHAGLADTGVPHV

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=504, Percent_Identity=40.2777777777778, Blast_Score=357, Evalue=1e-98,
Organism=Escherichia coli, GI1786634, Length=529, Percent_Identity=37.2400756143667, Blast_Score=336, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6226519, Length=536, Percent_Identity=37.5, Blast_Score=338, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6226524, Length=327, Percent_Identity=37.3088685015291, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6226523, Length=251, Percent_Identity=34.2629482071713, Blast_Score=120, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59855; Mature: 59724

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESYLWQDGTLRSWLLTRDHKRIGLLYLGSITAFFVLGSVGAALVRLQLLEPNGTILSD
CCCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEECC
ATYNRMFTMHGVVMVWLFLVPSIPVTLGNFLVPLMLGARDLAFPRLNLISWYLFVASGLL
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHH
VVYGLFRGGLETGWTFYTPLSSDYTEGRVLPVVLGIFLNGFSSIATGVNFIVSIHQLRAP
HHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GMTWYRLPLMLWALYATSVIFVLATPVLGITLLLLAFERLFHVGVFDPTLGGDPLLFQQM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
FWFYSHPAVYIMILPGMGVVSEIVSTFCHKPVFGYRFVAWSSVSIAAIGFIVWGHHMFVA
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
GTSLYSAIVFSMFSFFVSVPSAIKVFNWLGTMHGGSIRLDAPMLYAMGFIGLFTVGGLTG
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHH
LFLASLAADVHLTQTYFVVAHFHYIMVGGMVSAYFGGLHYWWPKITGRMYPEMWGRLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHH
LIFFGFNLTFFPQFILGFEGMPRRYATYPAQFQVLNVLSSAGASILAVAYAMPLVYFTWS
HHHHHCCHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LFRGARAPDNPWGATGLEWRTTSPPPTENFAVTPVVTTDAYDYADLDTHAGLADTGVPHV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SESYLWQDGTLRSWLLTRDHKRIGLLYLGSITAFFVLGSVGAALVRLQLLEPNGTILSD
CCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEECC
ATYNRMFTMHGVVMVWLFLVPSIPVTLGNFLVPLMLGARDLAFPRLNLISWYLFVASGLL
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHH
VVYGLFRGGLETGWTFYTPLSSDYTEGRVLPVVLGIFLNGFSSIATGVNFIVSIHQLRAP
HHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GMTWYRLPLMLWALYATSVIFVLATPVLGITLLLLAFERLFHVGVFDPTLGGDPLLFQQM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
FWFYSHPAVYIMILPGMGVVSEIVSTFCHKPVFGYRFVAWSSVSIAAIGFIVWGHHMFVA
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
GTSLYSAIVFSMFSFFVSVPSAIKVFNWLGTMHGGSIRLDAPMLYAMGFIGLFTVGGLTG
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHH
LFLASLAADVHLTQTYFVVAHFHYIMVGGMVSAYFGGLHYWWPKITGRMYPEMWGRLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHH
LIFFGFNLTFFPQFILGFEGMPRRYATYPAQFQVLNVLSSAGASILAVAYAMPLVYFTWS
HHHHHCCHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LFRGARAPDNPWGATGLEWRTTSPPPTENFAVTPVVTTDAYDYADLDTHAGLADTGVPHV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]