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The map label for this gene is iscS [H]

Identifier: 162148155

GI number: 162148155

Start: 2446856

End: 2448031

Strand: Reverse

Name: iscS [H]

Synonym: GDI_2372

Alternate gene names: 162148155

Gene position: 2448031-2446856 (Counterclockwise)

Preceding gene: 162148156

Following gene: 162148154

Centisome position: 62.07

GC content: 74.06

Gene sequence:

>1176_bases
GTGGAGGTCATGGATCGCGATTTTTTCTATTTCGATGCCAACGCGTCGGAGCCCGCGCGTCCCGCCGCGCTGGACGCCAT
GGCCCGCGCGGCCGCGATCACCGGCAATCCGTCATCGGTCCACCGGGCGGGGCGGCAGGCGCGCGCGATCCTCGAATCCG
CGCGGGAACGGCTGGCCGCGCTGTTCGGCGCGCGGGCGGATAATTGCGTCCTGACCTCGGGCGGGACCGAGGCCAACCTG
TTGGCGATCGCCGGACTGGGCGGGGGCCGGCGCATTCTGGCCTCGGCCGTCGAACACGACGCGGTGCGGGCCGCCGTGCC
GGCCGGCGCGGACCTGATACCCGTGGATGGGCAGGGCGTGGCGCGGCTGGAGGTGCTGGAGCAATGGCTGGTCGAAGCGG
ACGGCCCCCCGCCGCTGGTATGCCTGATGCTGGCGAACAACGAGGTCGGGACGATCCAGCCGGTGGCCGAGGCGGTGCGG
ATCTGCCACGCCCATGGGGCGCTGCTGCATGTCGATGCCGTGCAGGCGGCGGGACGGATACCCATCGACCTGGGCGCGCT
GGGGTGCCGACAGCAGGCGGTCTCGGGCCATAAATTCGGCGGCGTTAAGGGCGCGGGGGCCCTGCTGCTGGCCGGGGAGG
CGACGCGGGCGCTGCCGCCGATGATGGCCGGCGGCGGGCAGGAGCACGGCCGGCGCGGGGGCACGCCTGCCCTGCCGGCC
ATCGCGGCGATGGCCGAGGCGGCCGGGGACGCGGTGGCGGCCCTGGCGGGTGGCGGGGACGGACGCGCCGATCCCACGAC
GCTGGCACGGTGGCGCGACGCGATCGATGCGGCGGCGCGTGCCGCCGGTGCCGTCGTCTGTGGCGGCGACGCGCCGCGCC
TGCCCAACACCACGTCCCTGGCCCTGCCCGGTCGTGCGGCGCAGATCCAGTTGATCGCGCTGGACCTGGCGGGATTCGGC
GTATCGGCCGGGTCGGCCTGTTCGTCAGGCAAGGTCGCGCGGTCGCATGTGCTGCAGGCGATGGGCCACGGGTCGCTGGC
CGGCGAGGCGATTCGCGTCTCGCTGCCCTGGACGGTGCGCGAGGATGACGTGACGCGCTTCATCGCCGCCTGGCGTGCGA
TGGCGGCCCGGCTGCCGGCGCGTGCGAGATCGGAACGAACGGAGGTCCACGTATGA

Upstream 100 bases:

>100_bases
CCAAAATCGCCAATTGCCATATAAATCGTGTTTAGGTCGCGCCGCGCGACCCGGAATTCGGACAGAAGCGCGCATCGTGG
GGCAAGGACGGACGCGCAGG

Downstream 100 bases:

>100_bases
CGGACGGGCGCGAACTCTATCTGGACTACCAGGCCACCACGCCGTGCGATCCGGCGGTCGTCGCGGCGATGATGCCGTGG
TTCGCCGAATCGTTCGGCAA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MEVMDRDFFYFDANASEPARPAALDAMARAAAITGNPSSVHRAGRQARAILESARERLAALFGARADNCVLTSGGTEANL
LAIAGLGGGRRILASAVEHDAVRAAVPAGADLIPVDGQGVARLEVLEQWLVEADGPPPLVCLMLANNEVGTIQPVAEAVR
ICHAHGALLHVDAVQAAGRIPIDLGALGCRQQAVSGHKFGGVKGAGALLLAGEATRALPPMMAGGGQEHGRRGGTPALPA
IAAMAEAAGDAVAALAGGGDGRADPTTLARWRDAIDAAARAAGAVVCGGDAPRLPNTTSLALPGRAAQIQLIALDLAGFG
VSAGSACSSGKVARSHVLQAMGHGSLAGEAIRVSLPWTVREDDVTRFIAAWRAMAARLPARARSERTEVHV

Sequences:

>Translated_391_residues
MEVMDRDFFYFDANASEPARPAALDAMARAAAITGNPSSVHRAGRQARAILESARERLAALFGARADNCVLTSGGTEANL
LAIAGLGGGRRILASAVEHDAVRAAVPAGADLIPVDGQGVARLEVLEQWLVEADGPPPLVCLMLANNEVGTIQPVAEAVR
ICHAHGALLHVDAVQAAGRIPIDLGALGCRQQAVSGHKFGGVKGAGALLLAGEATRALPPMMAGGGQEHGRRGGTPALPA
IAAMAEAAGDAVAALAGGGDGRADPTTLARWRDAIDAAARAAGAVVCGGDAPRLPNTTSLALPGRAAQIQLIALDLAGFG
VSAGSACSSGKVARSHVLQAMGHGSLAGEAIRVSLPWTVREDDVTRFIAAWRAMAARLPARARSERTEVHV
>Mature_391_residues
MEVMDRDFFYFDANASEPARPAALDAMARAAAITGNPSSVHRAGRQARAILESARERLAALFGARADNCVLTSGGTEANL
LAIAGLGGGRRILASAVEHDAVRAAVPAGADLIPVDGQGVARLEVLEQWLVEADGPPPLVCLMLANNEVGTIQPVAEAVR
ICHAHGALLHVDAVQAAGRIPIDLGALGCRQQAVSGHKFGGVKGAGALLLAGEATRALPPMMAGGGQEHGRRGGTPALPA
IAAMAEAAGDAVAALAGGGDGRADPTTLARWRDAIDAAARAAGAVVCGGDAPRLPNTTSLALPGRAAQIQLIALDLAGFG
VSAGSACSSGKVARSHVLQAMGHGSLAGEAIRVSLPWTVREDDVTRFIAAWRAMAARLPARARSERTEVHV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=30.8290155440415, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI156713448, Length=368, Percent_Identity=31.25, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI48994898, Length=390, Percent_Identity=32.3076923076923, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787970, Length=201, Percent_Identity=32.3383084577114, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789175, Length=244, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=377, Percent_Identity=32.3607427055703, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17533177, Length=318, Percent_Identity=28.9308176100629, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319831, Length=380, Percent_Identity=31.5789473684211, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=32.2751322751323, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39732; Mature: 39732

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVMDRDFFYFDANASEPARPAALDAMARAAAITGNPSSVHRAGRQARAILESARERLAA
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LFGARADNCVLTSGGTEANLLAIAGLGGGRRILASAVEHDAVRAAVPAGADLIPVDGQGV
HHCCCCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCH
ARLEVLEQWLVEADGPPPLVCLMLANNEVGTIQPVAEAVRICHAHGALLHVDAVQAAGRI
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCC
PIDLGALGCRQQAVSGHKFGGVKGAGALLLAGEATRALPPMMAGGGQEHGRRGGTPALPA
CEECCCCCHHHHHCCCCCCCCCCCCCEEEEECCCHHCCCCHHCCCCHHHCCCCCCCHHHH
IAAMAEAAGDAVAALAGGGDGRADPTTLARWRDAIDAAARAAGAVVCGGDAPRLPNTTSL
HHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEE
ALPGRAAQIQLIALDLAGFGVSAGSACSSGKVARSHVLQAMGHGSLAGEAIRVSLPWTVR
ECCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEC
EDDVTRFIAAWRAMAARLPARARSERTEVHV
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
>Mature Secondary Structure
MEVMDRDFFYFDANASEPARPAALDAMARAAAITGNPSSVHRAGRQARAILESARERLAA
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LFGARADNCVLTSGGTEANLLAIAGLGGGRRILASAVEHDAVRAAVPAGADLIPVDGQGV
HHCCCCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCH
ARLEVLEQWLVEADGPPPLVCLMLANNEVGTIQPVAEAVRICHAHGALLHVDAVQAAGRI
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCC
PIDLGALGCRQQAVSGHKFGGVKGAGALLLAGEATRALPPMMAGGGQEHGRRGGTPALPA
CEECCCCCHHHHHCCCCCCCCCCCCCEEEEECCCHHCCCCHHCCCCHHHCCCCCCCHHHH
IAAMAEAAGDAVAALAGGGDGRADPTTLARWRDAIDAAARAAGAVVCGGDAPRLPNTTSL
HHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEE
ALPGRAAQIQLIALDLAGFGVSAGSACSSGKVARSHVLQAMGHGSLAGEAIRVSLPWTVR
ECCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEC
EDDVTRFIAAWRAMAARLPARARSERTEVHV
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA