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The map label for this gene is folK [H]

Identifier: 162147942

GI number: 162147942

Start: 2210742

End: 2211350

Strand: Reverse

Name: folK [H]

Synonym: GDI_2158

Alternate gene names: 162147942

Gene position: 2211350-2210742 (Counterclockwise)

Preceding gene: 162147945

Following gene: 162147941

Centisome position: 56.07

GC content: 71.59

Gene sequence:

>609_bases
TTGGTATGGGCGAATGGGGGCGGGGTCCGCTTTTTCGCCCGAACCGAAACAGGAACCGGAACAAGGACCGTTACGGTTGC
ATCTTCGCACGGGAACGCCATCCTGAAGGGCATGATCCTGATCGCAATAGGCGCCAACCTGCCGCGCGCCGAGGGGAGTA
CCCCGCTGGAGACCTGCCGCTGGGCGGTGGAGCACATCGCTTCCATCCCGGGGGTCCGGGTCGTGGCGGTGTCGGCCTGG
TACGAAAGCGCACCGATTCCCCCCTCGGGCCAGCCGCCCTATGTCAACGGCGTCGTCGCCGCGACGGGCGAGCTGGACCC
GGCCGTCCTGCTGGCGGCGCTGCAGGGAATCGAAGCCCGGGCCGGACGGCGCCGGACGGTGGCCAACGCCGCCCGGCCGC
TGGACCTGGACATCATCGCGATGGGTGACCTGGTGCGCGACGCCCCGGACCCGATCCTGCCGCACCCCCGGGCCGACGCA
CGGGCCTTCGTCCTGCTGCCGCTGCGCGACGTGGCCCCCGGATGGCGCGACCCCAGGTCCGGCCGGACGGTCGATGCGCT
GGTCGCGGACCTGCCCGACCAGCAGATCCGCCGGCTGGAGGCGGACTGA

Upstream 100 bases:

>100_bases
CGCCATACGGAGTTCTGAAATGACTGAAAATGCATGCGTATGAAATTGATACGCCTGCATCTTAATTGACGTCTGGCACG
TTAGAGGCGTCACAGCCAAA

Downstream 100 bases:

>100_bases
CCGGCCTGCCTTGCACTTTGGGGGCGCGGCGACTACATATGGTTCTTTGCAACTGACACTTACATCCGGAGGCCTGCCTC
ATGGCTCGCGTCACCGTCGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinas

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MVWANGGGVRFFARTETGTGTRTVTVASSHGNAILKGMILIAIGANLPRAEGSTPLETCRWAVEHIASIPGVRVVAVSAW
YESAPIPPSGQPPYVNGVVAATGELDPAVLLAALQGIEARAGRRRTVANAARPLDLDIIAMGDLVRDAPDPILPHPRADA
RAFVLLPLRDVAPGWRDPRSGRTVDALVADLPDQQIRRLEAD

Sequences:

>Translated_202_residues
MVWANGGGVRFFARTETGTGTRTVTVASSHGNAILKGMILIAIGANLPRAEGSTPLETCRWAVEHIASIPGVRVVAVSAW
YESAPIPPSGQPPYVNGVVAATGELDPAVLLAALQGIEARAGRRRTVANAARPLDLDIIAMGDLVRDAPDPILPHPRADA
RAFVLLPLRDVAPGWRDPRSGRTVDALVADLPDQQIRRLEAD
>Mature_202_residues
MVWANGGGVRFFARTETGTGTRTVTVASSHGNAILKGMILIAIGANLPRAEGSTPLETCRWAVEHIASIPGVRVVAVSAW
YESAPIPPSGQPPYVNGVVAATGELDPAVLLAALQGIEARAGRRRTVANAARPLDLDIIAMGDLVRDAPDPILPHPRADA
RAFVLLPLRDVAPGWRDPRSGRTVDALVADLPDQQIRRLEAD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=134, Percent_Identity=37.3134328358209, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 21369; Mature: 21369

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWANGGGVRFFARTETGTGTRTVTVASSHGNAILKGMILIAIGANLPRAEGSTPLETCR
CEEECCCCEEEEEEECCCCCEEEEEEECCCCCHHHHEEEEEEECCCCCCCCCCCHHHHHH
WAVEHIASIPGVRVVAVSAWYESAPIPPSGQPPYVNGVVAATGELDPAVLLAALQGIEAR
HHHHHHHHCCCEEEEEEEEHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
AGRRRTVANAARPLDLDIIAMGDLVRDAPDPILPHPRADARAFVLLPLRDVAPGWRDPRS
CCCCHHHHHCCCCCCEEEEEECHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCCC
GRTVDALVADLPDQQIRRLEAD
CCHHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure
MVWANGGGVRFFARTETGTGTRTVTVASSHGNAILKGMILIAIGANLPRAEGSTPLETCR
CEEECCCCEEEEEEECCCCCEEEEEEECCCCCHHHHEEEEEEECCCCCCCCCCCHHHHHH
WAVEHIASIPGVRVVAVSAWYESAPIPPSGQPPYVNGVVAATGELDPAVLLAALQGIEAR
HHHHHHHHCCCEEEEEEEEHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
AGRRRTVANAARPLDLDIIAMGDLVRDAPDPILPHPRADARAFVLLPLRDVAPGWRDPRS
CCCCHHHHHCCCCCCEEEEEECHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCCC
GRTVDALVADLPDQQIRRLEAD
CCHHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]