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The map label for this gene is hemF [H]

Identifier: 162147842

GI number: 162147842

Start: 2102804

End: 2103706

Strand: Direct

Name: hemF [H]

Synonym: GDI_2058

Alternate gene names: 162147842

Gene position: 2102804-2103706 (Clockwise)

Preceding gene: 162147838

Following gene: 162147843

Centisome position: 53.31

GC content: 69.1

Gene sequence:

>903_bases
ATGCCCGAGACCCGCGCGCCCGTCCCCCACGACCTGCTGAAGGCCGAGGCCAGCACCTGGTTCGAAGGGCTGCGCGACCG
GATCTGCGCGGCGTTCGAGCGAATCGAGCAGGATGCCGACAGCGTGCAGGCCCTGCCCGGCCACGCCGCCCCGGGCGCAT
TCCAGCGCACGGCATGGGACCGCACGAATGACGACGGAACCCCCGGCGGCGGCGGCGTCATCAGCCTGATGCGCGGCCGG
GTGTTCGAGAAGGTGGGCGTCAACGTATCCACGGTCGAGGGCACGTTCAGCCCGGAATTCCGCGCCTCGATCCCCGGCGC
CGCCGAGGACCCGCGCTTCTTCGCCACCGGGATCAGCCTGGTCGCCCATATGTGCAATCCGCTGGTCCCGGCCGCGCATT
TCAACACGCGGCTGATCGTCACCACCCAGGGCTGGTTCGGCGGCGGCGGCGACATCACCCCGATGTTCCCCGACAGCGCC
GAGGCCCAGGCCGACGCCGCCCGGTTCCATGCCGGGTTCCGCGCCGCCTGCGACCGGCATGACCCAACCTATTATCCGCG
CTTCAAGGAATGGTGCGACAGATACTTCTTCCTGCCGCACCGGGGCGAGGCGCGCGGCCTGGGGGGCATCTTCTACGACC
GGCTGAACAGCGGGGACGAAGCGGCCGATTTCGCCTTCACCCGGGATGTCGGGCTGGCGTTCCTGGAAACCTATCCGGCC
ATCGTGCGCCACCGCATGGGCGAACGGTGGACGGCCCACCAACGCGAGGCGCAACTGGTCCGGCGCGGCCGCTATGTGGA
ATTCAACCTGCTGCACGATCGCGGCACGCTGTTCGGCCTGAAGACCGGTGGAAATACCGAGGCGATCCTGATGAGTCTTC
CCCCCGAGGTCCGCTGGCCGTAA

Upstream 100 bases:

>100_bases
TTTCGCACTCCTTACCGGGCAGGGGGGGCTTCTTGCAATCGTCCGCGCGAACGGGCACCGGTAGGGCCGTTGCCCCCCAA
TCGCATGAGATGACCCGACC

Downstream 100 bases:

>100_bases
AGTCCCGCACTCGCCGCCGAGGGGGACCCCCGGCACCTGCCATAGACTTGCCCCATTTCGGCGCGACATACGCGCTGCAG
TGGCCCCTGCGTTGGAGATG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MPETRAPVPHDLLKAEASTWFEGLRDRICAAFERIEQDADSVQALPGHAAPGAFQRTAWDRTNDDGTPGGGGVISLMRGR
VFEKVGVNVSTVEGTFSPEFRASIPGAAEDPRFFATGISLVAHMCNPLVPAAHFNTRLIVTTQGWFGGGGDITPMFPDSA
EAQADAARFHAGFRAACDRHDPTYYPRFKEWCDRYFFLPHRGEARGLGGIFYDRLNSGDEAADFAFTRDVGLAFLETYPA
IVRHRMGERWTAHQREAQLVRRGRYVEFNLLHDRGTLFGLKTGGNTEAILMSLPPEVRWP

Sequences:

>Translated_300_residues
MPETRAPVPHDLLKAEASTWFEGLRDRICAAFERIEQDADSVQALPGHAAPGAFQRTAWDRTNDDGTPGGGGVISLMRGR
VFEKVGVNVSTVEGTFSPEFRASIPGAAEDPRFFATGISLVAHMCNPLVPAAHFNTRLIVTTQGWFGGGGDITPMFPDSA
EAQADAARFHAGFRAACDRHDPTYYPRFKEWCDRYFFLPHRGEARGLGGIFYDRLNSGDEAADFAFTRDVGLAFLETYPA
IVRHRMGERWTAHQREAQLVRRGRYVEFNLLHDRGTLFGLKTGGNTEAILMSLPPEVRWP
>Mature_299_residues
PETRAPVPHDLLKAEASTWFEGLRDRICAAFERIEQDADSVQALPGHAAPGAFQRTAWDRTNDDGTPGGGGVISLMRGRV
FEKVGVNVSTVEGTFSPEFRASIPGAAEDPRFFATGISLVAHMCNPLVPAAHFNTRLIVTTQGWFGGGGDITPMFPDSAE
AQADAARFHAGFRAACDRHDPTYYPRFKEWCDRYFFLPHRGEARGLGGIFYDRLNSGDEAADFAFTRDVGLAFLETYPAI
VRHRMGERWTAHQREAQLVRRGRYVEFNLLHDRGTLFGLKTGGNTEAILMSLPPEVRWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=280, Percent_Identity=41.0714285714286, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1788777, Length=253, Percent_Identity=44.2687747035573, Blast_Score=195, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=38.801261829653, Blast_Score=198, Evalue=8e-52,
Organism=Drosophila melanogaster, GI17864388, Length=294, Percent_Identity=43.1972789115646, Blast_Score=220, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33273; Mature: 33141

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETRAPVPHDLLKAEASTWFEGLRDRICAAFERIEQDADSVQALPGHAAPGAFQRTAWD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC
RTNDDGTPGGGGVISLMRGRVFEKVGVNVSTVEGTFSPEFRASIPGAAEDPRFFATGISL
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHCCCCCCCCCCHHHHHHHHH
VAHMCNPLVPAAHFNTRLIVTTQGWFGGGGDITPMFPDSAEAQADAARFHAGFRAACDRH
HHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DPTYYPRFKEWCDRYFFLPHRGEARGLGGIFYDRLNSGDEAADFAFTRDVGLAFLETYPA
CCCCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IVRHRMGERWTAHQREAQLVRRGRYVEFNLLHDRGTLFGLKTGGNTEAILMSLPPEVRWP
HHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
PETRAPVPHDLLKAEASTWFEGLRDRICAAFERIEQDADSVQALPGHAAPGAFQRTAWD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC
RTNDDGTPGGGGVISLMRGRVFEKVGVNVSTVEGTFSPEFRASIPGAAEDPRFFATGISL
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHCCCCCCCCCCHHHHHHHHH
VAHMCNPLVPAAHFNTRLIVTTQGWFGGGGDITPMFPDSAEAQADAARFHAGFRAACDRH
HHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DPTYYPRFKEWCDRYFFLPHRGEARGLGGIFYDRLNSGDEAADFAFTRDVGLAFLETYPA
CCCCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IVRHRMGERWTAHQREAQLVRRGRYVEFNLLHDRGTLFGLKTGGNTEAILMSLPPEVRWP
HHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA