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The map label for this gene is uppS [H]

Identifier: 162147933

GI number: 162147933

Start: 2202499

End: 2203263

Strand: Reverse

Name: uppS [H]

Synonym: GDI_2149

Alternate gene names: 162147933

Gene position: 2203263-2202499 (Counterclockwise)

Preceding gene: 162147934

Following gene: 162147932

Centisome position: 55.86

GC content: 71.11

Gene sequence:

>765_bases
GTGACGACGTCCGGTTCCACGGCGCCGGTGTCCGGGCTGGATCGCGGGCGGGGCGCCCCGGCCCTGCCGGCGCATGTCGC
GGTGATCATGGATGGAAACGGGCGCTGGGCCGCCGCGCGCGGCCTGCCGCGCGTCGCCGGGCACCGCGCGGGGGCCGAGG
CCGTCAGGCGCTGCATACGCGCCGCGATCACGCGCGGGGTCGGCTGCCTGACCCTGTATGCGTTCTCATCGGAAAACTGG
CGGCGCACCCCGGACGAGGTCGCGGACCTGACGGCGCTGCTGCGCTACTACCTGCGGCACAAGGTTGCCGAACTGTGCCG
CGAGGGCGTGCGCATCCGCATCATCGGCGACCTGTCGCGTTTCGACGCCGACGTCCGGGACGAGGCCAGGCGCGCCGAGG
ACATGACGGCCGCCAATACGCGCCTGACGCTGGTCCTGGCCCTGTCCTATGGCGGCCGGGCTGATATCGTGCAGGCGGCG
GCCCGCGTGGCCTTCGCCGCCCGCAGCGGCACGATCGATCCCGCCGAACTGGACGAGGCGCTGTTCAGCCGGTTCCTGCT
GACCGCCGACGTCCCCGATCCCGACCTGATCGTGCGCACCAGCGGCGAATGCCGGCTGTCCAATTTCCTGCTCTGGCAGT
CGGCCTATGCCGAACTGGTCTTTATCGAGACGCTCTGGCCCGATTTCGACGAGCACCATTTCGACGCGGCGCTGGACATG
TTCGCCCGGCGTGAGAGGCGATTCGGTGCCCGTCCCGCCCTCTGA

Upstream 100 bases:

>100_bases
GTCTGACGCGGCAGTGACCGTCAGTCCGGTGCCCGGCCCGCTGGCCGGGACGACAGCATCACTGGTCCCCCCGGCCACGA
CCGCGCCCATTTCGGCGCCC

Downstream 100 bases:

>100_bases
TCCCGTGTCGGGAGGCCGCCCGACGCAGGGAAAGCCTGGACGGAACTGGAAGGACCTTCGCGCCCGCCTGCTGTCGGCCG
CCGTGCTGGTGCCGGTGGCG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTTSGSTAPVSGLDRGRGAPALPAHVAVIMDGNGRWAAARGLPRVAGHRAGAEAVRRCIRAAITRGVGCLTLYAFSSENW
RRTPDEVADLTALLRYYLRHKVAELCREGVRIRIIGDLSRFDADVRDEARRAEDMTAANTRLTLVLALSYGGRADIVQAA
ARVAFAARSGTIDPAELDEALFSRFLLTADVPDPDLIVRTSGECRLSNFLLWQSAYAELVFIETLWPDFDEHHFDAALDM
FARRERRFGARPAL

Sequences:

>Translated_254_residues
MTTSGSTAPVSGLDRGRGAPALPAHVAVIMDGNGRWAAARGLPRVAGHRAGAEAVRRCIRAAITRGVGCLTLYAFSSENW
RRTPDEVADLTALLRYYLRHKVAELCREGVRIRIIGDLSRFDADVRDEARRAEDMTAANTRLTLVLALSYGGRADIVQAA
ARVAFAARSGTIDPAELDEALFSRFLLTADVPDPDLIVRTSGECRLSNFLLWQSAYAELVFIETLWPDFDEHHFDAALDM
FARRERRFGARPAL
>Mature_253_residues
TTSGSTAPVSGLDRGRGAPALPAHVAVIMDGNGRWAAARGLPRVAGHRAGAEAVRRCIRAAITRGVGCLTLYAFSSENWR
RTPDEVADLTALLRYYLRHKVAELCREGVRIRIIGDLSRFDADVRDEARRAEDMTAANTRLTLVLALSYGGRADIVQAAA
RVAFAARSGTIDPAELDEALFSRFLLTADVPDPDLIVRTSGECRLSNFLLWQSAYAELVFIETLWPDFDEHHFDAALDMF
ARRERRFGARPAL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=214, Percent_Identity=35.981308411215, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI45580738, Length=214, Percent_Identity=35.981308411215, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=50, Blast_Score=242, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71993029, Length=217, Percent_Identity=29.9539170506912, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=38.5321100917431, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=217, Percent_Identity=32.258064516129, Blast_Score=108, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18857969, Length=232, Percent_Identity=36.2068965517241, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27956; Mature: 27825

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSGSTAPVSGLDRGRGAPALPAHVAVIMDGNGRWAAARGLPRVAGHRAGAEAVRRCIR
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHCCCCHHHCCCCCHHHHHHHHH
AAITRGVGCLTLYAFSSENWRRTPDEVADLTALLRYYLRHKVAELCREGVRIRIIGDLSR
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHH
FDADVRDEARRAEDMTAANTRLTLVLALSYGGRADIVQAAARVAFAARSGTIDPAELDEA
HCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LFSRFLLTADVPDPDLIVRTSGECRLSNFLLWQSAYAELVFIETLWPDFDEHHFDAALDM
HHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEEHHCCCCCHHHHHHHHHH
FARRERRFGARPAL
HHHHHHHCCCCCCC
>Mature Secondary Structure 
TTSGSTAPVSGLDRGRGAPALPAHVAVIMDGNGRWAAARGLPRVAGHRAGAEAVRRCIR
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHCCCCHHHCCCCCHHHHHHHHH
AAITRGVGCLTLYAFSSENWRRTPDEVADLTALLRYYLRHKVAELCREGVRIRIIGDLSR
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHH
FDADVRDEARRAEDMTAANTRLTLVLALSYGGRADIVQAAARVAFAARSGTIDPAELDEA
HCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LFSRFLLTADVPDPDLIVRTSGECRLSNFLLWQSAYAELVFIETLWPDFDEHHFDAALDM
HHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEEHHCCCCCHHHHHHHHHH
FARRERRFGARPAL
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA