Click here to switch to the map view.

The map label for this gene is serS

Identifier: 162148003

GI number: 162148003

Start: 2274559

End: 2275833

Strand: Reverse

Name: serS

Synonym: GDI_2219

Alternate gene names: 162148003

Gene position: 2275833-2274559 (Counterclockwise)

Preceding gene: 162148004

Following gene: 162148001

Centisome position: 57.7

GC content: 70.67

Gene sequence:

>1275_bases
ATGCATGATCTTCGCGCCCTGCGCGCCGATCCGGCCGCCTTCGACGCCGCCCTGGCCCGCCGGGGCGAGGCCCCCGCCGC
GATCCATATCGCCAGCCTGGACGAGGACCGGCGGGCCGCCGTGACCGCGCTGCAGGACAAGCAGGCCCGGCGCAAGAGCC
TGTCGAAGGAAGTCGGCGCCCTGCGCCGCACCGGGGAAGACAGCACGGCGCTGGAAGCCGAGGCCGTGCAACTGCGCGAG
GACATCGAGAAGCTGGAGGTCCTGGTCCGCGAACTGGATGCCGAAATCCGCGACTGCCTGGTGGTCCTGCCCAACCGGCT
GGATGACGGCGTGCCCGAGGGCGCGGACGAATCCGCGAACGTCGTCGTCCACCAGGTCGGCGAGCGGCGCGACTTCGCCT
TCCCCCCGCGCGAGCATTTCGCGCTGGGCGAGGCGCTGGGCCTGATGGATTTCGAAACCGCCGGAAAGCTGTCCGGCGCG
CGCTTCGTCGTGCTGCGCGGCGCGCTGGCGCGCATGGAACGCGCGCTGGGCCAGTTCATGCTGGACCTGCATGTCCAGGA
ACACGGCTATACCGAAACGGCGGTACCGGTCCTGGTGAACGAGGCCGCGATGTTCGGCACCGACAAGCTGCCCAAGTTCG
CCGACCAGTCCTTCCGGACCGAGGACGGGCGCTGGCTGATTCCCACGGCCGAGGTCCCGCTGACCGCCAGCGTCGCGGGC
GACATCCTGCCGGCGTCGGCGCTGCCGCGCCGCATGGTCGCGCTGTCCTCGTGCTTCCGCAGCGAGGCCGGGGCCGCCGG
CCGCGACACGCGGGGCATGCTGCGCCAGCACCAGTTCCAGAAGGTCGAGATGGTGTCGATCACCGCGCCCGGGGACAGCG
ACGCCGAGCATGAGCGCATGACCCGCTGCGCCGAGAAGGTGCTGGAACGGCTGGGCATCCCGTATCGCCGCATGCTGCTG
TGCGCGGGCGACACCGGCTTCGGCGCGGCCAGGACCTTCGATCTCGAAGCCTGGCTGCCCGGCCAGGATGCGTGGCGCGA
AATTTCGTCCTGCTCCACCACGCGCGATTTCCAGGCGCGGCGGATGAATGCGCGCTACCGCCCGGCGGACGGTGCCGGCC
CGGAATTCGTCCATACGCTGAACGGCTCGGGCCTCGCCGTGGGACGCACGCTGATCGCGGTGATGGAAAACTACCAGAAC
GCCGATGGCAGCATCACCGTGCCGCAGGCGCTGCGCCCCTACATGAACGGGCTGGCGGCCATCAGCGCCCGCTGA

Upstream 100 bases:

>100_bases
GGTCTGGCGGTGCCGCTGATCGGGCTGTACGAAATTTCCATCTTCTGCGCGCGGCTGGTCCAGCCCAAGCGCGCCGACGA
TGCCGATCAGGAGAACCGAG

Downstream 100 bases:

>100_bases
CGGAATGTCGCGGGGGGCCTTTGCCGCCCCTGTTGCCGTTCCTGCCGCCGCCCTTGCGGTGCCCCCGTCCGGGGGCATGC
GGGGGCTGTCCGGGACGGGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MHDLRALRADPAAFDAALARRGEAPAAIHIASLDEDRRAAVTALQDKQARRKSLSKEVGALRRTGEDSTALEAEAVQLRE
DIEKLEVLVRELDAEIRDCLVVLPNRLDDGVPEGADESANVVVHQVGERRDFAFPPREHFALGEALGLMDFETAGKLSGA
RFVVLRGALARMERALGQFMLDLHVQEHGYTETAVPVLVNEAAMFGTDKLPKFADQSFRTEDGRWLIPTAEVPLTASVAG
DILPASALPRRMVALSSCFRSEAGAAGRDTRGMLRQHQFQKVEMVSITAPGDSDAEHERMTRCAEKVLERLGIPYRRMLL
CAGDTGFGAARTFDLEAWLPGQDAWREISSCSTTRDFQARRMNARYRPADGAGPEFVHTLNGSGLAVGRTLIAVMENYQN
ADGSITVPQALRPYMNGLAAISAR

Sequences:

>Translated_424_residues
MHDLRALRADPAAFDAALARRGEAPAAIHIASLDEDRRAAVTALQDKQARRKSLSKEVGALRRTGEDSTALEAEAVQLRE
DIEKLEVLVRELDAEIRDCLVVLPNRLDDGVPEGADESANVVVHQVGERRDFAFPPREHFALGEALGLMDFETAGKLSGA
RFVVLRGALARMERALGQFMLDLHVQEHGYTETAVPVLVNEAAMFGTDKLPKFADQSFRTEDGRWLIPTAEVPLTASVAG
DILPASALPRRMVALSSCFRSEAGAAGRDTRGMLRQHQFQKVEMVSITAPGDSDAEHERMTRCAEKVLERLGIPYRRMLL
CAGDTGFGAARTFDLEAWLPGQDAWREISSCSTTRDFQARRMNARYRPADGAGPEFVHTLNGSGLAVGRTLIAVMENYQN
ADGSITVPQALRPYMNGLAAISAR
>Mature_424_residues
MHDLRALRADPAAFDAALARRGEAPAAIHIASLDEDRRAAVTALQDKQARRKSLSKEVGALRRTGEDSTALEAEAVQLRE
DIEKLEVLVRELDAEIRDCLVVLPNRLDDGVPEGADESANVVVHQVGERRDFAFPPREHFALGEALGLMDFETAGKLSGA
RFVVLRGALARMERALGQFMLDLHVQEHGYTETAVPVLVNEAAMFGTDKLPKFADQSFRTEDGRWLIPTAEVPLTASVAG
DILPASALPRRMVALSSCFRSEAGAAGRDTRGMLRQHQFQKVEMVSITAPGDSDAEHERMTRCAEKVLERLGIPYRRMLL
CAGDTGFGAARTFDLEAWLPGQDAWREISSCSTTRDFQARRMNARYRPADGAGPEFVHTLNGSGLAVGRTLIAVMENYQN
ADGSITVPQALRPYMNGLAAISAR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=394, Percent_Identity=32.741116751269, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI16306548, Length=345, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI225579074, Length=340, Percent_Identity=34.7058823529412, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=51.7482517482517, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17539260, Length=434, Percent_Identity=29.2626728110599, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17542084, Length=329, Percent_Identity=31.6109422492401, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321799, Length=387, Percent_Identity=31.5245478036176, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320226, Length=416, Percent_Identity=29.5673076923077, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24581334, Length=443, Percent_Identity=30.9255079006772, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17737985, Length=356, Percent_Identity=32.8651685393258, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_GLUDA (A9HLG2)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602464.1
- RefSeq:   YP_002274848.1
- ProteinModelPortal:   A9HLG2
- SMR:   A9HLG2
- GeneID:   5792220
- GeneID:   6973831
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0437
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46375; Mature: 46375

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLRALRADPAAFDAALARRGEAPAAIHIASLDEDRRAAVTALQDKQARRKSLSKEVGA
CCCCHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LRRTGEDSTALEAEAVQLREDIEKLEVLVRELDAEIRDCLVVLPNRLDDGVPEGADESAN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCC
VVVHQVGERRDFAFPPREHFALGEALGLMDFETAGKLSGARFVVLRGALARMERALGQFM
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDLHVQEHGYTETAVPVLVNEAAMFGTDKLPKFADQSFRTEDGRWLIPTAEVPLTASVAG
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCCEEHHHHC
DILPASALPRRMVALSSCFRSEAGAAGRDTRGMLRQHQFQKVEMVSITAPGDSDAEHERM
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCHHHHHH
TRCAEKVLERLGIPYRRMLLCAGDTGFGAARTFDLEAWLPGQDAWREISSCSTTRDFQAR
HHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHH
RMNARYRPADGAGPEFVHTLNGSGLAVGRTLIAVMENYQNADGSITVPQALRPYMNGLAA
HCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
ISAR
HCCC
>Mature Secondary Structure
MHDLRALRADPAAFDAALARRGEAPAAIHIASLDEDRRAAVTALQDKQARRKSLSKEVGA
CCCCHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LRRTGEDSTALEAEAVQLREDIEKLEVLVRELDAEIRDCLVVLPNRLDDGVPEGADESAN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCC
VVVHQVGERRDFAFPPREHFALGEALGLMDFETAGKLSGARFVVLRGALARMERALGQFM
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDLHVQEHGYTETAVPVLVNEAAMFGTDKLPKFADQSFRTEDGRWLIPTAEVPLTASVAG
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCCEEHHHHC
DILPASALPRRMVALSSCFRSEAGAAGRDTRGMLRQHQFQKVEMVSITAPGDSDAEHERM
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCHHHHHH
TRCAEKVLERLGIPYRRMLLCAGDTGFGAARTFDLEAWLPGQDAWREISSCSTTRDFQAR
HHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHH
RMNARYRPADGAGPEFVHTLNGSGLAVGRTLIAVMENYQNADGSITVPQALRPYMNGLAA
HCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
ISAR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA