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The map label for this gene is clcA [H]

Identifier: 162148146

GI number: 162148146

Start: 2437238

End: 2438647

Strand: Direct

Name: clcA [H]

Synonym: GDI_2363

Alternate gene names: 162148146

Gene position: 2437238-2438647 (Clockwise)

Preceding gene: 162148145

Following gene: 162148157

Centisome position: 61.79

GC content: 69.57

Gene sequence:

>1410_bases
ATGATGAAAACCGACCTGACCGAACTGCGCATCCGCCATATGCGCCACCTGCGCCGATCCGCCCGGGTCACGACGGCGCA
GTGGCGGCGCAAGATCGTGTACTGGGCCGCGGCCATCGTCGTGGGGCTGGTCGCCGTGGGCTTCGCCACCGCCGCCGACG
CCGCCGCCGCCCTGCGTACGCGCCTGGTCCACTGGGACCCGTGGATCATGCTGGCGATCACCCCGGCGGGGCTGGCGCTG
TCCACCTGGCTGACCCGCACCTGGTTTCGCGGCGCCCAGGGATCGGGCATTCCCCAGACGATCGCGACCCTGCACCTGGA
CGATTTCGCGGTGGTCGACCGGCTGCTGTCGCTGCGCATCGCCTTCGGCAAGATCCTGCTGACCACGCTGGGCCTGCTGG
CCGGGGCATCGATCGGCCGCGAGGGCCCGACCGTGCAGGTGGGCGCCGCGATCATGCATGCGTTCGGCCGCTGGCTGAAC
CTGTCGGCGGTGGGGATGCGCCGGGGGCTGATCCTGGCGGGCGGCGCGTCGGGCGTGTCGGCGGCCTTCAACACGCCGCT
GGGCGGAATCGTGTTCGCGATCGAGGAACTGAGCCATTCCTTCGAGCAGCGCACCAGCGGCACGATGCTGACCGGCGTTA
TCCTGTCGGGCGTCACCGCCATCGCGCTGGTCGGCAATTATACCTATTTCGGCCATACCGACGTCGTGGTGCCGATCGGC
ATAAGCTGGATCGCGGTGCTGGCCTGCGGTATCCTGGGCGGGGTCAGCGGCGGGGCGTTCTCGGCCATCCTGATCCGCTC
CTCGGCCGGCCTGCCGGGCGTGCTGGGGCAGTTCGTCAGCCGCCGGCCGGTGGCCTTCGCGGCCGCGTGCGGCCTGGTAC
TGGCCGTCCTGGGCGTGGCATCGGGGGGCATCACCTACGGCACGGGCTATTTACAGGCGCGCGAGATCATCACGGGCCAG
ACCCATTATCCGGCGTCGTTCTTCATCCTGAAATACATCGCCACCATCGTGTCCTACTGCTCGGGCATTCCGGGGGGACT
GTTCGCGCCGTCGCTGGCCATCGGGGCGGGCATCGGCGGGTGGATCGCGCAGTTCCTGCCCCATACGACGCCCGGCGCGG
TCGTCCTGCTGGGCACCGTCGCCTATTTCTCGGCGGTGGTGCAGGCACCGCTGACGGCCACCGTCATCGTGATGGAAATG
TCGGACAACCAGCAGGTGACGCTGGCGCTGCTGGCGACGTCGTTCCTGGCCTATGCCGTGTCGCGCACGGTCTGCAGCCA
GTCGCTCTACAGCGCGCTGGCCGAAAAATTCCTCGATGTGGTGGAACATGCCCCCCCGCCGGCCGAGGAAACCGCCGCCC
CGCCCCGGGCCGCGATCGTCCCCGGCCCCACCGCGCCGGAACGGTTCTGA

Upstream 100 bases:

>100_bases
TTCCGCTGGAACCCGCCGGACAATCCGCGCTAAAGGGACGGATGGCCCCGAACCGACCCGCAGCCCCCATCCGGGCAGGC
CTGGCCTGCCTCGGGCGAGA

Downstream 100 bases:

>100_bases
CGAGATCCTGCGCGCGAGCGCTCAGCCGTGGTGGACCGGACAGCGTTGGGCCGACGCGGCTGCCGGGACCGGTCGGGTCC
CGGCGGCGGCCGTGCGCTTC

Product: H(+)/Cl(-) exchange transporter clcA

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MMKTDLTELRIRHMRHLRRSARVTTAQWRRKIVYWAAAIVVGLVAVGFATAADAAAALRTRLVHWDPWIMLAITPAGLAL
STWLTRTWFRGAQGSGIPQTIATLHLDDFAVVDRLLSLRIAFGKILLTTLGLLAGASIGREGPTVQVGAAIMHAFGRWLN
LSAVGMRRGLILAGGASGVSAAFNTPLGGIVFAIEELSHSFEQRTSGTMLTGVILSGVTAIALVGNYTYFGHTDVVVPIG
ISWIAVLACGILGGVSGGAFSAILIRSSAGLPGVLGQFVSRRPVAFAAACGLVLAVLGVASGGITYGTGYLQAREIITGQ
THYPASFFILKYIATIVSYCSGIPGGLFAPSLAIGAGIGGWIAQFLPHTTPGAVVLLGTVAYFSAVVQAPLTATVIVMEM
SDNQQVTLALLATSFLAYAVSRTVCSQSLYSALAEKFLDVVEHAPPPAEETAAPPRAAIVPGPTAPERF

Sequences:

>Translated_469_residues
MMKTDLTELRIRHMRHLRRSARVTTAQWRRKIVYWAAAIVVGLVAVGFATAADAAAALRTRLVHWDPWIMLAITPAGLAL
STWLTRTWFRGAQGSGIPQTIATLHLDDFAVVDRLLSLRIAFGKILLTTLGLLAGASIGREGPTVQVGAAIMHAFGRWLN
LSAVGMRRGLILAGGASGVSAAFNTPLGGIVFAIEELSHSFEQRTSGTMLTGVILSGVTAIALVGNYTYFGHTDVVVPIG
ISWIAVLACGILGGVSGGAFSAILIRSSAGLPGVLGQFVSRRPVAFAAACGLVLAVLGVASGGITYGTGYLQAREIITGQ
THYPASFFILKYIATIVSYCSGIPGGLFAPSLAIGAGIGGWIAQFLPHTTPGAVVLLGTVAYFSAVVQAPLTATVIVMEM
SDNQQVTLALLATSFLAYAVSRTVCSQSLYSALAEKFLDVVEHAPPPAEETAAPPRAAIVPGPTAPERF
>Mature_469_residues
MMKTDLTELRIRHMRHLRRSARVTTAQWRRKIVYWAAAIVVGLVAVGFATAADAAAALRTRLVHWDPWIMLAITPAGLAL
STWLTRTWFRGAQGSGIPQTIATLHLDDFAVVDRLLSLRIAFGKILLTTLGLLAGASIGREGPTVQVGAAIMHAFGRWLN
LSAVGMRRGLILAGGASGVSAAFNTPLGGIVFAIEELSHSFEQRTSGTMLTGVILSGVTAIALVGNYTYFGHTDVVVPIG
ISWIAVLACGILGGVSGGAFSAILIRSSAGLPGVLGQFVSRRPVAFAAACGLVLAVLGVASGGITYGTGYLQAREIITGQ
THYPASFFILKYIATIVSYCSGIPGGLFAPSLAIGAGIGGWIAQFLPHTTPGAVVLLGTVAYFSAVVQAPLTATVIVMEM
SDNQQVTLALLATSFLAYAVSRTVCSQSLYSALAEKFLDVVEHAPPPAEETAAPPRAAIVPGPTAPERF

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=435, Percent_Identity=25.0574712643678, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI189217923, Length=435, Percent_Identity=25.0574712643678, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI189217921, Length=435, Percent_Identity=25.0574712643678, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1786350, Length=473, Percent_Identity=29.5983086680761, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24665008, Length=428, Percent_Identity=26.8691588785047, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 49006; Mature: 49006

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTDLTELRIRHMRHLRRSARVTTAQWRRKIVYWAAAIVVGLVAVGFATAADAAAALRT
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLVHWDPWIMLAITPAGLALSTWLTRTWFRGAQGSGIPQTIATLHLDDFAVVDRLLSLRI
HHEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
AFGKILLTTLGLLAGASIGREGPTVQVGAAIMHAFGRWLNLSAVGMRRGLILAGGASGVS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCEEEECCCCCCC
AAFNTPLGGIVFAIEELSHSFEQRTSGTMLTGVILSGVTAIALVGNYTYFGHTDVVVPIG
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEECCCCEEEECC
ISWIAVLACGILGGVSGGAFSAILIRSSAGLPGVLGQFVSRRPVAFAAACGLVLAVLGVA
HHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC
SGGITYGTGYLQAREIITGQTHYPASFFILKYIATIVSYCSGIPGGLFAPSLAIGAGIGG
CCCCEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHH
WIAQFLPHTTPGAVVLLGTVAYFSAVVQAPLTATVIVMEMSDNQQVTLALLATSFLAYAV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHH
SRTVCSQSLYSALAEKFLDVVEHAPPPAEETAAPPRAAIVPGPTAPERF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MMKTDLTELRIRHMRHLRRSARVTTAQWRRKIVYWAAAIVVGLVAVGFATAADAAAALRT
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLVHWDPWIMLAITPAGLALSTWLTRTWFRGAQGSGIPQTIATLHLDDFAVVDRLLSLRI
HHEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
AFGKILLTTLGLLAGASIGREGPTVQVGAAIMHAFGRWLNLSAVGMRRGLILAGGASGVS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCEEEECCCCCCC
AAFNTPLGGIVFAIEELSHSFEQRTSGTMLTGVILSGVTAIALVGNYTYFGHTDVVVPIG
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEECCCCEEEECC
ISWIAVLACGILGGVSGGAFSAILIRSSAGLPGVLGQFVSRRPVAFAAACGLVLAVLGVA
HHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC
SGGITYGTGYLQAREIITGQTHYPASFFILKYIATIVSYCSGIPGGLFAPSLAIGAGIGG
CCCCEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHH
WIAQFLPHTTPGAVVLLGTVAYFSAVVQAPLTATVIVMEMSDNQQVTLALLATSFLAYAV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHH
SRTVCSQSLYSALAEKFLDVVEHAPPPAEETAAPPRAAIVPGPTAPERF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA