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The map label for this gene is 162148188

Identifier: 162148188

GI number: 162148188

Start: 2493571

End: 2496489

Strand: Reverse

Name: 162148188

Synonym: GDI_2405

Alternate gene names: NA

Gene position: 2496489-2493571 (Counterclockwise)

Preceding gene: 162148189

Following gene: 162148187

Centisome position: 63.3

GC content: 46.83

Gene sequence:

>2919_bases
GTGGAAATGATCGTAAAGCGAATGGCGCTGAAGGCGGGATCTGCAGCAGGCTGGACAAGAGAGGGAGATGCTGCCCGCGA
CAGGGGTGACTGGCCTGCGTCCGCGGCTGCTTACGAAAAGGCGCTCGAACTGCAGCCTCTGTTAGGACATATCTGGATTC
AATATGGGCACGCTCTGAAGGAAAGTGGGGAGTTGGACAAGGCCCACATCGCCTATCGTCGGGGAGTTGAGATTCTGCCG
ACTTCTTCAGATGCTTATATTCAACTAGGACACATTCTGAAATTAAAGAATGACCCATTGCGCGCAACTATTGCCTATCG
ACAAGCAGTGATTCTTGACCCGGATAACGATAATGCTCTCAGGGAACTTCGAACTGCCGAATGGACTGACGCTGAAATTA
TGGAAACCACATGTTCTCAGGAGGTGGGCAGGAAATGTCCTCCAACCCGTTCTGATTTTACACGATTAGTATCAAAGTCG
TTTATAAAATTTGATGCTCAAAATTACCGCGATCAGTTTCCAGATGTATCATTTTTGATTGATTTGGGGGTTATATATTC
ACCTGAGCAGCATTATCTGCATTACGGATATAGGGGGGGGAGGGATATTCTTCTTTCCCTAGAGCAAAAAGCTCCGTCGC
GGGCGTTTGTCCTGTGTCCAAGTTTTTTCAAGCGATGTGGTATCGGCGAACATGCTCGTTATCTGGCGCATAGTATCGAG
GCATCAGGATTAGAAACGCATCGAATCCGAACGACCGTTGAGTTGGAGCAATTTTCTCCGGCAATTCTTCAAGATGCGAT
TCTTATTATCAATCATGGTCCAGGCTTGTTTGATGCATATAATCCTGAACTCTCCGAGGGTGAGAGTGTAAGCGACGTTA
TTTCGAAATCAATCGATGTATTCGATAAATATAATACGCGCACCGTTGTGTTGATGCATTCCCTGCTCGACCGAGACAAC
AGAGAGATGTTTCCGCGGCAGCAGCTTTGGCTGGAAAGTCCGTTGCCGATTGTCACGACTATCCAAGCAGCGGCGACATT
TTTTAATCTCATCCATATCGAGCACGGAATGCAACCTGTGGAGGTGCCTCCCGCGGTGCCGAAAGCTAAAAATAGCCGAG
ATTATCCGACTATCGGATTTTTTGGTTTTTTCCAGTGGGGTGGAAAGAATTTCGACGCTCTCTTCAATGCGGTGGAACGG
CTGAAAGGTAAATTGGTTGGTTCGGTTGCCACTGGGAAAGAGTATGATATTGAAAAATTGCGGGAAACTTTAAAAGAACG
AGGTATTAATTGCGATCTCGGAACTGGATGGGTTGACGACTCCGAGTTGACGAGACGGCTATCGGAAGCTGATTATTTTT
ATCTTCCGCAGTACGATTATGATCATTGGAACAATAGCGGTACGGCGCGCTTGGTGATGAACTTTCGCCTCCCGGTCGTT
CTCCCGCCGCATAATCCGTTTCTTGATTTGCGTAAATATGCCATTTTTGCGGATGAGGCTGATGTCCCCGCGATTATGTC
GTGGATGCGTATTCCGAAAATTTACGAGGATGCGGCGACTCGCTCCGAGCGTTATGCAAAGGCGCATCCGATGCTCGTGG
AAATGCCGAAACTGGCGCATGGTCTGAAACAGGTGGTGGCCGCAAGCGGGGCGGATGTTTTTCTGGACCCCAATCTTTTT
AGCGTGTGGTCGCTGCTGAGTGTTTCGTCAGACGTGTTCCTGAAGCGTGTCTCTTTTCGGACGTCTGATGATGATCTGGA
TTTTCAATCGACCGATCCAGATAGTGATGAACGCCTGGAGCAGATCTTGGCATTGCGCGCGCATTATCCACATCTATTCG
GTTTGATTTTTAATGTCGTGCAACCTGTTCATTACTGGCGAGATCATTATGATCTTGATTCATTTTTCTTCCCGACATGG
GGAGAAACGATAACAAACGTCTGTCGTGTTATGTATAAAAATGAACCAAATTTTTCATATGTTAATAAAATTCTCAGTTT
GCTGGGTGTCGAACTACAAGGGATAAATGACGCTATTTCGCCCAGCCAGACACTTTCCCTGCTTCGCTGGCATATGTTCC
GAGAGCCCAATTTGGATTTTGCTCCTTGCGTGCAAATTTATCATGCGGGCAGTCCGTTGGCACTCGACAACTTGAGTTCG
TCTGATCTTCTCGCCACTTTTGAGGAGACCACGACTCGTCGACTTGCACTTTGTAAAAAGGTTCATATTTCCAATGAACC
TCTGTTCTGTCCTGAAAATGACCGGAATTTATTGAAGTTATTAACACTTCCGACTGAATGGGTGGATCGGGCTCTGACGG
AGTGTGCCCGTTCGGCGGGGAAAGATTTTGTATTCGAAGGGGTTGGTGAAATACAGGACATCTACCTTAGATATAATAAG
TTGCTATATTCTCTTAGTGGTAAGGATGTTAGAGTGTCTGACATTGGTCTGCTTGATAGGCCAATTGTTGATTCTGTAAA
TTTCCACCGTTTTGTTTATTCTATTGCAGATTTTTGGCATTTTGACGGTGACGGATTGATTTTTCAGGTGGTACGCTGTT
TGCTAAAGCGGGATCCTTCTCCTCGCGAGATGTTTGCGCTAAGCCAAATTTATGATCAAAAAGGGCGTCTGGCGGTCATT
CAATGTGTTGCTGCCTATCCCTATATAAGCACGCGTGTTGTCGATTTGAACGCGGATCATCTCGTGATGAAACTTGATGA
GATGCGCAAGGCTACCGAAGTTTTGGTCGGGCAGGTTCGTTCACCTTATGCTGGTGGTTGGGATTTGCGGAACAAATATC
TTGAAGATCGGCGGAACTTTGACCGGGCTTGGCTGCGAATGAAGAATATTAAAGACTTGTGGTGGTCTCAGTCCGGTGGC
AGCATAGACAGCATTGTTTCCCTCAACGTCCACTCCTAA

Upstream 100 bases:

>100_bases
GGTGCTGTTTTTTTTGCGAAACCGTGGCGGCATTGTGGACTGATATTTTTGATTAGTCTATAAATATTCTGGAACGTGCG
TAAATAGGTAAGGTTTATAC

Downstream 100 bases:

>100_bases
GTGCCGAAAATAGTTATAATAATTTATCGATTAGATGGCGGCGGTCTCATTTGCGAGATTGCCGCCGATATAGACGACAC
AGACACCGTCCATTCGTTCC

Product: hypothetical protein

Products: NA

Alternate protein names: Group 1 Glycosyl Transferase; O-Linked GlcNAc Transferase Protein; Peptidase S1 And S6 Chymotrypsin/Hap; Radical SAM Domain Protein

Number of amino acids: Translated: 972; Mature: 972

Protein sequence:

>972_residues
MEMIVKRMALKAGSAAGWTREGDAARDRGDWPASAAAYEKALELQPLLGHIWIQYGHALKESGELDKAHIAYRRGVEILP
TSSDAYIQLGHILKLKNDPLRATIAYRQAVILDPDNDNALRELRTAEWTDAEIMETTCSQEVGRKCPPTRSDFTRLVSKS
FIKFDAQNYRDQFPDVSFLIDLGVIYSPEQHYLHYGYRGGRDILLSLEQKAPSRAFVLCPSFFKRCGIGEHARYLAHSIE
ASGLETHRIRTTVELEQFSPAILQDAILIINHGPGLFDAYNPELSEGESVSDVISKSIDVFDKYNTRTVVLMHSLLDRDN
REMFPRQQLWLESPLPIVTTIQAAATFFNLIHIEHGMQPVEVPPAVPKAKNSRDYPTIGFFGFFQWGGKNFDALFNAVER
LKGKLVGSVATGKEYDIEKLRETLKERGINCDLGTGWVDDSELTRRLSEADYFYLPQYDYDHWNNSGTARLVMNFRLPVV
LPPHNPFLDLRKYAIFADEADVPAIMSWMRIPKIYEDAATRSERYAKAHPMLVEMPKLAHGLKQVVAASGADVFLDPNLF
SVWSLLSVSSDVFLKRVSFRTSDDDLDFQSTDPDSDERLEQILALRAHYPHLFGLIFNVVQPVHYWRDHYDLDSFFFPTW
GETITNVCRVMYKNEPNFSYVNKILSLLGVELQGINDAISPSQTLSLLRWHMFREPNLDFAPCVQIYHAGSPLALDNLSS
SDLLATFEETTTRRLALCKKVHISNEPLFCPENDRNLLKLLTLPTEWVDRALTECARSAGKDFVFEGVGEIQDIYLRYNK
LLYSLSGKDVRVSDIGLLDRPIVDSVNFHRFVYSIADFWHFDGDGLIFQVVRCLLKRDPSPREMFALSQIYDQKGRLAVI
QCVAAYPYISTRVVDLNADHLVMKLDEMRKATEVLVGQVRSPYAGGWDLRNKYLEDRRNFDRAWLRMKNIKDLWWSQSGG
SIDSIVSLNVHS

Sequences:

>Translated_972_residues
MEMIVKRMALKAGSAAGWTREGDAARDRGDWPASAAAYEKALELQPLLGHIWIQYGHALKESGELDKAHIAYRRGVEILP
TSSDAYIQLGHILKLKNDPLRATIAYRQAVILDPDNDNALRELRTAEWTDAEIMETTCSQEVGRKCPPTRSDFTRLVSKS
FIKFDAQNYRDQFPDVSFLIDLGVIYSPEQHYLHYGYRGGRDILLSLEQKAPSRAFVLCPSFFKRCGIGEHARYLAHSIE
ASGLETHRIRTTVELEQFSPAILQDAILIINHGPGLFDAYNPELSEGESVSDVISKSIDVFDKYNTRTVVLMHSLLDRDN
REMFPRQQLWLESPLPIVTTIQAAATFFNLIHIEHGMQPVEVPPAVPKAKNSRDYPTIGFFGFFQWGGKNFDALFNAVER
LKGKLVGSVATGKEYDIEKLRETLKERGINCDLGTGWVDDSELTRRLSEADYFYLPQYDYDHWNNSGTARLVMNFRLPVV
LPPHNPFLDLRKYAIFADEADVPAIMSWMRIPKIYEDAATRSERYAKAHPMLVEMPKLAHGLKQVVAASGADVFLDPNLF
SVWSLLSVSSDVFLKRVSFRTSDDDLDFQSTDPDSDERLEQILALRAHYPHLFGLIFNVVQPVHYWRDHYDLDSFFFPTW
GETITNVCRVMYKNEPNFSYVNKILSLLGVELQGINDAISPSQTLSLLRWHMFREPNLDFAPCVQIYHAGSPLALDNLSS
SDLLATFEETTTRRLALCKKVHISNEPLFCPENDRNLLKLLTLPTEWVDRALTECARSAGKDFVFEGVGEIQDIYLRYNK
LLYSLSGKDVRVSDIGLLDRPIVDSVNFHRFVYSIADFWHFDGDGLIFQVVRCLLKRDPSPREMFALSQIYDQKGRLAVI
QCVAAYPYISTRVVDLNADHLVMKLDEMRKATEVLVGQVRSPYAGGWDLRNKYLEDRRNFDRAWLRMKNIKDLWWSQSGG
SIDSIVSLNVHS
>Mature_972_residues
MEMIVKRMALKAGSAAGWTREGDAARDRGDWPASAAAYEKALELQPLLGHIWIQYGHALKESGELDKAHIAYRRGVEILP
TSSDAYIQLGHILKLKNDPLRATIAYRQAVILDPDNDNALRELRTAEWTDAEIMETTCSQEVGRKCPPTRSDFTRLVSKS
FIKFDAQNYRDQFPDVSFLIDLGVIYSPEQHYLHYGYRGGRDILLSLEQKAPSRAFVLCPSFFKRCGIGEHARYLAHSIE
ASGLETHRIRTTVELEQFSPAILQDAILIINHGPGLFDAYNPELSEGESVSDVISKSIDVFDKYNTRTVVLMHSLLDRDN
REMFPRQQLWLESPLPIVTTIQAAATFFNLIHIEHGMQPVEVPPAVPKAKNSRDYPTIGFFGFFQWGGKNFDALFNAVER
LKGKLVGSVATGKEYDIEKLRETLKERGINCDLGTGWVDDSELTRRLSEADYFYLPQYDYDHWNNSGTARLVMNFRLPVV
LPPHNPFLDLRKYAIFADEADVPAIMSWMRIPKIYEDAATRSERYAKAHPMLVEMPKLAHGLKQVVAASGADVFLDPNLF
SVWSLLSVSSDVFLKRVSFRTSDDDLDFQSTDPDSDERLEQILALRAHYPHLFGLIFNVVQPVHYWRDHYDLDSFFFPTW
GETITNVCRVMYKNEPNFSYVNKILSLLGVELQGINDAISPSQTLSLLRWHMFREPNLDFAPCVQIYHAGSPLALDNLSS
SDLLATFEETTTRRLALCKKVHISNEPLFCPENDRNLLKLLTLPTEWVDRALTECARSAGKDFVFEGVGEIQDIYLRYNK
LLYSLSGKDVRVSDIGLLDRPIVDSVNFHRFVYSIADFWHFDGDGLIFQVVRCLLKRDPSPREMFALSQIYDQKGRLAVI
QCVAAYPYISTRVVDLNADHLVMKLDEMRKATEVLVGQVRSPYAGGWDLRNKYLEDRRNFDRAWLRMKNIKDLWWSQSGG
SIDSIVSLNVHS

Specific function: Unknown

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 110900; Mature: 110900

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMIVKRMALKAGSAAGWTREGDAARDRGDWPASAAAYEKALELQPLLGHIWIQYGHALK
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESGELDKAHIAYRRGVEILPTSSDAYIQLGHILKLKNDPLRATIAYRQAVILDPDNDNAL
HCCCCCHHHHHHHCCCEEEECCCCCEEEECEEEEECCCCCEEEEEECEEEEECCCCCHHH
RELRTAEWTDAEIMETTCSQEVGRKCPPTRSDFTRLVSKSFIKFDAQNYRDQFPDVSFLI
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEE
DLGVIYSPEQHYLHYGYRGGRDILLSLEQKAPSRAFVLCPSFFKRCGIGEHARYLAHSIE
EECEEECCCHHEEECCCCCCCEEEEEECCCCCCCEEEECHHHHHHCCCCHHHHHHHHHHH
ASGLETHRIRTTVELEQFSPAILQDAILIINHGPGLFDAYNPELSEGESVSDVISKSIDV
CCCCCHHHEEEEEEHHHCCHHHHHCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FDKYNTRTVVLMHSLLDRDNREMFPRQQLWLESPLPIVTTIQAAATFFNLIHIEHGMQPV
HHCCCCCHHHHHHHHHCCCCHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
EVPPAVPKAKNSRDYPTIGFFGFFQWGGKNFDALFNAVERLKGKLVGSVATGKEYDIEKL
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RETLKERGINCDLGTGWVDDSELTRRLSEADYFYLPQYDYDHWNNSGTARLVMNFRLPVV
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEEECCCEE
LPPHNPFLDLRKYAIFADEADVPAIMSWMRIPKIYEDAATRSERYAKAHPMLVEMPKLAH
ECCCCCHHHHHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHEECHHHHH
GLKQVVAASGADVFLDPNLFSVWSLLSVSSDVFLKRVSFRTSDDDLDFQSTDPDSDERLE
HHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
QILALRAHYPHLFGLIFNVVQPVHYWRDHYDLDSFFFPTWGETITNVCRVMYKNEPNFSY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
VNKILSLLGVELQGINDAISPSQTLSLLRWHMFREPNLDFAPCVQIYHAGSPLALDNLSS
HHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEECCCCC
SDLLATFEETTTRRLALCKKVHISNEPLFCPENDRNLLKLLTLPTEWVDRALTECARSAG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHEEECCHHHHHHHHHHHHHHCC
KDFVFEGVGEIQDIYLRYNKLLYSLSGKDVRVSDIGLLDRPIVDSVNFHRFVYSIADFWH
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
FDGDGLIFQVVRCLLKRDPSPREMFALSQIYDQKGRLAVIQCVAAYPYISTRVVDLNADH
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHCCCCEEEEEECCCCH
LVMKLDEMRKATEVLVGQVRSPYAGGWDLRNKYLEDRRNFDRAWLRMKNIKDLWWSQSGG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
SIDSIVSLNVHS
CEEEEEEEEECC
>Mature Secondary Structure
MEMIVKRMALKAGSAAGWTREGDAARDRGDWPASAAAYEKALELQPLLGHIWIQYGHALK
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESGELDKAHIAYRRGVEILPTSSDAYIQLGHILKLKNDPLRATIAYRQAVILDPDNDNAL
HCCCCCHHHHHHHCCCEEEECCCCCEEEECEEEEECCCCCEEEEEECEEEEECCCCCHHH
RELRTAEWTDAEIMETTCSQEVGRKCPPTRSDFTRLVSKSFIKFDAQNYRDQFPDVSFLI
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEE
DLGVIYSPEQHYLHYGYRGGRDILLSLEQKAPSRAFVLCPSFFKRCGIGEHARYLAHSIE
EECEEECCCHHEEECCCCCCCEEEEEECCCCCCCEEEECHHHHHHCCCCHHHHHHHHHHH
ASGLETHRIRTTVELEQFSPAILQDAILIINHGPGLFDAYNPELSEGESVSDVISKSIDV
CCCCCHHHEEEEEEHHHCCHHHHHCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FDKYNTRTVVLMHSLLDRDNREMFPRQQLWLESPLPIVTTIQAAATFFNLIHIEHGMQPV
HHCCCCCHHHHHHHHHCCCCHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
EVPPAVPKAKNSRDYPTIGFFGFFQWGGKNFDALFNAVERLKGKLVGSVATGKEYDIEKL
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RETLKERGINCDLGTGWVDDSELTRRLSEADYFYLPQYDYDHWNNSGTARLVMNFRLPVV
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEEECCCEE
LPPHNPFLDLRKYAIFADEADVPAIMSWMRIPKIYEDAATRSERYAKAHPMLVEMPKLAH
ECCCCCHHHHHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHEECHHHHH
GLKQVVAASGADVFLDPNLFSVWSLLSVSSDVFLKRVSFRTSDDDLDFQSTDPDSDERLE
HHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
QILALRAHYPHLFGLIFNVVQPVHYWRDHYDLDSFFFPTWGETITNVCRVMYKNEPNFSY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
VNKILSLLGVELQGINDAISPSQTLSLLRWHMFREPNLDFAPCVQIYHAGSPLALDNLSS
HHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEECCCCC
SDLLATFEETTTRRLALCKKVHISNEPLFCPENDRNLLKLLTLPTEWVDRALTECARSAG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHEEECCHHHHHHHHHHHHHHCC
KDFVFEGVGEIQDIYLRYNKLLYSLSGKDVRVSDIGLLDRPIVDSVNFHRFVYSIADFWH
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
FDGDGLIFQVVRCLLKRDPSPREMFALSQIYDQKGRLAVIQCVAAYPYISTRVVDLNADH
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHCCCCEEEEEECCCCH
LVMKLDEMRKATEVLVGQVRSPYAGGWDLRNKYLEDRRNFDRAWLRMKNIKDLWWSQSGG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
SIDSIVSLNVHS
CEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA