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The map label for this gene is dcp [H]

Identifier: 162148366

GI number: 162148366

Start: 2676327

End: 2678480

Strand: Direct

Name: dcp [H]

Synonym: GDI_2583

Alternate gene names: 162148366

Gene position: 2676327-2678480 (Clockwise)

Preceding gene: 162148363

Following gene: 162148367

Centisome position: 67.86

GC content: 66.16

Gene sequence:

>2154_bases
ATGCCACCGCAGAAGGTCTGGAAACGCATGAATCGTACCGTCTGGCTTCGTACCGTCGCCGCGTGCCTGGGTGGCTGGGC
GGCCCTGTCCGGCCCGGCCCATGCCGCCGACAATCCGTTCCTGACCGCCAGCACGCTGCCGTTCCAGGCCCCGCGCTTCG
ACCTGATCCATGACGGCGACTACCAGCCCGCGTTCGAGCAGGGCATGGCGCAGCAGATGGCCGAAATCCAGGCAATCGCG
GATTATCCCGCGCCCCCGACCTTCGACAACACCATCGCGGCAATGGAACGTTCTGGCCGCGTGCTGGACCGGGTGTCCGA
GACCTTCGACGGGGTGTACCAGGCCAACACCAATCCGGCGCTGGATGCCGTGCAAACGGCCATCGCGCCGAAACTGGCCC
AGCATCAGGATGCGATCTACCTGAATCCCGGACTGTTCGCCCGGGTCCGCACGCTGTACGACGCGCGCGCCACGCTGCAC
CTGACGGAAGAGCAGGCGCAGCTCCTGACGGTCTATTATCAGCAATTCATCCATGCCGGCGCGCAATTGTCCGCCGCGGA
CCAGGCGACGCTGCGCGGATTGAACACGCACCTGTCGCAACTGGAAACCCGCTTCCAGCAGACCTTGCTGACAGCGACCC
GGCAGGGCGCGCTGGTCGTCTGGCGCCCCGCCGCCCTGCACGGGCTGGACCGGGCCGCACTGGATGCCGCCGCCGAAGCC
GCCAGGGGGCGCGGGCTGACGGACGCATGGGCGCTGCCGCTGCAGAACACGACGCAGCAGCCGGACCTGCAATCCCTGAC
CGATCGCGCCACGCGCCAGGCGCTGTTCGCCGATAGCTGGCTGCGCGCCGAACACGGCGACAGCGGGGACACGCGCGCCG
TCATCGCCGAACTGGCGCAGTTGCGCGCGCGCAAGGCAGCACTGCTGGGCTATCCCGATTACGCGTCATACGTGCTGTAT
GACCAGATGGCCGATACCCCTGCGAAGGTGCAGCGTTTCATCGCGCAGCTCGTGCCCGCGACGCTGGCCGAACAGAAGCG
CGAAATCGCGGATATCCGCGCCGCCATCCATGTGGACGGCCAGACCTTCCAGCCCCAGCCGTGGGACTGGACCCATTACG
CCGAACAGGTGCGCAAGGCGCGCTACGACCTGGACCAGAACCAGGTCAAACCCTATTTCGAACTGGACAGGGTGCTGCGC
GACGGCGTGTTCTTCGCCGCCAACCGGCTGTACGGGCTTACATTCACCGAACGCAAGGACATCCCCGTCTACAACCCCGA
CGTACGGGTGTTCCAGGTCACCGACAAGGACGGGTCGCCGCTGGCGCTGATCTATTTCGATTACTTCAAGCGCGACAACA
AGAACGGCGGCGCCTGGATGTCGAATTTCGTGGGGCAGTCGCACCTGCTGGGCACGAAGCCGGTGGTCTATAACGTCGCG
AACTTCACCAAGCCGGCGCCGGGGCAACCCGCCCTGATCAGTTTCGACGACGTCACCACGATGTTCCACGAATTCGGCCA
TGCGCTGCACGGCATGTTCGCCGACCAGACCTATCCCACCCTGTCCGGCACCGCCGTGGCCCGCGATTTCGTCGAATTCC
CGTCCCAGTTCAACGAACATTGGGCGCTGGACCCGATCGTCTTCGCCCATTACGCCAGACAGTACCAGACCGGCGCCGCG
ATGCCGCAGCCCCTGGTCGACAAGATCAGGAAGGCCGCGCGCTTCGACCAGGGCTACGCGCTGGGCGAGGTCATCGCCGC
CGCCAAGCTGGACATGGACTGGCACATGCTGCCCGCCGGCGCCCCGCGCCAGGACGTCGACCGGTTCGAAGCGGACTCGC
TGGCCCGATCCGGACTGGATACCACGGACGTTCCGCCCCGCTACCGGTCCAGCTATTTCCTGCACATCTGGGCCAACGGC
TATGCCGCCGGCTATTATGCCTATCTGTGGACCGAGATGCTGGACGACGCGGCGTTTTCCTGGTTCCGCGCCCACGGCGG
GCTGACGCGCGAAAACGGGCAGCGCTTCCGCGACATGATCCTGTCACGCGGGCATACGATGGCGTACGGCCCGATGTTCC
GCGCCTTCTACGGCCAGGACCCCGATATCACCCCGATGCTGCGACATCGCGGGCTGGTCCCGGGCCAGGAGTGA

Upstream 100 bases:

>100_bases
TATTTTGCAAATCCACCACGCCATCCACGGCCTTAAGCGGCCTGCCGGATCGTTTCGGGTCGGGTGGATTTTCATGCCCC
GTTGGCCCATCCTGCGCGCC

Downstream 100 bases:

>100_bases
CCCGCACGCGTTGAGGCAAATCATTGGCCAGGCGCGACGGATGGCGCACCATGGCCCCGATTTTCGACAAGGAGAGACCA
CCATGGCCCGCGTTTCCGGA

Product: peptidyl-dipeptidase dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 717; Mature: 716

Protein sequence:

>717_residues
MPPQKVWKRMNRTVWLRTVAACLGGWAALSGPAHAADNPFLTASTLPFQAPRFDLIHDGDYQPAFEQGMAQQMAEIQAIA
DYPAPPTFDNTIAAMERSGRVLDRVSETFDGVYQANTNPALDAVQTAIAPKLAQHQDAIYLNPGLFARVRTLYDARATLH
LTEEQAQLLTVYYQQFIHAGAQLSAADQATLRGLNTHLSQLETRFQQTLLTATRQGALVVWRPAALHGLDRAALDAAAEA
ARGRGLTDAWALPLQNTTQQPDLQSLTDRATRQALFADSWLRAEHGDSGDTRAVIAELAQLRARKAALLGYPDYASYVLY
DQMADTPAKVQRFIAQLVPATLAEQKREIADIRAAIHVDGQTFQPQPWDWTHYAEQVRKARYDLDQNQVKPYFELDRVLR
DGVFFAANRLYGLTFTERKDIPVYNPDVRVFQVTDKDGSPLALIYFDYFKRDNKNGGAWMSNFVGQSHLLGTKPVVYNVA
NFTKPAPGQPALISFDDVTTMFHEFGHALHGMFADQTYPTLSGTAVARDFVEFPSQFNEHWALDPIVFAHYARQYQTGAA
MPQPLVDKIRKAARFDQGYALGEVIAAAKLDMDWHMLPAGAPRQDVDRFEADSLARSGLDTTDVPPRYRSSYFLHIWANG
YAAGYYAYLWTEMLDDAAFSWFRAHGGLTRENGQRFRDMILSRGHTMAYGPMFRAFYGQDPDITPMLRHRGLVPGQE

Sequences:

>Translated_717_residues
MPPQKVWKRMNRTVWLRTVAACLGGWAALSGPAHAADNPFLTASTLPFQAPRFDLIHDGDYQPAFEQGMAQQMAEIQAIA
DYPAPPTFDNTIAAMERSGRVLDRVSETFDGVYQANTNPALDAVQTAIAPKLAQHQDAIYLNPGLFARVRTLYDARATLH
LTEEQAQLLTVYYQQFIHAGAQLSAADQATLRGLNTHLSQLETRFQQTLLTATRQGALVVWRPAALHGLDRAALDAAAEA
ARGRGLTDAWALPLQNTTQQPDLQSLTDRATRQALFADSWLRAEHGDSGDTRAVIAELAQLRARKAALLGYPDYASYVLY
DQMADTPAKVQRFIAQLVPATLAEQKREIADIRAAIHVDGQTFQPQPWDWTHYAEQVRKARYDLDQNQVKPYFELDRVLR
DGVFFAANRLYGLTFTERKDIPVYNPDVRVFQVTDKDGSPLALIYFDYFKRDNKNGGAWMSNFVGQSHLLGTKPVVYNVA
NFTKPAPGQPALISFDDVTTMFHEFGHALHGMFADQTYPTLSGTAVARDFVEFPSQFNEHWALDPIVFAHYARQYQTGAA
MPQPLVDKIRKAARFDQGYALGEVIAAAKLDMDWHMLPAGAPRQDVDRFEADSLARSGLDTTDVPPRYRSSYFLHIWANG
YAAGYYAYLWTEMLDDAAFSWFRAHGGLTRENGQRFRDMILSRGHTMAYGPMFRAFYGQDPDITPMLRHRGLVPGQE
>Mature_716_residues
PPQKVWKRMNRTVWLRTVAACLGGWAALSGPAHAADNPFLTASTLPFQAPRFDLIHDGDYQPAFEQGMAQQMAEIQAIAD
YPAPPTFDNTIAAMERSGRVLDRVSETFDGVYQANTNPALDAVQTAIAPKLAQHQDAIYLNPGLFARVRTLYDARATLHL
TEEQAQLLTVYYQQFIHAGAQLSAADQATLRGLNTHLSQLETRFQQTLLTATRQGALVVWRPAALHGLDRAALDAAAEAA
RGRGLTDAWALPLQNTTQQPDLQSLTDRATRQALFADSWLRAEHGDSGDTRAVIAELAQLRARKAALLGYPDYASYVLYD
QMADTPAKVQRFIAQLVPATLAEQKREIADIRAAIHVDGQTFQPQPWDWTHYAEQVRKARYDLDQNQVKPYFELDRVLRD
GVFFAANRLYGLTFTERKDIPVYNPDVRVFQVTDKDGSPLALIYFDYFKRDNKNGGAWMSNFVGQSHLLGTKPVVYNVAN
FTKPAPGQPALISFDDVTTMFHEFGHALHGMFADQTYPTLSGTAVARDFVEFPSQFNEHWALDPIVFAHYARQYQTGAAM
PQPLVDKIRKAARFDQGYALGEVIAAAKLDMDWHMLPAGAPRQDVDRFEADSLARSGLDTTDVPPRYRSSYFLHIWANGY
AAGYYAYLWTEMLDDAAFSWFRAHGGLTRENGQRFRDMILSRGHTMAYGPMFRAFYGQDPDITPMLRHRGLVPGQE

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=678, Percent_Identity=28.023598820059, Blast_Score=209, Evalue=9e-54,
Organism=Homo sapiens, GI14149738, Length=617, Percent_Identity=25.2836304700162, Blast_Score=176, Evalue=9e-44,
Organism=Homo sapiens, GI156105687, Length=406, Percent_Identity=25.3694581280788, Blast_Score=132, Evalue=9e-31,
Organism=Escherichia coli, GI1787819, Length=675, Percent_Identity=52.7407407407407, Blast_Score=699, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=31.0495626822157, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6319793, Length=601, Percent_Identity=25.1247920133111, Blast_Score=173, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322715, Length=471, Percent_Identity=23.7791932059448, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21356111, Length=544, Percent_Identity=23.1617647058824, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20129717, Length=404, Percent_Identity=25.990099009901, Blast_Score=113, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 80393; Mature: 80262

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPQKVWKRMNRTVWLRTVAACLGGWAALSGPAHAADNPFLTASTLPFQAPRFDLIHDGD
CCHHHHHHHHCHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEECCC
YQPAFEQGMAQQMAEIQAIADYPAPPTFDNTIAAMERSGRVLDRVSETFDGVYQANTNPA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCEECCCCHH
LDAVQTAIAPKLAQHQDAIYLNPGLFARVRTLYDARATLHLTEEQAQLLTVYYQQFIHAG
HHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHCC
AQLSAADQATLRGLNTHLSQLETRFQQTLLTATRQGALVVWRPAALHGLDRAALDAAAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCHHHHHHHHHHH
ARGRGLTDAWALPLQNTTQQPDLQSLTDRATRQALFADSWLRAEHGDSGDTRAVIAELAQ
HHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LRARKAALLGYPDYASYVLYDQMADTPAKVQRFIAQLVPATLAEQKREIADIRAAIHVDG
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
QTFQPQPWDWTHYAEQVRKARYDLDQNQVKPYFELDRVLRDGVFFAANRLYGLTFTERKD
CCCCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCHHHHHHHEEEEEECCCCC
IPVYNPDVRVFQVTDKDGSPLALIYFDYFKRDNKNGGAWMSNFVGQSHLLGTKPVVYNVA
CCCCCCCEEEEEEECCCCCCEEEEEEEHHHCCCCCCCHHHHHHCCCHHCCCCCCCEEEHH
NFTKPAPGQPALISFDDVTTMFHEFGHALHGMFADQTYPTLSGTAVARDFVEFPSQFNEH
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
WALDPIVFAHYARQYQTGAAMPQPLVDKIRKAARFDQGYALGEVIAAAKLDMDWHMLPAG
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCC
APRQDVDRFEADSLARSGLDTTDVPPRYRSSYFLHIWANGYAAGYYAYLWTEMLDDAAFS
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
WFRAHGGLTRENGQRFRDMILSRGHTMAYGPMFRAFYGQDPDITPMLRHRGLVPGQE
HHHHHCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
PPQKVWKRMNRTVWLRTVAACLGGWAALSGPAHAADNPFLTASTLPFQAPRFDLIHDGD
CHHHHHHHHCHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEECCC
YQPAFEQGMAQQMAEIQAIADYPAPPTFDNTIAAMERSGRVLDRVSETFDGVYQANTNPA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCEECCCCHH
LDAVQTAIAPKLAQHQDAIYLNPGLFARVRTLYDARATLHLTEEQAQLLTVYYQQFIHAG
HHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHCC
AQLSAADQATLRGLNTHLSQLETRFQQTLLTATRQGALVVWRPAALHGLDRAALDAAAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCHHHHHHHHHHH
ARGRGLTDAWALPLQNTTQQPDLQSLTDRATRQALFADSWLRAEHGDSGDTRAVIAELAQ
HHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LRARKAALLGYPDYASYVLYDQMADTPAKVQRFIAQLVPATLAEQKREIADIRAAIHVDG
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
QTFQPQPWDWTHYAEQVRKARYDLDQNQVKPYFELDRVLRDGVFFAANRLYGLTFTERKD
CCCCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCHHHHHHHEEEEEECCCCC
IPVYNPDVRVFQVTDKDGSPLALIYFDYFKRDNKNGGAWMSNFVGQSHLLGTKPVVYNVA
CCCCCCCEEEEEEECCCCCCEEEEEEEHHHCCCCCCCHHHHHHCCCHHCCCCCCCEEEHH
NFTKPAPGQPALISFDDVTTMFHEFGHALHGMFADQTYPTLSGTAVARDFVEFPSQFNEH
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
WALDPIVFAHYARQYQTGAAMPQPLVDKIRKAARFDQGYALGEVIAAAKLDMDWHMLPAG
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCC
APRQDVDRFEADSLARSGLDTTDVPPRYRSSYFLHIWANGYAAGYYAYLWTEMLDDAAFS
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
WFRAHGGLTRENGQRFRDMILSRGHTMAYGPMFRAFYGQDPDITPMLRHRGLVPGQE
HHHHHCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]