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The map label for this gene is cynT [H]

Identifier: 162147972

GI number: 162147972

Start: 2241383

End: 2242078

Strand: Direct

Name: cynT [H]

Synonym: GDI_2188

Alternate gene names: 162147972

Gene position: 2241383-2242078 (Clockwise)

Preceding gene: 162147971

Following gene: 162147973

Centisome position: 56.83

GC content: 66.24

Gene sequence:

>696_bases
ATGGCCGATACGGACGCCAGGACTTCGCTGATCTCGCTCCTCCAGGGAGTCGAGAAATTCAATACCGAGGTCTTCCCCCA
AAATCGCGAGCTGTTTGCCGAACTGGCCGACCAGCAATCGCCCGATACGCTGTTCATCGCCTGCGCCGACAGCCGGGTGA
ATCCCAGCATGATCACGCAGACACGGCCCGGCGACCTGTTCGTGCTGCGCAATATCGGCAACATCGTGCCGGCCTATGGC
GAAATGCTGGGCGGCGTGTCGTCGGCGATCGAATATGCCGTGCTGGCGCTGGGCGTGTCGCACATCATCGTCTGCGGCCA
TTCGGATTGCGGGGCGATGAAGGCCCTGCTGGACCCCGACCCCACGAAGCTGGCCAGGATGCCGACCGTCGCGTCCTGGC
TGCGCAATGCCGAGGCCGCGCGGGCGGTTGCCGGCGTGCTGCAGGCCACCGATGCCGGCCCCCAGTCGGTCCGCAGCCTG
GCCGAGCAGAACGTGCTGCTGCAGATCGCGCATCTGCGCACCCATCCCGCCGTGGCAGCCGGGCTGGCGCGCAACACCCT
GATCCTGCAGGGCTGGTTCTATGACATCGCCAGCGGCGAGGTCGTGGTGCTGGACGAGACGACCCGCACCAGCATCCATG
TCGATGAAGCCATCGCCCGCCTGAACAAGACCGGCACGGAGACGCCCGCGGCATAG

Upstream 100 bases:

>100_bases
CCCGACGGTACGCGTCATTCGAGAGCGACCGTTCGAACGCCACTGTGGACCCTGCCGGCGCGTGTGCGTCAGGGCAGGCT
CCTGGATAAAGGGACCTTCG

Downstream 100 bases:

>100_bases
TCCGCTTGGGGAACGTCCTGCGGCAATGGGCCTGCGCCGGGCTGGTTGCCGTTGCCCTCGCCCATCCCGCCGCCGGCCGG
ACGATCAAGGTCTCGACCTG

Product: carbonic anhydrase 1

Products: NA

Alternate protein names: Carbonate dehydratase 1 [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MADTDARTSLISLLQGVEKFNTEVFPQNRELFAELADQQSPDTLFIACADSRVNPSMITQTRPGDLFVLRNIGNIVPAYG
EMLGGVSSAIEYAVLALGVSHIIVCGHSDCGAMKALLDPDPTKLARMPTVASWLRNAEAARAVAGVLQATDAGPQSVRSL
AEQNVLLQIAHLRTHPAVAAGLARNTLILQGWFYDIASGEVVVLDETTRTSIHVDEAIARLNKTGTETPAA

Sequences:

>Translated_231_residues
MADTDARTSLISLLQGVEKFNTEVFPQNRELFAELADQQSPDTLFIACADSRVNPSMITQTRPGDLFVLRNIGNIVPAYG
EMLGGVSSAIEYAVLALGVSHIIVCGHSDCGAMKALLDPDPTKLARMPTVASWLRNAEAARAVAGVLQATDAGPQSVRSL
AEQNVLLQIAHLRTHPAVAAGLARNTLILQGWFYDIASGEVVVLDETTRTSIHVDEAIARLNKTGTETPAA
>Mature_230_residues
ADTDARTSLISLLQGVEKFNTEVFPQNRELFAELADQQSPDTLFIACADSRVNPSMITQTRPGDLFVLRNIGNIVPAYGE
MLGGVSSAIEYAVLALGVSHIIVCGHSDCGAMKALLDPDPTKLARMPTVASWLRNAEAARAVAGVLQATDAGPQSVRSLA
EQNVLLQIAHLRTHPAVAAGLARNTLILQGWFYDIASGEVVVLDETTRTSIHVDEAIARLNKTGTETPAA

Specific function: Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to c

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=200, Percent_Identity=47.5, Blast_Score=196, Evalue=9e-52,
Organism=Escherichia coli, GI1786318, Length=178, Percent_Identity=31.4606741573034, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25147564, Length=239, Percent_Identity=27.6150627615063, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115532990, Length=242, Percent_Identity=29.7520661157025, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324292, Length=179, Percent_Identity=26.8156424581006, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24645213, Length=238, Percent_Identity=27.7310924369748, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 24631; Mature: 24500

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTDARTSLISLLQGVEKFNTEVFPQNRELFAELADQQSPDTLFIACADSRVNPSMITQ
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHEEC
TRPGDLFVLRNIGNIVPAYGEMLGGVSSAIEYAVLALGVSHIIVCGHSDCGAMKALLDPD
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCC
PTKLARMPTVASWLRNAEAARAVAGVLQATDAGPQSVRSLAEQNVLLQIAHLRTHPAVAA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
GLARNTLILQGWFYDIASGEVVVLDETTRTSIHVDEAIARLNKTGTETPAA
HHHHCEEEEEEEEEEECCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADTDARTSLISLLQGVEKFNTEVFPQNRELFAELADQQSPDTLFIACADSRVNPSMITQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHEEC
TRPGDLFVLRNIGNIVPAYGEMLGGVSSAIEYAVLALGVSHIIVCGHSDCGAMKALLDPD
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCC
PTKLARMPTVASWLRNAEAARAVAGVLQATDAGPQSVRSLAEQNVLLQIAHLRTHPAVAA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
GLARNTLILQGWFYDIASGEVVVLDETTRTSIHVDEAIARLNKTGTETPAA
HHHHCEEEEEEEEEEECCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]