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The map label for this gene is mutT [H]

Identifier: 162147962

GI number: 162147962

Start: 2228705

End: 2229733

Strand: Direct

Name: mutT [H]

Synonym: GDI_2178

Alternate gene names: 162147962

Gene position: 2228705-2229733 (Clockwise)

Preceding gene: 162147961

Following gene: 162147964

Centisome position: 56.51

GC content: 69.78

Gene sequence:

>1029_bases
ATGACGATCGACCTGGGAACGGATCGGACGGACGCGGCCCTGCAGGCCGGGCCCTACCGCCTGCGCACGCTTCTGCCGTC
CGATGCCGGCACGATGCACCGGCTGGTCAATGACTGGAGCGTCATCCGGATGCTCAGCCGGGTGCCGTTCCCCTATCCGC
GCGGCCTGACGGATGACTGGATCGCCTCGACCCAGGACCTGTCCCGGCGGGGCGCGGCCTATCATTTCGCCATCACCCAC
CCCGAATCGGACGACCCCGATTCGCTGATGGGCTGTATCGGGGTGCAGGTGAATGCCGCCGCCCGGTCGGCCACCGTCGG
GTACTGGGTCGGCCGTCCCTACTGGAATCGCAAGGTGGCCTCGACCACCGTGGAACGAATCGCGCGCTGGGCGCTGGCCA
CCCTGCCGATCGAACGCGTGGCCGCCGCCGTCGCGCATGACAACCCGGCCTCGATCGCCGTGCTGCGCCGCATCGGCTTT
CGCGAGACCGGATCGGGGCGTCAGGCCTTCGTATCGCGCGGCACGGGGGACCATCCCGTGCTGCTGTTCGAAGCGACGCG
CGCCGACCTGGCGATGGATGACCCCGGGGTCGGGTCCGCCCCGCTTCCGGCGGGCCGGACGCCGGAACAGAAGCGCGTCA
TCCTGGTGGCCGCCGTGGCGCTGGTCGATACGGACGGGCGAATCCTGCTGGCCCGCCGGCCCGAGGGCAAGCCGATGGCC
GGCCTGTGGGAATTCCCCGGCGGCAAGGTCGAAACCGGGGAAACGCCCGAAGCGGCGCTGATCCGCGAGCTGGACGAGGA
ACTGGGGCTGGACGTCGCCCGGTCGTGCCTGGCCCCCTATACATTCGTGTCGCACGATTACGGGCATTTCCACCTGCTGA
TGCCCGTCTATGTCTGCCGGCGATGGAAGAACGTCCCCCACCCGCGCGAGGGCCAGACCCTGGCCTGGGTCCGGGCCGAC
GACCTGTCGCACTATCCGATGCCCGAGGCCGACCTGCCGCTGATCCCCCTGCTGCGGGACCTTCTTTAA

Upstream 100 bases:

>100_bases
CATAACCAGGAAGTCTTCCCCGTCATTCGCAGCCTGCGCGAATTGCTGGCCGAATGCGGTATCCCCGCCGCCCGATCCTG
AAAGCATGATGCATGACGGC

Downstream 100 bases:

>100_bases
GTTTACAGCACGATCGACCGGTCGAGCGGGAACACCGCCTGTTTCTGTCCGGGAATGCTGGTGCCGAACGAGAACAGTCC
GCCGGTCAGGGGCTCCGCGT

Product: bifunctional acetyltransferase

Products: CMP; diphosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTIDLGTDRTDAALQAGPYRLRTLLPSDAGTMHRLVNDWSVIRMLSRVPFPYPRGLTDDWIASTQDLSRRGAAYHFAITH
PESDDPDSLMGCIGVQVNAAARSATVGYWVGRPYWNRKVASTTVERIARWALATLPIERVAAAVAHDNPASIAVLRRIGF
RETGSGRQAFVSRGTGDHPVLLFEATRADLAMDDPGVGSAPLPAGRTPEQKRVILVAAVALVDTDGRILLARRPEGKPMA
GLWEFPGGKVETGETPEAALIRELDEELGLDVARSCLAPYTFVSHDYGHFHLLMPVYVCRRWKNVPHPREGQTLAWVRAD
DLSHYPMPEADLPLIPLLRDLL

Sequences:

>Translated_342_residues
MTIDLGTDRTDAALQAGPYRLRTLLPSDAGTMHRLVNDWSVIRMLSRVPFPYPRGLTDDWIASTQDLSRRGAAYHFAITH
PESDDPDSLMGCIGVQVNAAARSATVGYWVGRPYWNRKVASTTVERIARWALATLPIERVAAAVAHDNPASIAVLRRIGF
RETGSGRQAFVSRGTGDHPVLLFEATRADLAMDDPGVGSAPLPAGRTPEQKRVILVAAVALVDTDGRILLARRPEGKPMA
GLWEFPGGKVETGETPEAALIRELDEELGLDVARSCLAPYTFVSHDYGHFHLLMPVYVCRRWKNVPHPREGQTLAWVRAD
DLSHYPMPEADLPLIPLLRDLL
>Mature_341_residues
TIDLGTDRTDAALQAGPYRLRTLLPSDAGTMHRLVNDWSVIRMLSRVPFPYPRGLTDDWIASTQDLSRRGAAYHFAITHP
ESDDPDSLMGCIGVQVNAAARSATVGYWVGRPYWNRKVASTTVERIARWALATLPIERVAAAVAHDNPASIAVLRRIGFR
ETGSGRQAFVSRGTGDHPVLLFEATRADLAMDDPGVGSAPLPAGRTPEQKRVILVAAVALVDTDGRILLARRPEGKPMAG
LWEFPGGKVETGETPEAALIRELDEELGLDVARSCLAPYTFVSHDYGHFHLLMPVYVCRRWKNVPHPREGQTLAWVRADD
LSHYPMPEADLPLIPLLRDLL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=127, Percent_Identity=37.7952755905512, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786288, Length=128, Percent_Identity=33.59375, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 37662; Mature: 37531

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDLGTDRTDAALQAGPYRLRTLLPSDAGTMHRLVNDWSVIRMLSRVPFPYPRGLTDDW
CEECCCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
IASTQDLSRRGAAYHFAITHPESDDPDSLMGCIGVQVNAAARSATVGYWVGRPYWNRKVA
HHCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCEEEECCCCCCEEEEECCCCCCCCHHH
STTVERIARWALATLPIERVAAAVAHDNPASIAVLRRIGFRETGSGRQAFVSRGTGDHPV
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCE
LLFEATRADLAMDDPGVGSAPLPAGRTPEQKRVILVAAVALVDTDGRILLARRPEGKPMA
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHCEEEEEEEEEECCCCCEEEEECCCCCCCC
GLWEFPGGKVETGETPEAALIRELDEELGLDVARSCLAPYTFVSHDYGHFHLLMPVYVCR
CEEECCCCEECCCCCCHHHHHHHHHHHHCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
RWKNVPHPREGQTLAWVRADDLSHYPMPEADLPLIPLLRDLL
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHC
>Mature Secondary Structure 
TIDLGTDRTDAALQAGPYRLRTLLPSDAGTMHRLVNDWSVIRMLSRVPFPYPRGLTDDW
EECCCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
IASTQDLSRRGAAYHFAITHPESDDPDSLMGCIGVQVNAAARSATVGYWVGRPYWNRKVA
HHCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCEEEECCCCCCEEEEECCCCCCCCHHH
STTVERIARWALATLPIERVAAAVAHDNPASIAVLRRIGFRETGSGRQAFVSRGTGDHPV
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCE
LLFEATRADLAMDDPGVGSAPLPAGRTPEQKRVILVAAVALVDTDGRILLARRPEGKPMA
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHCEEEEEEEEEECCCCCEEEEECCCCCCCC
GLWEFPGGKVETGETPEAALIRELDEELGLDVARSCLAPYTFVSHDYGHFHLLMPVYVCR
CEEECCCCEECCCCCCHHHHHHHHHHHHCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
RWKNVPHPREGQTLAWVRADDLSHYPMPEADLPLIPLLRDLL
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; H2O [C]

Specific reaction: CTP + H2O = CMP + diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]