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The map label for this gene is mltA [H]

Identifier: 162147850

GI number: 162147850

Start: 2111186

End: 2112403

Strand: Reverse

Name: mltA [H]

Synonym: GDI_2066

Alternate gene names: 162147850

Gene position: 2112403-2111186 (Counterclockwise)

Preceding gene: 162147851

Following gene: 162147849

Centisome position: 53.56

GC content: 70.53

Gene sequence:

>1218_bases
TTGTCTCATTCCTTCGTGACCAAGATCCTGCGGGGCGCCTCCGCCGGCGCCATTCTCCTGCTATCCGCCTGTGCCGCGAC
CGATCTGGAGGGGACGGGGCAGCCGCTCGCGTTTTCCGACATCAAGGGCTGGGGAAGCGATGAGGCGGTCCGCGCCCTGC
CGGTCTTCCTGGGGGAATGCCGCTATCTGGGCCGCCTGCCGGCCGATGCCGGCCTGGGCGCCGATAGCGGGCGCGGCACG
CATGTCGGCGACTGGCTGCCGGCGTGCCGCGCTGCTGCCGCGCTGCCGACCGGGGACGCCCCGGCGGCCCGGCAGTTCTT
CGAGACATGGTTCCAGCCGGTGCTGACCGCCGGTCAGGCCCTGTTCACCGGCTATTACGAACCGGAAATCCGCGGTTCGC
TGTCGCGTGGCGGCGTGTACCAGACCCCGGTCTATGGCGTGCCAGACGACCTGGTCCGCACCCGCGCCACCGATGGGCGC
ATGGTCACGGGCCGCTGGCAGGGCAGCCAGTTCATGCCGTACTGGACGCGGGCGCAGATCGATGCCGGCGCGCTGGCAGG
CCGCAACCTGGAACTGCTCTGGGTCGCGGACCCTGCCGACCTGTTCTTCCTCCAGATCCAGGGATCGGGTCGTGTCCGCC
TGCCCAGCGGACAGGTGGTACGCCTGGGCTTCGGCGCCAAGAACGGCCAGGAATACGTACCGCTGGGCCGCGTCCTGGTG
CGGCAGGGCGAAATGGATGCGGACGCCGTCAGCATGCAGTCGATCCGCGCCTGGCTGACCGCCCATCCCGACCAGGCCCG
CACGGTGATGGAGGACAATCCGAATTACGTGTTCTTCACCGTGCTGGACCATGTCTATGCCGACCAGGGGGCACCCGGGG
CGCTGGGTGTGCCGCTGACGCCGGGCCGGTCGGTGGCGGTCGACAGGCGGTCGATCCCGCTGGCCTCGCCCGTCTGGGTG
GAAACGACGCTGCCCGGCCCCGCGGGGTCAAGCTGGCAGCGGCTGGTTTTCGCCCAGGATACCGGGACGGATATCCAGGG
GCCGGCGCGGGCCGACCTGTTCATGGGCTGGGGCCCCGACGCCGAACAGACCGCCGGCGCGATGCAGCAGCGGGGCCGGA
CGATTACGTTCGTGCCGCGCCCCGTCGTGGTCATGGAGCCCGCTTCGATGGGCGCCGCCCCCACGGCGAAGATCGTCGGG
ATCGCGGGCGAACCATGA

Upstream 100 bases:

>100_bases
GGCGCGGCATGGCGCCTGGCGGCCAGCCGCAGCGCCTGATCCCTCTGATCCGTCCGCCATCTTTCCTTTCACCCCGTCCG
AAACCTGTCTGGCCTTATCC

Downstream 100 bases:

>100_bases
CCGCCGCCCGCGCCCCGCGAACGCTGCGCTACGCCATCGGGCCGCATCAGCTGGTGCGCGGCGACTGCCTGCGGGTGCTG
CGGCGGATGGACGCGGATTC

Product: membrane-bound lytic murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSHSFVTKILRGASAGAILLLSACAATDLEGTGQPLAFSDIKGWGSDEAVRALPVFLGECRYLGRLPADAGLGADSGRGT
HVGDWLPACRAAAALPTGDAPAARQFFETWFQPVLTAGQALFTGYYEPEIRGSLSRGGVYQTPVYGVPDDLVRTRATDGR
MVTGRWQGSQFMPYWTRAQIDAGALAGRNLELLWVADPADLFFLQIQGSGRVRLPSGQVVRLGFGAKNGQEYVPLGRVLV
RQGEMDADAVSMQSIRAWLTAHPDQARTVMEDNPNYVFFTVLDHVYADQGAPGALGVPLTPGRSVAVDRRSIPLASPVWV
ETTLPGPAGSSWQRLVFAQDTGTDIQGPARADLFMGWGPDAEQTAGAMQQRGRTITFVPRPVVVMEPASMGAAPTAKIVG
IAGEP

Sequences:

>Translated_405_residues
MSHSFVTKILRGASAGAILLLSACAATDLEGTGQPLAFSDIKGWGSDEAVRALPVFLGECRYLGRLPADAGLGADSGRGT
HVGDWLPACRAAAALPTGDAPAARQFFETWFQPVLTAGQALFTGYYEPEIRGSLSRGGVYQTPVYGVPDDLVRTRATDGR
MVTGRWQGSQFMPYWTRAQIDAGALAGRNLELLWVADPADLFFLQIQGSGRVRLPSGQVVRLGFGAKNGQEYVPLGRVLV
RQGEMDADAVSMQSIRAWLTAHPDQARTVMEDNPNYVFFTVLDHVYADQGAPGALGVPLTPGRSVAVDRRSIPLASPVWV
ETTLPGPAGSSWQRLVFAQDTGTDIQGPARADLFMGWGPDAEQTAGAMQQRGRTITFVPRPVVVMEPASMGAAPTAKIVG
IAGEP
>Mature_404_residues
SHSFVTKILRGASAGAILLLSACAATDLEGTGQPLAFSDIKGWGSDEAVRALPVFLGECRYLGRLPADAGLGADSGRGTH
VGDWLPACRAAAALPTGDAPAARQFFETWFQPVLTAGQALFTGYYEPEIRGSLSRGGVYQTPVYGVPDDLVRTRATDGRM
VTGRWQGSQFMPYWTRAQIDAGALAGRNLELLWVADPADLFFLQIQGSGRVRLPSGQVVRLGFGAKNGQEYVPLGRVLVR
QGEMDADAVSMQSIRAWLTAHPDQARTVMEDNPNYVFFTVLDHVYADQGAPGALGVPLTPGRSVAVDRRSIPLASPVWVE
TTLPGPAGSSWQRLVFAQDTGTDIQGPARADLFMGWGPDAEQTAGAMQQRGRTITFVPRPVVVMEPASMGAAPTAKIVGI
AGEP

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=312, Percent_Identity=31.7307692307692, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43124; Mature: 42993

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSFVTKILRGASAGAILLLSACAATDLEGTGQPLAFSDIKGWGSDEAVRALPVFLGEC
CCHHHHHHHHHCCCCCHHHEEHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
RYLGRLPADAGLGADSGRGTHVGDWLPACRAAAALPTGDAPAARQFFETWFQPVLTAGQA
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
LFTGYYEPEIRGSLSRGGVYQTPVYGVPDDLVRTRATDGRMVTGRWQGSQFMPYWTRAQI
HHCCCCCHHHCCCCCCCCEEECCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCEEEECCC
DAGALAGRNLELLWVADPADLFFLQIQGSGRVRLPSGQVVRLGFGAKNGQEYVPLGRVLV
CCHHCCCCCEEEEEEECCCEEEEEEEECCCEEECCCCCEEEEECCCCCCCCCCCHHHHHH
RQGEMDADAVSMQSIRAWLTAHPDQARTVMEDNPNYVFFTVLDHVYADQGAPGALGVPLT
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCCC
PGRSVAVDRRSIPLASPVWVETTLPGPAGSSWQRLVFAQDTGTDIQGPARADLFMGWGPD
CCCCEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCC
AEQTAGAMQQRGRTITFVPRPVVVMEPASMGAAPTAKIVGIAGEP
HHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SHSFVTKILRGASAGAILLLSACAATDLEGTGQPLAFSDIKGWGSDEAVRALPVFLGEC
CHHHHHHHHHCCCCCHHHEEHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
RYLGRLPADAGLGADSGRGTHVGDWLPACRAAAALPTGDAPAARQFFETWFQPVLTAGQA
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
LFTGYYEPEIRGSLSRGGVYQTPVYGVPDDLVRTRATDGRMVTGRWQGSQFMPYWTRAQI
HHCCCCCHHHCCCCCCCCEEECCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCEEEECCC
DAGALAGRNLELLWVADPADLFFLQIQGSGRVRLPSGQVVRLGFGAKNGQEYVPLGRVLV
CCHHCCCCCEEEEEEECCCEEEEEEEECCCEEECCCCCEEEEECCCCCCCCCCCHHHHHH
RQGEMDADAVSMQSIRAWLTAHPDQARTVMEDNPNYVFFTVLDHVYADQGAPGALGVPLT
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCCC
PGRSVAVDRRSIPLASPVWVETTLPGPAGSSWQRLVFAQDTGTDIQGPARADLFMGWGPD
CCCCEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCC
AEQTAGAMQQRGRTITFVPRPVVVMEPASMGAAPTAKIVGIAGEP
HHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]